{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:46:34Z","timestamp":1773665194481,"version":"3.50.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25 CA094880"],"award-info":[{"award-number":["R25 CA094880"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R25 CA094880"],"award-info":[{"award-number":["R25 CA094880"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K05 CA154337"],"award-info":[{"award-number":["K05 CA154337"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA094954"],"award-info":[{"award-number":["R01 CA094954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178444","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T13:44:07Z","timestamp":1495719847000},"page":"e0178444","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-2935","authenticated-orcid":true,"given":"Xiaoliang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shojaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Shelley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna W.","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"AM Algra","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1158\/1940-6207.CAPR-11-0107","article-title":"Nonsteroidal anti-inflammatory drug use and risk of adenomatous and hyperplastic polyps","volume":"4","author":"HJ Murff","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(10)61543-7","article-title":"Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials","volume":"376","author":"PM Rothwell","year":"2010","journal-title":"Lancet"},{"key":"ref4","article-title":"Aspirin Use for the Prevention of Colorectal Cancer: An Updated Systematic Evidence Review for the US Preventive Services Task Force","author":"J Chubak","year":"2015"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/jnci\/94.4.252","article-title":"Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues","volume":"94","author":"MJ Thun","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35094017","article-title":"Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2","volume":"1","author":"RA Gupta","year":"2001","journal-title":"Nat Rev Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrc1801","article-title":"Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics","volume":"6","author":"CM Ulrich","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1038\/sj.onc.1209658","article-title":"Effect of aspirin on the Wnt\/beta-catenin pathway is mediated via protein phosphatase 2A","volume":"25","author":"CL Bos","year":"2006","journal-title":"Oncogene"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.cellsig.2008.02.004","article-title":"Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras\/c-Raf interaction and activation of MAP kinase phosphatases","volume":"20","author":"MR Pan","year":"2008","journal-title":"Cell Signal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/jnci\/djt331","article-title":"Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations","volume":"105","author":"H Nan","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/carcin\/bgs296","article-title":"IkappaBKbeta and NFkappaB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry","volume":"34","author":"BL Seufert","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/1471-2407-10-484","article-title":"Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes","volume":"10","author":"V Andersen","year":"2010","journal-title":"BMC Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1001\/jama.2015.1815","article-title":"Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants","volume":"313","author":"H Nan","year":"2015","journal-title":"JAMA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/apt.12807","article-title":"Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer","volume":"40","author":"V Andersen","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1755-8794-3-5","article-title":"Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study","volume":"3","author":"MJ van Erk","year":"2010","journal-title":"BMC Med Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e0117534","DOI":"10.1371\/journal.pone.0117534","article-title":"Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans","volume":"10","author":"S Navarro","year":"2015","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1074\/mcp.M900496-MCP200","article-title":"Use of a single-chain antibody library for ovarian cancer biomarker discovery","volume":"9","author":"AB Ramirez","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molonc.2007.08.004","article-title":"Use of high density antibody arrays to validate and discover cancer serum biomarkers","volume":"1","author":"CM Loch","year":"2007","journal-title":"Mol Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10549-015-3554-5","article-title":"Candidate early detection protein biomarkers for ER+\/PR+ invasive ductal breast carcinoma identified using pre-clinical plasma from the WHI observational study","volume":"153","author":"MF Buas","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1158\/1078-0432.CCR-13-3474","article-title":"Cross-species antibody microarray interrogation identifies a 3-protein panel of plasma biomarkers for early diagnosis of pancreas cancer","volume":"21","author":"JE Mirus","year":"2015","journal-title":"Clin Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1074\/mcp.M113.036517","article-title":"Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine\/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease","volume":"13","author":"JE Mirus","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"ref22","article-title":"Protein and glycomic plasma markers for early detection of adenoma and colon cancer","author":"JH Rho","year":"2016","journal-title":"Gut"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1021\/acs.jproteome.6b00611","article-title":"Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity","volume":"16","author":"CB Garrison","year":"2017","journal-title":"J Proteome Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.surg.2016.08.025","article-title":"Discovery of novel plasma proteins as biomarkers for the development of incisional hernias after midline incision in patients with colorectal cancer: The ColoCare study","volume":"161","author":"J Bohm","year":"2017","journal-title":"Surgery"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12881-015-0161-6","article-title":"Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial","volume":"16","author":"SS Thomas","year":"2015","journal-title":"BMC Med Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1158\/1055-9965.EPI-15-0697","article-title":"Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial","volume":"25","author":"DB Liesenfeld","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000327782","article-title":"Determinants of aspirin metabolism in healthy men and women: effects of dietary inducers of UDP-glucuronosyltransferases","volume":"4","author":"SL Navarro","year":"2011","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1021\/pr4001674","article-title":"High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays","volume":"12","author":"JH Rho","year":"2013","journal-title":"J Proteome Res"},{"key":"ref29","first-page":"397","article-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","author":"GK Smyth","year":"2005"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10549-012-2204-4","article-title":"Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study","volume":"135","author":"CI Li","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/CBM-2011-0215","article-title":"Discovery and validation of ovarian cancer biomarkers utilizing high density antibody microarrays","volume":"8","author":"AB Ramirez","year":"2010","journal-title":"Cancer Biomark"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2466\/pr0.1966.19.1.3","article-title":"The intraclass correlation coefficient as a measure of reliability","volume":"19","author":"JJ Bartko","year":"1966","journal-title":"Psychol Rep"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/bioinformatics\/bth499","article-title":"Missing value estimation for DNA microarray gene expression data: local least squares imputation","volume":"21","author":"H Kim","year":"2005","journal-title":"Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/bioinformatics\/bti260","article-title":"Significance analysis of functional categories in gene expression studies: a structured permutation approach","volume":"21","author":"WT Barry","year":"2005","journal-title":"Bioinformatics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1093\/nar\/gks461","article-title":"Camera: a competitive gene set test accounting for inter-gene correlation","volume":"40","author":"D Wu","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1198\/jasa.2011.ap10599","article-title":"A regularized Hotelling's test for pathway analysis in proteomic studies","volume":"106","author":"LS Chen","year":"2011","journal-title":"J Am Stat Assoc"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2014.02.023","article-title":"Mitochondrial dysfunctions in cancer: genetic defects and oncogenic signaling impinging on TCA cycle activity","volume":"356","author":"E Desideri","year":"2015","journal-title":"Cancer Lett"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.1079605","article-title":"Architecture of succinate dehydrogenase and reactive oxygen species generation","volume":"299","author":"V Yankovskaya","year":"2003","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1042\/bj0360706","article-title":"The effect of salicylate and cinchophen on enzymes and metabolic processes","volume":"36","author":"C Lutwak-Mann","year":"1942","journal-title":"Biochem J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0003-9861(54)90452-X","article-title":"Effects of salicylate and other benzoates on oxidative enzymes of the tricarboxylic acid cycle in rat tissue homogenates","volume":"51","author":"EH Kaplan","year":"1954","journal-title":"Arch Biochem Biophys"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/exnr.1996.0042","article-title":"Mitochondrial oxidation in rat hippocampus can be preconditioned by selective chemical inhibition of succinic dehydrogenase","volume":"138","author":"MW Riepe","year":"1996","journal-title":"Exp Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/01.STR.28.10.2006","article-title":"Acetylsalicylic acid increases tolerance against hypoxic and chemical hypoxia","volume":"28","author":"MW Riepe","year":"1997","journal-title":"Stroke"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"AJ Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature10898","article-title":"Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation","volume":"483","author":"P Koivunen","year":"2012","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1124\/dmd.105.005652","article-title":"Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes","volume":"34","author":"GE Kuehl","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1128\/jb.178.13.3885-3892.1996","article-title":"Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage","volume":"178","author":"MM Slupska","year":"1996","journal-title":"J Bacteriol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0960-9822(02)00686-3","article-title":"Replication-associated repair of adenine:8-oxoguanine mispairs by MYH","volume":"12","author":"H Hayashi","year":"2002","journal-title":"Curr Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/ng828","article-title":"Inherited variants of MYH associated with somatic G:C\u2014>T:A mutations in colorectal tumors","volume":"30","author":"N Al-Tassan","year":"2002","journal-title":"Nat Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gcc.20011","article-title":"Role of inherited defects of MYH in the development of sporadic colorectal cancer","volume":"40","author":"T Kambara","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1053\/j.gastro.2008.12.050","article-title":"Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study","volume":"136","author":"SP Cleary","year":"2009","journal-title":"Gastroenterology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2014.01.022","article-title":"Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer","volume":"146","author":"AK Win","year":"2014","journal-title":"Gastroenterology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/sj.bjc.6603421","article-title":"The role of MYH and microsatellite instability in the development of sporadic colorectal cancer","volume":"95","author":"A Colebatch","year":"2006","journal-title":"Br J Cancer"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.200510155","article-title":"IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression","volume":"173","author":"JD Kearns","year":"2006","journal-title":"J Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.canlet.2003.08.029","article-title":"The IKK\/NF-kappaB activation pathway-a target for prevention and treatment of cancer","volume":"206","author":"FR Greten","year":"2004","journal-title":"Cancer Lett"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2005.04.003","article-title":"Inflammation-associated cancer: NF-kappaB is the lynchpin","volume":"26","author":"Q Li","year":"2005","journal-title":"Trends Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1084\/jem.20142009","article-title":"Functional loss of IkappaBepsilon leads to NF-kappaB deregulation in aggressive chronic lymphocytic leukemia","volume":"212","author":"L Mansouri","year":"2015","journal-title":"J Exp Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ng.3382","article-title":"Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway","volume":"47","author":"AH Shain","year":"2015","journal-title":"Nat Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/23948","article-title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta","volume":"396","author":"MJ Yin","year":"1998","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1245\/s10434-011-1567-9","article-title":"Msi-1 is a predictor of survival and a novel therapeutic target in colon cancer","volume":"18","author":"D Li","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1211\/jpp.61.11.0010","article-title":"Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome","volume":"61","author":"XR Gao","year":"2009","journal-title":"J Pharm Pharmacol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0002-9149(03)00897-X","article-title":"Influence of aspirin on inflammatory markers in patients after acute myocardial infarction","volume":"92","author":"S Solheim","year":"2003","journal-title":"Am J Cardiol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.100.8.793","article-title":"Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin","volume":"100","author":"I Ikonomidis","year":"1999","journal-title":"Circulation"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1096\/fj.201500150R","article-title":"Human plasma platelet-derived exosomes: effects of aspirin","volume":"30","author":"EJ Goetzl","year":"2016","journal-title":"FASEB J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:08:28Z","timestamp":1569370108000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178444"}},"subtitle":[],"editor":[{"given":"Hong-Liang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178444","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]}}}