{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:56Z","timestamp":1788449336783,"version":"build-2803163510"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01KX1012"],"award-info":[{"award-number":["01KX1012"]}]},{"name":"Translational and Clinical Projects Fund of the Helmholtz Center Munich"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178563","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T17:48:39Z","timestamp":1496339319000},"page":"e0178563","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma"],"prefix":"10.1371","volume":"12","author":[{"given":"Antonio","family":"Aguilar-Pimentel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Graessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Alessandrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gailus-Durner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Russkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Chaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ollert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-1078","authenticated-orcid":true,"given":"Simon","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gutermuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten B.","family":"Schmidt-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"issue":"8","key":"ref1","first-page":"CD001186","article-title":"Injection allergen immunotherapy for asthma","author":"MJ Abramson","year":"2010","journal-title":"The Cochrane database of systematic reviews"},{"issue":"1","key":"ref2","first-page":"CD001936","article-title":"Allergen injection immunotherapy for seasonal allergic rhinitis","author":"MA Calderon","year":"2007","journal-title":"The Cochrane database of systematic reviews"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2217\/imt.12.154","article-title":"Long-term efficacy of allergen immunotherapy: what do we expect?","volume":"5","author":"F Frati","year":"2013","journal-title":"Immunotherapy"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1710-1492-7-S1-S5","article-title":"Allergen-specific immunotherapy","volume":"7","author":"W Moote","year":"2011","journal-title":"Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1468-3083.2012.04636.x","article-title":"Guidelines for treatment of atopic eczema (atopic dermatitis) Part II","volume":"26","author":"J Ring","year":"2012","journal-title":"Journal of the European Academy of Dermatology and Venereology: JEADV"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.iac.2007.03.008","article-title":"Insect sting anaphylaxis","volume":"27","author":"DB Golden","year":"2007","journal-title":"Immunology and allergy clinics of North America"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40413-015-0063-2","article-title":"Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens","volume":"8","author":"CA Akdis","year":"2015","journal-title":"The World Allergy Organization journal"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.iac.2015.08.009","article-title":"The Use of Adjuvants for Enhancing Allergen Immunotherapy Efficacy","volume":"36","author":"J Chesne","year":"2016","journal-title":"Immunology and allergy clinics of North America"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/187152806775269321","article-title":"Immunological mechanisms of specific allergen immunotherapy","volume":"5","author":"CB Schmidt-Weber","year":"2006","journal-title":"Inflammation & allergy drug targets"},{"issue":"1\u20132","key":"ref10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cellimm.2013.06.014","article-title":"Antigen specific immunotherapy generates CD27(+) CD35(+) tolerogenic dendritic cells","volume":"283","author":"Z Wu","year":"2013","journal-title":"Cellular immunology"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.jaci.2008.03.013","article-title":"Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa","volume":"121","author":"S Radulovic","year":"2008","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2013.12.1088","article-title":"Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens","volume":"133","author":"M Akdis","year":"2014","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pbio.0050329","article-title":"GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells","volume":"5","author":"PY Mantel","year":"2007","journal-title":"PLoS biology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.22414","article-title":"Proinflammatory mediator-induced reversal of CD4+, CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis","volume":"56","author":"JM van Amelsfort","year":"2007","journal-title":"Arthritis and rheumatism"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1016\/j.transproceed.2009.08.043","article-title":"Inhibitory effects of cyclosporine on human regulatory T cells in vitro","volume":"41","author":"C Miroux","year":"2009","journal-title":"Transplantation proceedings"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jaci.2004.04.048","article-title":"Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism","volume":"114","author":"X Dao Nguyen","year":"2004","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jaci.2004.07.014","article-title":"Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma","volume":"114","author":"C Karagiannidis","year":"2004","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1600-6143.2010.03200.x","article-title":"The Jak inhibitor CP-690,550 preserves the function of CD4CD25FoxP3 regulatory T cells and inhibits effector T cells","volume":"10","author":"VD Sewgobind","year":"2010","journal-title":"American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: impact on human disease and therapeutic intervention","volume":"66","author":"JJ O'Shea","year":"2015","journal-title":"Annual review of medicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.phrs.2016.07.038","article-title":"Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases","volume":"111","author":"R Roskoski Jr","year":"2016","journal-title":"Pharmacological research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1471-2474-14-298","article-title":"Efficacy and safety of tofacitinib in the treatment of rheumatoid arthritis: a systematic review and meta-analysis","volume":"14","author":"Y He","year":"2013","journal-title":"BMC musculoskeletal disorders"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1164\/rccm.200902-0190OC","article-title":"Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype","volume":"181","author":"JA Aguilar-Pimentel","year":"2010","journal-title":"American journal of respiratory and critical care medicine"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ymeth.2010.08.006","article-title":"Mouse phenotyping","volume":"53","author":"H Fuchs","year":"2011","journal-title":"Methods"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nmeth0605-403","article-title":"Introducing the German Mouse Clinic: open access platform for standardized phenotyping","volume":"2","author":"V Gailus-Durner","year":"2005","journal-title":"Nature methods"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jaci.2005.11.046","article-title":"Effects of ultrafine carbon particle inhalation on allergic inflammation of the lung","volume":"117","author":"F Alessandrini","year":"2006","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.2353\/ajpath.2009.080987","article-title":"Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications","volume":"174","author":"S Andre","year":"2009","journal-title":"The American journal of pathology"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2004.02.041","article-title":"Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model","volume":"113","author":"JL Vissers","year":"2004","journal-title":"The Journal of allergy and clinical immunology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-9255-7-41","article-title":"Anti-inflammatory activity and neutrophil reductions mediated by the JAK1\/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis","volume":"7","author":"DM Meyer","year":"2010","journal-title":"Journal of inflammation"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jaci.2013.10.036","article-title":"Janus kinase 1\/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses","volume":"133","author":"S Ashino","year":"2014","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01535075","article-title":"The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11","volume":"15","author":"JS Lee","year":"1989","journal-title":"Somatic cell and molecular genetics"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.1101270","article-title":"Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity","volume":"188","author":"M Ikutani","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4049\/jimmunol.162.1.238","article-title":"IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement","volume":"162","author":"CB Schmidt-Weber","year":"1999","journal-title":"Journal of immunology"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.4049\/jimmunol.0903909","article-title":"Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice","volume":"185","author":"S Shirinbak","year":"2010","journal-title":"Journal of immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2016.10.005","article-title":"Impact of tofacitinib treatment on human B-cells in vitro and in vivo","volume":"77","author":"M Rizzi","year":"2017","journal-title":"Journal of autoimmunity"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/09680519020080060501","article-title":"Modulating macrophage function with IgG immune complexes","volume":"8","author":"CF Anderson","year":"2002","journal-title":"J Endotoxin Res"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.imlet.2010.07.004","article-title":"The influence of IgG density and macrophage Fc (gamma) receptor cross-linking on phagocytosis and IL-10 production","volume":"133","author":"P Gallo","year":"2010","journal-title":"Immunology letters"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1124\/dmd.113.054940","article-title":"The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans","volume":"42","author":"ME Dowty","year":"2014","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"e85463","DOI":"10.1371\/journal.pone.0085463","article-title":"Fate of lymphocytes after withdrawal of tofacitinib treatment","volume":"9","author":"E Piscianz","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/cei.12234","article-title":"Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis","volume":"175","author":"K Migita","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/jid.2013.476","article-title":"Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib","volume":"134","author":"N Okiyama","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.4049\/jimmunol.176.6.3593","article-title":"Molecular mechanisms underlying FOXP3 induction in human T cells","volume":"176","author":"PY Mantel","year":"2006","journal-title":"Journal of immunology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5021537","DOI":"10.1155\/2016\/5021537","article-title":"Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17\/Treg Balance","volume":"2016","author":"Y Zhou","year":"2016","journal-title":"Journal of immunology research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:34:05Z","timestamp":1692826445000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178563"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178563","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]}}}