{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:18Z","timestamp":1790270778195,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["81260250, 81401679"],"award-info":[{"award-number":["81260250, 81401679"]}]},{"name":"Special Founds for the Cultivation of Outstanding Youth Talents of Science and Technology in Guizhou Province","award":["Qian Ke He Ren Word [2015] 09"],"award-info":[{"award-number":["Qian Ke He Ren Word [2015] 09"]}]},{"name":"Special Funds for High-Level Creative Talents Cultivation Guizhou Province","award":["Qian Ke He (2016)4021"],"award-info":[{"award-number":["Qian Ke He (2016)4021"]}]},{"name":"Special Funds for Construction of Talent Base for Infectious Disease Control and Prevention","award":["Qian Ren Ling Fa [2013] 15"],"award-info":[{"award-number":["Qian Ren Ling Fa [2013] 15"]}]},{"name":"State Scholarship Fund from China Scholarship Council","award":["201408525061"],"award-info":[{"award-number":["201408525061"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178618","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T17:47:10Z","timestamp":1496425630000},"page":"e0178618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of reactive oxygen intermediates in the intracellular fate of Leptospira interrogans in the macrophages of different hosts"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-6301","authenticated-orcid":true,"given":"Shijun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangpeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"AR Bharti","year":"2003","journal-title":"The Lancet Infectious diseases"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2008.07.005","article-title":"Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil","volume":"108","author":"MT de Faria","year":"2008","journal-title":"Acta Trop"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","article-title":"Leptospirosis","volume":"14","author":"PN Levett","year":"2001","journal-title":"Clinical microbiology reviews"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"e0005117","DOI":"10.1371\/journal.pntd.0005117","article-title":"High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection","volume":"10","author":"K Lourdault","year":"2016","journal-title":"PLoS neglected tropical diseases"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-3156.2008.02028.x","article-title":"Detection and modelling of case clusters for urban leptospirosis","volume":"13","author":"WS Tassinari","year":"2008","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"e0003898","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global Morbidity and Mortality of Leptospirosis: A Systematic Review","volume":"9","author":"F Costa","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.4049\/jimmunol.175.9.6022","article-title":"Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells","volume":"175","author":"MA Nahori","year":"2005","journal-title":"Journal of immunology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/IAI.74.2.887-895.2006","article-title":"Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden","volume":"74","author":"S Viriyakosol","year":"2006","journal-title":"Infection and immunity"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.qco.0000178824.05715.2c","article-title":"Leptospirosis","volume":"18","author":"AJ McBride","year":"2005","journal-title":"Current opinion in infectious diseases"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1354\/vp.08-VP-0265-N-REV","article-title":"Review paper: Host-pathogen interactions in the kidney during chronic leptospirosis","volume":"46","author":"AM Monahan","year":"2009","journal-title":"Veterinary pathology"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1371\/journal.pntd.0000463","article-title":"Leptospira interrogans stably infects zebrafish embryos, altering phagocyte behavior and homing to specific tissues","volume":"3","author":"JM Davis","year":"2009","journal-title":"PLoS neglected tropical diseases"},{"issue":"10","key":"ref12","first-page":"1642","article-title":"p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species","volume":"15","author":"W Hu","year":"2013","journal-title":"Cellular microbiology"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/1753425909105580","article-title":"Replication or death: distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin","volume":"16","author":"S Li","year":"2010","journal-title":"Innate Immun"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1128\/IAI.68.6.3587-3593.2000","article-title":"Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages","volume":"68","author":"PA Darrah","year":"2000","journal-title":"Infection and immunity"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/AAC.48.6.2132-2139.2004","article-title":"Interaction of antimycobacterial drugs with the anti-Mycobacterium avium complex effects of antimicrobial effectors, reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids produced by macrophages","volume":"48","author":"K Sano","year":"2004","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.4049\/jimmunol.171.10.5447","article-title":"Localized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages","volume":"171","author":"JT Myers","year":"2003","journal-title":"Journal of immunology"},{"issue":"16","key":"ref17","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","article-title":"Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens","volume":"97","author":"C Nathan","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.micinf.2004.11.020","article-title":"The contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophages","volume":"7","author":"H Lindgren","year":"2005","journal-title":"Microbes and infection \/ Institut Pasteur"},{"issue":"19","key":"ref19","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.3748\/wjg.v12.i19.3077","article-title":"Production of reactive oxygen species and expression of inducible nitric oxide synthase in rat isolated Kupffer cells stimulated by Leptospira interrogans and Borrelia burgdorferi","volume":"12","author":"A Marangoni","year":"2006","journal-title":"World journal of gastroenterology"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00203-007-0280-3","article-title":"Comparison of invasion of fibroblasts and macrophages by high- and low-virulence Leptospira strains: colonization of the host-cell nucleus and induction of necrosis by the virulent strain","volume":"188","author":"L Li","year":"2007","journal-title":"Arch Microbiol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1128\/IAI.65.2.729-738.1997","article-title":"Invasion of Vero cells and induction of apoptosis in macrophages by pathogenic Leptospira interrogans are correlated with virulence","volume":"65","author":"F Merien","year":"1997","journal-title":"Infection and immunity"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.4049\/jimmunol.174.9.5687","article-title":"Mycobacteria inhibition of IFN-gamma induced HLA-DR gene expression by up-regulating histone deacetylation at the promoter region in human THP-1 monocytic cells","volume":"174","author":"Y Wang","year":"2005","journal-title":"Journal of immunology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1128\/IAI.00914-08","article-title":"Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways","volume":"77","author":"D Jin","year":"2009","journal-title":"Infection and immunity"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ddr.21321","article-title":"Apocynin Suppresses Lipopolysaccharide-Induced Inflammatory Responses Through the Inhibition of MAP Kinase Signaling Pathway in RAW264.7 Cells","volume":"77","author":"YJ Hwang","year":"2016","journal-title":"Drug development research"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1128\/IAI.05443-11","article-title":"The CovS\/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages","volume":"80","author":"NJ Cumley","year":"2012","journal-title":"Infection and immunity"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10495-014-0993-0","article-title":"Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid","volume":"19","author":"Q Qiu","year":"2014","journal-title":"Apoptosis: an international journal on programmed cell death"},{"issue":"1\u20132","key":"ref27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-8981(99)00246-6","article-title":"A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)","volume":"293","author":"AV Peskin","year":"2000","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00430-007-0047-0","article-title":"Pathogenesis of leptospirosis: interaction of Leptospira interrogans with in vitro cultured mammalian cells","volume":"196","author":"Y Liu","year":"2007","journal-title":"Medical microbiology and immunology"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/IAI.68.3.1005-1013.2000","article-title":"Differential bacterial survival, replication, and apoptosis-inducing ability of Salmonella serovars within human and murine macrophages","volume":"68","author":"WR Schwan","year":"2000","journal-title":"Infection and immunity"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1128\/IAI.73.6.3702-3713.2005","article-title":"Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytes","volume":"73","author":"BH Bellaire","year":"2005","journal-title":"Infection and immunity"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.4049\/jimmunol.169.8.4488","article-title":"Coxiella burnetii survival in THP-1 monocytes involves the impairment of phagosome maturation: IFN-gamma mediates its restoration and bacterial killing","volume":"169","author":"E Ghigo","year":"2002","journal-title":"Journal of immunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2180-6-92","article-title":"Use of CFSE staining of borreliae in studies on the interaction between borreliae and human neutrophils","volume":"6","author":"H Tuominen-Gustafsson","year":"2006","journal-title":"BMC microbiology"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1128\/IAI.46.3.809-813.1984","article-title":"Role of specific antibody in interaction of leptospires with human monocytes and monocyte-derived macrophages","volume":"46","author":"B Wang","year":"1984","journal-title":"Infection and immunity"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12177","DOI":"10.1038\/ncomms12177","article-title":"Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution","volume":"7","author":"B Luo","year":"2016","journal-title":"Nature communications"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1128\/IAI.63.5.1876-1886.1995","article-title":"Intracellular killing of Listeria monocytogenes in the J774.1 macrophage-like cell line and the lipopolysaccharide (LPS)-resistant mutant LPS1916 cell line defective in the generation of reactive oxygen intermediates after LPS treatment","volume":"63","author":"S Inoue","year":"1995","journal-title":"Infection and immunity"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0891-5849(00)00470-6","article-title":"Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress","volume":"30","author":"R Ogawa","year":"2001","journal-title":"Free radical biology & medicine"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1074-7613(00)80004-7","article-title":"Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase","volume":"10","author":"MU Shiloh","year":"1999","journal-title":"Immunity"},{"issue":"21","key":"ref38","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/18.21.6027","article-title":"p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2","volume":"18","author":"PF Li","year":"1999","journal-title":"The EMBO journal"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1369-5274(02)00286-2","article-title":"A phagosome of one's own: a microbial guide to life in the macrophage","volume":"5","author":"AO Amer","year":"2002","journal-title":"Current opinion in microbiology"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1128\/IAI.71.10.5940-5950.2003","article-title":"An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells","volume":"71","author":"I Golovliov","year":"2003","journal-title":"Infection and immunity"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T09:57:28Z","timestamp":1602237448000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178618"}},"subtitle":[],"editor":[{"given":"Yung-Fu","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178618","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}