{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:36:04Z","timestamp":1770136564644,"version":"3.49.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178711","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T13:49:25Z","timestamp":1496411365000},"page":"e0178711","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage"],"prefix":"10.1371","volume":"12","author":[{"given":"Arttu","family":"Kurtelius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roope A.","family":"Kallionp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Huttunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terhi J.","family":"Huttunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katariina","family":"Helin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhana","family":"Fr\u00f6sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"von und zu Fraunberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirkku","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-7667","authenticated-orcid":true,"given":"Antti E.","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"ref1","article-title":"Molecular and cellular biology","author":"M Upadhyaya","year":"2012"},{"key":"ref2","first-page":"575","article-title":"Neurofibromatosis. Conference statement. National institutes of health consensus development conference","volume":"45","author":"D Stumpf","year":"1988","journal-title":"Arch Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.ajpath.2010.12.056","article-title":"The pathoetiology of neurofibromatosis 1","volume":"178","author":"E Jouhilahti","year":"2011","journal-title":"Am J Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1212\/01.WNL.0000150544.00016.69","article-title":"Cerebrovascular abnormalities in a population of children with neurofibromatosis type 1","volume":"64","author":"T Rosser","year":"2005","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/jnnp.2007.136457","article-title":"Cerebrovascular dysplasia in neurofibromatosis type 1","volume":"79","author":"AG Cairns","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ajmg.a.30475","article-title":"Frequency of incidental intracranial aneurysms in neurofibromatosis type 1","volume":"134A","author":"WI Schievink","year":"2005","journal-title":"Am J Med Genet A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jvs.2007.03.055","article-title":"Vascular abnormalities in patients with neurofibromatosis syndrome type I: Clinical spectrum, management, and results","volume":"46","author":"GS Oderich","year":"2007","journal-title":"J Vasc Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1474-4422(14)70063-8","article-title":"Neurofibromatosis type 1: A multidisciplinary approach to care","volume":"13","author":"AC Hirbe","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1161\/hs1101.098329","article-title":"Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms: Autopsy study and review of the literature","volume":"32","author":"JE Conway","year":"2001","journal-title":"Stroke"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3174\/ajnr.A4718","article-title":"Prevalence of intracranial aneurysms in patients with connective tissue diseases: A retrospective study","volume":"37","author":"ST Kim","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/STROKEAHA.115.011406","article-title":"Increased risk of cerebrovascular disease among patients with neurofibromatosis type 1: Population-based approach","volume":"47","author":"AR Terry","year":"2016","journal-title":"Stroke"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis","volume":"10","author":"MH Vlak","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1161\/01.STR.0000190838.02954.e8","article-title":"Risk factors for subarachnoid hemorrhage: An updated systematic review of epidemiological studies","volume":"36","author":"VL Feigin","year":"2005","journal-title":"Stroke"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e1004134","DOI":"10.1371\/journal.pgen.1004134","article-title":"High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms","volume":"10","author":"MI Kurki","year":"2014","journal-title":"PLoS Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1212\/WNL.0000000000001643","article-title":"Epilepsy after aneurysmal subarachnoid hemorrhage: A population-based, long-term follow-up study","volume":"84","author":"J Huttunen","year":"2015","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/jid.2014.465","article-title":"Incidence and mortality of neurofibromatosis: A total population study in Finland","volume":"135","author":"E Uusitalo","year":"2015","journal-title":"J Invest Dermatol"},{"key":"ref17","unstructured":"Statistics Finland. Preliminary population statistics [e-publication]. Official Statistics of Finland (OSF);ISSN = 2243\u20133627:7.3.2016."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1227\/01.NEU.0000367634.89384.4B","article-title":"Saccular intracranial aneurysm disease: Distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern finnish patients","volume":"66","author":"T Huttunen","year":"2010","journal-title":"Neurosurgery"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/07853890.2014.883168","article-title":"Hypertension predisposes to the formation of saccular intracranial aneurysms in 467 unruptured and 1053 ruptured patients in eastern finland","volume":"46","author":"AE Lindgren","year":"2014","journal-title":"Ann Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1474-4422(14)70015-8","article-title":"Unruptured intracranial aneurysms: Epidemiology, natural history, management options, and familial screening","volume":"13","author":"RD Brown Jr","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e476","DOI":"10.1542\/peds.2009-0152","article-title":"Cerebral arteriopathy in children with neurofibromatosis type 1","volume":"124","author":"D Rea","year":"2009","journal-title":"Pediatrics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0883073812448531","article-title":"Spectrum and prevalence of vasculopathy in pediatric neurofibromatosis type 1","volume":"28","author":"B Kaas","year":"2013","journal-title":"J Child Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/0883073812441059","article-title":"Cerebral vasculopathy in children with neurofibromatosis type 1","volume":"28","author":"PS Ghosh","year":"2013","journal-title":"J Child Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pjnns.2013.05.002","article-title":"Circle of willis abnormalities in children with neurofibromatosis type 1","volume":"48","author":"M Bekiesi\u0144ska-Figatowska","year":"2014","journal-title":"Neurol Neurochir Pol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4103\/0976-9668.160029","article-title":"Giant malignant peripheral nerve sheath tumor with cauda equina syndrome and subarachnoid hemorrhage: Complications in a case of type 1 neurofibromatosis","volume":"6","author":"TB Patil","year":"2015","journal-title":"J Nat Sci Biol Med"},{"key":"ref26","first-page":"135","article-title":"Giant thrombosed intracavernous carotid artery aneurysm presenting as Tolosa-Hunt syndrome in a patient harboring a new pathogenic neurofibromatosis type 1 mutation: A case report and review of the literature","volume":"10","author":"R Conforti","year":"2014","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3171\/2010.12.JNS101589","article-title":"Chronic spontaneous diploic hematoma","volume":"114","author":"J Gonzalez-Tortosa","year":"2011","journal-title":"J Neurosurg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5469\/neuroint.2011.6.1.34","article-title":"Intracranial and extracranial fusiform aneurysms in a patient with neurofibromatosis type 1: A case report","volume":"6","author":"MW You","year":"2011","journal-title":"Neurointervention"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3171\/2011.7.PEDS11151","article-title":"Intracerebral malignant peripheral nerve sheath tumor in a child with neurofibromatosis type 1 and middle cerebral artery aneurysm treated with endovascular coil embolization","volume":"8","author":"MJ Ellis","year":"2011","journal-title":"J Neurosurg Pediatr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0028-3886.16415","article-title":"Cerebral aneurysms associated with von recklinghausen&apos;s neurofibromatosis: Report of a case and review of the literature","volume":"53","author":"J Baldauf","year":"2005","journal-title":"Neurol India"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2169\/internalmedicine.40.948","article-title":"Neurofibromatosis type 1 with basilar artery fusiform aneurysm manifesting wallenberg&apos;s syndrome","volume":"40","author":"Y Mitsui","year":"2001","journal-title":"Intern Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0090-3019(97)00376-5","article-title":"Cerebral aneurysm associated with von Recklinghausen&apos;s neurofibromatosis: A case report","volume":"50","author":"JZ Zhao","year":"1998","journal-title":"Surg Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/jmg.37.8.632","article-title":"Epidemiology of neurofibromatosis type 1 (NF1) in Northern Finland","volume":"37","author":"M P\u00f6yh\u00f6nen","year":"2000","journal-title":"J Med Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ajmg.a.33139","article-title":"Birth incidence and prevalence of tumor-prone syndromes: Estimates from a UK family genetic register service","volume":"152A","author":"DG Evans","year":"2010","journal-title":"Am J Med Genet A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrneurol.2015.228","article-title":"Controversies in epidemiology of intracranial aneurysms and SAH","volume":"12","author":"M Korja","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/nbdi.1995.0002","article-title":"Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle","volume":"2","author":"KK Norton","year":"1995","journal-title":"Neurobiol Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/1531003506296488","article-title":"Neurofibromatosis type 1: From presentation and diagnosis to vascular and endovascular therapy","volume":"18","author":"KT Delis","year":"2006","journal-title":"Perspect Vasc Surg Endovasc Ther"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00401-011-0939-3","article-title":"Saccular intracranial aneurysm: pathology and mechanisms","volume":"123","author":"J Fr\u00f6sen","year":"2012","journal-title":"Acta Neuropathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00467-015-3191-6","article-title":"High prevalence of elevated blood pressure among children with neurofibromatosis type 1","volume":"31","author":"T Dubov","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"ref40","first-page":"113","article-title":"Finnish health and social welfare registers in epidemiological research","volume":"14","author":"M Gissler","year":"2004","journal-title":"Norsk Epidemiologi"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T09:52:04Z","timestamp":1569405124000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178711"}},"subtitle":[],"editor":[{"given":"Stephan","family":"Meckel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178711","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}