{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:27:15Z","timestamp":1778225235348,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Se837\/6-2"],"award-info":[{"award-number":["Se837\/6-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Ha1755\/10-1"],"award-info":[{"award-number":["Ha1755\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Open Access Publishing Fund of University of T\u00fcbingen"],"award-info":[{"award-number":["Open Access Publishing Fund of University of T\u00fcbingen"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["GRK 1874"],"award-info":[{"award-number":["GRK 1874"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178753","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T17:50:16Z","timestamp":1496425816000},"page":"e0178753","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-8072","authenticated-orcid":true,"given":"Susanne C.","family":"Beck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vithiyanjali","family":"Sothilingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Garcia Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyazi","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenliang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Seebauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Hammes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias W.","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1172\/JCI42142","article-title":"Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life","volume":"120","author":"P Sapieha","year":"2010","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/db10-0454","article-title":"Diabetic retinopathy: targeting vasoregression","volume":"60","author":"H-P Hammes","year":"2011","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng0692-199","article-title":"Isolation of a candidate gene for Norrie disease by positional cloning","author":"W Berger","year":"1992","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1755-3768.1975.tb01156.x","article-title":"Norrie&apos;s disease\u2014differential diagnosis and treatment","author":"M Warburg","year":"1975","journal-title":"Acta Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng1093-180","article-title":"A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy","volume":"5","author":"ZY Chen","year":"1993","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archopht.1997.01100150653015","article-title":"Identification of Missense Mutations in the Norrie Disease Gene Associated With Advanced Retinopathy of Prematurity","volume":"115","author":"BS Shastry","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/hmg\/8.11.2031","article-title":"Coats&apos; disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for Norrin in retinal angiogenesis","author":"GC Black","year":"1999","journal-title":"Hum. Mol. Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/hmg\/5.1.51","article-title":"An Animal Model for Norrie Disease (ND): Gene Targeting of the Mouse Nd Gene","volume":"5","author":"W Berger","year":"1996","journal-title":"Human Molecular Genetics"},{"key":"ref9","first-page":"710","article-title":"Retinoschisis-like alterations in the mouse eye caused by gene targeting of the Norrie disease gene","author":"K Ruether","year":"1997","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1523\/JNEUROSCI.22-11-04286.2002","article-title":"Vascular defects and sensorineural deafness in a mouse model of Norrie disease","author":"HL Rehm","year":"2002","journal-title":"J. Neurosci"},{"key":"ref11","first-page":"2450","article-title":"Retinal vasculature changes in Norrie disease mice","author":"M Richter","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1167\/iovs.05-0174","article-title":"Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature","volume":"46","author":"UFO Luhmann","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/hmg\/dds087","article-title":"Norrin stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cells","volume":"21","author":"J Zuercher","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0092-8674(04)00216-8","article-title":"Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair","volume":"116","author":"Q Xu","year":"2004","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2012.10.042","article-title":"Norrin\/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity","volume":"151","author":"Y Wang","year":"2012","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1016\/j.visres.2005.08.014","article-title":"<italic>In vivo<\/italic> confocal imaging of the retina in animal models using scanning laser ophthalmoscopy","volume":"45","author":"MW Seeliger","year":"2005","journal-title":"Vision Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-62703-068-7_19","article-title":"Retinal digest preparation: a method to study diabetic retinopathy","volume":"933","author":"N Dietrich","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-62703-080-9_4","article-title":"Functional phenotyping of mouse models with ERG","volume":"935","author":"N Tanimoto","year":"2013","journal-title":"Methods Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s004290050289","article-title":"Regression of the hyaloid vessels and pupillary membrane of the mouse","author":"M Ito","year":"1999","journal-title":"Anat. Embryol. (Berl)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","article-title":"Pericytes and the Pathogenesis of Diabetic Retinopathy","volume":"51","author":"H-P Hammes","year":"2002","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/mvre.2000.2244","article-title":"Pericyte migration from the vascular wall in response to traumatic brain injury","volume":"60","author":"P Dore-Duffy","year":"2000","journal-title":"Microvasc Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/mvre.2002.2413","article-title":"Early pericyte response to brain hypoxia in cats: an ultrastructural study","volume":"64","author":"E Gonul","year":"2002","journal-title":"Microvasc Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.2002.030676","article-title":"Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation","volume":"547","author":"K Howell","year":"2003","journal-title":"J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.0021-8782.2004.00351.x","article-title":"Chronic systemic hypoxia causes intra-retinal angiogenesis","volume":"205","author":"AJ Shortt","year":"2004","journal-title":"J Anat"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/0-387-29540-2_14","article-title":"Chronic hypoxia modulates endothelium-dependent vasorelaxation through multiple independent mechanisms in ovine cranial arteries","volume":"578","author":"WJ Pearce","year":"2006","journal-title":"Adv Exp Med Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/187152506777698290","article-title":"Expression and Functions of Vasoactive Substances Regulated by Hypoxia-Inducible Factor-1 in Chronic Hypoxemia","volume":"4","author":"G Tipoe","year":"2006","journal-title":"CHAMC"},{"issue":"Pt 6","key":"ref27","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/eye.1989.120","article-title":"Retinal vessel responses to exercise and hypoxia before and after high altitude acclimatisation","volume":"3","author":"O Brinchmann-Hansen","year":"1989","journal-title":"Eye (Lond)"},{"key":"ref28","first-page":"395","article-title":"Retinal changes in Himalayan climbers","author":"D Rennie","year":"1975","journal-title":"Acta Ophthalmol"},{"key":"ref29","first-page":"401","article-title":"High altitude retinal hemorrhage","author":"M Wiedman","year":"1975","journal-title":"Acta Ophthalmol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"A Stahl","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref31","first-page":"691","article-title":"The electroretinogram of the living extracorporeal bovine eye. The influence of anoxia and hypothermia","author":"Y Tazawa","year":"1972","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/978-3-319-17121-0_82","article-title":"In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination","volume":"854","author":"N Tanimoto","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice","volume":"277","author":"P Lindahl","year":"1997","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.ajpath.2014.06.011","article-title":"Retinal microangiopathy in a mouse model of inducible mural cell loss","volume":"184","author":"CN Valdez","year":"2014","journal-title":"Am J Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2337\/db08-0325","article-title":"Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy","volume":"57","author":"F Pfister","year":"2008","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2337\/diabetes.53.12.3233","article-title":"Effect of Long-Term Administration of -Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats","volume":"53","author":"RA Kowluru","year":"2004","journal-title":"Diabetes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00424-013-1272-6","article-title":"Pericytes in the eye","volume":"465","author":"F Pfister","year":"2013","journal-title":"Pflugers Arch"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00109-013-0993-5","article-title":"Ocular neovascularization","volume":"91","author":"PA Campochiaro","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/343362a0","article-title":"Saccadic oscillations facilitate ocular perfusion from the avian pecten","volume":"343","author":"JD Pettigrew","year":"1990","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T14:54:48Z","timestamp":1719240888000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178753"}},"subtitle":[],"editor":[{"given":"Alfred S","family":"Lewin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,2]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178753","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,2]]}}}