{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:54:34Z","timestamp":1783515274772,"version":"3.55.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0178883","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T13:35:56Z","timestamp":1497015356000},"page":"e0178883","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":true,"given":"Tyng-Yuan","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-I","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lun","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Cheng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Pien","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Yau","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Cherng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Fu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Shin","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Long","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","article-title":"Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity","volume":"30","author":"JJ Ott","year":"2012","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.26141","article-title":"Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"K Mohd Hanafiah","year":"2013","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7150\/ijms.2.50","article-title":"Epidemiology and Prevention of Hepatitis B Virus Infection","volume":"2","author":"J Hou","year":"2005","journal-title":"Int J Med Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/oxfordjournals.epirev.a017921","article-title":"Transmission of hepatitis C virus: rates, routes, and cofactors","volume":"18","author":"M MacDonald","year":"1996","journal-title":"Epidemiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000100506","article-title":"SEN and hepatitis virus infections in nontransfused children and pediatric thalassemia patients with multiple transfusions in Taiwan","volume":"74","author":"SS Chiou","year":"2006","journal-title":"Digestion"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1046\/j.1440-1746.2000.02359.x","article-title":"Status and natural course of GB virus C\/hepatitis G virus infection among high-risk groups and volunteer blood donors in Taiwan","volume":"15","author":"ML Yu","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1023\/B:DDAS.0000037809.87654.73","article-title":"Prevalence and clinical significance of SEN virus infection among volunteer blood donors in southern Taiwan","volume":"49","author":"CY Dai","year":"2004","journal-title":"Dig Dis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/infdis\/162.4.817","article-title":"Hepatitis C virus infection in an area hyperendemic for hepatitis B and chronic liver disease: the Taiwan experience","volume":"162","author":"DS Chen","year":"1990","journal-title":"J Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1203\/00006450-199602000-00022","article-title":"Hepatitis C viral infection in thalassemic children: clinical and molecular studies","volume":"39","author":"YH Ni","year":"1996","journal-title":"Pediatr Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0140-6736(88)92288-X","article-title":"Virus safety of solvent\/detergent-treated antihaemophilic factor concentrate","volume":"2","author":"MS Horowitz","year":"1988","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/80394","article-title":"Clinical Medical Research Award. Hepatitis C virus and eliminating post-transfusion hepatitis","volume":"6","author":"HJ Alter","year":"2000","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1046\/j.1537-2995.2002.00174.x","article-title":"Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population","volume":"42","author":"RY Dodd","year":"2002","journal-title":"Transfusion"},{"key":"ref13","first-page":"767","article-title":"Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990\u20132000","volume":"169","author":"JA Chiavetta","year":"2003","journal-title":"CMAJ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2807\/esm.10.02.00516-en","article-title":"Blood safety and nucleic acid testing in Europe","volume":"10","author":"S Laperche","year":"2005","journal-title":"Euro Surveill"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(08)61116-2","article-title":"Acute hepatitis C","volume":"372","author":"A Maheshwari","year":"2008","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1182\/blood-2005-07-2781","article-title":"Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia","volume":"107","author":"M Zhang","year":"2006","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/ejh.12086","article-title":"Natural history of hepatitis C in thalassemia major: a long-term prospective study","volume":"90","author":"ME Lai","year":"2013","journal-title":"Eur J Haematol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3324\/haematol.2011.050351","article-title":"IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection","volume":"97","author":"V Di Marco","year":"2012","journal-title":"Haematologica"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jhep.2013.09.023","article-title":"High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients","volume":"60","author":"ML Yu","year":"2014","journal-title":"J Hepatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/gut.2006.116384","article-title":"The role of gender on clearance of hepatitis C virus: a different story in an area endemic for hepatitis B and C","volume":"56","author":"CY Dai","year":"2007","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcv.2011.07.007","article-title":"Multi-center evaluation of the Abbott RealTime HCV assay for monitoring patients undergoing antiviral therapy for chronic hepatitis C","volume":"52","author":"J Vermehren","year":"2011","journal-title":"J Clin Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/00365540902875073","article-title":"Performance characteristics of two real-time PCR assays for quantification of hepatitis B virus DNA","volume":"41","author":"YY Lin","year":"2009","journal-title":"Scand J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e58882","DOI":"10.1371\/journal.pone.0058882","article-title":"Virological predictors of response to retreatment in hepatitis C genotype 2 infected patients","volume":"8","author":"CF Huang","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/hep.23976","article-title":"Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients","volume":"53","author":"ML Yu","year":"2011","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jhep.2011.03.029","article-title":"Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon\/ribavirin","volume":"56","author":"CF Huang","year":"2012","journal-title":"J Hepatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.kjms.2011.10.027","article-title":"Towards the eradication of hepatitis B in Taiwan","volume":"28","author":"S Wait","year":"2012","journal-title":"Kaohsiung J Med Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.patbio.2009.11.002","article-title":"Hepatitis B vaccination in children: the Taiwan experience","volume":"58","author":"YH Ni","year":"2010","journal-title":"Pathol Biol (Paris)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"a021493","DOI":"10.1101\/cshperspect.a021493","article-title":"Prevention of hepatitis B","volume":"5","author":"MH Chang","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ypmed.2009.02.002","article-title":"HBV infection in indigenous children, 20 years after immunization in Taiwan: a community-based study","volume":"48","author":"CF Huang","year":"2009","journal-title":"Prev Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e690","DOI":"10.1097\/MD.0000000000000690","article-title":"Huge gap between clinical efficacy and community effectiveness in the treatment of chronic hepatitis C: a nationwide survey in Taiwan","volume":"94","author":"ML Yu","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0929-6646(09)60231-X","article-title":"Estimation of seroprevalence of hepatitis B virus and hepatitis C virus in Taiwan from a large-scale survey of free hepatitis screening participants","volume":"106","author":"CH Chen","year":"2007","journal-title":"J Formos Med Assoc"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.trstmh.2008.05.018","article-title":"Changing prevalence of hepatitis C virus infection among teenagers in an endemic area in Taiwan","volume":"102","author":"CF Huang","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1607-551X(10)70073-5","article-title":"Viral hepatitis infections in southern Taiwan: a multicenter community-based study","volume":"26","author":"JF Yang","year":"2010","journal-title":"Kaohsiung J Med Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1440-1746.1992.tb01019.x","article-title":"Relationship between fatty liver, alanine aminotransferase, HBsAg and hepatitis C virus","volume":"7","author":"WY Chang","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e94791","DOI":"10.1371\/journal.pone.0094791","article-title":"Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection","volume":"9","author":"MH Hsieh","year":"2014","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1440-1746.1992.tb00948.x","article-title":"Anti-HCV antibody in Chinese cirrhotic patients with or without hepatocellular carcinoma: relation to multitransfusion","volume":"7","author":"WY Chang","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"ref37","first-page":"54","article-title":"Epidemiological and clinical characteristics of HCV infection in transfusion-dependent thalassemia","volume":"18","author":"K.H. Katsanos","year":"2005","journal-title":"Annals of Gastroenterology"},{"issue":"Suppl 3","key":"ref38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2516.2008.01708.x","article-title":"Back to the future: a recent history of haemophilia treatment","volume":"14","author":"PM Mannucci","year":"2008","journal-title":"Haemophilia"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1182\/blood-2006-08-038349","article-title":"Progression to end-stage liver disease in patients with inherited bleeding disorders and hepatitis C: an international, multicenter cohort study","volume":"109","author":"D Posthouwer","year":"2007","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1590\/S0074-02762002000500009","article-title":"Prevalence of hepatitis C Virus infection among hemophiliacs in Central Brazil","volume":"97","author":"AP Barbosa","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"Suppl 3","key":"ref41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02779290","article-title":"Hepatitis C virus infection in Taiwan","volume":"26","author":"DS Chen","year":"1991","journal-title":"Gastroenterol Jpn"},{"key":"ref42","first-page":"289","article-title":"Implementation of donor screening for infectious agents transmitted by blood by nucleic acid technology: update to 2003","volume":"88","author":"J Coste","year":"2005","journal-title":"Vox Sang"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3349\/ymj.2013.54.1.71","article-title":"Prevalence, incidence, and factor concentrate usage trends of hemophiliacs in Taiwan","volume":"54","author":"TC Tu","year":"2013","journal-title":"Yonsei Med J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2516.2011.02506.x","article-title":"Comparing bleed frequency and factor concentrate use between haemophilia A and B patients","volume":"17","author":"K Nagel","year":"2011","journal-title":"Haemophilia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2009.11.017","article-title":"Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan","volume":"52","author":"CY Dai","year":"2010","journal-title":"J Hepatol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2893.2011.01497.x","article-title":"IL28B genetic variants and gender are associated with spontaneous clearance of hepatitis C virus infection","volume":"19","author":"HY Rao","year":"2012","journal-title":"J Viral Hepat"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-2516.2012.02932.x","article-title":"Genetic polymorphism of IL28B in hepatitis C-infected haemophilia patients in Israel","volume":"19","author":"Y Maor","year":"2013","journal-title":"Haemophilia"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0178883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T17:11:37Z","timestamp":1569431497000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0178883"}},"subtitle":[],"editor":[{"given":"Yury E","family":"Khudyakov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,9]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0178883","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,9]]}}}