{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:57:12Z","timestamp":1740146232108,"version":"3.37.3"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["(\"Institute for Clinical and Experimental Medicine - IKEM, IN 0002301\""],"award-info":[{"award-number":["(\"Institute for Clinical and Experimental Medicine - IKEM, IN 0002301\""]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["14-36804G"],"award-info":[{"award-number":["14-36804G"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179063","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T17:39:10Z","timestamp":1496770750000},"page":"e0179063","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls"],"prefix":"10.1371","volume":"12","author":[{"given":"Jaroslava","family":"Trnovsk\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"\u0160ilhav\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Kuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Landa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e1clav","family":"Z\u00eddek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Mlejnek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"\u0160im\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hynek","family":"Strnad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojt\u011bch","family":"\u0160kop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Oliyarnyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Kazdov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Haluz\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-5871","authenticated-orcid":true,"given":"Michal","family":"Pravenec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men","volume":"288","author":"HM Lakka","year":"2002","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archinte.163.4.427","article-title":"The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"163","author":"YW Park","year":"2003","journal-title":"Arch Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"SE Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"JM Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrendo.2009.264","article-title":"Inflammatory lipid mediators in adipocyte function and obesity","volume":"6","author":"A Iyer","year":"2010","journal-title":"Nat Rev Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"W Wahli","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"LA O'Neill","year":"2013","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/13543784.2015.974804","article-title":"Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease","volume":"24","author":"N Esser","year":"2015","journal-title":"Exp Opin Investig Drugs"},{"key":"ref9","first-page":"381","article-title":"Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment","volume":"7","author":"X Wang","year":"2014","journal-title":"Diabetes Metab Syndr Obes"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/HYPERTENSIONAHA.110.164350","article-title":"Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome","volume":"57","author":"M Pravenec","year":"2011","journal-title":"Hypertension"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/1755-5922.12061","article-title":"Rosuvastatin can block pro-inflammatory actions of transgenic human C-reactive protein without reducing its circulating levels","volume":"32","author":"J \u0160ilhav\u00fd","year":"2014","journal-title":"Cardiovasc Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e101906","DOI":"10.1371\/journal.pone.0101906","article-title":"Fumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats","volume":"9","author":"J \u0160ilhav\u00fd","year":"2014","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0150924","DOI":"10.1371\/journal.pone.0150924","article-title":"Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein","volume":"11","author":"H Mal\u00ednsk\u00e1","year":"2016","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"891","DOI":"10.33549\/physiolres.933304","article-title":"Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein","volume":"65","author":"V \u0160kop","year":"2016","journal-title":"Physiol Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1258\/la.2011.011021","article-title":"A simple procedure for estimation of total body surface area and determination of a new value of Meeh&apos;s constant in rats","volume":"46","author":"E Gouma","year":"2012","journal-title":"Lab Anim"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1111\/bph.13315","article-title":"Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes","volume":"172","author":"W Liang","year":"2015","journal-title":"Br J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.2337\/db16-0385","article-title":"Docosahexaenoic acid-derived fatty acid esters of hydroxy fatty acids (FAHFAs) with anti-inflammatory properties","volume":"65","author":"O Kuda","year":"2016","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1172\/JCI112001","article-title":"Systemic complement activation, lung injury, and products of lipid peroxidation","volume":"76","author":"PA Ward","year":"1985","journal-title":"J Clin Invest"},{"key":"ref19","first-page":"397","article-title":"Bioinformatics and computational biology solutions using R and bioconductor","author":"GK Smyth","year":"2005"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1214\/aos\/1074290335","article-title":"The positive false discovery rate: a Bayesian interpretation and the q-value","volume":"31","author":"JD Storey","year":"2003","journal-title":"Annals Statistics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"RC Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/bioinformatics\/btn577","article-title":"A novel signaling pathway impact analysis","volume":"25","author":"AL Tarca","year":"2009","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J R Stat Soc. Series B"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"MW Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/db14-1125","article-title":"Salsalate activates brown adipose tissue in mice","volume":"64","author":"AD van Dam","year":"2015","journal-title":"Diabetes"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta","volume":"293","author":"M Yuan","year":"2001","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"35105","DOI":"10.1074\/jbc.M201575200","article-title":"The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands","volume":"277","author":"LA Cowart","year":"2002","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1126\/science.1215327","article-title":"The ancient drug salicylate directly activates AMP-activated protein kinase","volume":"336","author":"SA Hawley","year":"2012","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.2337\/db16-0564","article-title":"Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK \u03b21","volume":"65","author":"BK Smith","year":"2016","journal-title":"Diabetes"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1152\/physiolgenomics.00122.2015","article-title":"Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue","volume":"48","author":"M Pravenec","year":"2016","journal-title":"Physiol Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cyto.2003.12.001","article-title":"IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes","volume":"26","author":"T Mr\u00e1\u010dek","year":"2004","journal-title":"Cytokine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/thy.1999.9.359","article-title":"Salsalate and salicylate binding to and their displacement of thyroxine from thyroxine-binding globulin, transthyrin, and albumin","volume":"9","author":"R Wang","year":"1999","journal-title":"Thyroid"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neulet.2006.08.057","article-title":"Thyroidectomy alters the daily pattern of expression of the clock protein, PER2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats","volume":"407","author":"S Amir","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1210\/endo.137.12.8940379","article-title":"Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity","volume":"137","author":"SD Carvalho","year":"1996","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4239\/wjd.v5.i5.697","article-title":"Targeting inflammation in diabetes: Newer therapeutic options","volume":"5","author":"NK Agrawal","year":"2014","journal-title":"World J Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12020-016-0993-7","article-title":"Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?","volume":"55","author":"MI Maiorino","year":"2017","journal-title":"Endocrine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-152-6-201003160-00004","article-title":"TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial","volume":"152","author":"AB Goldfine","year":"2010","journal-title":"Ann Intern Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-159-1-201307020-00003","article-title":"Targeting inflammation using salsalate in type 2 diabetes study team. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial","volume":"159","author":"AB Goldfine","year":"2013","journal-title":"Ann Intern Med"},{"key":"ref39","first-page":"231","article-title":"Salsalate, an old, inexpensive drug with potential new indications: a review of the evidence from 3 recent studies","volume":"7","author":"K Anderson","year":"2014","journal-title":"Am Health Drug Benefits"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:08:10Z","timestamp":1719245290000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179063"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179063","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,6,6]]}}}