{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:17:21Z","timestamp":1790720241968,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO250 project 7"],"award-info":[{"award-number":["KFO250 project 7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO250 project 7"],"award-info":[{"award-number":["KFO250 project 7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TR 127 project A4"],"award-info":[{"award-number":["SFB TR 127 project A4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6880\/2-1"],"award-info":[{"award-number":["HA6880\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","award":["Young Faculty Program"],"award-info":[{"award-number":["Young Faculty Program"]}],"id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179074","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T17:47:47Z","timestamp":1496944067000},"page":"e0179074","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-2496","authenticated-orcid":true,"given":"Richard","family":"Taubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hardtke-Wolenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Noyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Lalanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Jonigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Schlue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Krech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Lichtinghagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Schlaphoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Bantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Jaeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2013.10.020","article-title":"Autoimmune hepatitis in Denmark: incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study","volume":"60","author":"L Gronbaek","year":"2014","journal-title":"Journal of hepatology"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"YS de Boer","year":"2014","journal-title":"Gastroenterology"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3748\/wjg.15.1025","article-title":"Influence of genes, sex, age and environment on the onset of autoimmune hepatitis","volume":"15","author":"K Beland","year":"2009","journal-title":"World journal of gastroenterology: WJG"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hep.26380","article-title":"Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells","volume":"58","author":"M Hardtke-Wolenski","year":"2013","journal-title":"Hepatology"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/hep.27639","article-title":"Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigens","volume":"61","author":"M Hardtke-Wolenski","year":"2015","journal-title":"Hepatology"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1053\/j.gastro.2010.06.046","article-title":"Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis","volume":"139","author":"MP Manns","year":"2010","journal-title":"Gastroenterology"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"51","author":"MP Manns","year":"2010","journal-title":"Hepatology"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.09.009","article-title":"Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission","volume":"58","author":"NM van Gerven","year":"2013","journal-title":"Journal of hepatology"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/hep.23924","article-title":"Application of the 2010 American Association for the study of liver diseases criteria of remission to a cohort of Italian patients with autoimmune hepatitis","volume":"52","author":"L Muratori","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.jhep.2009.01.020","article-title":"Autoimmune hepatitis in Italy: the Bologna experience","volume":"50","author":"P Muratori","year":"2009","journal-title":"J Hepatol"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ajg.2015.139","article-title":"Long-Term Prognostic Significance of Persisting Histological Activity Despite Biochemical Remission in Autoimmune Hepatitis","volume":"110","author":"HK Dhaliwal","year":"2015","journal-title":"The American journal of gastroenterology"},{"key":"ref12","article-title":"Prediction of short- and long-term outcome in patients with autoimmune hepatitis","author":"MM Kirstein","year":"2015","journal-title":"Hepatology"},{"key":"ref13","article-title":"Predictive factors of poor response to therapy in Autoimmune Hepatitis","author":"P Muratori","year":"2016","journal-title":"Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1572-0241.2004.30457.x","article-title":"Factors predicting relapse and poor outcome in type I autoimmune hepatitis: role of cirrhosis development, patterns of transaminases during remission and plasma cell activity in the liver biopsy","volume":"99","author":"S Verma","year":"2004","journal-title":"The American journal of gastroenterology"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/eci.12032","article-title":"Iron homeostasis in the metabolic syndrome","volume":"43","author":"C Datz","year":"2013","journal-title":"European journal of clinical investigation"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1172\/JCI59411","article-title":"Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation","volume":"122","author":"F Bohne","year":"2012","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"F Alvarez","year":"1999","journal-title":"Journal of hepatology"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jhep.2014.05.034","article-title":"Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies","volume":"61","author":"R Taubert","year":"2014","journal-title":"Journal of hepatology"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/hep.1840180613","article-title":"Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: a study of 185 patients","volume":"18","author":"YM Deugnier","year":"1993","journal-title":"Hepatology"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1111\/j.1600-6143.2012.04264.x","article-title":"Enrichment of regulatory T cells in acutely rejected human liver allografts","volume":"12","author":"R Taubert","year":"2012","journal-title":"Am J Transplant"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-61779-163-5_5","article-title":"Optimized RNA extraction from non-deparaffinized, laser-microdissected material","volume":"755","author":"D Jonigk","year":"2011","journal-title":"Methods in molecular biology"},{"issue":"6 Pt 1","key":"ref22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/clinchem\/46.6.885","article-title":"Plasma ferritin in acute hepatocellular damage","volume":"46","author":"CI Bhagat","year":"2000","journal-title":"Clinical chemistry"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.25615","article-title":"Inhibition of hepcidin transcription by growth factors","volume":"56","author":"JB Goodnough","year":"2012","journal-title":"Hepatology"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1053\/j.gastro.2010.04.053","article-title":"Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis","volume":"139","author":"AJ Czaja","year":"2010","journal-title":"Gastroenterology"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1053\/jhep.2002.32485","article-title":"Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis","volume":"35","author":"AJ Czaja","year":"2002","journal-title":"Hepatology"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1572-0241.2007.01153.x","article-title":"Improving the end point of corticosteroid therapy in type 1 autoimmune hepatitis to reduce the frequency of relapse","volume":"102","author":"AJ Montano-Loza","year":"2007","journal-title":"The American journal of gastroenterology"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cgh.2008.08.018","article-title":"Effects of serum aspartate aminotransferase levels in patients with autoimmune hepatitis influence disease course and outcome","volume":"6","author":"T Al-Chalabi","year":"2008","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/00365520903555861","article-title":"Characteristics and long-term outcome of patients with autoimmune hepatitis related to the initial treatment response","volume":"45","author":"M Werner","year":"2010","journal-title":"Scandinavian journal of gastroenterology"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/1319-3767.27849","article-title":"Clinical presentation, response to therapy, and predictors of fibrosis in patients with autoimmune hepatitis in Saudi Arabia","volume":"12","author":"AA Abdo","year":"2006","journal-title":"Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association"},{"key":"ref30","first-page":"1","article-title":"Prognostic value of clinical variables and liver histology for development of fibrosis and cirrhosis in autoimmune hepatitis","author":"L Puustinen","year":"2016","journal-title":"Scandinavian journal of gastroenterology"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/hep.24635","article-title":"Serum ferritin concentration and transferrin saturation before liver transplantation predict decreased long-term recipient survival","volume":"54","author":"TJ Weismuller","year":"2011","journal-title":"Hepatology"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hep.23537","article-title":"Serum ferritin concentration predicts mortality in patients awaiting liver transplantation","volume":"51","author":"NM Walker","year":"2010","journal-title":"Hepatology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fphar.2014.00152","article-title":"Iron at the interface of immunity and infection","volume":"5","author":"M Nairz","year":"2014","journal-title":"Frontiers in pharmacology"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.autrev.2007.01.016","article-title":"Ferritin in autoimmune diseases","volume":"6","author":"G Zandman-Goddard","year":"2007","journal-title":"Autoimmunity reviews"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s10753-008-9060-8","article-title":"Serum pro-hepcidin levels in rheumatoid arthritis and systemic lupus erythematosus","volume":"31","author":"SS Koca","year":"2008","journal-title":"Inflammation"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"e0135486","DOI":"10.1371\/journal.pone.0135486","article-title":"Low Serum Hepcidin in Patients with Autoimmune Liver Diseases","volume":"10","author":"A Lyberopoulou","year":"2015","journal-title":"PloS one"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.autrev.2014.11.013","article-title":"Hepatocyte growth factor: A regulator of inflammation and autoimmunity","volume":"14","author":"N Molnarfi","year":"2015","journal-title":"Autoimmunity reviews"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4161\/viru.28508","article-title":"Hepcidin and the iron enigma in HCV infection","volume":"5","author":"U Georgopoulou","year":"2014","journal-title":"Virulence"},{"issue":"37","key":"ref39","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.3748\/wjg.v13.i37.4925","article-title":"Role of alcohol in the regulation of iron metabolism","volume":"13","author":"DD Harrison-Findik","year":"2007","journal-title":"World journal of gastroenterology: WJG"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:48:09Z","timestamp":1750297689000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179074"}},"subtitle":[],"editor":[{"given":"Ferruccio","family":"Bonino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,8]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179074","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,8]]}}}