{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:17:02Z","timestamp":1788455822438,"version":"build-2803163510"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EFRE ProFIT","award":["10158447"],"award-info":[{"award-number":["10158447"]}]},{"name":"Lost Voices Foundation e.V.","award":["07-905"],"award-info":[{"award-number":["07-905"]}]},{"name":"EFRE ProFIT","award":["10158447"],"award-info":[{"award-number":["10158447"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179124","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T17:38:12Z","timestamp":1497289092000},"page":"e0179124","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":72,"title":["Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray"],"prefix":"10.1371","volume":"12","author":[{"given":"Madlen","family":"Loebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Eckey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Sotzny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zerweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo","family":"Holenya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif G.","family":"Hanitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Wittke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Borchmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Ulrich","family":"R\u00fcffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Hiepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Behrends","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Meindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Scheibenbogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"6599","DOI":"10.4049\/jimmunol.174.11.6599","article-title":"EBV and systemic lupus erythematosus: a new perspective","volume":"174","author":"AJ Gross","year":"2005","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.172.2.1287","article-title":"Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus","volume":"172","author":"I Kang","year":"2004","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/art.10933","article-title":"Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: accurate quantification using real-time polymerase chain reaction","volume":"48","author":"N Balandraud","year":"2003","journal-title":"Arthritis and rheumatism"},{"issue":"4","key":"ref4","first-page":"866","article-title":"Epstein-Barr virus infection in peripheral blood mononuclear cells, synovial fluid cells, and synovial membranes of patients with rheumatoid arthritis","volume":"27","author":"S Blaschke","year":"2000","journal-title":"The Journal of rheumatology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00296-012-2504-3","article-title":"EBV reactivation serological profile in primary Sjogren&apos;s syndrome: an underlying trigger of active articular involvement?","volume":"33","author":"SG Pasoto","year":"2013","journal-title":"Rheumatology international"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1038\/cti.2014.25","article-title":"Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy","volume":"3","author":"MP Pender","year":"2014","journal-title":"Clinical & translational immunology"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012496","article-title":"An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis","volume":"5","author":"AE Handel","year":"2010","journal-title":"PloS one"},{"key":"ref8","article-title":"Multiple sclerosis: The elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1","author":"K Ruprecht","year":"2014","journal-title":"Journal of neuroimmunology"},{"key":"ref9","first-page":"365","article-title":"EBV and Autoimmunity","volume":"390","author":"A Ascherio","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1096\/fj.11-190769","article-title":"Combinatorial antibody library from multiple sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV antigen","volume":"25","author":"AG Gabibov","year":"2011","journal-title":"Faseb j"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2741\/4010","article-title":"Cross-reactivity of autoreactive T cells with MBP and viral antigens in patients with MS","volume":"17","author":"W Cheng","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jaut.2008.08.007","article-title":"Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments","volume":"31","author":"BD Poole","year":"2008","journal-title":"J Autoimmun"},{"key":"ref13","unstructured":"Centers for Disease Control and Prevention. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwcdcgov\/cfs\/indexhtml\" xlink:type=\"simple\">http:\/\/wwwcdcgov\/cfs\/indexhtml<\/ext-link>. June 2015;(Chronic Fatigue Syndrome (CFS))."},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","article-title":"Myalgic encephalomyelitis: International Consensus Criteria","volume":"270","author":"BM Carruthers","year":"2011","journal-title":"Journal of internal medicine"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11920-013-0353-8","article-title":"The neuropsychiatric and neuropsychological features of chronic fatigue syndrome: revisiting the enigma","volume":"15","author":"Y Christley","year":"2013","journal-title":"Curr Psychiatry Rep"},{"issue":"5","key":"ref16","first-page":"880","article-title":"Biomarkers of stress and fatigue","volume":"70","author":"Y Tanaka","year":"2012","journal-title":"Nihon Rinsho"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2011.06.016","article-title":"Chronic fatigue syndrome, the immune system and viral infection","volume":"26","author":"AS Bansal","year":"2012","journal-title":"Brain, behavior, and immunity"},{"issue":"7342","key":"ref18","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/bmj.324.7342.914","article-title":"Editorial on CFS was biased, inaccurate, and misleading","volume":"324","author":"C Shepherd","year":"2002","journal-title":"Bmj"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0301-0511(01)00120-X","article-title":"Symptom occurrence in persons with chronic fatigue syndrome","volume":"59","author":"LA Jason","year":"2002","journal-title":"Biol Psychol"},{"issue":"2","key":"ref20","first-page":"335","article-title":"Chronisches Fatigue Syndrom: Heutige Vorstellungen zur Pathogenese, Diagnostik und Therapie\/ Chronic Fatigue Syndrom: current concepts in pathogenesis, diagnostic approaches and treatment","volume":"54","author":"C Scheibenbogen","year":"2014","journal-title":"Internistische Praxis"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2249.2005.02935.x","article-title":"Chronic fatigue syndrome is associated with diminished intracellular perforin","volume":"142","author":"KJ Maher","year":"2005","journal-title":"Clin Exp Immunol"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/1097-4679(200012)56:12<1497::AID-2>3.0.CO;2-Z","article-title":"Chronic fatigue syndrome: an examination of the phases","volume":"56","author":"LA Jason","year":"2000","journal-title":"J Clin Psychol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1479-5876-9-81","article-title":"Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome\/Myalgic Encephalomyelitis","volume":"9","author":"EW Brenu","year":"2011","journal-title":"Journal of translational medicine"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/00007611-198411000-00007","article-title":"Chronic mononucleosis syndrome","volume":"77","author":"RE DuBois","year":"1984","journal-title":"Southern medical journal"},{"issue":"5a","key":"ref25","first-page":"71","article-title":"The &apos;chronic mononucleosis&apos; syndromes","volume":"22","author":"AL Komaroff","year":"1987","journal-title":"Hospital practice (Office ed)"},{"issue":"26","key":"ref26","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1056\/NEJM198812293192602","article-title":"Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial","volume":"319","author":"SE Straus","year":"1988","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref27","first-page":"707","article-title":"Valacyclovir treatment in Epstein-Barr virus subset chronic fatigue syndrome: thirty-six months follow-up","volume":"21","author":"AM Lerner","year":"2007","journal-title":"In vivo (Athens, Greece)"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/jmv.23713","article-title":"Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome","volume":"85","author":"JG Montoya","year":"2013","journal-title":"Journal of medical virology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-102-1-7","article-title":"Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection","volume":"102","author":"SE Straus","year":"1985","journal-title":"Annals of internal medicine"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/archinte.1988.00380090047012","article-title":"Antibodies to Epstein-Barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome","volume":"148","author":"JF Jones","year":"1988","journal-title":"Archives of internal medicine"},{"issue":"17","key":"ref31","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1001\/jama.1987.03390170059028","article-title":"Frequency of &apos;chronic active Epstein-Barr virus infection&apos; in a general medical practice","volume":"257","author":"D Buchwald","year":"1987","journal-title":"Jama"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1001\/jama.1988.03410070099036","article-title":"Chronic fatigue syndrome and the diagnostic utility of antibody to Epstein-Barr virus early antigen","volume":"260","author":"WC Hellinger","year":"1988","journal-title":"Jama"},{"issue":"17","key":"ref33","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1001\/jama.1987.03390170053027","article-title":"A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause?","volume":"257","author":"GP Holmes","year":"1987","journal-title":"Jama"},{"issue":"2","key":"ref34","first-page":"101","article-title":"IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome","volume":"18","author":"AM Lerner","year":"2004","journal-title":"In Vivo"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"e47891","DOI":"10.1371\/journal.pone.0047891","article-title":"Antibody to Epstein-Barr virus deoxyuridine triphosphate nucleotidohydrolase and deoxyribonucleotide polymerase in a chronic fatigue syndrome subset","volume":"7","author":"AM Lerner","year":"2012","journal-title":"PloS one"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000150450","article-title":"Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome","volume":"38","author":"T Sairenji","year":"1995","journal-title":"Intervirology"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2169\/internalmedicine.31.313","article-title":"Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan","volume":"31","author":"K Kawai","year":"1992","journal-title":"Intern Med"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/jmv.21873","article-title":"Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome","volume":"82","author":"B Cameron","year":"2010","journal-title":"J Med Virol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/CDLI.6.2.216-223.1999","article-title":"Human herpesviruses in chronic fatigue syndrome","volume":"6","author":"HL Wallace 2nd","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"issue":"6","key":"ref40","first-page":"939","article-title":"Sleep, Epstein-Barr virus infection, musculoskeletal pain, and depressive symptoms in chronic fatigue syndrome","volume":"19","author":"CL Whelton","year":"1992","journal-title":"J Rheumatol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"e85387","DOI":"10.1371\/journal.pone.0085387","article-title":"Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome","volume":"9","author":"M Loebel","year":"2014","journal-title":"PloS one"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1056\/NEJM198503213121204","article-title":"Antibody responses to two Epstein-Barr virus nuclear antigens defined by gene transfer","volume":"312","author":"G Miller","year":"1985","journal-title":"The New England journal of medicine"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.84.2.570","article-title":"Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection","volume":"84","author":"W Henle","year":"1987","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1128\/JVI.64.9.4084-4092.1990","article-title":"Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes","volume":"64","author":"J Sample","year":"1990","journal-title":"J Virol"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/JVI.35.3.603-618.1980","article-title":"Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs","volume":"35","author":"GW Bornkamm","year":"1980","journal-title":"Journal of virology"},{"issue":"5974","key":"ref46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/310207a0","article-title":"DNA sequence and expression of the B95-8 Epstein-Barr virus genome","volume":"310","author":"R Baer","year":"1984","journal-title":"Nature"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1086\/323992","article-title":"Persistent productive Epstein-Barr virus replication in normal epithelial cells in vivo","volume":"184","author":"DM Walling","year":"2001","journal-title":"The Journal of infectious diseases"},{"issue":"Pt 12","key":"ref48","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1099\/0022-1317-83-12-2995","article-title":"Epstein-Barr virus replication in tongue epithelial cells","volume":"83","author":"K Herrmann","year":"2002","journal-title":"The Journal of general virology"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1086\/426823","article-title":"Epstein-Barr virus (EBV) infection in epithelial cells in vivo: rare detection of EBV replication in tongue mucosa but not in salivary glands","volume":"191","author":"P Frangou","year":"2005","journal-title":"The Journal of infectious diseases"},{"issue":"25","key":"ref50","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJM198512193132502","article-title":"Replication of Epstein-Barr virus within the epithelial cells of oral &quot;hairy&quot; leukoplakia, an AIDS-associated lesion","volume":"313","author":"JS Greenspan","year":"1985","journal-title":"N Engl J Med"},{"issue":"19","key":"ref51","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1056\/NEJM198405103101905","article-title":"Epstein-Barr virus replication in oropharyngeal epithelial cells","volume":"310","author":"JW Sixbey","year":"1984","journal-title":"N Engl J Med"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/ijc.2910080312","article-title":"The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV","volume":"8","author":"K Nilsson","year":"1971","journal-title":"Int J Cancer"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1073\/pnas.81.12.3806","article-title":"A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells","volume":"81","author":"J Yates","year":"1984","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"38","key":"ref54","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1073\/pnas.0605985103","article-title":"Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV&apos;s transforming genes","volume":"103","author":"M Altmann","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","article-title":"EBV persistence in memory B cells in vivo","volume":"9","author":"GJ Babcock","year":"1998","journal-title":"Immunity"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0952-7915(99)80062-4","article-title":"The biology of Epstein-Barr virus: lessons learned from the virus and the host","volume":"11","author":"JI Cohen","year":"1999","journal-title":"Curr Opin Immunol"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.humpath.2007.05.020","article-title":"Epstein-Barr virus-associated lymphoproliferative disorders","volume":"38","author":"SA Rezk","year":"2007","journal-title":"Hum Pathol"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2010.02.146","article-title":"Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes","volume":"396","author":"G Klein","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rmv.441","article-title":"Latent and lytic Epstein-Barr virus replication strategies","volume":"15","author":"T Tsurumi","year":"2005","journal-title":"Rev Med Virol"},{"issue":"1\u20132","key":"ref60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virusres.2005.11.020","article-title":"Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes","volume":"118","author":"I G\u00f6rzer","year":"2006","journal-title":"Virus Research"},{"issue":"15","key":"ref61","doi-asserted-by":"crossref","first-page":"7456","DOI":"10.1128\/JVI.00223-08","article-title":"Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2","volume":"82","author":"W Lucchesi","year":"2008","journal-title":"Journal of virology"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1300\/J092v11n01_02","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols","author":"BM JA Carruthers","year":"2003","journal-title":"J Chronic Fatigue Syndr"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1128\/JCM.31.4.911-916.1993","article-title":"Identification of group-common linear epitopes in structural and nonstructural proteins of enteroviruses by using synthetic peptides","volume":"31","author":"J Cello","year":"1993","journal-title":"Journal of clinical microbiology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4939-3037-1_2","article-title":"High-Throughput Microarray Incubations Using Multi-Well Chambers","volume":"1352","author":"J Zerweck","year":"2016","journal-title":"Methods in molecular biology"},{"issue":"21","key":"ref65","doi-asserted-by":"crossref","first-page":"e89376","DOI":"10.1172\/jci.insight.89376","article-title":"Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy\/chronic fatigue syndrome","volume":"1","author":"O Fluge","year":"2016","journal-title":"JCI insight"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"34990","DOI":"10.1038\/srep34990","article-title":"Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles","volume":"6","author":"E Yamano","year":"2016","journal-title":"Scientific reports"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1212\/NXI.0000000000000190","article-title":"Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS","volume":"3","author":"R Zivadinov","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"2","key":"ref68","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/imm.12200","article-title":"Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA","volume":"141","author":"I Fattal","year":"2014","journal-title":"Immunology"},{"issue":"6","key":"ref69","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1468-1331.2011.03636.x","article-title":"High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis","volume":"19","author":"D Csuka","year":"2012","journal-title":"Eur J Neurol"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00296-010-1573-4","article-title":"Serologic response to Epstein-Barr virus antigens in patients with systemic lupus erythematosus: a controlled study","volume":"32","author":"BA Esen","year":"2012","journal-title":"Rheumatol Int"},{"issue":"7","key":"ref71","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/1352458510368051","article-title":"Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis","volume":"16","author":"M Castellazzi","year":"2010","journal-title":"Mult Scler"},{"issue":"1","key":"ref72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/421245","article-title":"Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects","volume":"190","author":"J Fachiroh","year":"2004","journal-title":"J Infect Dis"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/1097-0142(19941101)74:9<2414::AID-CNCR2820740905>3.0.CO;2-8","article-title":"A possible prognostic role of immunoglobulin-G antibody against recombinant Epstein-Barr virus BZLF-1 transactivator protein ZEBRA in patients with nasopharyngeal carcinoma","volume":"74","author":"TT Yip","year":"1994","journal-title":"Cancer"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/intimm\/12.3.281","article-title":"A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4(+) T lymphocytes","volume":"12","author":"E Rajnavolgyi","year":"2000","journal-title":"Int Immunol"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/03009742.2012.665944","article-title":"Epstein-Barr virus early antigen diffuse (EBV-EA\/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients","volume":"41","author":"AH Draborg","year":"2012","journal-title":"Scand J Rheumatol"},{"issue":"10","key":"ref76","doi-asserted-by":"crossref","first-page":"e1002328","DOI":"10.1371\/journal.ppat.1002328","article-title":"Exhausted cytotoxic control of Epstein-Barr virus in human lupus","volume":"7","author":"M Larsen","year":"2011","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nm1167","article-title":"Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry","volume":"11","author":"MT McClain","year":"2005","journal-title":"Nat Med"},{"issue":"9","key":"ref78","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1021\/jf991378n","article-title":"Lactoperoxidase-induced protein oxidation in milk","volume":"48","author":"H Ostdal","year":"2000","journal-title":"J Agric Food Chem"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2174\/1389203716666150316114956","article-title":"Disorder in milk proteins: structure, functional disorder, and biocidal potentials of lactoperoxidase","volume":"16","author":"HA Almehdar","year":"2015","journal-title":"Curr Protein Pept Sci"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.20.2.456-463.1978","article-title":"Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl oxidation with antimicrobial action","volume":"20","author":"EL Thomas","year":"1978","journal-title":"Infect Immun"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbi.2015.09.013","article-title":"Antibodies to beta adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome","volume":"52","author":"M Loebel","year":"2016","journal-title":"Brain, behavior, and immunity"},{"issue":"2","key":"ref82","first-page":"209","article-title":"Analysis of Epstein-Barr virus strains and variants in classical Hodgkin&apos;s lymphoma by laser microdissection","volume":"23","author":"M Garcia-Cosio","year":"2008","journal-title":"Histol Histopathol"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1600-0609.2010.01460.x","article-title":"Epstein-Barr virus (EBV) genotypes among human immunodeficiency virus (HIV)-related B-cell lymphomas and B-cell post-transplant lymphoproliferative disorders (B-PTLD)\u2014late-onset lymphomas, especially in the HIV setting, are associated with type-B-EBV","volume":"85","author":"HA Ibrahim","year":"2010","journal-title":"Eur J Haematol"},{"issue":"17","key":"ref84","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1128\/JVI.79.17.11128-11134.2005","article-title":"Epstein-Barr virus can establish infection in the absence of a classical memory B-cell population","volume":"79","author":"M Conacher","year":"2005","journal-title":"J Virol"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Hudnall S. Viruses and Human Cancer. Epstein-Barr Virus: Pathogenesis and Host Immune Response Springer. 2014;Chapter 2.","DOI":"10.1007\/978-1-4939-0870-7_2"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:27:49Z","timestamp":1659108469000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179124"}},"subtitle":[],"editor":[{"given":"Joseph S","family":"Pagano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,12]]},"references-count":85,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179124","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,12]]}}}