{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:51:35Z","timestamp":1767905495385,"version":"3.49.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81471900"],"award-info":[{"award-number":["81471900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["2015A030311001"],"award-info":[{"award-number":["2015A030311001"]}]},{"name":"Science and Technology Program of Guangzhou","award":["201508020262"],"award-info":[{"award-number":["201508020262"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179279","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T13:39:48Z","timestamp":1497447588000},"page":"e0179279","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unlocking the vital role of host cells in hair follicle reconstruction by semi-permeable capsules"],"prefix":"10.1371","volume":"12","author":[{"given":"Zhexiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shune","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.drudis.2008.05.010","article-title":"Male pattern baldness: current treatments, future prospects","volume":"13","author":"JA Ellis","year":"2008","journal-title":"Drug Discov Today"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"13475","DOI":"10.1073\/pnas.0902944106","article-title":"Fully functional bioengineered tooth replacement as an organ replacement therapy","volume":"106","author":"E Ikeda","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/SLA.0b013e31829c79cf","article-title":"Organ bioengineering and regeneration as the new Holy Grail for organ transplantation","volume":"258","author":"G Orlando","year":"2013","journal-title":"Ann Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/rme.15.11","article-title":"Avoiding immunological rejection in regenerative medicine","volume":"10","author":"EM Bolton","year":"2015","journal-title":"Regen Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"14452","DOI":"10.1073\/pnas.1508520112","article-title":"Regenerative medicine: current therapies and future directions","volume":"112","author":"AS Mao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/srep00424","article-title":"Hair organ regeneration via the bioengineered hair follicular unit transplantation","volume":"2","author":"K Asakawa","year":"2012","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/ncomms1784","article-title":"Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches","volume":"3","author":"KE Toyoshima","year":"2012","journal-title":"Nat Commun"},{"issue":"R1","key":"ref8","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1093\/hmg\/ddn086","article-title":"Skin and hair: models for exploring organ regeneration","volume":"17","author":"BD Yu","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"E286","DOI":"10.1002\/term.1802","article-title":"Neonatal murine skin-derived cells transplanted using a mini-chamber model produce robust and normal hair","volume":"10","author":"S Xiao","year":"2016","journal-title":"J Tissue Eng Regen Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nprot.2008.50","article-title":"Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice","volume":"3","author":"U Lichti","year":"2008","journal-title":"Nat Protoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.0022-202X.2005.23716.x","article-title":"Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells","volume":"124","author":"Y Zheng","year":"2005","journal-title":"J Invest Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/ced.12563","article-title":"A simple and rapid model for hair-follicle regeneration in the nude mouse","volume":"40","author":"YS Su","year":"2015","journal-title":"Clin Exp Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1600-0625.2007.00661.x","article-title":"A graft model for hair development","volume":"17","author":"J Qiao","year":"2008","journal-title":"Exp Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2217\/17460751.3.5.683","article-title":"Hair morphogenesis in vitro: formation of hair structures suitable for implantation","volume":"3","author":"J Qiao","year":"2008","journal-title":"Regen Med"},{"key":"ref15","first-page":"e4344","article-title":"Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration","author":"WM Woo","year":"2013","journal-title":"J Vis Exp"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"19679","DOI":"10.1073\/pnas.1309970110","article-title":"Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth","volume":"110","author":"CA Higgins","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1089\/ten.tea.2013.0547","article-title":"Controllable production of transplantable adult human high-passage dermal papilla spheroids using 3D matrigel culture","volume":"20","author":"Y Miao","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1021\/acsami.6b00202","article-title":"Surface tension guided hanging-drop: producing controllable 3D spheroid of high-passaged human dermal papilla cells and forming inductive microtissues for hair-follicle regeneration","volume":"8","author":"B Lin","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.trsl.2013.11.010","article-title":"Lung regeneration and translational implications of the postpneumonectomy model","volume":"163","author":"K Thane","year":"2014","journal-title":"Transl Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1582-4934.2007.00162.x","article-title":"Hepatic tissue engineering: from transplantation to customized cell-based liver directed therapies from the laboratory","volume":"12","author":"HC Fiegel","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.semcdb.2012.08.011","article-title":"Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling","volume":"23","author":"R Sennett","year":"2012","journal-title":"Semin Cell Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/jid.2014.475","article-title":"Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions","volume":"135","author":"JE Kloepper","year":"2015","journal-title":"J Invest Dermatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jdermsci.2013.02.004","article-title":"Strategies to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering","volume":"70","author":"M Ohyama","year":"2013","journal-title":"J Dermatol Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.biotechadv.2013.03.002","article-title":"Engineering the human pluripotent stem cell microenvironment to direct cell fate","volume":"31","author":"LB Hazeltine","year":"2013","journal-title":"Biotechnol Adv"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/wrr.12451","article-title":"Regeneration of hair and other skin appendages: A microenvironment-centric view","volume":"24","author":"C Huang","year":"2016","journal-title":"Wound Repair Regen"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/JOE-10-0377","article-title":"Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor","volume":"209","author":"SH Kim","year":"2011","journal-title":"J Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/stem.525","article-title":"Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins","volume":"28","author":"H Jinno","year":"2010","journal-title":"Stem Cells"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/dsu.12292","article-title":"Promotional effect of platelet-rich plasma on hair follicle reconstitution in vivo","volume":"39","author":"Y Miao","year":"2013","journal-title":"Dermatol Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00418-008-0428-5","article-title":"Tracking of human cells in mice[J]","volume":"130","author":"W Schormann","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/dvdy.22398","article-title":"Mature hair follicles generated from dissociated cells: a universal mechanism of folliculoneogenesis","volume":"239","author":"Y Zheng","year":"2010","journal-title":"Dev Dyn"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/978-1-4419-5786-3_9","article-title":"Therapeutic application of cell microencapsulation in cancer","volume":"670","author":"B Salmons","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(00)04749-8","article-title":"Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma","volume":"57","author":"M Lohr","year":"2001","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1016\/j.biomaterials.2010.02.014","article-title":"High-throughput reconstitution of epithelial-mesenchymal interaction in folliculoid microtissues by biomaterial-facilitated self-assembly of dissociated heterotypic adult cells","volume":"31","author":"CM Yen","year":"2010","journal-title":"Biomaterials"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"a008292","DOI":"10.1101\/cshperspect.a008292","article-title":"Signaling and transcriptional networks in heart development and regeneration","volume":"5","author":"BG Bruneau","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1089\/scd.2011.0230","article-title":"Dynamic signals for hair follicle development and regeneration","volume":"21","author":"X Wang","year":"2012","journal-title":"Stem Cells Dev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T19:35:33Z","timestamp":1540236933000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179279"}},"subtitle":[],"editor":[{"given":"Meijia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179279","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}