{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:41:21Z","timestamp":1773963681242,"version":"3.50.1"},"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179315","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T13:40:17Z","timestamp":1497447617000},"page":"e0179315","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Modelling community-control strategies to protect hospital resources during an influenza pandemic in Ottawa, Canada"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-0842","authenticated-orcid":true,"given":"Patrick","family":"Saunders-Hastings","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-592X","authenticated-orcid":true,"given":"Bryson","family":"Quinn Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Smith?","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Krewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0753-3322(00)89025-3","article-title":"The epidemiology and history of influenza","volume":"54","author":"K Kuszewski","year":"2000","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"i5","key":"ref2","first-page":"374","article-title":"Prevalence of preventive behaviors and associated factors during early phase of the H1N1 influenza epidemic","volume":"38","author":"JTF Lau","year":"2010","journal-title":"American Journal of Infection Control"},{"key":"ref3","first-page":"1","article-title":"Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008","volume":"57","author":"A Fiore","year":"2008","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"7125","key":"ref4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/445237a","article-title":"Concern as revived 1918 flu virus kills monkeys","volume":"445","author":"K Smith","year":"2007","journal-title":"Nature"},{"issue":"33","key":"ref5","first-page":"1057","article-title":"Updated estimates of mortality associated with seasonal influenza through the 2006\u20132007 influenza season","volume":"59","author":"M Thompson","year":"2010","journal-title":"MMWR"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/irv.12011","article-title":"Statistical estimates of respiratory admissions attributable to seasonal and pandemic influenza for Canada","volume":"7","author":"DL Schanzer","year":"2013","journal-title":"Influenza and other respiratory viruses"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"e80481","DOI":"10.1371\/journal.pone.0080481","article-title":". Estimating influenza deaths in Canada, 1992\u20132009","volume":"8","author":"DL Schanzer","year":"2013","journal-title":"PloS one"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jac\/44.suppl_2.3","article-title":"Epidemiology and pathogenesis of influenza","volume":"44","author":"M Zambon","year":"1999","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s13238-010-0008-z","article-title":"The emergence of pandemic influenza viruses","volume":"1","author":"Y Guan","year":"2010","journal-title":"Protein Cell"},{"issue":"3","key":"ref10","first-page":"265","article-title":"Public health and medical responses to the 1957\u201358 influenza pandemic. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and","volume":"7","author":"D Henderson","year":"2009","journal-title":"Science"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0968344513504525","article-title":"Paths of infection: The First World War and the origins of the 1918 influenza pandemic","volume":"21","author":"M Humphries","year":"2013","journal-title":"War in History"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"e1001558","DOI":"10.1371\/journal.pmed.1001558","article-title":"Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study","volume":"10","author":"L Simonsen","year":"2013","journal-title":"PLoS Med"},{"issue":"66","key":"ref13","article-title":"Reviewing the History of Pandemic Influenza: Understanding Patterns of Emergence and Transmission","volume":"5","author":"P Saunders-Hastings","year":"2016","journal-title":"Pathogens"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","article-title":"Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study","volume":"12","author":"F Dawood","year":"2012","journal-title":"The Lancet Infectious Diseases"},{"issue":"1719","key":"ref15","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1098\/rspb.2010.2688","article-title":"Modelling the impact of local reactive school closures on critical care provision during an influenza pandemic","volume":"278","author":"T House","year":"2011","journal-title":"Proc Biol Sci"},{"key":"ref16","unstructured":"Madhav N. Modelling a modern-day spanish flu pandemic. 2013."},{"issue":"5","key":"ref17","first-page":"240","article-title":"Introduction to pandemic influenza","volume":"49","author":"P Daly","year":"2007","journal-title":"BC Medical Journal"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1365-2672.2001.01492.x","article-title":"A history of influenza","volume":"91","author":"C Potter","year":"2001","journal-title":"Journal of Applied Microbiology"},{"key":"ref19","unstructured":"Garfors G. 100,000 flights a day 2014 [cited 2016 April 7]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.garfors.com\/2014\/06\/100000-flights-day.html\" xlink:type=\"simple\">http:\/\/www.garfors.com\/2014\/06\/100000-flights-day.html<\/ext-link>."},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrmicro1208","article-title":"Influenza: lessons from past pandemics, warnings from current incidents","volume":"3","author":"T Horimoto","year":"2005","journal-title":"Nat Rev Micro"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/512813","article-title":"Cases of swine influenza in humans: A review of the literature","volume":"44","author":"KP Myers","year":"2007","journal-title":"Clinical Infectious Diseases"},{"key":"ref22","first-page":"31","article-title":"Pandemic Influenza","author":"LA Reperant","year":"2013"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"13432","DOI":"10.1128\/JVI.05266-11","article-title":"Indications that Live Poultry Markets Are a Major Source of Human H5N1 Influenza Virus Infection in China","volume":"85","author":"X-F Wan","year":"2011","journal-title":"Journal of Virology"},{"issue":"19","key":"ref24","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1128\/JVI.00840-15","article-title":"Molecular Epidemiology and Evolution of Influenza Viruses Circulating within European Swine between 2009 and 2013","volume":"89","author":"SJ Watson","year":"2015","journal-title":"Journal of Virology"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"e10520","DOI":"10.1371\/journal.pone.0010520","article-title":"Optimal pandemic influenza vaccine allocation strategies for the Canadian population","volume":"5","author":"AR Tuite","year":"2010","journal-title":"PloS one"},{"issue":"30","key":"ref26","article-title":"Modeling Influenza epidemics and pandemics: insights into the future of swine flu (H1N1)","volume":"7","author":"B Coburn","year":"2009","journal-title":"BMC Medicine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1098\/rsif.2006.0112","article-title":"Simple models for containment of a pandemic","volume":"3","author":"J Arino","year":"2006","journal-title":"The Royal Society Interface"},{"issue":"1609","key":"ref28","first-page":"599","article-title":"How generation intervals shape the relationship between growth rates and reproductive numbers. Proceedings of the Royal Society B","volume":"274","author":"J Wallinga","year":"2007","journal-title":"Biological Sciences"},{"issue":"3","key":"ref29","article-title":"Trends in parameterization, economics and host behaviour in influenza pandemic modelling: a review and reporting protocol","volume":"10","author":"L Carrasco","year":"2013","journal-title":"Emerging Themes in Epidemiology"},{"issue":"15","key":"ref30","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1073\/pnas.0601266103","article-title":". Mitigation strategies for pandemic influenza in the United States","volume":"103","author":"TC Germann","year":"2006","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/aje\/kwh092","article-title":"Containing pandemic influenza with antiviral agents","volume":"159","author":"I Longini","year":"2004","journal-title":"American Journal of Epidemiology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1115717","article-title":"Containing Pandemic Influenza at the source","volume":"309","author":"I Longini","year":"2005","journal-title":"Science"},{"issue":"Suppl 1","key":"ref33","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2458-11-S1-S1","article-title":"Reactive strategies for containing developing outbreaks of pandemic influenza","volume":"11","author":"S Andradottir","year":"2011","journal-title":"BMC public health"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1073\/pnas.0706849105","article-title":"Modeling targeted layered containment of an influenza pandemic in the United States","volume":"105","author":"ME Halloran","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5953","key":"ref35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1126\/science.1177373","article-title":"The transmissibility and control of pandemic influenza A (H1N1) virus","volume":"326","author":"Y Yang","year":"2009","journal-title":"Science"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"e1000656","DOI":"10.1371\/journal.pcbi.1000656","article-title":"FluTE, a publicly available stochastic influenza epidemic simulation model","volume":"6","author":"DL Chao","year":"2010","journal-title":"PLoS computational biology"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/aje\/kwq497","article-title":"Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States","volume":"173","author":"DL Chao","year":"2011","journal-title":"American Journal of Epidemiology"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.socnet.2007.04.005","article-title":"Mixing patterns between age groups in social networks","volume":"29","author":"SY Del Valle","year":"2007","journal-title":"Social Networks"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1503\/cmaj.091641","article-title":"Modelling mitigation strategies for pandemic (H1N1) 2009","volume":"181","author":"MZ Gojovic","year":"2009","journal-title":"CMAJ"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/aje\/kwp237","article-title":"Strategies for pandemic and seasonal influenza vaccination of schoolchildren in the United States","volume":"170","author":"NE Basta","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"0","key":"ref41","first-page":"1475","article-title":"Mathematical models of contact patterns between age groups for predicting the spread of infectious diseases","volume":"10","author":"SY Del Valle","year":"2013","journal-title":"Mathematical Biosciences and Engineering"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0025-5564(02)00108-6","article-title":"Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission","volume":"180","author":"P van den Driessche","year":"2002","journal-title":"Mathematical biosciences"},{"issue":"20","key":"ref43","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa0906453","article-title":"Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1","volume":"361","author":"K Hancock","year":"2009","journal-title":"Influenza Virus. New England Journal of Medicine"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature03063","article-title":"Transmissibility of 1918 pandemic influenza","volume":"432","author":"C Mills","year":"2004","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1016\/j.vaccine.2006.05.067","article-title":"Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic","volume":"24","author":"C Viboud","year":"2006","journal-title":"Vaccine"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jtbi.2005.11.026","article-title":"Transmission dynamics of the great influenza pandemic of 1918 in Geneva, Switzerland: Assessing the effects of hypothetical interventions","volume":"241","author":"G Chowell","year":"2006","journal-title":"Journal of theoretical biology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF01719679","article-title":"A mathematical model for the European spread of influenza","volume":"10","author":"A Flahault","year":"1994","journal-title":"European Journal of Epidemiology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1017\/S0950268806007084","article-title":"Real-time epidemic forecasting for pandemic influenza","volume":"3","author":"I Hall","year":"2007","journal-title":"Epidmiology and Infection"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-4682-3-38","article-title":"Key transmission parameters of an institutional outbreak during the 1918 influenza pandemic estimated by mathematical modelling","volume":"3","author":"G Sertsou","year":"2006","journal-title":"Theoretical Biology and Medical Modeling"},{"key":"ref50","unstructured":"CIHI. Number of Hospital Beds Staffed and In Operation: Breakdown by grouped functional centre. Canadian MIS Database; 2016."},{"key":"ref51","unstructured":"SSSQ. Institutions: Legal entities 2016 [cited 2016 October 4]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wpp01.msss.gouv.qc.ca\/appl\/M02\/M02ListeEtab.asp\" xlink:type=\"simple\">http:\/\/wpp01.msss.gouv.qc.ca\/appl\/M02\/M02ListeEtab.asp<\/ext-link>."},{"key":"ref52","article-title":"Discount rates for the evaluation of public private partnerships","author":"D Burgess","year":"2010"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jval.2012.06.009","article-title":"An evaluation framework for funding drugs for rare diseases","volume":"15","author":"E Winquist","year":"2012","journal-title":"Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1056\/NEJMp1405158","article-title":"Updating cost-effectiveness\u2014the curious resilience of the $50,000-per-QALY threshold","volume":"371","author":"PJ Neumann","year":"2014","journal-title":"The New England journal of medicine"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1046\/j.1525-1497.1998.00211.x","article-title":"Interpretation of Cost-Effectiveness Analyses","volume":"13","author":"DK Owens","year":"1998","journal-title":"Journal of General Internal Medicine"},{"issue":"38","key":"ref56","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1016\/j.vaccine.2010.07.010","article-title":"Is a mass immunization program for pandemic (H1N1) 2009 good value for money? Evidence from the Canadian Experience","volume":"28","author":"B Sander","year":"2010","journal-title":"Vaccine"},{"key":"ref57","doi-asserted-by":"crossref","DOI":"10.1111\/j.1524-4733.2008.00437.x","article-title":"Economic Evaluation of Influenza Pandemic Mitigation Strategies in the United States Using a Stochastic Microsimulation transmission model","volume":"12","author":"B Sander","year":"2009","journal-title":"Value in Health"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/649867","article-title":"Health Outcomes and Costs of Community Mitigation Strategies for an Influenza Pandemic in the United States","volume":"50","author":"DJ Perlroth","year":"2010","journal-title":"Clinical Infectious Diseases"},{"key":"ref59","unstructured":"StatsCan. Earnings, average weekly, by province and territory 2016 [cited 2016 October 26]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.statcan.gc.ca\/tables-tableaux\/sum-som\/l01\/cst01\/labr79-eng.htm\" xlink:type=\"simple\">http:\/\/www.statcan.gc.ca\/tables-tableaux\/sum-som\/l01\/cst01\/labr79-eng.htm<\/ext-link>."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2458-13-211","article-title":"Economic analysis of pandemic influenza mitigation strategies for five pandemic severity categories","volume":"13","author":"JK Kelso","year":"2013","journal-title":"BMC public health"},{"key":"ref61","unstructured":"PHAC. Vaccine coverage amongst adult Canadians: Results from the 2012 adult National Immunization Coverage (aNIC) survey 2014 [cited 2016 November 7]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.phac-aspc.gc.ca\/im\/nics-enva\/vcac-cvac-eng.php\" xlink:type=\"simple\">http:\/\/www.phac-aspc.gc.ca\/im\/nics-enva\/vcac-cvac-eng.php<\/ext-link>."},{"issue":"8","key":"ref62","article-title":"Vaccines for preventing influenza in healthy children","author":"T Jefferson","year":"2014","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1473-3099(11)70295-X","article-title":"Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis","volume":"12","author":"MT Osterholm","year":"2012","journal-title":"The Lancet Infectious Diseases"},{"issue":"21","key":"ref64","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1016\/j.vaccine.2012.02.048","article-title":"Impacts on influenza A(H1N1)pdm09 infection from cross-protection of seasonal trivalent influenza vaccines and A(H1N1)pdm09 vaccines: Systematic review and meta-analyses","volume":"30","author":"JK Yin","year":"2012","journal-title":"Vaccine"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/aje\/kwn259","article-title":"Estimating influenza vaccine efficacy from challenge and community-based study data","volume":"168","author":"NE Basta","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref66","first-page":"1","article-title":"revention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010","volume":"59","author":"A Fiore","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"e67253","DOI":"10.1371\/journal.pone.0067253","article-title":"Using a Dynamic Model to Consider Optimal Antiviral Stockpile Size in the Face of Pandemic Influenza Uncertainty","volume":"8","author":"AL Greer","year":"2013","journal-title":"PloS one"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-2334-9-129","article-title":"Potential for a global dynamic of Influenza A (H1N1)","volume":"9","author":"A Flahault","year":"2009","journal-title":"BMC infectious diseases"},{"issue":"5934","key":"ref69","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1126\/science.1176062","article-title":"Pandemic potential of a strain of influenza A (H1N1): early findings","volume":"324","author":"C Fraser","year":"2009","journal-title":"Science"},{"issue":"7","key":"ref70","doi-asserted-by":"crossref","first-page":"464","DOI":"10.7326\/0003-4819-151-7-200910060-00143","article-title":"Systematic review: safety and efficacy of extended-duration antiviral chemoprophylaxis against pandemic and seasonal influenza","volume":"151","author":"N Khazeni","year":"2009","journal-title":"Annals of internal medicine"},{"key":"ref71","first-page":"CD008965","article-title":"Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children","volume":"4","author":"T Jefferson","year":"2014","journal-title":"The Cochrane database of systematic reviews"},{"issue":"Suppl 1","key":"ref72","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1093\/cid\/ciq033","article-title":"Closing schools in response to the 2009 pandemic influenza A H1N1 virus in New York City: economic impact on households","volume":"52","author":"RH Borse","year":"2011","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jtbi.2008.02.026","article-title":"A model for influenza with vaccination and antiviral treatment","volume":"253","author":"J Arino","year":"2008","journal-title":"Journal of theoretical biology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtbi.2015.05.008","article-title":"A spatial-temporal transmission model and early intervention policies of 2009 A\/H1N1 influenza in South Korea","volume":"380","author":"J Lee","year":"2015","journal-title":"Journal of theoretical biology"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ypmed.2012.04.009","article-title":"Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization","volume":"54","author":"P Godoy","year":"2012","journal-title":"Preventive medicine"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jcv.2010.11.012","article-title":"Epidemiological investigation of an outbreak of pandemic influenza A (H1N1) 2009 in a boarding school: Serological analysis of 1570 cases","volume":"50","author":"T Li","year":"2011","journal-title":"Journal of Clinical Virology"},{"issue":"7","key":"ref77","first-page":"509","article-title":"A case-control study of the transmission of pandemic influenza A (H1N1) virus in families","volume":"34","author":"WT Liu","year":"2011","journal-title":"Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s12889-015-1890-3","article-title":"Effectiveness of non-pharmaceutical measures in preventing pediatric influenza: a case-control study","volume":"15","author":"N Torner","year":"2015","journal-title":"BMC public health"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/irv.12025","article-title":"Factors associated with the transmission of pandemic (H1N1) 2009 among hospital healthcare workers in Beijing, China","volume":"7","author":"Y Zhang","year":"2012","journal-title":"Influenza and other respiratory viruses"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1186\/1471-2334-14-509","article-title":"Associations of hand-washing frequency with incidence of acute respiratory tract infection and influenza-like illness in adults: a population-based study in Sweden","volume":"14","author":"H Merk","year":"2014","journal-title":"BMC infectious diseases"},{"issue":"6","key":"ref81","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/irv.12103","article-title":"Community knowledge, behaviours and attitudes about the 2009 H1N1 Influenza pandemic: a systematic review","volume":"7","author":"R Tooher","year":"2013","journal-title":"Influenza and other respiratory viruses"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2334-10-99","article-title":"Why do I need it? I am not at risk! Public perceptions towards the pandemic (H1N1) 2009 vaccine","volume":"10","author":"H Seale","year":"2010","journal-title":"BMC infectious diseases"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jhin.2009.09.009","article-title":"Prevention of nosocomial transmission of swine-origin pandemic influenza virus A\/H1N1 by infection control bundle","volume":"74","author":"VCC Cheng","year":"2010","journal-title":"The Journal of hospital infection"},{"issue":"12","key":"ref84","first-page":"1075","article-title":"Pandemic influenza A (H1N1) virus infection factors among healthcare workers\u2014a case-control study","volume":"44","author":"Y Deng","year":"2010","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"issue":"12","key":"ref85","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1086\/662709","article-title":"Transmission of 2009 Pandemic Influenza A (H1N1) Virus among Healthcare Personnel-Southern California, 2009","volume":"32","author":"JL Jaeger","year":"2011","journal-title":"Infection Control & Hospital Epidemiology"},{"issue":"3","key":"ref86","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1750-2659.2012.00407.x","article-title":"Preventable and non-preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009\/2010","volume":"7","author":"C Remschmidt","year":"2013","journal-title":"Influenza and other respiratory viruses"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2334-12-26","article-title":"The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009\u20132011","volume":"12","author":"T Suess","year":"2012","journal-title":"BMC infectious diseases"},{"issue":"5","key":"ref88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1750-2659.2011.00318.x","article-title":"Is abdominal obesity associated with the 2009 influenza A (H1N1) pandemic in Korean school-aged children?","volume":"6","author":"CO Kim","year":"2012","journal-title":"Influenza and other respiratory viruses"},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2458-11-2","article-title":"Perceived risk, anxiety, and behavioural responses of the general public during the early phase of the Influenza A (H1N1) pandemic in the Netherlands: results of three consecutive online surveys","volume":"11","author":"M Bults","year":"2011","journal-title":"BMC public health"},{"issue":"8","key":"ref90","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.3390\/ijerph120809750","article-title":"Assessing the Role of Voluntary Self-Isolation in the Control of Pandemic Influenza Using a Household Epidemic Model","volume":"12","author":"Q Zhang","year":"2015","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"4","key":"ref91","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3201\/eid1304.060828","article-title":"Effectiveness of Interventions to Reduce Contact Rates during a Simulated Influenza Pandemic","volume":"13","author":"JH Michael","year":"2007","journal-title":"Emerging Infectious Disease journal"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2458-9-488","article-title":"Quantifying the impact of community quarantine on SARS transmission in Ontario: estimation of secondary case count difference and number needed to quarantine","volume":"9","author":"SJ Bondy","year":"2009","journal-title":"BMC public health"},{"key":"ref93","doi-asserted-by":"crossref","DOI":"10.1503\/cmaj.091641","article-title":"Modeling mitigation strategies for pandemic (H1N1)","volume":"181","author":"MZ Gojovic","year":"2009","journal-title":"CMAJ"},{"key":"ref94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000256","article-title":"Economic appraisal of Ontario\u2019s universal influenza immunization program: cost-utility analysis","volume":"7","author":"B Sander","year":"2010","journal-title":"Plos Med"},{"issue":"2","key":"ref95","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1503\/cmaj.091807","article-title":"Estimated epidemiologic parameters and morbidity associated with pandemic H1N1 influenza","volume":"182","author":"AR Tuite","year":"2010","journal-title":"CMAJ"},{"key":"ref96","article-title":"Mathematical models to characterize early epidemic growth: a review","author":"G Chowell","year":"2016","journal-title":"Physics of Life Reviews"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.mbs.2006.01.007","article-title":"Semi-empirical power-law scaling of new infection rate to model epidemic dynamics with inhomogenous mixing","volume":"203","author":"P Stroud","year":"2006","journal-title":"Mathematical Biosciences and Engineering"},{"issue":"2","key":"ref98","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001169.pub3","article-title":"Amantadine and rimantadine for influenza A in adults","author":"T Jefferson","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"ref99","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1287\/mnsc.1070.0787","article-title":"Heterogeneity and network structure in the dynamics of diffusion: comparing agent-based and differential equation models","volume":"54","author":"H Rahmandad","year":"2008","journal-title":"Management Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T17:08:14Z","timestamp":1540228094000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179315"}},"subtitle":[],"editor":[{"given":"Gerardo","family":"Chowell","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":99,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179315","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}