{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:04:10Z","timestamp":1777561450051,"version":"3.51.4"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["N N402 194235"],"award-info":[{"award-number":["N N402 194235"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179348","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T21:13:54Z","timestamp":1497561234000},"page":"e0179348","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["The association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-0475","authenticated-orcid":true,"given":"Bart\u0142omiej","family":"Kisiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kisiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Szyma\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Mackiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Bia\u0142o-W\u00f3jcicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Uczniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Fogtman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roksana","family":"Iwanicka-Nowicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Koblowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Kossowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Placha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Sykulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Bachta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"T\u0142ustochowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"P\u0142oski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Kaszuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(03)12954-6","article-title":"Psoriasis","volume":"361","author":"M Lebwohl","year":"2003","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0190-9622(85)70188-0","article-title":"Psoriasis of early and late onset: characterization of two types of psoriasis","volume":"13","author":"T Henseler","year":"1985","journal-title":"J Am Acad Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.genom.6.080604.162324","article-title":"The genetics of psoriasis and autoimmunity","volume":"6","author":"AM Bowcock","year":"2005","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"Suppl 2","key":"ref4","doi-asserted-by":"crossref","first-page":"ii14","DOI":"10.1136\/ard.2004.032482","article-title":"Psoriatic arthritis: epidemiology, clinical features, course, and outcome","volume":"64","author":"DD Gladman","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1468-3083.2009.03364.x","article-title":"Approach to managing patients with nail psoriasis","volume":"23","author":"K Reich","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","article-title":"Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis","volume":"34","author":"V Chandran","year":"2010","journal-title":"J Autoimmun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000251595","article-title":"The natural history of psoriasis in 5,600 patients","volume":"148","author":"EM Farber","year":"1974","journal-title":"Dermatologica"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1689","article-title":"Getting under the skin: the immunogenetics of psoriasis","volume":"5","author":"AM Bowcock","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/6.5.813","article-title":"Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis","volume":"6","author":"RC Trembath","year":"1997","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"WH Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/ard.2008.089367","article-title":"Familial aggregation of psoriatic arthritis","volume":"68","author":"V Chandran","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.jid.5700118","article-title":"Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients\u2014an analysis of 1019 HLA-C- and HLA-B-typed patients","volume":"126","author":"JE Gudjonsson","year":"2006","journal-title":"J Invest Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1046\/j.1365-2133.2000.03885.x","article-title":"HLA-C and guttate psoriasis","volume":"143","author":"E Mallon","year":"2000","journal-title":"Br J Dermatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/ard.32.3.181","article-title":"Familial occurrence of PsA","volume":"32","author":"JM Moll","year":"1973","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1101\/gr.6665407","article-title":"Prediction of individual genetic risk to disease from genome-wide association studies","volume":"17","author":"NR Wray","year":"2007","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1003348","DOI":"10.1371\/journal.pgen.1003348","article-title":"Power and Predictive Accuracy of Polygenic Risk Scores","volume":"9","author":"F Dudbridge","year":"2013","journal-title":"PLoS Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1056\/NEJMoa0804742","article-title":"Genotype score in addition to common risk factors for prediction of type 2 diabetes","volume":"359","author":"JB Meigs","year":"2008","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1371\/journal.pmed.0030374","article-title":"Combining information from common type 2 diabetes risk polymorphisms improves disease prediction","volume":"3","author":"MN Weedon","year":"2006","journal-title":"PLoS Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1136\/ard.2009.120170","article-title":"Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk","volume":"69","author":"EW Karlson","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S1474-4422(09)70275-3","article-title":"Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score","volume":"8","author":"PL De Jager","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1161\/STROKEAHA.113.002938","article-title":"Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies","volume":"45","author":"R Malik","year":"2014","journal-title":"Stroke"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.cjca.2016.05.014","article-title":"Anand SS; INTERHEART Investigators. Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations","volume":"32","author":"PG Joseph","year":"2016","journal-title":"Can J Cardiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e19454","DOI":"10.1371\/journal.pone.0019454","article-title":"A genetic risk score combining ten psoriasis risk loci improves disease prediction","volume":"6","author":"H Chen","year":"2011","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e0125369","DOI":"10.1371\/journal.pone.0125369","article-title":"A Weighted Polygenic Risk Score Using 14 Known Susceptibility Variants to Estimate Risk and Age Onset of Psoriasis in Han Chinese","volume":"10","author":"X Yin","year":"2015","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e0163185","DOI":"10.1371\/journal.pone.0163185","article-title":"Evaluation of Psoriasis genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland","volume":"11","author":"M Macieja-Stawczyk","year":"2016","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000250839","article-title":"Severe psoriasis\u2014oral therapy with a new retinoid","volume":"157","author":"T Fredriksson","year":"1978","journal-title":"Dermatologica"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000083509","article-title":"The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis","volume":"210","author":"J Schmitt","year":"2005","journal-title":"Dermatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"LC Tsoi","year":"2012","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/511051","article-title":"A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes","volume":"80","author":"M Cargill","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar3284","article-title":"Association between the PTPN22 +1858 C\/T polymorphism and psoriatic arthritis","volume":"13","author":"K Juneblad","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/jid.2010.350","article-title":"Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6","volume":"131","author":"E Riveira-Munoz","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1000041","DOI":"10.1371\/journal.pgen.1000041","article-title":"A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci","volume":"4","author":"Y Liu","year":"2008","journal-title":"PLoS Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"A Strange","year":"2010","journal-title":"Nat Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways","volume":"41","author":"RP Nair","year":"2009","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ng.690","article-title":"Association analyses identify six new psoriasis susceptibility loci in the Chinese population","volume":"42","author":"LD Sun","year":"2010","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/gene.2009.51","article-title":"Differential contribution of CDKAL1 variants to psoriasis, Crohn&apos;s disease and type II diabetes","volume":"10","author":"M Quaranta","year":"2009","journal-title":"Genes Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/ard.2010.133561","article-title":"High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis","volume":"70","author":"P Rahman","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1093\/hmg\/dds295","article-title":"Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes","volume":"21","author":"A Juli\u00e0","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e1000606","DOI":"10.1371\/journal.pgen.1000606","article-title":"Multiple Loci within the Major Histocompatibility Complex Confer Risk of Psoriasis","volume":"5","author":"B-J Feng","year":"2009","journal-title":"PLoS Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ajhg.2012.02.020","article-title":"Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci","volume":"90","author":"D Ellinghaus","year":"2012","journal-title":"Am J Hum Genet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ng.693","article-title":"Genome-wide association analysis identifies three psoriasis susceptibility loci","volume":"42","author":"PE Stuart","year":"2010","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.humimm.2012.10.019","article-title":"Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet&apos;s disease","volume":"74","author":"MC C\u00e9nit","year":"2013","journal-title":"Hum Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/jid.2014.517","article-title":"A single SNP surrogate for genotyping HLA-C*06:02 in diverse populations","volume":"135","author":"PE Stuart","year":"2015","journal-title":"J Invest Dermatol"},{"issue":"8","key":"ref44","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"DM Evans","year":"2011","journal-title":"Nat Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"SA Miller","year":"1988","journal-title":"Nucleic Acids Research"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1093\/hmg\/ddh094","article-title":"The genetics of psoriasis, psoriatic arthritis and atopic dermatitis","volume":"13","author":"AM Bowcock","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM197210122871503","article-title":"Histocompatibility (HL-A) antigens associated with psoriasis","volume":"287","author":"TJ Russell","year":"1972","journal-title":"N Engl J Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00439-005-0048-2","article-title":"Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR","volume":"118","author":"C Helms","year":"2005","journal-title":"Hum Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e1000038","DOI":"10.1371\/journal.pgen.1000038","article-title":"Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population","volume":"4","author":"X Fan","year":"2008","journal-title":"PLoS Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0165-2478(02)00212-2","article-title":"Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients","volume":"85","author":"W \u0141uszczek","year":"2002","journal-title":"Immunol Let"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF03195223","article-title":"Lack of association of HLA-C alleles with late-onset psoriasis in the northern Polish population","volume":"48","author":"A Szczerkowska-Dobosz","year":"2007","journal-title":"J Appl Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T17:23:33Z","timestamp":1750353813000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179348"}},"subtitle":[],"editor":[{"given":"Sunil K.","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179348","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]}}}