{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:33:37Z","timestamp":1790084017683,"version":"4.0.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Ostergotland"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179401","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T13:29:15Z","timestamp":1497619755000},"page":"e0179401","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and Troponin T"],"prefix":"10.1371","volume":"12","author":[{"given":"Boris","family":"Keselman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-1000","authenticated-orcid":true,"given":"Fredrik H.","family":"Nystrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"WC Knowler","year":"2002","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.2337\/dc10-1881","article-title":"Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis","volume":"34","author":"A Chudyk","year":"2011","journal-title":"Diabetes care"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.mcna.2011.06.007","article-title":"Exercise and the treatment of diabetes and obesity","volume":"95","author":"DJ O'Gorman","year":"2011","journal-title":"Med Clin North Am"},{"issue":"15","key":"ref4","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1001\/archinternmed.2011.275","article-title":"Lifestyle modification and prevention of type 2 diabetes in overweight Japanese with impaired fasting glucose levels: a randomized controlled trial","volume":"171","author":"T Saito","year":"2011","journal-title":"Archives of internal medicine"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2165\/00007256-200636030-00005","article-title":"The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss","volume":"36","author":"P Stiegler","year":"2006","journal-title":"Sports Med"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1123\/ijspp.6.3.396","article-title":"The relationship between serum and salivary cortisol levels in response to different intensities of exercise","volume":"6","author":"MD VanBruggen","year":"2011","journal-title":"Int J Sports Physiol Perform"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/vhrm.2005.1.4.291","article-title":"Cardiovascular consequences of cortisol excess","volume":"1","author":"JA Whitworth","year":"2005","journal-title":"Vasc Health Risk Manag"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s00125-007-0713-1","article-title":"Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual","volume":"50","author":"N Franck","year":"2007","journal-title":"Diabetologia"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0898-6568(99)00025-X","article-title":"Insulin signalling: metabolic pathways and mechanisms for specificity","volume":"11","author":"FH Nystrom","year":"1999","journal-title":"Cell Signal"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1249\/01.mss.0000233798.62153.50","article-title":"Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise","volume":"38","author":"WW Winder","year":"2006","journal-title":"Medicine and science in sports and exercise"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1249\/01.MSS.0000106171.38299.64","article-title":"AMP-activated protein kinase: a key system mediating metabolic responses to exercise","volume":"36","author":"DG Hardie","year":"2004","journal-title":"Medicine and science in sports and exercise"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.mayocp.2012.04.005","article-title":"Potential adverse cardiovascular effects from excessive endurance exercise","volume":"87","author":"JH O'Keefe","year":"2012","journal-title":"Mayo Clinic proceedings"},{"issue":"12","key":"ref13","first-page":"927","article-title":"Cortisol in saliva\u2014reference ranges and relation to cortisol in serum","volume":"33","author":"E Aardal","year":"1995","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"A Katz","year":"2000","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/00365513.2010.491125","article-title":"Comparison of the subjective sense of high or low metabolism and objectively measured resting metabolic rate","volume":"70","author":"A Wallhuss","year":"2010","journal-title":"Scand J Clin Lab Invest"},{"key":"ref16","first-page":"1","article-title":"Two weeks of overfeeding with candy, but not peanuts, increases insulin levels and body weight","author":"AL Claesson","year":"2009","journal-title":"Scand J Clin Lab Invest"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03009734.2013.825348","article-title":"Effects of exercise with or without blueberries in the diet on cardio-metabolic risk factors: An exploratory pilot study in healthy subjects","volume":"118","author":"S Nyberg","year":"2013","journal-title":"Ups J Med Sci"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF00618491","article-title":"Plasma catecholamine and cortisol concentrations during acceleration stress","volume":"70","author":"Y Miyamoto","year":"1995","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"3\u20134","key":"ref19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00357593","article-title":"Beta-endorphin, adrenocorticotropic hormone, cortisol and catecholamines during aerobic and anaerobic exercise","volume":"61","author":"L Schwarz","year":"1990","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1210\/jc.2006-2263","article-title":"Glucose requirements to maintain euglycemia after moderate-intensity afternoon exercise in adolescents with type 1 diabetes are increased in a biphasic manner","volume":"92","author":"SK McMahon","year":"2007","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0026-0495(86)90128-9","article-title":"Acute cortisol excess results in unimpaired insulin action on lipolysis and branched chain amino acids, but not on glucose kinetics and C-peptide concentrations in man","volume":"35","author":"D Clerc","year":"1986","journal-title":"Metabolism: clinical and experimental"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuroimage.2009.05.074","article-title":"The brain and the stress axis: the neural correlates of cortisol regulation in response to stress","volume":"47","author":"K Dedovic","year":"2009","journal-title":"Neuroimage"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.psyneuen.2008.10.026","article-title":"Salivary cortisol as a biomarker in stress research","volume":"34","author":"DH Hellhammer","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2174\/157016110791330889","article-title":"The role of the stress-related anti-inflammatory hormones ACTH and cortisol in atherosclerosis","volume":"8","author":"P Fantidis","year":"2010","journal-title":"Curr Vasc Pharmacol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1758-5996-3-23","article-title":"Correlation between measures of insulin resistance in fasting and non-fasting blood","volume":"3","author":"RJ Hancox","year":"2011","journal-title":"Diabetol Metab Syndr"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00456122","article-title":"Effect of adrenal steroids on insulin release from cultured rat islets of Langerhans","volume":"29","author":"J Pierluissi","year":"1986","journal-title":"Diabetologia"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1210\/endo-111-5-1648","article-title":"Direct effect of cortisol and cortisone on insulin and glucagon secretion","volume":"111","author":"G Barseghian","year":"1982","journal-title":"Endocrinology"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s00125-007-0727-8","article-title":"A 10-s sprint performed prior to moderate-intensity exercise prevents early post-exercise fall in glycaemia in individuals with type 1 diabetes","volume":"50","author":"VA Bussau","year":"2007","journal-title":"Diabetologia"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2337\/diacare.28.6.1289","article-title":"The decline in blood glucose levels is less with intermittent high-intensity compared with moderate exercise in individuals with type 1 diabetes","volume":"28","author":"KJ Guelfi","year":"2005","journal-title":"Diabetes care"},{"issue":"3","key":"ref30","article-title":"Effect of cortisol on energy expenditure and amino acid metabolism in humans","volume":"268","author":"DJ Brillon","year":"1995","journal-title":"Am J Physiol"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1210\/jc.2007-0445","article-title":"Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure","volume":"92","author":"JJ Christiansen","year":"2007","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"1","key":"ref32","first-page":"5","article-title":"High-sensitivity troponin after running\u2014a systematic review","volume":"72","author":"EM Vilela","year":"2014","journal-title":"Neth J Med"},{"issue":"47","key":"ref33","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1093\/eurheartj\/eht188","article-title":"Risk of arrhythmias in 52 755 long-distance cross-country skiers: a cohort study","volume":"34","author":"K Andersen","year":"2013","journal-title":"European heart journal"},{"key":"ref34","article-title":"Increased risk of atrial fibrillation among elderly Norwegian men with a history of long-term endurance sport practice","author":"M Myrstad","year":"2013","journal-title":"Scandinavian journal of medicine & science in sports"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T11:23:42Z","timestamp":1540293822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179401"}},"subtitle":[],"editor":[{"given":"Harald","family":"Staiger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179401","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,16]]}}}