{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:01:03Z","timestamp":1761663663380,"version":"3.37.3"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179942","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T17:40:47Z","timestamp":1498671647000},"page":"e0179942","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Regulatory T cell frequencies and phenotypes following anti-viral vaccination"],"prefix":"10.1371","volume":"12","author":[{"given":"A. Charlotte M. T.","family":"de Wolf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"van Aalst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene S.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline L.","family":"Bodinham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruurd","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"van Eden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-0111","authenticated-orcid":true,"given":"Femke","family":"Broere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nri3605","article-title":"Homeostatic control of regulatory T cell diversity","volume":"14","author":"A Liston","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref2","article-title":"From IPEX syndrome to FOXP3 mutation: A lesson on immune dysregulation","author":"R Bacchetta","year":"2016","journal-title":"Ann New York Acad Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nri3650","article-title":"FOXP3 and scurfy: How it all began","volume":"14","author":"F Ramsdell","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","article-title":"Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease","volume":"212","author":"S Sakaguchi","year":"2006","journal-title":"Immunol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1089\/vim.2015.0039","article-title":"Regulatory T cells are critical for clearing influenza a virus in neonatal mice","volume":"28","author":"S Oliphant","year":"2015","journal-title":"Viral Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/pr.2015.143","article-title":"The role of Th17 and Treg responses in the pathogenesis of RSV infection","volume":"78","author":"TC Mangodt","year":"2015","journal-title":"Pediatr Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2011.03551.x","article-title":"Foxp3 + regulatory T cells, immune stimulation and host defence against infection","volume":"136","author":"JH Rowe","year":"2012","journal-title":"Immunology"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151717","article-title":"Characterization of the Treg response in the hepatitis B virus hydrodynamic injection mouse model","volume":"11","author":"KK Dietze","year":"2016","journal-title":"PLoS ONE"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/hep.25765","article-title":"Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice","volume":"56","author":"L Stross","year":"2012","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1751-7915.2011.00299.x","article-title":"Tregs in infection and vaccinology: Heroes or traitors?","volume":"5","author":"L Berod","year":"2012","journal-title":"Microb Biotechnol"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2014.00477","article-title":"Targeting regulatory T cells to improve vaccine immunogenicity in early life","volume":"5","author":"J Ndure","year":"2014","journal-title":"Front Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2013.12.005","article-title":"Regulatory T cells in cancer immunotherapy","volume":"27","author":"H Nishikawa","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s13337-013-0187-3","article-title":"Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy","volume":"25","author":"J Bayry","year":"2014","journal-title":"VirusDisease"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.imlet.2008.11.007","article-title":"Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction","volume":"122","author":"KH Mills","year":"2009","journal-title":"Immunol Lett"},{"key":"ref15","article-title":"Application of &quot;systems Vaccinology&quot; to Evaluate Inflammation and Reactogenicity of Adjuvanted Preventative Vaccines","volume":"2015","author":"DJM Lewis","year":"2015","journal-title":"J Immunol Res"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157066","article-title":"Early rise of blood T follicular helper cell subsets and baseline immunity as predictors of persisting late functional antibody responses to vaccination in humans","volume":"11","author":"F Spensieri","year":"2016","journal-title":"PLoS ONE"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor","volume":"30","author":"M Miyara","year":"2009","journal-title":"Immunity"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3 + regulatory T cells in the human immune system","volume":"10","author":"S Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2567.2009.03053.x","article-title":"Regulatory T cells overturned: The effectors fight back","volume":"126","author":"LSK Walker","year":"2009","journal-title":"Immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1189\/jlb.70.6.849","article-title":"Modes of action of Freund&apos;s adjuvants in experimental models of autoimmune diseases","volume":"70","author":"A Billiau","year":"2001","journal-title":"J Leukocyte Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.clim.2009.09.014","article-title":"Influenza vaccine administration in rheumatoid arthritis patients under treatment with TNFa blockers: Safety and immunogenicity","volume":"134","author":"S Salemi","year":"2010","journal-title":"Clin Immunol"},{"key":"ref22","article-title":"Dynamic variations in the peripheral blood lymphocyte subgroups of patients with 2009 pandemic H1N1 swine-origin influenza A virus infection","volume":"8","author":"X Guo","year":"2011","journal-title":"Virol J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1007\/s00705-013-1692-9","article-title":"Innate and adaptive immune responses in patients with pandemic influenza A(H1N1)pdm09","volume":"158","author":"Y Huang","year":"2013","journal-title":"Arch Virol"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008393","article-title":"Effect of the novel influenza a (H1N1) virus in the human immune system","volume":"4","author":"EJ Giamarellos-Bourboulis","year":"2009","journal-title":"PLoS ONE"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1128\/JVI.05685-11","article-title":"Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated foxp3 + regulatory T cell response","volume":"86","author":"RJ Betts","year":"2012","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/hdi.12326","article-title":"Role of T-regulatory cells in the response to hepatitis B vaccine in hemodialysis patients","volume":"20","author":"RO Mathew","year":"2016","journal-title":"Hemodial Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10620-013-3022-1","article-title":"Regulatory role of CD4+CD25+Foxp3+ regulatory T cells on IL-17-secreting T cells in chronic hepatitis B patients","volume":"59","author":"J Li","year":"2014","journal-title":"Dig Dis Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1016\/j.vaccine.2012.06.063","article-title":"Regulatory T cells are the most important determinant factor of hepatitis B infection prognosis: A systematic review and meta-analysis","volume":"30","author":"SH Aalaei-Andabili","year":"2012","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.humimm.2012.01.014","article-title":"Relations of regulatory T cells with hepatitis markers in chronic hepatitis B virus infection","volume":"73","author":"O El-Badawy","year":"2012","journal-title":"Hum Immunol"},{"key":"ref30","first-page":"1046","article-title":"CD4 + CD25 + FoxP3 + T regulatory cells in subjects responsive or unresponsive to hepatitis B vaccination","volume":"36","author":"J Li","year":"2011","journal-title":"J Cent South Univ Med Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1517\/14712598.2010.529125","article-title":"Regulatory T cells in HBV and HCV liver diseases: Implication of regulatory T lymphocytes in the control of immune response","volume":"10","author":"C Miroux","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.10.004","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects","volume":"47","author":"C Perricone","year":"2013","journal-title":"J Autoimmun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1111\/j.1600-6143.2010.03291.x","article-title":"Expression of CD39 by human peripheral blood CD4+CD25 + T cells denotes a regulatory memory phenotype","volume":"10","author":"KM Dwyer","year":"2010","journal-title":"Am J Transplant"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"S Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"G Borsellino","year":"2007","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2172-13-17","article-title":"Expression of CD39 on FoxP3 + T regulatory cells correlates with progression of HBV infection","volume":"13","author":"Y Tang","year":"2012","journal-title":"BMC Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.4049\/jimmunol.1202234","article-title":"Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response","volume":"190","author":"K Blom","year":"2013","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2249.2006.03317.x","article-title":"Activation\/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: Is this the key to prevent severe adverse reactions following immunization?","volume":"148","author":"M\u00c2 Martins","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1172\/JCI23963","article-title":"A peripheral circulating compartment of natural naive CD4+ Tregs","volume":"115","author":"D Valmori","year":"2005","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"F Sallusto","year":"1999","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.194.6.847","article-title":"Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells","volume":"194","author":"A Iellem","year":"2001","journal-title":"J Exp Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3727\/096368911X566217","article-title":"The time is crucial for ex vivo expansion of t regulatory cells for therapy","volume":"20","author":"N Marek","year":"2011","journal-title":"Cell Transplant"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.vaccine.2015.12.057","article-title":"Comparable immune responsiveness but increased reactogenicity after subcutaneous versus intramuscular administration of tick borne encephalitis (TBE) vaccine","volume":"34","author":"S Hopf","year":"2016","journal-title":"Vaccine"},{"key":"ref44","article-title":"How neutrophils shape adaptive immune responses","volume":"6","author":"PHC Leliefeld","year":"2015","journal-title":"Front Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T05:59:52Z","timestamp":1692856792000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179942"}},"subtitle":[],"editor":[{"given":"Aric","family":"Gregson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179942","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,6,28]]}}}