{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:35:26Z","timestamp":1790141726101,"version":"4.0.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0179991","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T17:46:05Z","timestamp":1498758365000},"page":"e0179991","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Actinic keratosis modelling in mice: A translational study"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7057-5980","authenticated-orcid":true,"given":"Arnaud","family":"Pillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cartron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"C\u00e8be","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sibaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Guilbaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Audoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kruczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"ref1","first-page":"S785","article-title":"Actinic keratoses: prevalence, pathogenesis, presentation and prevention","volume":"6","author":"M Alam","year":"2006","journal-title":"Adv Stud Med"},{"issue":"Suppl 2","key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2133.2007.08267.x","article-title":"Pathology and pathobiology of actinic (solar) keratosis\u2014an update","volume":"157","author":"J Roewert-Huber","year":"2007","journal-title":"Br J Dermatol"},{"issue":"1 Suppl 1","key":"ref3","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jaad.2012.09.053","article-title":"Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation","volume":"68","author":"B Berman","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"E484","DOI":"10.1152\/ajpendo.00217.2011","article-title":"Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation","volume":"301","author":"C Skobowiat","journal-title":"Am J Physiol Endocrinol Metab 20177"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1684\/ejd.2013.1923","article-title":"Therapeutic strategies for actinic keratoses\u2014a systematic review","volume":"23","author":"D Nashan","year":"2013","journal-title":"Eur J Dermatol"},{"issue":"Suppl. 2","key":"ref6","first-page":"5","article-title":"From actinic keratosis to squamous cell carcinoma: pathophysiology revisited","volume":"31","author":"MTF Figueras","year":"2017","journal-title":"JEADV"},{"issue":"2","key":"ref7","first-page":"167","article-title":"Mechanisms of action of new treatment modalities for actinic keratosis","volume":"5","author":"B Berman","year":"2006","journal-title":"J Drugs Dermatol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/mc.21901","article-title":"Imiquimod attenuates the growth of UVB-induced SCC in mice through Th1\/Th17 cells","volume":"52","author":"M Yokogawa","year":"2013","journal-title":"Mol Carcinog"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00403-012-1270-0","article-title":"Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH-1 mice","volume":"305","author":"SJ Cozzi","year":"2013","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/carcin\/bgs349","article-title":"Preventative topical diclofenac treatment differentially decreases tumor burden in male and female SKH-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma","volume":"34","author":"EM Burns","year":"2013","journal-title":"Carcinogenesis"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0733-8635(02)00035-9","article-title":"Dermoscopy: a review","volume":"20","author":"CM Grin","year":"2002","journal-title":"Dermatol Clin"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1158\/1535-7163.MCT-10-0207","article-title":"Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice","volume":"9","author":"BS Schaffer","year":"2010","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/bjd.12343","article-title":"Network meta-analysis of the outcome 'participant complete clearance' in nonimmunosuppressed participants of eight interventions for actinic keratosis: a follow-up on a Cochrane review","volume":"169","author":"AK Gupta","year":"2013","journal-title":"Br J Dermatol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jdermsci.2008.08.012","article-title":"The hairless mouse in skin research","volume":"53","author":"F Benavides","year":"2009","journal-title":"J Dermatol Sci"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/jid.2013.278","article-title":"RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness","volume":"134","author":"N Meyer","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"2","key":"ref16","first-page":"83","article-title":"Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway","volume":"63","author":"CH Wu","year":"2011","journal-title":"J Dermatol Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000366534","article-title":"Mouse models for actinic keratosis and squamous cell carcinoma","volume":"46","author":"HY Handoko","year":"2015","journal-title":"Curr Probl Dermatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/bjd.12096","article-title":"Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo","volume":"168","author":"C Skobowiat","year":"2013","journal-title":"Br J Dermatol"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1172\/JCI57415","article-title":"From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma","volume":"122","author":"V Ratushny","year":"2012","journal-title":"J Clin Invest"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1056\/NEJMoa1111170","article-title":"Ingenol mebutate gel for actinic keratosis","volume":"366","author":"M Lebwohl","year":"2012","journal-title":"N Engl J Med"},{"key":"ref21","unstructured":"George J, Delalleau A. Visual observation device, especially for a dermatological application. patent WO\/2015\/075177. 2014 2014."},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1109\/TIP.2011.2142003","article-title":"An a priori shading correction technique for contact imaging devices","volume":"20","author":"A Delalleau","year":"2011","journal-title":"IEEE Trans Image Process"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1109\/42.875195","article-title":"An imaging system with calibrated color image acquisition for use in dermatology","volume":"19","author":"HY Vander","year":"2000","journal-title":"IEEE Trans Med Imaging"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0179991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T05:27:44Z","timestamp":1602394064000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0179991"}},"subtitle":[],"editor":[{"given":"Andrzej T","family":"Slominski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,29]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0179991","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,29]]}}}