{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:47:15Z","timestamp":1783694835881,"version":"3.55.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0180128","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T17:37:44Z","timestamp":1500658664000},"page":"e0180128","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography"],"prefix":"10.1371","volume":"12","author":[{"given":"Tiago S.","family":"Prata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio S.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor G.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-4826","authenticated-orcid":true,"given":"Syril","family":"Dorairaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael L.","family":"Furlanetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto M.","family":"Vessani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Paranhos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"CF Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"ref2","first-page":"505","article-title":"The mechanism of optic nerve damage in experimental acute intraocular pressure elevation","volume":"19","author":"HA Quigley","year":"1980","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"MR Hernandez","year":"2000","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archopht.1969.00990020792015","article-title":"Ultrastructure of Human and Monkey Lamina Cribrosa and Optic Nerve Head","volume":"82","author":"DR Anderson","year":"1969","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1001\/archopht.1981.03930021035010","article-title":"Anatomy of the Lamina Cribrosa in Human Eyes","volume":"99","author":"RL Radius","year":"1981","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic Nerve Damage in Human Glaucoma","volume":"99","author":"HA Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","article-title":"Regional Differences in the Structure of the Lamina Cribrosa and Their Relation to Glaucomatous Optic Nerve Damage","volume":"99","author":"HA Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1167\/iovs.04-0133","article-title":"Finite Element Modeling of Optic Nerve Head Biomechanics","volume":"45","author":"IA Sigal","year":"2004","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Downs JC, Roberts MD, Burgoyne CF, Hart RT. Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye. 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society; 2009\/09: Institute of Electrical and Electronics Engineers (IEEE); 2009.","DOI":"10.1109\/IEMBS.2009.5332755"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1167\/iovs.03-0174","article-title":"Anatomic Relationship between Lamina Cribrosa, Intraocular Space, and Cerebrospinal Fluid Space","volume":"44","author":"JB Jonas","year":"2003","journal-title":"Investigative Opthalmology & Visual Science"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(83)90389-6","article-title":"Morphologic Changes in the Lamina Cribrosa Correlated with Neural Loss in Open-Angle Glaucoma","volume":"95","author":"HA Quigley","year":"1983","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0002-9394(14)75984-7","article-title":"Changes in the Extracellular Matrix of the Human Optic Nerve Head in Primary Open-Angle Glaucoma","volume":"109","author":"MR Hernandez","year":"1990","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0969-9961(03)00101-3","article-title":"Altered expression of 3\u03b1-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes","volume":"14","author":"O Agapova","year":"2003","journal-title":"Neurobiol Dis"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/bjo.2003.019281","article-title":"Alterations in the morphology of lamina cribrosa pores in glaucomatous eyes","volume":"88","author":"G Tezel","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1167\/iovs.11-7448","article-title":"Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma","volume":"52","author":"H Yang","year":"2011","journal-title":"Investigative Opthalmology & Visual Science"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1364\/JOSAA.24.001417","article-title":"Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa","volume":"24","author":"AS Vilupuru","year":"2007","journal-title":"Journal of the Optical Society of America A"},{"issue":"4 Suppl","key":"ref17","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.3928\/15428877-20080715-07","article-title":"Ultrahigh-resolution spectral domain optical coherence tomography imaging of the lamina cribrosa","volume":"39","author":"L Kagemann","year":"2008","journal-title":"Ophthalmic Surg Lasers Imaging"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1167\/iovs.09-3984","article-title":"A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology","volume":"51","author":"NG Strouthidis","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography","volume":"146","author":"RF Spaide","year":"2008","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ajo.2011.01.024","article-title":"Visualization of the Lamina Cribrosa Using Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography","volume":"152","author":"EJ Lee","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ophtha.2011.07.012","article-title":"Enhanced Depth Imaging Optical Coherence Tomography of Deep Optic Nerve Complex Structures in Glaucoma","volume":"119","author":"SC Park","year":"2012","journal-title":"Ophthalmology"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ophtha.2011.07.033","article-title":"Enhanced Depth Imaging Detects Lamina Cribrosa Thickness Differences in Normal Tension Glaucoma and Primary Open-Angle Glaucoma","volume":"119","author":"H-YL Park","year":"2012","journal-title":"Ophthalmology"},{"issue":"1","key":"ref23","article-title":"Analysis of neuroretinal rim distribution and vascular pattern in eyes with presumed large physiological cupping: a comparative study","volume":"14","author":"FSS Lopes","year":"2014","journal-title":"BMC Ophthalmol"},{"issue":"3","key":"ref24","first-page":"91","article-title":"Eyes with large disc cupping and normal intraocular pressure: using optical coherence tomography to discriminate those with and without glaucoma","volume":"3","author":"TS Prata","year":"2014","journal-title":"Medical hypothesis, discovery and innovation in ophthalmology"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1167\/iovs.12-11530","article-title":"Posterior Displacement of the Lamina Cribrosa in Glaucoma: In Vivo Interindividual and Intereye Comparisons","volume":"54","author":"RL Furlanetto","year":"2013","journal-title":"Investigative Opthalmology & Visual Science"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1167\/iovs.14-14903","article-title":"Lamina Cribrosa Visibility Using Optical Coherence Tomography: Comparison of Devices and Effects of Image Enhancement Techniques","volume":"56","author":"MJA Girard","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.ophtha.2016.06.001","article-title":"Optic Disc Hemorrhages and Laminar Disinsertions in Glaucoma","volume":"123","author":"GP Sharpe","year":"2016","journal-title":"Ophthalmology"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1442-9071.2012.02790.x","article-title":"Association between corneal biomechanical properties and optic nerve head morphology in newly diagnosed glaucoma patients","volume":"40","author":"TS Prata","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1167\/iovs.04-0851","article-title":"Central corneal thickness and thickness of the lamina cribrosa in human eyes","volume":"46","author":"JB Jonas","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00417-010-1369-y","article-title":"Central corneal thickness, lamina cribrosa and peripapillary scleral histomophometry in non-glaucomatous Chinese eyes","volume":"248","author":"R Ren","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0180128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T04:19:58Z","timestamp":1602562798000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0180128"}},"subtitle":[],"editor":[{"given":"Sanjoy","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0180128","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}