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Hackbarth","year":"2010","journal-title":"Chem Biol Drug Des"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0168-1702(96)01311-1","article-title":"Immunological analysis of the protective responses to the chimeric synthetic peptide representing T- and B-cell epitopes from the fusion protein of measles virus","volume":"42","author":"OE Obeid","year":"1996","journal-title":"Virus Res"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0264-410X(90)90053-O","article-title":"Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination","volume":"8","author":"Y Hirabayashi","year":"1990","journal-title":"Vaccine"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(02)00341-2","article-title":"Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo","volume":"17","author":"A Phalipon","year":"2002","journal-title":"Immunity"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/JCM.27.1.162-167.1989","article-title":"Immunoglobulin M, A, and G antibody response to lipopolysaccharide O antigen in symptomatic and asymptomatic Shigella infections","volume":"27","author":"D Cohen","year":"1989","journal-title":"J Clin Microbiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.icb7100025","article-title":"Shigella&apos;s ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?","volume":"85","author":"A Phalipon","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/IAI.59.7.2341-2350.1991","article-title":"Prospective study of systemic and mucosal immune responses in dysenteric patients to specific Shigella invasion plasmid antigens and 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HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model","volume":"21","author":"L Zhang","year":"2013","journal-title":"Oncol Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e17712","DOI":"10.1371\/journal.pone.0017712","article-title":"Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses","volume":"6","author":"C Chen","year":"2011","journal-title":"PLoS One"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3892\/ijmm.2016.2512","article-title":"Streptococcus pneumoniae fructose-1,6-bisphosphate aldolase, a protein vaccine candidate, elicits Th1\/Th2\/Th17-type cytokine responses in mice","volume":"37","author":"S Elhaik Goldman","year":"2016","journal-title":"Int J Mol Med"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1080\/21645515.2015.1037057","article-title":"Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine","volume":"11","author":"X Teng","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1128\/IAI.63.8.2941-2949.1995","article-title":"Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease","volume":"63","author":"D Islam","year":"1995","journal-title":"Infect Immun"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/IAI.63.1.289-296.1995","article-title":"Persistence of local cytokine production in shigellosis in acute and convalescent stages","volume":"63","author":"R Raqib","year":"1995","journal-title":"Infect Immun"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/gut.34.2.194","article-title":"Concentrations of interleukin 6 and tumour necrosis factor in serum and stools of children with Shigella dysenteriae 1 infection","volume":"34","author":"DG de Silva","year":"1993","journal-title":"Gut"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1128\/IAI.72.11.6666-6675.2004","article-title":"Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections","volume":"72","author":"RE Brennan","year":"2004","journal-title":"Infect Immun"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"e93907","DOI":"10.1371\/journal.pone.0093907","article-title":"MP3: a software tool for the prediction of pathogenic proteins in genomic and metagenomic data","volume":"9","author":"A Gupta","journal-title":"PLoS One"}],"container-title":["PLOS 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