{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:22:15Z","timestamp":1776903735129,"version":"3.51.2"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0180645","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T13:44:03Z","timestamp":1499435043000},"page":"e0180645","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["A retrospective case-cohort study comparing treatment outcomes in abacavir versus stavudine containing first line antiretroviral treatment regimens in children <3yrs old, at a paediatric programme based in Soweto, South Africa"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3709-6547","authenticated-orcid":true,"given":"Haseena","family":"Cassim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy","family":"Otwombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afaaf","family":"Liberty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda E.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oppel B. W.","family":"Greeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avy","family":"Violari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Global update on HIV treatment 2013: results, impact and opportunities. Accessed on 23 Nov 2016 at http:\/\/www.who.int\/hiv\/pub\/progressreports\/update2013\/en\/<\/ext-link>. 2013 9241505737."},{"key":"ref2","unstructured":"UNICEF. Paediatric treatment and care. Accessed on the 5th of June 2016 [internet]. 2015. http:\/\/data.unicef.org\/topic\/hivaids\/paediatric-treatment-and-care\/<\/ext-link>."},{"key":"ref3","unstructured":"UNAIDS. The gap report. 2014. Accessed on the 5th of June 2016. [http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_Gap_report_en.pdf<\/ext-link>]."},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMoa0800971","article-title":"Early Antiretroviral Therapy and Mortality among HIV-Infected Infants","volume":"359","author":"A Violari","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"9904","key":"ref5","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0140-6736(13)61409-9","article-title":"Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial","volume":"382","author":"MF Cotton","year":"2013","journal-title":"The Lancet"},{"key":"ref6","unstructured":"World Health Organisation. Antiretroviral therapy for HIV infection in infants and children: towards universal access. Recommendations for a public health approach. 2006. Accessed on 23 Nov 2016 at http:\/\/www.who.int\/hiv\/pub\/guidelines\/WHOpaediatric.pdf<\/ext-link>. 2006."},{"key":"ref7","unstructured":"World Health Organisation. Antiretroviral therapy for HIV infection in infants and children. Accessed on 23 Nov 2016 at http:\/\/www.who.int\/hiv\/pub\/paediatric\/infants2010\/en\/<\/ext-link>. internet. 2010."},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1468-1293.2009.00759.x","article-title":"PENTA 2009 guidelines for the use of antiretroviral therapy in paediatric HIV-1 infection","volume":"10","author":"PS Committee","year":"2009","journal-title":"HIV Medicine"},{"key":"ref9","article-title":"Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial","volume":"359","year":"2002","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Technau K, Lazarus E, Louise K, Abrahams E, Sorour G, Strehlau R, et al. Poor Early Virologic Performance and Durability of Abacavir-based First-line Regimens for HIV-infected Children 2013.","DOI":"10.1097\/INF.0b013e31828c3738"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1097\/INF.0000000000000222","article-title":"Virologic response in children treated with abacavir compared with stavudine-based antiretroviral treatment\u2013a South African multi-cohort analysis","volume":"33","author":"KG Technau","year":"2014","journal-title":"The Pediatric infectious disease journal"},{"key":"ref12","article-title":"CHAPAS 3: A randomised trial comparing stavudine vs zidovudine vs abacavir as NRTI backbone in NNRTI-based first-line ART in 478 HIV-infected children in Uganda and Zambia","volume":"6","author":"V Musiime","year":"2014","journal-title":"Rev Antiviral Ther Infect Dis"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-015-1183-6","article-title":"Efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV infected children and adolescents: a systematic review and meta-analysis","volume":"15","author":"OO Adetokunboh","year":"2015","journal-title":"BMC Infectious Diseases"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1542\/peds.2011-3020","article-title":"Variability of Growth in Children Starting Antiretroviral Treatment in Southern Africa","volume":"130","author":"T Gsponer","year":"2012","journal-title":"Pediatrics"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-11-54","article-title":"Weight and height z-scores improve after initiating ART among HIV-infected children in rural Zambia: a cohort study","volume":"11","author":"CG Sutcliffe","year":"2011","journal-title":"BMC Infectious Diseases"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1365-3156.2010.02561.x","article-title":"Growth response to antiretroviral treatment in HIV-infected children: a cohort study from Lilongwe, Malawi","volume":"15","author":"R Weigel","year":"2010","journal-title":"Tropical Medicine & International Health"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0180645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T20:32:56Z","timestamp":1569702776000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0180645"}},"subtitle":[],"editor":[{"given":"Graciela","family":"Andrei","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0180645","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]}}}