{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:56:05Z","timestamp":1790632565572,"version":"4.1.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"The Thailand Research Fund","doi-asserted-by":"crossref","award":["TRG5780086"],"award-info":[{"award-number":["TRG5780086"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Invitation Research of the Faculty of Medicine, Khon Kaen University","award":["IN59312"],"award-info":[{"award-number":["IN59312"]}]},{"name":"Neuroscience Research and Development Group at Khon Kaen University"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0180650","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T13:40:23Z","timestamp":1499694023000},"page":"e0180650","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy"],"prefix":"10.1371","volume":"12","author":[{"given":"Pornthip","family":"Chaisawang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apiwat","family":"Sirichoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wunnee","family":"Chaijaroonkhanarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanassanun","family":"Pannangrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bungorn","family":"Sripanidkulchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wigmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-1542","authenticated-orcid":true,"given":"Jariya Umka","family":"Welbat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"e30010","DOI":"10.1371\/journal.pone.0030010","article-title":"Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery","volume":"7","author":"L Lyons","year":"2012","journal-title":"PloS one"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.brainresbull.2012.05.005","article-title":"The effect of 5-fluorouracil on the long term survival and proliferation of cells in the rat hippocampus","volume":"88","author":"M ELBeltagy","year":"2012","journal-title":"Brain research bulletin"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2325\/jbcs.12.279","article-title":"Mild cognitive impairment after adjuvant chemotherapy in breast cancer patients\u2014evaluation of appropriate research design and methodology to measure symptoms","volume":"12","author":"T Matsuda","year":"2005","journal-title":"Breast cancer"},{"issue":"Suppl 3","key":"ref4","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.3816\/CBC.2002.s.018","article-title":"Breast cancer chemotherapy-related cognitive dysfunction","volume":"3","author":"TA Ahles","year":"2002","journal-title":"Clinical breast cancer"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00213-008-1175-y","article-title":"Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory","volume":"199","author":"JJ Foley","year":"2008","journal-title":"Psychopharmacology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bandc.2005.05.001","article-title":"The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: a meta-analysis of the current literature","volume":"59","author":"MG Falleti","year":"2005","journal-title":"Brain and cognition"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pbb.2006.07.010","article-title":"The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice","volume":"85","author":"G Winocur","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"issue":"Suppl 1","key":"ref8","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1007\/s00280-003-0625-9","article-title":"Thymidylate synthase inhibitors as anticancer agents: from bench to bedside","volume":"52","author":"E Chu","year":"2003","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2009.08.003","article-title":"Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action","volume":"20","author":"PJ Lucassen","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"J Altman","year":"1965","journal-title":"The Journal of comparative neurology"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00441-007-0478-3","article-title":"Neurogenesis in the adult hippocampus","volume":"331","author":"D Ehninger","year":"2008","journal-title":"Cell and tissue research"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"GL Ming","year":"2011","journal-title":"Neuron"},{"issue":"23","key":"ref13","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"H van Praag","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6882-11-7","article-title":"Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice","volume":"11","author":"R Crupi","year":"2011","journal-title":"BMC complementary and alternative medicine"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1073\/pnas.0910072107","article-title":"Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance","volume":"107","author":"DC Lagace","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/187152706778559273","article-title":"Stress, depression and hippocampal apoptosis","volume":"5","author":"PJ Lucassen","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00213-010-2122-2","article-title":"Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy","volume":"215","author":"L Lyons","year":"2011","journal-title":"Psychopharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aanat.2016.04.029","article-title":"Kaempferia parviflora extract ameliorates the cognitive impairments and the reduction in cell proliferation induced by valproic acid treatment in rats","volume":"206","author":"JU Welbat","year":"2016","journal-title":"Annals of anatomy = Anatomischer Anzeiger: official organ of the Anatomische Gesellschaft"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(98)00141-X","article-title":"In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica","volume":"65","author":"A Shukla","year":"1999","journal-title":"Journal of ethnopharmacology"},{"key":"ref20","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/895857","article-title":"Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice","volume":"2011","author":"SS Huang","year":"2011","journal-title":"Evidence-based complementary and alternative medicine: eCAM"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/jnr.22071","article-title":"Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia","volume":"87","author":"RG Krishnamurthy","year":"2009","journal-title":"Journal of neuroscience research"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/aps.2012.3","article-title":"Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells","volume":"33","author":"MF Xu","year":"2012","journal-title":"Acta pharmacologica Sinica"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/946259","article-title":"Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential","volume":"2012","author":"IE Orhan","year":"2012","journal-title":"Evidence-based complementary and alternative medicine: eCAM"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jep.2010.12.010","article-title":"Effects of asiatic acid on passive and active avoidance task in male Spraque-Dawley rats","volume":"134","author":"MN Nasir","year":"2011","journal-title":"Journal of ethnopharmacology"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"8413","DOI":"10.3390\/nu7105401","article-title":"Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus","volume":"7","author":"A Sirichoat","year":"2015","journal-title":"Nutrients"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","DOI":"10.3390\/nu8050303","article-title":"Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival","volume":"8","author":"J Umka Welbat","year":"2016","journal-title":"Nutrients"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0166-4328(98)00079-5","article-title":"Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition","volume":"99","author":"SL Dix","year":"1999","journal-title":"Behavioural brain research"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuroscience.2009.11.073","article-title":"Valproic acid reduces spatial working memory and cell proliferation in the hippocampus","volume":"166","author":"J Umka","year":"2010","journal-title":"Neuroscience"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0143-4004(88)90001-X","article-title":"Methodological problems in placental morphometry: apologia for the use of stereology based on sound sampling practice","volume":"9","author":"TM Mayhew","year":"1988","journal-title":"Placenta"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbr.2009.11.017","article-title":"Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil","volume":"208","author":"M ElBeltagy","year":"2010","journal-title":"Behavioural brain research"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0090-8258(90)90127-7","article-title":"5-Fluorouracil neurotoxicity","volume":"36","author":"DH Moore","year":"1990","journal-title":"Gynecologic oncology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00000421-199112000-00012","article-title":"High-dose 24-hour infusion of 5-fluorouracil in metastatic prostate cancer. A phase II trial of the Piedmont Oncology Association","volume":"14","author":"JN Atkins","year":"1991","journal-title":"American journal of clinical oncology"},{"issue":"8","key":"ref33","first-page":"721","article-title":"Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid","volume":"93","author":"KH Yeh","year":"1994","journal-title":"Journal of the Formosan Medical Association = Taiwan yi zhi"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1460-9568.2008.06325.x","article-title":"5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus","volume":"28","author":"S Mustafa","year":"2008","journal-title":"The European journal of neuroscience"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1200\/JCO.2007.14.3248","article-title":"Behavioral symptoms in patients with breast cancer and survivors","volume":"26","author":"JE Bower","year":"2008","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"31","key":"ref36","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1200\/JCO.2005.01.6550","article-title":"Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study","volume":"23","author":"HG Fan","year":"2005","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3816\/CBC.2008.n.006","article-title":"Persistent neurocognitive problems after adjuvant chemotherapy for breast cancer","volume":"8","author":"BP Kreukels","year":"2008","journal-title":"Clinical breast cancer"},{"issue":"9701","key":"ref38","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0140-6736(09)61299-X","article-title":"CNS complications of radiotherapy and chemotherapy","volume":"374","author":"C Soussain","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neubiorev.2007.01.005","article-title":"The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents","volume":"31","author":"E Dere","year":"2007","journal-title":"Neuroscience and biobehavioral reviews"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00213-011-2466-2","article-title":"Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity","volume":"220","author":"JE Fardell","year":"2012","journal-title":"Psychopharmacology"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/hbm.21102","article-title":"Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer","volume":"32","author":"MB de Ruiter","year":"2011","journal-title":"Human brain mapping"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.critrevonc.2007.06.001","article-title":"Cognitive function after chemotherapy in adults with solid tumours","volume":"63","author":"J Vardy","year":"2007","journal-title":"Critical reviews in oncology\/hematology"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/physrev.00055.2003","article-title":"Adult neurogenesis: from precursors to network and physiology","volume":"85","author":"DN Abrous","year":"2005","journal-title":"Physiological reviews"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"C Zhao","year":"2008","journal-title":"Cell"},{"key":"ref45","first-page":"57","article-title":"Hippocampus-dependent learning influences hippocampal neurogenesis","volume":"7","author":"JR Epp","year":"2013","journal-title":"Frontiers in neuroscience"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/6365","article-title":"Learning enhances adult neurogenesis in the hippocampal formation","volume":"2","author":"E Gould","year":"1999","journal-title":"Nature neuroscience"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"e1959","DOI":"10.1371\/journal.pone.0001959","article-title":"Spatial relational memory requires hippocampal adult neurogenesis","volume":"3","author":"D Dupret","year":"2008","journal-title":"PloS one"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1440-169X.2009.01094.x","article-title":"Continuous neurogenesis in the adult brain","volume":"51","author":"I Imayoshi","year":"2009","journal-title":"Development, growth & differentiation"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1460-9568.2005.03875.x","article-title":"New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment","volume":"21","author":"E Bruel-Jungerman","year":"2005","journal-title":"The European journal of neuroscience"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0306-4522(03)00199-4","article-title":"Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat","volume":"119","author":"TM Madsen","year":"2003","journal-title":"Neuroscience"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuroscience.2004.10.009","article-title":"A role for adult neurogenesis in spatial long-term memory","volume":"130","author":"JS Snyder","year":"2005","journal-title":"Neuroscience"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2007.08.004","article-title":"Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat","volume":"186","author":"R Seigers","year":"2008","journal-title":"Behavioural brain research"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1200\/JCO.1988.6.10.1653","article-title":"Fluorouracil: biochemistry and pharmacology","volume":"6","author":"HM Pinedo","year":"1988","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.2741\/1408","article-title":"Thymidylate synthase: a critical target in cancer therapy?","volume":"9","author":"YM Rustum","year":"2004","journal-title":"Frontiers in bioscience: a journal and virtual library"},{"issue":"1\u20132","key":"ref55","first-page":"75","article-title":"Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity","volume":"108","author":"MK Lee","year":"2000","journal-title":"Res Commun Mol Pathol Pharmacol"},{"issue":"1","key":"ref56","first-page":"22","article-title":"Standardized Centella Asiatica Increased Brain- Derived Neurotrophic Factor and Decreased Apoptosis of Dopaminergic Neuron in Rotenone-Induced Zebrafish","volume":"2","author":"H Khotimah","year":"2015","journal-title":"Journal of Psychology"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbrc.2006.02.180","article-title":"Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell","volume":"343","author":"SH Chiou","year":"2006","journal-title":"Biochemical and biophysical research communications"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2011.12.013","article-title":"Expression of doublecortin, a neuronal migration protein, in unipolar brush cells of the vestibulocerebellum and dorsal cochlear nucleus of the adult rat","volume":"202","author":"S Manohar","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.0953-816X.2003.03123.x","article-title":"Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus","volume":"19","author":"MS Rao","year":"2004","journal-title":"The European journal of neuroscience"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neulet.2008.07.030","article-title":"Doublecortin expression continues into adulthood in horizontal cells in the rat retina","volume":"442","author":"T Wakabayashi","year":"2008","journal-title":"Neuroscience letters"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.neuron.2011.01.004","article-title":"Activity-induced Notch signaling in neurons requires Arc\/Arg3.1 and is essential for synaptic plasticity in hippocampal networks","volume":"69","author":"L Alberi","year":"2011","journal-title":"Neuron"},{"issue":"51","key":"ref62","doi-asserted-by":"crossref","first-page":"20558","DOI":"10.1073\/pnas.0710156104","article-title":"Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus","volume":"104","author":"JJ Breunig","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"25","key":"ref63","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1073\/pnas.0308126101","article-title":"Involvement of Notch signaling in hippocampal synaptic plasticity","volume":"101","author":"Y Wang","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0180650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:33:22Z","timestamp":1540258402000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0180650"}},"subtitle":[],"editor":[{"given":"Michelle M.","family":"Adams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,10]]},"references-count":63,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0180650","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,10]]}}}