{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:50:15Z","timestamp":1773640215434,"version":"3.50.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comprehensive Cancer Center Vienna","award":["10207014"],"award-info":[{"award-number":["10207014"]}]},{"DOI":"10.13039\/501100004061","name":"Oesterreichische Nationalbank","doi-asserted-by":"publisher","award":["14788"],"award-info":[{"award-number":["14788"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guerbet France"},{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0180790","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T13:30:54Z","timestamp":1500384654000},"page":"e0180790","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multiparametric [11C]Acetate positron emission tomography-magnetic resonance imaging in the assessment and staging of prostate cancer"],"prefix":"10.1371","volume":"12","author":[{"given":"Stephan H.","family":"Polanec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Andrzejewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal A. T.","family":"Baltzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Helbich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Stiglbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Georg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Karanikas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Susani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wadsak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Margreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Mitterhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Pinker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"ref1","first-page":"754","article-title":"Current role of multiparametric magnetic resonance imaging for prostate cancer","volume":"5","author":"R Loffroy","year":"2015","journal-title":"Quantitative imaging in medicine and surgery"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/CCO.0b013e32835b651e","article-title":"Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy","volume":"25","author":"P Hainaut","year":"2013","journal-title":"Current opinion in oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2214\/AJR.13.11046","article-title":"Accuracy of multiparametric MRI for prostate cancer detection: a meta-analysis","volume":"202","author":"M de Rooij","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1148\/rg.2016150059","article-title":"Molecular Imaging of Prostate Cancer","volume":"36","author":"AG Wibmer","year":"2016","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1148\/radiol.2016160220","article-title":"18F Fluorocholine Dynamic Time-of-Flight PET\/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons","volume":"282","author":"JY Choi","year":"2017","journal-title":"Radiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2014.02.019","article-title":"Acetate\/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application","volume":"356","author":"Y Yoshii","year":"2015","journal-title":"Cancer letters"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2967\/jnumed.111.096032","article-title":"11C-Acetate PET\/CT in localized prostate cancer: a study with MRI and histopathologic correlation","volume":"53","author":"E Mena","year":"2012","journal-title":"Journal of nuclear medicine: official publication, Society of Nuclear Medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/bju.12279","article-title":"Application of C-11-acetate positron-emission tomography (PET) imaging in prostate cancer: systematic review and meta-analysis of the literature","volume":"112","author":"B Mohsen","year":"2013","journal-title":"BJU international"},{"key":"ref10","first-page":"33","article-title":"The clinical use of PET with (11)C-acetate","volume":"2","author":"I Grassi","year":"2012","journal-title":"American journal of nuclear medicine and molecular imaging"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.21873\/anticanres.11246","article-title":"11C-Acetate-PET\/CT Compared to 99mTc-HDP Bone Scintigraphy in Primary Staging of High-risk Prostate Cancer","volume":"36","author":"S Strandberg","year":"2016","journal-title":"Anticancer research"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10334-012-0365-0","article-title":"MR\/PET or PET\/MRI: does it matter?","volume":"26","author":"T Beyer","year":"2013","journal-title":"MAGMA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"D Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref14","unstructured":"American College of Radiology. MR Prostate Imaging Reporting and Data System version 2.0. 2015."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s00330-011-2377-y","article-title":"ESUR prostate MR guidelines 2012","volume":"22","author":"JO Barentsz","year":"2012","journal-title":"European radiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1148\/radiol.2451061444","article-title":"Three-dimensional proton MR spectroscopy of human prostate at 3 T without endorectal coil: feasibility","volume":"245","author":"TW Scheenen","year":"2007","journal-title":"Radiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1055\/s-0033-1355546","article-title":"Magnetic resonance imaging-guided prostate biopsy: institutional analysis and systematic review","volume":"186","author":"SH Polanec","year":"2014","journal-title":"Rofo"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.eururo.2015.08.038","article-title":"Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic Resonance Imaging and Recommendations for Use","volume":"69","author":"JO Barentsz","year":"2016","journal-title":"Eur Urol"},{"key":"ref19","article-title":"Multiparametric MRI of the prostate at 3 T: limited value of 3D H-MR spectroscopy as a fourth parameter","author":"SH Polanec","year":"2015","journal-title":"World journal of urology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00345-013-1106-3","article-title":"Can high-spatial resolution T2-weighted endorectal MRI rule out clinically significant prostate cancer?","volume":"32","author":"MC Roethke","year":"2014","journal-title":"World J Urol"},{"key":"ref21","article-title":"Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: critical evaluation using whole-mount pathology as standard of reference","author":"HA Vargas","year":"2015","journal-title":"European radiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1148\/radiol.12120281","article-title":"Transition zone prostate cancer: detection and localization with 3-T multiparametric MR imaging","volume":"266","author":"CM Hoeks","year":"2013","journal-title":"Radiology"},{"key":"ref23","article-title":"Performance of PI-RADS version 1 versus version 2 regarding the relation with histopathological results","author":"T Auer","year":"2016","journal-title":"World J Urol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ejrad.2016.03.025","article-title":"Head-to-head comparison of PI-RADS v2 and PI-RADS v1","volume":"85","author":"S Polanec","year":"2016","journal-title":"Eur J Radiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00345-015-1670-9","article-title":"Multiparametric MRI of the prostate at 3 T: limited value of 3D (1)H-MR spectroscopy as a fourth parameter","volume":"34","author":"SH Polanec","year":"2016","journal-title":"World J Urol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00330-013-3017-5","article-title":"Evaluation of the ESUR PI-RADS scoring system for multiparametric MRI of the prostate with targeted MR\/TRUS fusion-guided biopsy at 3.0 Tesla","volume":"24","author":"MC Roethke","year":"2014","journal-title":"Eur Radiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.ejrad.2014.08.006","article-title":"Predictive power of the ESUR scoring system for prostate cancer diagnosis verified with targeted MR-guided in-bore biopsy","volume":"83","author":"L Schimmoller","year":"2014","journal-title":"Eur J Radiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1158\/1078-0432.CCR-13-2810","article-title":"Improved differentiation of benign and malignant breast tumors with multiparametric 18fluorodeoxyglucose positron emission tomography magnetic resonance imaging: a feasibility study","volume":"20","author":"K Pinker","year":"2014","journal-title":"Clin Cancer Res"},{"key":"ref29","article-title":"Clinical application of PET\/MRI in oncology","author":"H Sotoudeh","year":"2016","journal-title":"J Magn Reson Imaging"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00259-013-2540-6","article-title":"First imaging results of an intraindividual comparison of (11)C-acetate and (18)F-fluorocholine PET\/CT in patients with prostate cancer at early biochemical first or second relapse after prostatectomy or radiotherapy","volume":"41","author":"F Buchegger","year":"2014","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-0038-1623902","article-title":"Intraindividual comparison of [11C]acetate and [11C]choline PET for detection of metastases of prostate cancer","volume":"42","author":"J Kotzerke","year":"2003","journal-title":"Nuklearmedizin"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1097\/RLU.0000000000001609","article-title":"Long-term Results of a Comparative PET\/CT and PET\/MRI Study of 11C-Acetate and 18F-Fluorocholine for Restaging of Early Recurrent Prostate Cancer","volume":"42","author":"G Lamanna","year":"2017","journal-title":"Clin Nucl Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13244-015-0411-3","article-title":"False positive and false negative diagnoses of prostate cancer at multi-parametric prostate MRI in active surveillance","volume":"6","author":"JS Quon","year":"2015","journal-title":"Insights into imaging"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2007.10.034","article-title":"MRI\/linac integration","volume":"86","author":"JJ Lagendijk","year":"2008","journal-title":"Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"ref35","article-title":"Magnetic resonance imaging for prostate cancer radiotherapy","author":"CV Dinh","year":"2016","journal-title":"Physica medica: PM: an international journal devoted to the applications of physics to medicine and biology: official journal of the Italian Association of Biomedical Physics"},{"key":"ref36","article-title":"Early Outcome of Prostate Intensity Modulated Radiation Therapy (IMRT) Incorporating a Simultaneous Intra-Prostatic MRI Directed Boost","volume":"3","author":"MH Schild","year":"2014","journal-title":"OMICS journal of radiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.radonc.2009.12.034","article-title":"Validation of functional imaging with pathology for tumor delineation in the prostate","volume":"94","author":"G Groenendaal","year":"2010","journal-title":"Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1464-410X.2010.09291.x","article-title":"Accuracy of multiparametric magnetic resonance imaging in detecting recurrent prostate cancer after radiotherapy","volume":"106","author":"N Arumainayagam","year":"2010","journal-title":"BJU international"},{"issue":"Suppl 1","key":"ref39","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1007\/s00259-013-2358-2","article-title":"18F-Choline, 11C-choline and 11C-acetate PET\/CT: comparative analysis for imaging prostate cancer patients","volume":"40","author":"C Brogsitter","year":"2013","journal-title":"European journal of nuclear medicine and molecular imaging"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.18383\/j.tom.2015.00130","article-title":"Positron Emission Tomography in Prostate Cancer: Summary of Systematic Reviews and Meta-Analysis","volume":"1","author":"H Jadvar","year":"2015","journal-title":"Tomography"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/pros.23061","article-title":"Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [(11) C]acetate PET as a prognostic marker","volume":"75","author":"A Leisser","year":"2015","journal-title":"The Prostate"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00259-013-2353-7","article-title":"Sensitivity of PET\/MRI to detect recurrence of prostate cancer","volume":"40","author":"P Arce-Calisaya","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2967\/jnumed.115.161299","article-title":"The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET\/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions","volume":"56","author":"A Afshar-Oromieh","year":"2015","journal-title":"J Nucl Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/pros.22956","article-title":"Prostate-specific membrane antigen-based imaging in prostate cancer: impact on clinical decision making process","volume":"75","author":"MO Demirkol","year":"2015","journal-title":"The Prostate"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MOU.0000000000000309","article-title":"Rapidly changing landscape of PET\/CT imaging in prostate cancer","volume":"26","author":"JJ Morigi","year":"2016","journal-title":"Current opinion in urology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.juro.2016.05.026","article-title":"Re: Molecular Imaging of Prostate Cancer","volume":"196","author":"C Siegel","year":"2016","journal-title":"The Journal of urology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1016\/j.ijrobp.2011.11.030","article-title":"Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI study","volume":"82","author":"E Arrayeh","year":"2012","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0360-3016(02)02795-5","article-title":"Analysis of intraprostatic failures in patients treated with hormonal therapy and radiotherapy: implications for conformal therapy planning","volume":"53","author":"N Cellini","year":"2002","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijrobp.2007.03.065","article-title":"Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence","volume":"69","author":"D Pucar","year":"2007","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0360-3016(00)00467-3","article-title":"Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality","volume":"47","author":"CC Ling","year":"2000","journal-title":"International journal of radiation oncology, biology, physics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0180790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T16:20:41Z","timestamp":1569860441000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0180790"}},"subtitle":[],"editor":[{"given":"Juri G.","family":"Gelovani","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,18]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0180790","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,18]]}}}