{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:36:57Z","timestamp":1787236617733,"version":"build-2736575974"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R03DC011840"],"award-info":[{"award-number":["R03DC011840"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC012552"],"award-info":[{"award-number":["R01DC012552"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC014437"],"award-info":[{"award-number":["R01DC014437"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23228003"],"award-info":[{"award-number":["23228003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0180817","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T13:47:49Z","timestamp":1499435269000},"page":"e0180817","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR"],"prefix":"10.1371","volume":"12","author":[{"given":"Chul","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karessa","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongjun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Tanokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yamasoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Linser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-6227","authenticated-orcid":true,"given":"Shinichi","family":"Someya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1749-6632.1999.tb08633.x","article-title":"Free radicals and hearing. Cause, consequence, and criteria","volume":"884","author":"P Evans","year":"1999","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"G Wu","year":"2004","journal-title":"J Nutr"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.bbagen.2012.09.018","article-title":"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes","volume":"1830","author":"M Deponte","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1089\/ars.2009.2695","article-title":"Mitochondrial glutathione, a key survival antioxidant","volume":"11","author":"M Mar\u00ed","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"736837","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: potential targets for medical interventions","volume":"2012","author":"VI Lushchak","year":"2012","journal-title":"J Amino Acids"},{"issue":"13\u201314","key":"ref6","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.addr.2008.06.001","article-title":"Pro-oxidant shift in glutathione redox state during aging","volume":"60","author":"I Rebrin","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/toxsci\/kfh268","article-title":"Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout","volume":"82","author":"LK Rogers","year":"2004","journal-title":"Toxicol Sci"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1182\/blood-2006-08-042531","article-title":"Molecular basis of glutathione reductase deficiency in human blood cells","volume":"109","author":"NM Kamerbeek","year":"2007","journal-title":"Blood"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/sj.onc.1209373","article-title":"Glutathione S-transferase polymorphisms: cancer incidence and therapy","volume":"25","author":"CC McIlwain","year":"2006","journal-title":"Oncogene"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/cdd.2010.80","article-title":"Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death","volume":"17","author":"E Laborde","year":"2010","journal-title":"Cell Death Differ"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1007\/s11064-010-0304-2","article-title":"Oxidative stress, redox homeostasis and cellular stress response in Meniere&apos;s disease: role of vitagenes","volume":"35","author":"V Calabrese","year":"2010","journal-title":"Neurochem Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1749-6632.1999.tb08655.x","article-title":"The role of antioxidants in protection from impulse noise","volume":"884","author":"D Henderson","year":"1999","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"ref13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0378-5955(00)00096-4","article-title":"Glutathione limits noise-induced hearing loss","volume":"146","author":"Y Ohinata","year":"2000","journal-title":"Hear Res"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(98)00660-X","article-title":"Influence of intense sound exposure on glutathione synthesis in the cochlea","volume":"804","author":"T Yamasoba","year":"1998","journal-title":"Brain Res"},{"issue":"1\u20132","key":"ref15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(97)01156-6","article-title":"Role of glutathione in protection against noise-induced hearing loss","volume":"784","author":"T Yamasoba","year":"1998","journal-title":"Brain Res"},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-5955(97)00214-1","article-title":"Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla","volume":"117","author":"AA Jacono","year":"1998","journal-title":"Hear Res"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"1842 e1","DOI":"10.1016\/j.neurobiolaging.2011.12.027","article-title":"Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344\/NHsd rat cochlea","volume":"33","author":"C Tanaka","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"KK Ohlemiller","year":"2000","journal-title":"J Assoc Res Otolaryngol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.freeradbiomed.2013.04.015","article-title":"Glutathione reductase is essential for host defense against bacterial infection","volume":"61","author":"J Yan","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.taap.2006.08.012","article-title":"Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice","volume":"217","author":"LK Rogers","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"issue":"13","key":"ref21","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1096\/fasebj.13.13.1733","article-title":"Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia","volume":"13","author":"RJ Mockett","year":"1999","journal-title":"FASEB J"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"K Noben-Trauth","year":"2003","journal-title":"Nat Genet"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.cell.2010.10.002","article-title":"Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction","volume":"143","author":"S Someya","year":"2010","journal-title":"Cell"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2006.01.107","article-title":"Auditory brainstem responses in 10 inbred strains of mice","volume":"1091","author":"X Zhou","year":"2006","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2014.08.004","article-title":"Prolonged noise exposure-induced auditory threshold shifts in rats","volume":"317","author":"GD Chen","year":"2014","journal-title":"Hear Res"},{"issue":"11","key":"ref26","first-page":"510","article-title":"Cochleogram for assessing hair cells and efferent fibers in carboplatin-treated ear","volume":"13","author":"D Ding","year":"1999","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"e79817","DOI":"10.1371\/journal.pone.0079817","article-title":"Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures","volume":"8","author":"D Ding","year":"2013","journal-title":"PLoS One"},{"issue":"1\u20132","key":"ref28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2004.08.011","article-title":"A physiological place-frequency map of the cochlea in the CBA\/J mouse","volume":"202","author":"M Muller","year":"2005","journal-title":"Hear Res"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"730","DOI":"10.18632\/aging.100927","article-title":"N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in \u03b3-glutamyl transferase 1 deficient mice","volume":"8","author":"D Ding","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neurobiolaging.2016.03.023","article-title":"Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL\/6 mice","volume":"43","author":"C Han","year":"2016","journal-title":"Neurobiol Aging"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3892\/br.2014.359","article-title":"Altered glutamate cysteine ligase expression and activity in renal cell carcinoma","volume":"2","author":"M Li","year":"2014","journal-title":"Biomed Rep"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nprot.2009.197","article-title":"Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue","volume":"5","author":"CJ Weydert","year":"2010","journal-title":"Nat Protoc"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"I Rahman","year":"2006","journal-title":"Nat Protoc"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0003-2697(87)90506-9","article-title":"Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure","volume":"164","author":"CR Zerez","year":"1987","journal-title":"Anal Biochem"},{"key":"ref35","first-page":"372","volume":"xvii","author":"A Agresti","year":"2007"},{"issue":"1\u20132","key":"ref36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0378-5955(99)00003-9","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"130","author":"QY Zheng","year":"1999","journal-title":"Hear Res"},{"issue":"9491","key":"ref37","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"GA Gates","year":"2005","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss: epidemiology and mechanistic pathways","volume":"303","author":"T Yamasoba","year":"2013","journal-title":"Hear Res"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1288\/00005537-197410000-00012","article-title":"Atrophy of the stria vascularis, a common cause for hearing loss","volume":"84","author":"HF Schuknecht","year":"1974","journal-title":"Laryngoscope"},{"issue":"40","key":"ref40","doi-asserted-by":"crossref","first-page":"33766","DOI":"10.1074\/jbc.M504604200","article-title":"Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels","volume":"280","author":"Y Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"ref41","article-title":"GeneReviews(R)","author":"S DiMauro","year":"1993"},{"issue":"51","key":"ref42","doi-asserted-by":"crossref","first-page":"40180","DOI":"10.1074\/jbc.M007633200","article-title":"The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited","volume":"275","author":"SM Kanzok","year":"2000","journal-title":"J Biol Chem"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1073\/pnas.0900206106","article-title":"The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis","volume":"106","author":"L Marty","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1074\/jbc.M109.062844","article-title":"The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae","volume":"285","author":"SX Tan","year":"2010","journal-title":"J Biol Chem"},{"issue":"5504","key":"ref45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.291.5504.643","article-title":"Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster","volume":"291","author":"SM Kanzok","year":"2001","journal-title":"Science"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1165\/rcmb.2006-0376OC","article-title":"Thioredoxin-related mechanisms in hyperoxic lung injury in mice","volume":"37","author":"TE Tipple","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2011.07.056","article-title":"Glutathione is essential for early embryogenesis\u2014analysis of a glutathione synthetase knockout mouse","volume":"412","author":"A Winkler","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.2000.3930","article-title":"Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous","volume":"279","author":"TP Dalton","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000013847","article-title":"Targeted deletion of the cytosolic Cu\/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss","volume":"4","author":"KK Ohlemiller","year":"1999","journal-title":"Audiol Neurootol"},{"issue":"1\u20132","key":"ref50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.exger.2004.11.004","article-title":"Glutathione metabolism in long-living Ames dwarf mice","volume":"40","author":"HM Brown-Borg","year":"2005","journal-title":"Exp Gerontol"},{"issue":"17","key":"ref51","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00018-005-5163-7","article-title":"Glutathione synthetase deficiency","volume":"62","author":"R Nj\u00e5lsson","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"J Lu","year":"2014","journal-title":"Free Radic Biol Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0180817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T23:39:12Z","timestamp":1588981152000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0180817"}},"subtitle":[],"editor":[{"given":"Luis Eduardo Soares","family":"Netto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0180817","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]}}}