{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:06:09Z","timestamp":1790431569685,"version":"4.1.0"},"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA215134"],"award-info":[{"award-number":["R01 CA215134"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA160684"],"award-info":[{"award-number":["R01 CA160684"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181086","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T13:50:00Z","timestamp":1499694600000},"page":"e0181086","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-5826","authenticated-orcid":true,"given":"Marie-Laure","family":"Crouch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Knowels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph","family":"Stuppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan G.","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Bielas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Marcinek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Syrjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0140-6736(03)14186-4","article-title":"Assessment and management of cancer-related fatigue in adults","volume":"362","author":"K Ahlberg","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/109980040100200304","article-title":"Cancer-induced fatigue and skeletal muscle wasting: the role of exercise","volume":"2","author":"S al-Majid","year":"2001","journal-title":"Biol Res Nurs"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10865-006-9053-8","article-title":"Correspondence between daily and weekly fatigue reports in breast cancer survivors","volume":"29","author":"R Banthia","year":"2006","journal-title":"J Behav Med"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.6004\/jnccn.2010.0067","article-title":"Cancer-related fatigue","volume":"8","author":"AM Berger","year":"2010","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1515\/hsz-2012-0247","article-title":"Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy","volume":"394","author":"R Calvani","year":"2013","journal-title":"Biol Chem"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10552-014-0421-3","article-title":"Trajectory of overall health from self-report and factors contributing to health declines among cancer survivors","volume":"25","author":"JL Petrick","year":"2014","journal-title":"Cancer Causes Control"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jgo.2014.06.002","article-title":"Functional status declines among cancer survivors: trajectory and contributing factors","volume":"5","author":"JL Petrick","year":"2014","journal-title":"J Geriatr Oncol"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/gerona\/58.1.M82","article-title":"Cancer survivors in the United States: age, health, and disability","volume":"58","author":"M Hewitt","year":"2003","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10549-010-1236-x","article-title":"Improvement in self-reported physical health predicts longer survival among women with a history of breast cancer","volume":"127","author":"RE Patterson","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mehy.2006.01.045","article-title":"Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty?","volume":"67","author":"RE Maccormick","year":"2006","journal-title":"Med Hypotheses"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1046\/j.1532-5415.2002.50605.x","article-title":"Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels","volume":"50","author":"L Ferrucci","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"20","key":"ref12","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1200\/JCO.2011.39.9014","article-title":"Cardiopulmonary Function and Age-Related Decline Across the Breast Cancer Survivorship Continuum","volume":"30","author":"LW Jones","year":"2012","journal-title":"J Clin Oncol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1590\/S0100-720320140005004","article-title":"Short-term changes in handgrip strength, body composition, and lymphedema induced by breast cancer surgery","volume":"36","author":"PR Gomes","year":"2014","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"E126","DOI":"10.1188\/13.ONF.E126-E134","article-title":"Frailty in older breast cancer survivors: age, prevalence, and associated factors","volume":"40","author":"JA Bennett","year":"2013","journal-title":"Oncol Nurs Forum"},{"issue":"19","key":"ref15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/jnci\/djq344","article-title":"Long-term prognostic role of functional limitations among women with breast cancer","volume":"102","author":"D Braithwaite","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10552-010-9714-3","article-title":"Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: findings from the WHEL Study","volume":"22","author":"LAC Bertram","year":"2011","journal-title":"Cancer Causes Control"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/pon.1742","article-title":"Poor physical health predicts time to additional breast cancer events and mortality in breast cancer survivors","volume":"20","author":"N Saquib","year":"2011","journal-title":"Psycho-Oncology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11764-012-0239-5","article-title":"Decline in physical functioning in first 2 years after breast cancer diagnosis predicts 10-year survival in older women","volume":"7","author":"M Sehl","year":"2013","journal-title":"J Cancer Surviv"},{"issue":"22","key":"ref19","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1200\/JCO.2012.47.8081","article-title":"Deficits in physical function among young childhood cancer survivors","volume":"31","author":"MC Hoffman","year":"2013","journal-title":"J Clin Oncol"},{"issue":"36","key":"ref20","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1200\/JCO.2013.52.2268","article-title":"Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study","volume":"31","author":"KK Ness","year":"2013","journal-title":"J Clin Oncol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/cncr.29211","article-title":"Frailty in childhood cancer survivors","volume":"121","author":"KK Ness","year":"2015","journal-title":"Cancer"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11764-010-0126-x","article-title":"Measuring musculoskeletal symptoms in cancer survivors who receive hematopoietic cell transplantation","volume":"4","author":"KL Syrjala","year":"2010","journal-title":"J Cancer Surviv"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.urology.2010.11.024","article-title":"Obese frailty, physical performance deficits, and falls in older men with biochemical recurrence of prostate cancer on androgen deprivation therapy: a case-control study","volume":"77","author":"K Bylow","year":"2011","journal-title":"Urology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/pbc.25601","article-title":"Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes","volume":"62","author":"C Wei","year":"2015","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1152\/japplphysiol.00776.2009","article-title":"Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle","volume":"107","author":"LA Gilliam","year":"2009","journal-title":"J Appl Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.freeradbiomed.2013.08.191","article-title":"The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle","volume":"65","author":"LA Gilliam","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mus.21809","article-title":"Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy","volume":"43","author":"LA Gilliam","year":"2011","journal-title":"Muscle Nerve"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"L225","DOI":"10.1152\/ajplung.00264.2010","article-title":"TNF\/TNFR1 signaling mediates doxorubicin-induced diaphragm weakness","volume":"300","author":"LA Gilliam","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.00217.2011","article-title":"Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes","volume":"302","author":"LA Gilliam","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1089\/ars.2011.3965","article-title":"Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress","volume":"15","author":"LA Gilliam","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jcsm.12023","article-title":"Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved","volume":"6","author":"JA Chen","year":"2015","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1038\/srep08717","article-title":"Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle","volume":"5","author":"G Gouspillou","year":"2015","journal-title":"Sci Rep"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"e106489","DOI":"10.1371\/journal.pone.0106489","article-title":"Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle","volume":"9","author":"TP Braun","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1200\/JCO.2000.18.4.743","article-title":"Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life","volume":"18","author":"JE Bower","year":"2000","journal-title":"J Clin Oncol"},{"issue":"22","key":"ref35","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1200\/JCO.2003.04.196","article-title":"Breast cancer in younger women: reproductive and late health effects of treatment","volume":"21","author":"PA Ganz","year":"2003","journal-title":"J Clin Oncol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/cncr.26337","article-title":"Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses","volume":"118","author":"KK Ness","year":"2012","journal-title":"Cancer"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bbmt.2015.04.007","article-title":"Physical activity, fitness, and cardiometabolic risk factors in adult survivors of childhood cancer with a history of hematopoietic cell transplantation","volume":"21","author":"ME Slater","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/cncr.21752","article-title":"Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor study","volume":"106","author":"JG Gurney","year":"2006","journal-title":"Cancer"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.bbmt.2013.04.017","article-title":"Relationship of body mass index and arm anthropometry to outcomes after pediatric allogeneic hematopoietic cell transplantation for hematologic malignancies","volume":"19","author":"PA Hoffmeister","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10549-012-2200-8","article-title":"Body composition changes in females treated for breast cancer: a review of the evidence","volume":"135","author":"PM Sheean","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"ref41","first-page":"102","article-title":"Body Composition and Breast Cancer: The Role of Lean Body Mass","volume":"35","author":"JD Bauer","year":"2011","journal-title":"Cancer Forum"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10549-011-1444-z","article-title":"Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial","volume":"127","author":"KM Winters-Stone","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1517\/17425255.2010.487861","article-title":"Oxazaphosphorines: new therapeutic strategies for an old class of drugs","volume":"6","author":"B Giraud","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"10","key":"ref44","first-page":"5029","article-title":"Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells","volume":"46","author":"TR Crook","year":"1986","journal-title":"Cancer Res"},{"issue":"10","key":"ref45","first-page":"5035","article-title":"Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide","volume":"46","author":"TR Crook","year":"1986","journal-title":"Cancer Res"},{"issue":"26","key":"ref46","doi-asserted-by":"crossref","first-page":"16058","DOI":"10.1074\/jbc.273.26.16058","article-title":"Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins","volume":"273","author":"K Uchida","year":"1998","journal-title":"J Biol Chem"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/toxsci\/kfu233","article-title":"Molecular mechanisms of acrolein toxicity: relevance to human disease","volume":"143","author":"A Moghe","year":"2015","journal-title":"Toxicol Sci"},{"issue":"7","key":"ref48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.neuint.2005.07.002","article-title":"Acrolein-induced cell death in PC12 cells: role of mitochondria-mediated oxidative stress","volume":"47","author":"J Luo","year":"2005","journal-title":"Neurochem Int"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuint.2004.09.001","article-title":"Acrolein induces oxidative stress in brain mitochondria","volume":"46","author":"J Luo","year":"2005","journal-title":"Neurochem Int"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.freeradbiomed.2013.06.024","article-title":"The effects of acetaldehyde and acrolein on muscle catabolism in C2 myotubes","volume":"65","author":"O Rom","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"9\u201310","key":"ref51","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.mad.2012.08.002","article-title":"Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle","volume":"133","author":"MP Siegel","year":"2012","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"C457","DOI":"10.1152\/ajpcell.00237.2003","article-title":"Mitochondrial coupling in vivo in mouse skeletal muscle","volume":"286","author":"DJ Marcinek","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/mrm.1910130316","article-title":"NMR spectral analysis of kinetic data using natural lineshapes","volume":"13","author":"FW Heineman","year":"1990","journal-title":"Magn Reson Med"},{"issue":"1","key":"ref54","first-page":"77","article-title":"Bioenergetics of intact human muscle. A 31P nuclear magnetic resonance study","volume":"1","author":"DJ Taylor","year":"1983","journal-title":"Mol Biol Med"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"C1739","DOI":"10.1152\/ajpcell.1997.272.5.C1739","article-title":"Multiple equilibria of cations with metabolites in muscle bioenergetics","volume":"272","author":"MJ Kushmerick","year":"1997","journal-title":"Am J Physiol"},{"issue":"Pt 8","key":"ref56","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/jeb.198.8.1775","article-title":"Adjustment of K&apos; to varying pH and pMg for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria permitting quantitative bioenergetic assessment","volume":"198","author":"EM Golding","year":"1995","journal-title":"J Exp Biol"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1366\/000370207781745928","article-title":"Accurate myoglobin oxygen saturation by optical spectroscopy measured in blood-perfused rat muscle","volume":"61","author":"LS Arakaki","year":"2007","journal-title":"Appl Spectrosc"},{"issue":"15","key":"ref58","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1073\/pnas.90.15.7396","article-title":"Individual variation in contractile cost and recovery in a human skeletal muscle","volume":"90","author":"ML Blei","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1993.sp019673","article-title":"Separate measures of ATP utilization and recovery in human skeletal muscle","volume":"465","author":"ML Blei","year":"1993","journal-title":"J Physiol"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1152\/japplphysiol.00426.2006","article-title":"Myosin and actin expression and oxidation in aging muscle","volume":"101","author":"LV Thompson","year":"2006","journal-title":"J Appl Physiol (1985)"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"D Pesta","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"e26963","DOI":"10.1371\/journal.pone.0026963","article-title":"Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice","volume":"6","author":"MP Siegel","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/acel.12146","article-title":"Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain","volume":"13","author":"SD Taylor","year":"2014","journal-title":"Aging Cell"},{"key":"ref64","first-page":"170309","article-title":"Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34","volume":"2015","author":"Y Sun","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12013-014-0376-8","article-title":"Acrolein-Induced Oxidative Stress and Cell Death Exhibiting Features of Apoptosis in the Yeast Saccharomyces cerevisiae Deficient in SOD1","volume":"71","author":"M Kwolek-Mirek","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"8","key":"ref66","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/tox.21818","article-title":"Acrolein induction of oxidative stress and degranulation in mast cells","volume":"29","author":"DJ Hochman","year":"2014","journal-title":"Environ Toxicol"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4161\/oxim.3.5.13107","article-title":"Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues","volume":"3","author":"YA Asiri","year":"2010","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"ref68","first-page":"2925","article-title":"Viscum album L. extract and quercetin reduce cyclophosphamide-induced cardiotoxicity, urotoxicity and genotoxicity in mice","volume":"12","author":"V Sekeroglu","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"issue":"5","key":"ref69","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/acel.12102","article-title":"Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice","volume":"12","author":"MP Siegel","year":"2013","journal-title":"Aging Cell"},{"key":"ref70","article-title":"Inhibition of Gene Expression of Carnitine Palmitoyltransferase I and Heart Fatty Acid Bindin","author":"MM Sayed-Ahmed","year":"2014","journal-title":"g"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131394","article-title":"Mechanisms of fatal cardiotoxicity following high-dose cyclophosphamide therapy and a method for its prevention","volume":"10","author":"T Nishikawa","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/bcpt.12086","article-title":"Activity of dexrazoxane and amifostine against late cardiotoxicity induced by the combination of doxorubicin and cyclophosphamide in vivo","volume":"113","author":"SK Bjelogrlic","year":"2013","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1742-7843.2005.pto_166.x","article-title":"Activity of d,l-alpha-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice","volume":"97","author":"SK Bjelogrlic","year":"2005","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0009-2797(94)90091-4","article-title":"Effect of sulfhydryl compounds and glutathione depletion on rat heart myocyte toxicity induced by 4-hydroperoxycyclophosphamide and acrolein in vitro","volume":"93","author":"RT Dorr","year":"1994","journal-title":"Chem Biol Interact"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2613.2002.00208.x","article-title":"Delayed toxicity of cyclophosphamide on the bladder of DBA\/2 and C57BL\/6 female mouse","volume":"83","author":"E Anton","year":"2002","journal-title":"Int J Exp Pathol"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1124\/jpet.109.156513","article-title":"Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity","volume":"331","author":"DJ Conklin","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"ref77","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1177\/0960327111402240","article-title":"Ultrastructural changes in the rat kidney after single dose of cyclophosphamide\u2014possible roles for peroxisome proliferation and lysosomal dysfunction in cyclophosphamide-induced renal damage","volume":"30","author":"P Abraham","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cbi.2015.02.016","article-title":"Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats","volume":"232","author":"G Cuce","year":"2015","journal-title":"Chem Biol Interact"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"17536","DOI":"10.1038\/srep17536","article-title":"Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid","volume":"5","author":"H Zhu","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"204","DOI":"10.5625\/lar.2013.29.4.204","article-title":"Protective effect of diallyl disulfide on cyclophosphamide-induced testicular toxicity in rats","volume":"29","author":"SH Kim","year":"2013","journal-title":"Lab Anim Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.neuroscience.2011.07.006","article-title":"Cyclophosphamide-induced disruption of umami taste functions and taste epithelium","volume":"192","author":"N Mukherjee","year":"2011","journal-title":"Neuroscience"},{"key":"ref82","article-title":"The role of IL-1beta and TNF-alpha signaling in the genesis of cancer treatment related symptoms (CTRS): A study using cytokine receptor-deficient mice","author":"LB Smith","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10863-012-9423-6","article-title":"Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide","volume":"44","author":"KK Kumari","year":"2012","journal-title":"J Bioenerg Biomembr"},{"issue":"19","key":"ref84","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1161\/01.CIR.0000093196.59829.DF","article-title":"Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy","volume":"108","author":"D Lebrecht","year":"2003","journal-title":"Circulation"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/path.1863","article-title":"Tissue-specific mtDNA lesions and radical-associated mitochondrial dysfunction in human hearts exposed to doxorubicin","volume":"207","author":"D Lebrecht","year":"2005","journal-title":"J Pathol"},{"issue":"1\u20132","key":"ref86","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0027-5107(02)00313-5","article-title":"Changes in the human mitochondrial genome after treatment of malignant disease","volume":"525","author":"TM Wardell","year":"2003","journal-title":"Mutat Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.exger.2014.11.012","article-title":"Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice","volume":"61","author":"J Wanagat","year":"2015","journal-title":"Exp Gerontol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T14:19:20Z","timestamp":1659190760000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181086"}},"subtitle":[],"editor":[{"given":"Dhyan","family":"Chandra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,10]]},"references-count":87,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181086","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,10]]}}}