{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:22:59Z","timestamp":1790623379179,"version":"4.1.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK44863"],"award-info":[{"award-number":["DK44863"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK90728"],"award-info":[{"award-number":["DK90728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181087","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T17:46:12Z","timestamp":1501177572000},"page":"e0181087","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Generation and phenotypic characterization of Pde1a mutant mice"],"prefix":"10.1371","volume":"12","author":[{"given":"Xiaofang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wells B.","family":"LaRiviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Bakeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda V.","family":"Irazabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad T.","family":"Chebib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van Deursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline R.","family":"Sussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atta","family":"Behfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-1576","authenticated-orcid":true,"given":"Vicente E.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"issue":"9981","key":"ref1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","article-title":"Diseases E-EWGfIK. Autosomal dominant polycystic kidney disease: the changing face of clinical management","volume":"385","author":"AC Ong","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"AB Chapman","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1681\/ASN.2013040398","article-title":"Strategies targeting cAMP signaling in the treatment of polycystic kidney disease","volume":"25","author":"VE Torres","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Calvet JP. The Role of Calcium and Cyclic AMP in PKD. In: Li X, editor. Polycystic Kidney Disease. Brisbane (AU)2015.","DOI":"10.15586\/codon.pkd.2015.ch8"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrneph.2015.39","article-title":"Vasopressin and disruption of calcium signalling in polycystic kidney disease","author":"FT Chebib","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm935","article-title":"Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist","volume":"9","author":"VH Gattone","year":"2003","journal-title":"Nature Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm1004","article-title":"Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease","volume":"10","author":"VE Torres","year":"2004","journal-title":"Nature Med"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1681\/ASN.2007060688","article-title":"Vasopressin directly regulates cyst growth in polycystic kidney disease","volume":"19","author":"X Wang","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00243.2011","article-title":"Tolvaptan inhibits ERK-dependent cell proliferation, Cl(-) secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","volume":"301","author":"GA Reif","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"25","key":"ref10","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","article-title":"Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease","volume":"367","author":"VE Torres","year":"2012","journal-title":"N Engl J Med"},{"issue":"9903","key":"ref11","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0140-6736(13)61407-5","article-title":"Effect of long acting somatostatin analogue on kidney and cyst growth in autosomal dominant polycystic kidney disease (ALADIN): a randomised, placebo-controlled, multicentre trial","volume":"382","author":"A Caroli","year":"2013","journal-title":"Lancet"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1681\/ASN.2013040421","article-title":"Phosphodiesterase 1A Modulates Cystogenesis in Zebrafish","volume":"25","author":"CR Sussman","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.str.2004.10.004","article-title":"Structural basis for the activity of drugs that inhibit phosphodiesterases","volume":"12","author":"GL Card","year":"2004","journal-title":"Structure"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jneumeth.2008.05.003","article-title":"The use of total protein stains as loading controls: an alternative to high-abundance single-protein controls in semi-quantitative immunoblotting","volume":"172","author":"GM Aldridge","year":"2008","journal-title":"J Neurosci Methods"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1681\/ASN.2015010057","article-title":"Modulation of Polycystic Kidney Disease Severity by PDE1 and PDE3 Subfamilies","volume":"27","author":"H Ye","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"ref16","first-page":"F957","article-title":"Cyclic 3&apos;,5&apos;-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells","volume":"262","author":"M Yamaki","year":"1992","journal-title":"Am J Physiol"},{"issue":"6","key":"ref17","first-page":"F956","article-title":"Effects of calcium on the vasopressin-sensitive cAMP metabolism in medullary tubules","volume":"249","author":"E Kusano","year":"1985","journal-title":"Am J Physiol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1681\/ASN.2006020132","article-title":"Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells","volume":"18","author":"E Stefan","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/endo-129-1-287","article-title":"High activity of low-Michaelis-Menten constant 3&apos;, 5&apos;-cyclic adenosine monophosphate-phosphodiesterase isozymes in renal inner medulla of mice with hereditary nephrogenic diabetes insipidus","volume":"129","author":"S Takeda","year":"1991","journal-title":"Endocrinology"},{"key":"ref20","article-title":"Effects of hydration in rats and mice with polycystic kidney disease","author":"K Hopp","year":"2015","journal-title":"Am J Physiol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ki.2009.438","article-title":"Cyclic nucleotide signaling in polycystic kidney disease","volume":"77","author":"X Wang","year":"2010","journal-title":"Kidney Int"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573402111309010002","article-title":"Cardiovascular complications in autosomal dominant polycystic kidney disease","volume":"9","author":"T Ecder","year":"2013","journal-title":"Curr Hypertens Rev"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ekir.2017.05.014","article-title":"Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies","author":"FT Chebib","year":"2017"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1681\/ASN.2013010077","article-title":"Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease","volume":"25","author":"S Rees","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1523-1755.1999.00233.x","article-title":"Cyclic-3&apos;,5&apos;-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney","volume":"55","author":"TP Dousa","year":"1999","journal-title":"Kidney Int"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"AT Bender","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1055\/s-0032-1312646","article-title":"Cyclic nucleotide phosphodiesterase 3 signaling complexes","volume":"44","author":"F Ahmad","year":"2012","journal-title":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101672","article-title":"Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity","volume":"17","author":"M Brescia","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cellsig.2004.12.017","article-title":"Ca<sup>2+<\/sup>-calmodulin-dependent phosphodiesterase (PDE1): current perspectives","volume":"17","author":"TA Goraya","year":"2005","journal-title":"Cell Sig"},{"issue":"1","key":"ref30","first-page":"95","article-title":"Regulation of calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1): review","volume":"18","author":"RK Sharma","year":"2006","journal-title":"Int J Mol Med"},{"issue":"8\u20139","key":"ref31","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1007\/s000180050364","article-title":"Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)","volume":"55","author":"R Kakkar","year":"1999","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.coph.2011.09.002","article-title":"PDE1 isozymes, key regulators of pathological vascular remodeling","volume":"11","author":"S Chan","year":"2011","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1620\/tjem.193.207","article-title":"Nephron distribution of total low Km cyclic AMP phosphodiesterase in mouse, rat and rabbit kidney","volume":"193","author":"E Kusano","year":"2001","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1159\/000189151","article-title":"Effect of a nonpeptide vasopressin V1 antagonist (OPC-21268) on experimental accelerated focal glomerulosclerosis","volume":"73","author":"I Kurihara","year":"1996","journal-title":"Nephron"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/jcp.1040810212","article-title":"The ability of calcium to change cyclic AMP from a stimulator to an inhibitor to thymic lymphoblast proliferation","volume":"81","author":"JF Whitfield","year":"1973","journal-title":"J Cell Physiol"},{"issue":"14","key":"ref36","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1111\/j.1742-4658.2005.04763.x","article-title":"Integrating signals between cAMP and the RAS\/RAF\/MEK\/ERK signalling pathways\u2014Based on the Anniversary Prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the special FEBS meeting in Brussels","volume":"272","author":"N Dumaz","year":"2005","journal-title":"Febs J"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0962-8924(02)02294-8","article-title":"Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation","volume":"12","author":"PJ Stork","year":"2002","journal-title":"Trends Cell Biol"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"cAMP stimulates the <italic>in vitro<\/italic> proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway","volume":"57","author":"T Yamaguchi","year":"2000","journal-title":"Kidney Int"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.V1171179","article-title":"cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells","volume":"11","author":"K Hanaoka","year":"2000","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"T Yamaguchi","year":"2003","journal-title":"Kidney Int"},{"issue":"15","key":"ref41","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1074\/jbc.272.15.9854","article-title":"Compartmentalization of cAMP signaling in mesangial cells by phosphodiesterase isozymes PDE3 and PDE4. Regulation of superoxidation and mitogenesis","volume":"272","author":"CC Chini","year":"1997","journal-title":"J Biol Chem"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"F940","DOI":"10.1152\/ajprenal.00079.2004","article-title":"Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4","volume":"287","author":"J Cheng","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0006-2952(00)00328-2","article-title":"Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis","volume":"60","author":"MT Osinski","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-2143(97)90125-6","article-title":"Inhibitors of cyclic nucleotide phosphodiesterase isozymes block renal tubular cell proliferation induced by folic acid","volume":"130","author":"K Matousovic","year":"1997","journal-title":"J Lab Clin Med"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/153537020623100308","article-title":"Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells","volume":"231","author":"J Cheng","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/hh0202.104108","article-title":"Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation","volume":"90","author":"SD Rybalkin","year":"2002","journal-title":"Circ Res"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.0000215576.27615.fd","article-title":"Role of nuclear Ca2+\/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival","volume":"98","author":"DJ Nagel","year":"2006","journal-title":"Circ Res"},{"issue":"7","key":"ref48","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/CIRCRESAHA.116.304408","article-title":"Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia","volume":"116","author":"Y Cai","year":"2015","journal-title":"Circ Res"},{"key":"ref49","article-title":"Morpholino and mutant studies of Pde3A and Pde1a in renal cystogenesis using zebrafish","author":"CR Sussman","year":"2015"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1681\/ASN.2015010047","article-title":"Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease","volume":"27","author":"CS Pinto","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"F1166","DOI":"10.1152\/ajprenal.00196.2007","article-title":"Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL","volume":"293","author":"K Mutig","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1523-1755.2005.00426.x","article-title":"Differential distribution of the vasopressin V receptor along the rat nephron during renal ontogeny and maturation","volume":"68","author":"JM Sarmiento","year":"2005","journal-title":"Kidney Int"},{"key":"ref53","first-page":"376A","article-title":"Cardiac expression of polycystin 1 and polycystin 2 and idiopathic dilated cardiomyopathy in autosomal dominant polycystic kidney disease (ADPKD)","volume":"8","author":"DA O'Sullivan","year":"1997","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0008-6363(02)00858-1","article-title":"A polycystin-2-like large conductance cation channel in rat left ventricular myocytes","volume":"58","author":"T Volk","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1681\/ASN.V84616","article-title":"Vascular expression of polycystin","volume":"8","author":"MD Griffin","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1681\/ASN.V1211","article-title":"Vascular expression of polycystin 2","volume":"12","author":"VE Torres","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yjmcc.2013.01.015","article-title":"Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy","volume":"58","author":"J Paavola","year":"2013","journal-title":"J Mol Cell Cardiol"},{"issue":"46","key":"ref58","doi-asserted-by":"crossref","first-page":"16604","DOI":"10.1073\/pnas.1415933111","article-title":"Decreased polycystin 2 expression alters calcium-contraction coupling and changes beta-adrenergic signaling pathways","volume":"111","author":"IY Kuo","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.kint.2016.04.028","article-title":"Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout","volume":"90","author":"BE Balbo","year":"2016","journal-title":"Kidney Int"},{"issue":"24","key":"ref60","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1161\/CIRCULATIONAHA.114.013537","article-title":"Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability","volume":"131","author":"Z Pedrozo","year":"2015","journal-title":"Circulation"},{"key":"ref61","article-title":"Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases","author":"K Kokkonen","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1161\/01.RES.68.4.1070","article-title":"Cellular distribution of phosphodiesterase isoforms in rat cardiac tissue","volume":"68","author":"DC Bode","year":"1991","journal-title":"Circ Res"},{"issue":"11","key":"ref63","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1006\/jmcc.1997.0544","article-title":"Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart","volume":"29","author":"MM Kostic","year":"1997","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/meth.1997.0561","article-title":"Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases","volume":"14","author":"WK Sonnenburg","year":"1998","journal-title":"Methods"},{"issue":"5A","key":"ref65","doi-asserted-by":"crossref","first-page":"3C","DOI":"10.1016\/S0002-9149(99)00042-9","article-title":"Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro","volume":"83","author":"RM Wallis","year":"1999","journal-title":"Am J Cardiol"},{"issue":"47","key":"ref66","doi-asserted-by":"crossref","first-page":"39168","DOI":"10.1074\/jbc.M506760200","article-title":"Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium","volume":"280","author":"R Hambleton","year":"2005","journal-title":"J Biol Chem"},{"issue":"45","key":"ref67","doi-asserted-by":"crossref","first-page":"32749","DOI":"10.1074\/jbc.M703173200","article-title":"Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes","volume":"282","author":"F Vandeput","year":"2007","journal-title":"J Biol Chem"},{"issue":"10","key":"ref68","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/CIRCRESAHA.109.198515","article-title":"Role of Ca2+\/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy","volume":"105","author":"CL Miller","year":"2009","journal-title":"Circ Res"},{"issue":"12","key":"ref69","doi-asserted-by":"crossref","first-page":"e14227","DOI":"10.1371\/journal.pone.0014227","article-title":"Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II","volume":"5","author":"W Mokni","year":"2010","journal-title":"PLoS One"},{"issue":"6","key":"ref70","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuropharm.2010.05.004","article-title":"Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues","volume":"59","author":"V Lakics","year":"2010","journal-title":"Neuropharmacology"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00395-011-0228-2","article-title":"Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart","volume":"106","author":"CL Miller","year":"2011","journal-title":"Basic Res Cardiol"},{"issue":"9\u201310","key":"ref72","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.lfs.2011.11.016","article-title":"Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: comparison with rat and guinea pig","volume":"90","author":"WB Johnson","year":"2012","journal-title":"Life Sci"},{"key":"ref73","article-title":"PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction","author":"WE Knight","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2016.06.064","article-title":"Ca(2+)\/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function","volume":"98","author":"YO Lukyanenko","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"24","key":"ref75","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1111\/j.1742-4658.2010.07908.x","article-title":"Ca2+\/calmodulin-stimulated PDE1 regulates the beta-catenin\/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells","volume":"277","author":"KI Jeon","year":"2010","journal-title":"Febs J"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajhg.2013.12.016","article-title":"Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci","volume":"94","author":"V Tragante","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/jhg.2016.32","article-title":"A PDE3A mutation in familial hypertension and brachydactyly syndrome","volume":"61","author":"H Boda","year":"2016","journal-title":"J Hum Genet"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"R1469","DOI":"10.1152\/ajpregu.00121.2009","article-title":"Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells","volume":"297","author":"MC Ortiz-Capisano","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00424-012-1126-7","article-title":"Regulation of renin secretion by renal juxtaglomerular cells","volume":"465","author":"UG Friis","year":"2013","journal-title":"Pflugers Arch"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"e2623","DOI":"10.1097\/MD.0000000000002623","article-title":"New-onset Atrial Fibrillation is Associated With Polycystic Kidney Disease: A Nationwide Population-based Cohort Study","volume":"95","author":"TM Yu","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"6\u20137","key":"ref81","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.acvd.2016.02.004","article-title":"Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective","volume":"109","author":"P Bobin","year":"2016","journal-title":"Arch Cardiovasc Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T15:11:23Z","timestamp":1659280283000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181087"}},"subtitle":[],"editor":[{"given":"Giovanna","family":"Valenti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":81,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181087","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}