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Biol"},{"issue":"12","key":"ref91","first-page":"3940","article-title":"The muscle-specific ubiquitin ligase atrogin-1\/MAFbx mediates statin-induced muscle toxicity","volume":"117","author":"J Hanai","year":"2007","journal-title":"J Clin Invest"},{"issue":"5","key":"ref92","doi-asserted-by":"crossref","first-page":"e0128398","DOI":"10.1371\/journal.pone.0128398","article-title":"Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1alpha Protein and Mitochondrial Content","volume":"10","author":"CA Goodman","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref93","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2015.08.002","article-title":"Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition","volume":"22","author":"TJ Schirris","year":"2015","journal-title":"Cell 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