{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:07:35Z","timestamp":1760299655086,"version":"3.37.3"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD42174"],"award-info":[{"award-number":["HD42174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181466","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T17:47:38Z","timestamp":1500659258000},"page":"e0181466","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of pulmonary \u03b2-carotene 15, 15\u2019-oxygenase expression by glucocorticoid involves PPAR\u03b1"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-5611","authenticated-orcid":true,"given":"Xiaoming","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Marisiddaiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis P.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"1234S","DOI":"10.3945\/ajcn.112.034629","article-title":"Provitamin A metabolism and functions in mammalian biology","volume":"96","author":"J von Lintig","year":"2012","journal-title":"The American journal of clinical nutrition"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1194\/jlr.R037028","article-title":"Enzymology of retinoic acid biosynthesis and degradation","volume":"54","author":"NY Kedishvili","year":"2013","journal-title":"Journal of lipid research"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1194\/jlr.R037648","article-title":"Retinol and retinyl esters: biochemistry and physiology","volume":"54","author":"SM O'Byrne","year":"2013","journal-title":"J Lipid Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0083-6729(06)75014-2","article-title":"Vitamin A and emphysema","volume":"75","author":"RC Baybutt","year":"2007","journal-title":"Vitam Horm"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1165\/rcmb.F263","article-title":"Retinoids, alveolus formation, and alveolar deficiency: clinical implications","volume":"28","author":"D Massaro","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1445","key":"ref6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1098\/rstb.2004.1470","article-title":"Retinoic acid in alveolar development, maintenance and regeneration","volume":"359","author":"M Maden","year":"2004","journal-title":"Philosophical transactions of the Royal Society of London Series B, Biological sciences"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"L249","DOI":"10.1152\/ajplung.00140.2003","article-title":"Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation","volume":"286","author":"G Dirami","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"L715","DOI":"10.1152\/ajplung.00166.2004","article-title":"Critical period for alveologenesis and early determinants of adult pulmonary disease","volume":"287","author":"D Massaro","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1183\/09031936.03.00119103","article-title":"Retinoic acid induces alveolar regeneration in the adult mouse lung","volume":"23","author":"M Hind","year":"2004","journal-title":"The European respiratory journal: official journal of the European Society for Clinical Respiratory Physiology"},{"issue":"4 Pt 1","key":"ref10","first-page":"L463","article-title":"Retinoids, retinoic acid receptors, and cytoplasmic retinoid binding proteins in perinatal rat lung fibroblasts","volume":"269","author":"SE McGowan","year":"1995","journal-title":"Am J Physiol"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/jn\/130.5.1159","article-title":"Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes","volume":"130","author":"RC Baybutt","year":"2000","journal-title":"J Nutr"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1006\/bbrc.1994.1480","article-title":"Depletion of retinyl esters in the lungs coincides with lung prenatal morphological maturation","volume":"200","author":"SK Geevarghese","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"ref13","first-page":"457","article-title":"Stage-dependent responses of the developing lung to retinoic acid signaling","volume":"44","author":"R Mollard","year":"2000","journal-title":"Int J Dev Biol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0022-3476(81)80484-2","article-title":"Plasma vitamin A and retinol-binding protein in premature and term neonates","volume":"99","author":"JP Shenai","year":"1981","journal-title":"J Pediatr"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1203\/00006450-198502000-00007","article-title":"Vitamin A status of neonates with bronchopulmonary dysplasia","volume":"19","author":"JP Shenai","year":"1985","journal-title":"Pediatr Res"},{"issue":"25","key":"ref16","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1056\/NEJM199906243402505","article-title":"Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network","volume":"340","author":"JE Tyson","year":"1999","journal-title":"N Engl J Med"},{"issue":"19","key":"ref17","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1056\/NEJMoa0907441","article-title":"Maternal vitamin A supplementation and lung function in offspring","volume":"362","author":"W Checkley","year":"2010","journal-title":"N Engl J Med"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1074\/jbc.M009030200","article-title":"Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15&apos;-dioxygenase","volume":"276","author":"TM Redmond","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1074\/jbc.275.16.11915","article-title":"Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal","volume":"275","author":"J von Lintig","year":"2000","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/002215540405200407","article-title":"Cell type-specific expression of beta-carotene 15,15&apos;-mono-oxygenase in human tissues","volume":"52","author":"A Lindqvist","year":"2004","journal-title":"J Histochem Cytochem"},{"issue":"Pt 3","key":"ref21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj3540521","article-title":"Expression pattern and localization of beta,beta-carotene 15,15&apos;-dioxygenase in different tissues","volume":"354","author":"A Wyss","year":"2001","journal-title":"Biochem J"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1096\/fj.10-175448","article-title":"beta-Carotene and its cleavage enzyme beta-carotene-15,15&apos;-oxygenase (CMOI) affect retinoid metabolism in developing tissues","volume":"25","author":"YK Kim","year":"2011","journal-title":"FASEB J"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1194\/jlr.M300116-JLR200","article-title":"Absorption and retinol equivalence of beta-carotene in humans is influenced by dietary vitamin A intake","volume":"44","author":"SL Lemke","year":"2003","journal-title":"J Lipid Res"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.abb.2004.04.028","article-title":"Carotenoid and retinoid metabolism: insights from isotope studies","volume":"430","author":"BJ Burri","year":"2004","journal-title":"Arch Biochem Biophys"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1093\/jn\/132.12.3616","article-title":"Feedback regulation of beta,beta-carotene 15,15&apos;-monooxygenase by retinoic acid in rats and chickens","volume":"132","author":"H Bachmann","year":"2002","journal-title":"J Nutr"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1096\/fj.02-0690fje","article-title":"Identification of beta-carotene 15, 15&apos;-monooxygenase as a peroxisome proliferator-activated receptor target gene","volume":"17","author":"A Boulanger","year":"2003","journal-title":"FASEB J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2199-7-7","article-title":"Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15&apos;-monooxygenase gene expression","volume":"7","author":"X Gong","year":"2006","journal-title":"BMC molecular biology"},{"issue":"3 Spec No","key":"ref28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/adc.68.3_Spec_No.330","article-title":"The effectiveness and side effects of dexamethasone in preterm infants with bronchopulmonary dysplasia","volume":"68","author":"PC Ng","year":"1993","journal-title":"Arch Dis Child"},{"issue":"2 Pt 1","key":"ref29","first-page":"L305","article-title":"Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats","volume":"270","author":"GD Massaro","year":"1996","journal-title":"Am J Physiol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000079983","article-title":"Effects of mild vitamin a deficiency on lung maturation in newborn rats: a morphometric and morphologic study","volume":"86","author":"G Frey","year":"2004","journal-title":"Biol Neonate"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nm0697-675","article-title":"Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats","volume":"3","author":"GD Massaro","year":"1997","journal-title":"Nat Med"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1172\/JCI112103","article-title":"Postnatal development of alveoli. Regulation and evidence for a critical period in rats","volume":"76","author":"D Massaro","year":"1985","journal-title":"J Clin Invest"},{"issue":"2","key":"ref33","first-page":"93","article-title":"Effect of maternal dexamethasone treatment on fetal lung vitamin A stores in the perinatal rat","volume":"64","author":"JP Shenai","year":"1994","journal-title":"Int J Vitam Nutr Res"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.abb.2013.09.013","article-title":"beta-carotene regulates expression of beta-carotene 15,15&apos;-monoxygenase in human alveolar epithelial cells","volume":"539","author":"X Gong","year":"2013","journal-title":"Archives of biochemistry and biophysics"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/jn\/131.11.2921","article-title":"Lysophosphatidylcholine enhances carotenoid uptake from mixed micelles by Caco-2 human intestinal cells","volume":"131","author":"T Sugawara","year":"2001","journal-title":"J Nutr"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11745-003-1118-5","article-title":"Phospholipids affect the intestinal absorption of carotenoids in mice","volume":"38","author":"V Baskaran","year":"2003","journal-title":"Lipids"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00394-006-0601-3","article-title":"Molecular cloning of the rat beta-carotene 15,15&apos;-monooxygenase gene and its regulation by retinoic acid","volume":"45","author":"K Takitani","year":"2006","journal-title":"Eur J Nutr"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1006\/bbrc.1998.9160","article-title":"Characterization of beta-carotene 15,15&apos;-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2","volume":"249","author":"A During","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0070-2153(04)61007-6","article-title":"Retinoids in lung development and regeneration","volume":"61","author":"M Maden","year":"2004","journal-title":"Current topics in developmental biology"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1242\/dev.00437","article-title":"Provitamin A conversion to retinal via the beta,beta-carotene-15,15&apos;-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis","volume":"130","author":"JM Lampert","year":"2003","journal-title":"Development"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/mnfr.201100387","article-title":"Importance of beta,beta-carotene 15,15&apos;-monooxygenase 1 (BCMO1) and beta,beta-carotene 9&apos;,10&apos;-dioxygenase 2 (BCDO2) in nutrition and health","volume":"56","author":"G Lietz","year":"2012","journal-title":"Mol Nutr Food Res"},{"issue":"46","key":"ref43","doi-asserted-by":"crossref","first-page":"33553","DOI":"10.1074\/jbc.M706763200","article-title":"CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice","volume":"282","author":"S Hessel","year":"2007","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.abb.2015.01.002","article-title":"Tissue- and sex-specific effects of beta-carotene 15,15&apos; oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice","volume":"572","author":"YK Kim","year":"2015","journal-title":"Archives of biochemistry and biophysics"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/MCB.21.3.771-780.2001","article-title":"Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38","volume":"21","author":"M Lasa","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"40","key":"ref46","doi-asserted-by":"crossref","first-page":"24527","DOI":"10.1016\/S0021-9258(17)31420-5","article-title":"Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids","volume":"269","author":"T Lemberger","year":"1994","journal-title":"J Biol Chem"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(01)00828-7","article-title":"Monoamine oxidase in developing rat renal cortex: effect of dexamethasone treatment","volume":"415","author":"G Bompart","year":"2001","journal-title":"European journal of pharmacology"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1124\/mol.107.041475","article-title":"Peroxisome proliferator-activated receptor-alpha contributes to the anti-inflammatory activity of glucocorticoids","volume":"73","author":"S Cuzzocrea","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pupt.2007.08.001","article-title":"Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation","volume":"21","author":"J Becker","year":"2008","journal-title":"Pulmonary pharmacology & therapeutics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"925309","DOI":"10.1155\/2009\/925309","article-title":"Cross-Talk between PPARs and the Partners of RXR: A Molecular Perspective","volume":"2009","author":"LS Chan","year":"2009","journal-title":"PPAR Res"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"e20644","DOI":"10.1371\/journal.pone.0020644","article-title":"Beta-carotene reduces body adiposity of mice via BCMO1","volume":"6","author":"J Amengual","year":"2011","journal-title":"PloS one"},{"issue":"36","key":"ref52","doi-asserted-by":"crossref","first-page":"27891","DOI":"10.1074\/jbc.M110.132571","article-title":"Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner","volume":"285","author":"GP Lobo","year":"2010","journal-title":"The Journal of biological chemistry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T18:09:53Z","timestamp":1719338993000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181466"}},"subtitle":[],"editor":[{"given":"Jean-Marc A","family":"Lobaccaro","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,21]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181466","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,7,21]]}}}