{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:09:02Z","timestamp":1773421742723,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD060860"],"award-info":[{"award-number":["HD060860"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD085652"],"award-info":[{"award-number":["HD085652"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["Predoctoral Fellowship"],"award-info":[{"award-number":["Predoctoral Fellowship"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181597","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T13:50:00Z","timestamp":1500558600000},"page":"e0181597","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation"],"prefix":"10.1371","volume":"12","author":[{"given":"Mahita","family":"Kadmiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke C.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott T.","family":"Espenschied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.","family":"Lenhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10409238.2015.1128875","article-title":"The expanding repertoire of receptor activity modifying protein (RAMP) function","volume":"51","author":"KR Klein","year":"2016","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/ATVBAHA.109.185066","article-title":"G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases","volume":"29","author":"WP Dunworth","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-4614-2364-5_6","article-title":"RAMPs as drug targets","volume":"744","author":"PM Sexton","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4614-2364-5_5","article-title":"Understanding RAMPs through genetically engineered mouse models","volume":"744","author":"M Kadmiel","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.molcel.2015.04.018","article-title":"Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor","volume":"58","author":"JM Booe","year":"2015","journal-title":"Mol Cell"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbrc.2010.01.030","article-title":"Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2","volume":"392","author":"K Kuwasako","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"ref7","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1074\/jbc.M115.688218","article-title":"Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties","volume":"291","author":"HA Watkins","year":"2016","journal-title":"J Biol Chem"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/bph.12508","article-title":"Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology","volume":"171","author":"HA Watkins","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"6683","key":"ref9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","author":"LM McLatchie","year":"1998","journal-title":"Nature"},{"issue":"25","key":"ref10","doi-asserted-by":"crossref","first-page":"18094","DOI":"10.1074\/jbc.M703544200","article-title":"Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age","volume":"282","author":"R Dackor","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI33302","article-title":"Adrenomedullin signaling is necessary for murine lymphatic vascular development","volume":"118","author":"KL Fritz-Six","year":"2008","journal-title":"J Clin Invest"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/HYPERTENSIONAHA.116.07191","article-title":"Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy","volume":"68","author":"DO Kechele","year":"2016","journal-title":"Hypertension"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1210\/me.2010-0400","article-title":"Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice","volume":"25","author":"M Kadmiel","year":"2011","journal-title":"Mol Endocrinol"},{"issue":"2-3-4","key":"ref14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1387\/ijdb.140032kc","article-title":"Uterine natural killer cells as modulators of the maternal-fetal vasculature","volume":"58","author":"BC Matson","year":"2014","journal-title":"Int J Dev Biol"},{"key":"ref15","article-title":"Haploinsufficiency for Adrenomedullin Reduces Pinopodes and Diminishes Uterine Receptivity in Mice","author":"M Li","year":"2008","journal-title":"Biol Reprod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","volume":"31","author":"A Erlebacher","year":"2013","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"SL Adamson","year":"2002","journal-title":"Dev Biol"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"J Hanna","year":"2006","journal-title":"Nat Med"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1701-2163(16)32862-6","article-title":"The role of decidual natural killer cells in normal placentation and in the pathogenesis of preeclampsia","volume":"30","author":"G Eastabrook","year":"2008","journal-title":"J Obstet Gynaecol Can"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1172\/JCI67039","article-title":"Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta","volume":"123","author":"M Li","year":"2013","journal-title":"J Clin Invest"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: current understanding of its pathophysiology","volume":"10","author":"T Chaiworapongsa","year":"2014","journal-title":"Nat Rev Nephrol"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1210\/jcem.86.10.8099","article-title":"Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension","volume":"86","author":"Y Makino","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1210\/endo.142.11.8509","article-title":"PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP","volume":"142","author":"CS Kovacs","year":"2001","journal-title":"Endocrinology"},{"issue":"26","key":"ref24","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.93.26.15233","article-title":"Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH\/PTHrP receptor","volume":"93","author":"CS Kovacs","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1359\/jbmr.090825","article-title":"Parathyroid hormone regulates fetal-placental mineral homeostasis","volume":"25","author":"CS Simmonds","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/jme.0.0170159","article-title":"The role of fetal parathyroid hormone-related protein in transplacental calcium transport","volume":"17","author":"J Tucci","year":"1996","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1634\/theoncologist.2009-0185","article-title":"Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics","volume":"15","author":"M Abdelgadir Adam","year":"2010","journal-title":"Oncologist"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4614-0254-1_12","article-title":"Parathyroid Hormone Related Protein (PTHrP) in Tumor Progression","volume":"720","author":"R Kremer","year":"2011","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/157488611795684712","article-title":"Emerging anabolic treatments in osteoporosis","volume":"6","author":"L Mosekilde","year":"2011","journal-title":"Curr Drug Saf"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.14310\/horm.2002.1308","article-title":"Targeting the osteoblast: approved and experimental anabolic agents for the treatment of osteoporosis","volume":"10","author":"KA Toulis","year":"2011","journal-title":"Hormones (Athens)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T23:13:02Z","timestamp":1540249982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181597"}},"subtitle":[],"editor":[{"given":"Colette","family":"Kanellopoulos-Langevin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,20]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181597","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,20]]}}}