{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:29:59Z","timestamp":1787311799079,"version":"build-2736575974"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RBFR13209E"],"award-info":[{"award-number":["RBFR13209E"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181734","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T13:41:34Z","timestamp":1500990094000},"page":"e0181734","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["DNA-immunisation with dengue virus E protein domains I\/II, but not domain III, enhances Zika, West Nile and Yellow Fever virus infection"],"prefix":"10.1371","volume":"12","author":[{"given":"Jose L.","family":"Slon Campos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Poggianella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mossenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Arnoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bestagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-7332","authenticated-orcid":true,"given":"Oscar R.","family":"Burrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"ref1","first-page":"299","article-title":"Epidemiology of dengue: past, present and future prospects","volume":"5","author":"NE Murray","year":"2013","journal-title":"Clinical epidemiology"},{"issue":"7446","key":"ref2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"issue":"15","key":"ref3","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"CP Simmons","year":"2012","journal-title":"The New England journal of medicine"},{"key":"ref4","article-title":"Fields' Virology","author":"BD Lindenbach","year":"2007"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1128\/JVI.79.2.1223-1231.2005","article-title":"Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein","volume":"79","author":"Y Modis","year":"2005","journal-title":"Journal of virology"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","article-title":"Structure of dengue virus: implications for flavivirus organization, maturation, and fusion","volume":"108","author":"RJ Kuhn","year":"2002","journal-title":"Cell"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"e0003749","DOI":"10.1371\/journal.pntd.0003749","article-title":"The Complexity of a Dengue Vaccine: A Review of the Human Antibody Response","volume":"9","author":"J Flipse","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"16","key":"ref8","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/0264-410X(95)00097-K","article-title":"Finer mapping of neutralizing epitope(s) on the C-terminal of Japanese encephalitis virus E-protein expressed in recombinant Escherichia coli system","volume":"13","author":"SA Seif","year":"1995","journal-title":"Vaccine"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.virol.2005.02.020","article-title":"Characterization of neutralizing antibodies to West Nile virus","volume":"336","author":"MD Sanchez","year":"2005","journal-title":"Virology"},{"issue":"16","key":"ref10","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1128\/JVI.01314-13","article-title":"Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection","volume":"87","author":"S Sukupolvi-Petty","year":"2013","journal-title":"Journal of virology"},{"issue":"16","key":"ref11","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1128\/JVI.75.16.7769-7773.2001","article-title":"Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells","volume":"75","author":"WD Crill","year":"2001","journal-title":"Journal of virology"},{"issue":"17","key":"ref12","doi-asserted-by":"crossref","first-page":"8828","DOI":"10.1128\/JVI.00606-08","article-title":"Characterization of dengue virus complex-specific neutralizing epitopes on envelope protein domain III of dengue 2 virus","volume":"82","author":"GD Gromowski","year":"2008","journal-title":"Journal of virology"},{"issue":"19","key":"ref13","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.1200566109","article-title":"Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions","volume":"109","author":"R de Alwis","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ni.3058","article-title":"A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus","volume":"16","author":"W Dejnirattisai","year":"2015","journal-title":"Nature immunology"},{"issue":"7545","key":"ref15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature14130","article-title":"Recognition determinants of broadly neutralizing human antibodies against dengue viruses","volume":"520","author":"A Rouvinski","year":"2015","journal-title":"Nature"},{"issue":"7614","key":"ref16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature18938","article-title":"Structural basis of potent Zika-dengue virus antibody cross-neutralization","volume":"536","author":"G Barba-Spaeth","year":"2016","journal-title":"Nature"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01123-16","article-title":"Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus","volume":"7","author":"JA Swanstrom","year":"2016","journal-title":"mBio"},{"issue":"24","key":"ref18","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.1128\/JVI.01732-06","article-title":"Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein","volume":"80","author":"T Oliphant","year":"2006","journal-title":"Journal of virology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virol.2009.06.037","article-title":"Dengue virus neutralization by human immune sera: role of envelope protein domain III-reactive antibody","volume":"392","author":"WM Wahala","year":"2009","journal-title":"Virology"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"e1003458","DOI":"10.1371\/journal.ppat.1003458","article-title":"Dissection of antibody specificities induced by yellow fever vaccination","volume":"9","author":"O Vratskikh","year":"2013","journal-title":"PLoS pathogens"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity","volume":"8","author":"M Beltramello","year":"2010","journal-title":"Cell host & microbe"},{"issue":"9951","key":"ref22","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(14)61060-6","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"MR Capeding","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1411037","article-title":"Efficacy of a tetravalent dengue vaccine in children in Latin America","volume":"372","author":"L Villar","year":"2015","journal-title":"The New England journal of medicine"},{"issue":"13","key":"ref24","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","volume":"373","author":"SR Hadinegoro","year":"2015","journal-title":"The New England journal of medicine"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3390\/v2122649","article-title":"The complexity of antibody-dependent enhancement of dengue virus infection","volume":"2","author":"MG Guzman","year":"2010","journal-title":"Viruses"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3201\/eid2110.150847","article-title":"Zika Virus Outbreak, Bahia, Brazil","volume":"21","author":"GS Campos","year":"2015","journal-title":"Emerging infectious diseases"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/CMR.00072-15","article-title":"Zika Virus","volume":"29","author":"D Musso","year":"2016","journal-title":"Clinical microbiology reviews"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"W Dejnirattisai","year":"2016","journal-title":"Nature immunology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4269\/ajtmh.1988.38.205","article-title":"Heterologous flavivirus infection-enhancing antibodies in sera of Nigerians","volume":"38","author":"A Fagbami","year":"1988","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"16164","DOI":"10.1038\/nmicrobiol.2016.164","article-title":"Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity","volume":"1","author":"KR Chan","year":"2016","journal-title":"Nature microbiology"},{"issue":"28","key":"ref31","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1073\/pnas.1607931113","article-title":"Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus","volume":"113","author":"L Priyamvada","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6301","key":"ref32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"K Stettler","year":"2016","journal-title":"Science (New York, NY)"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2016.07.020","article-title":"Structural Basis of Zika Virus-Specific Antibody Protection","volume":"166","author":"H Zhao","year":"2016","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fimmu.2014.00151","article-title":"Mouse models to study dengue virus immunology and pathogenesis","volume":"5","author":"RM Zellweger","year":"2014","journal-title":"Frontiers in immunology"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/v4010062","article-title":"Animal models of dengue virus infection","volume":"4","author":"S Zompi","year":"2012","journal-title":"Viruses"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/protein\/10.6.731","article-title":"Mammalian cell expression of dimeric small immune proteins (SIP)","volume":"10","author":"E Li","year":"1997","journal-title":"Protein engineering"},{"issue":"Pt 3","key":"ref37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1099\/0022-1317-73-3-653","article-title":"Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen","volume":"73","author":"T Hanke","year":"1992","journal-title":"The Journal of general virology"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"e0003947","DOI":"10.1371\/journal.pntd.0003947","article-title":"Dengue E Protein Domain III-Based DNA Immunisation Induces Strong Antibody Responses to All Four Viral Serotypes","volume":"9","author":"M Poggianella","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1099\/jgv.0.000278","article-title":"Secretion of dengue virus envelope protein ectodomain from mammalian cells is dependent on domain II serotype and affects the immune response upon DNA vaccination","volume":"96","author":"JL Slon Campos","year":"2015","journal-title":"The Journal of general virology"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1110\/ps.8.4.921","article-title":"A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation","volume":"8","author":"D Beckett","year":"1999","journal-title":"Protein science: a publication of the Protein Society"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1472-6750-8-41","article-title":"In vivo site-specific biotinylation of proteins within the secretory pathway using a single vector system","volume":"8","author":"A Predonzani","year":"2008","journal-title":"BMC biotechnology"},{"key":"ref42","author":"J Sambrook","year":"1989"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1128\/JCM.42.4.1782-1784.2004","article-title":"Use of an immunoglobulin G avidity test to discriminate between primary and secondary dengue virus infections","volume":"42","author":"VA de Souza","year":"2004","journal-title":"Journal of clinical microbiology"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"e1004386","DOI":"10.1371\/journal.ppat.1004386","article-title":"Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera","volume":"10","author":"R de Alwis","year":"2014","journal-title":"PLoS pathogens"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/JVI.02273-12","article-title":"Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop","volume":"87","author":"JM Costin","year":"2013","journal-title":"Journal of virology"},{"issue":"6284","key":"ref46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8 A resolution cryo-EM structure of Zika virus","volume":"352","author":"D Sirohi","year":"2016","journal-title":"Science (New York, NY)"},{"issue":"7603","key":"ref47","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature17994","article-title":"Structure of the thermally stable Zika virus","volume":"533","author":"VA Kostyuchenko","year":"2016","journal-title":"Nature"},{"issue":"6334","key":"ref48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"SV Bardina","year":"2017","journal-title":"Science (New York, NY)"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"e65231","DOI":"10.1371\/journal.pone.0065231","article-title":"Dengue virus neutralization in cells expressing Fc gamma receptors","volume":"8","author":"T Chawla","year":"2013","journal-title":"PloS one"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chom.2007.03.002","article-title":"The Stoichiometry of Antibody-Mediated Neutralization and Enhancement of West Nile Virus Infection","volume":"1","author":"TC Pierson","year":"2007","journal-title":"Cell host & microbe"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.virol.2010.12.020","article-title":"Antibody-mediated neutralization of flaviviruses: a reductionist view","volume":"411","author":"KA Dowd","year":"2011","journal-title":"Virology"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"e2274","DOI":"10.1371\/journal.pntd.0002274","article-title":"Correlation between dengue-specific neutralizing antibodies and serum avidity in primary and secondary dengue virus 3 natural infections in humans","volume":"7","author":"A Puschnik","year":"2013","journal-title":"PLoS neglected tropical diseases"},{"issue":"6304","key":"ref53","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.aah6157","article-title":"Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys","volume":"353","author":"P Abbink","year":"2016","journal-title":"Science (New York, NY)"},{"issue":"7617","key":"ref54","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature18952","article-title":"Vaccine protection against Zika virus from Brazil","volume":"536","author":"RA Larocca","year":"2016","journal-title":"Nature"},{"issue":"6309","key":"ref55","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aai9137","article-title":"Rapid development of a DNA vaccine for Zika virus","volume":"354","author":"KA Dowd","year":"2016","journal-title":"Science (New York, NY)"},{"issue":"7644","key":"ref56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature21428","article-title":"Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination","volume":"543","author":"N Pardi","year":"2017","journal-title":"Nature"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.cell.2017.02.017","article-title":"Modified mRNA Vaccines Protect against Zika Virus Infection","volume":"168","author":"JM Richner","year":"2017","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ebiom.2016.09.028","article-title":"Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation","volume":"13","author":"E Kim","year":"2016","journal-title":"EBioMedicine"},{"issue":"5979","key":"ref59","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.1185181","article-title":"Cross-reacting antibodies enhance dengue virus infection in humans","volume":"328","author":"W Dejnirattisai","year":"2010","journal-title":"Science (New York, NY)"},{"issue":"51","key":"ref60","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1016\/j.vaccine.2010.10.004","article-title":"A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice","volume":"28","author":"OK Block","year":"2010","journal-title":"Vaccine"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"30648","DOI":"10.1038\/srep30648","article-title":"Immunogenicity of a novel tetravalent vaccine formulation with four recombinant lipidated dengue envelope protein domain IIIs in mice","volume":"6","author":"CY Chiang","year":"2016","journal-title":"Scientific reports"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41598-017-01097-5","article-title":"Temperature-dependent folding allows stable dimerization of secretory and virus-associated E proteins of Dengue and Zika viruses in mammalian cells","volume":"7","author":"JL Slon Campos","year":"2017","journal-title":"Scientific reports"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"15411","DOI":"10.1038\/ncomms15411","article-title":"Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope","volume":"8","author":"A Rouvinski","year":"2017","journal-title":"Nature communications"},{"issue":"26","key":"ref64","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1016\/j.vaccine.2010.04.045","article-title":"Report of an NIAID workshop on dengue animal models","volume":"28","author":"MC Cassetti","year":"2010","journal-title":"Vaccine"},{"issue":"6323","key":"ref65","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.aai8128","article-title":"IgG antibodies to dengue enhanced for FcgammaRIIIA binding determine disease severity","volume":"355","author":"TT Wang","year":"2017","journal-title":"Science (New York, NY)"},{"issue":"50","key":"ref66","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1016\/j.vaccine.2015.09.102","article-title":"Nucleic acid (DNA) immunization as a platform for dengue vaccine development","volume":"33","author":"KR Porter","year":"2015","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:05:49Z","timestamp":1589033149000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181734"}},"subtitle":[],"editor":[{"given":"Dong-Yan","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":66,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181734","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]}}}