{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:23:30Z","timestamp":1790447010691,"version":"4.1.0"},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Bio & Medical Technology Development Program","award":["NRF-2014M3A9B6069340"],"award-info":[{"award-number":["NRF-2014M3A9B6069340"]}]},{"name":"the Basic Science Research Program","award":["2013R1A1A2064418 and 2016R1D1A1B03931783"],"award-info":[{"award-number":["2013R1A1A2064418 and 2016R1D1A1B03931783"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0181758","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T17:40:42Z","timestamp":1501090842000},"page":"e0181758","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Metabolomic profiling of CSF in multiple sclerosis and neuromyelitis optica spectrum disorder by nuclear magnetic resonance"],"prefix":"10.1371","volume":"12","author":[{"given":"Hyun-Hwi","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hye","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja-Shil","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Soo","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jean","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"issue":"9995","key":"ref1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"T Vos","year":"2015","journal-title":"The Lancet"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ni1507","article-title":"Multiple sclerosis: a complicated picture of autoimmunity","volume":"8","author":"HF McFarland","year":"2007","journal-title":"Nature immunology"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"CA Dendrou","year":"2015","journal-title":"Nature Reviews Immunology"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","article-title":"Revised diagnostic criteria for neuromyelitis optica","volume":"66","author":"DM Wingerchuk","year":"2006","journal-title":"Neurology"},{"issue":"9451","key":"ref5","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"VA Lennon","year":"2004","journal-title":"The Lancet"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"VA Lennon","year":"2005","journal-title":"The Journal of experimental medicine"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"DM Wingerchuk","year":"2007","journal-title":"The Lancet Neurology"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1212\/WNL.0000000000001367","article-title":"MRI characteristics of neuromyelitis optica spectrum disorder An international update","volume":"84","author":"HJ Kim","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"DM Wingerchuk","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"CH Polman","year":"2011","journal-title":"Annals of neurology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1177\/1352458512439439","article-title":"Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder?","volume":"18","author":"S-H Kim","year":"2012","journal-title":"Multiple Sclerosis Journal"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/1352458511431973","article-title":"Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder","volume":"18","author":"J-H Min","year":"2012","journal-title":"Multiple Sclerosis Journal"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1039\/B906712B","article-title":"Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy","volume":"40","author":"WB Dunn","year":"2011","journal-title":"Chemical Society Reviews"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s11306-014-0746-7","article-title":"Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review","volume":"11","author":"A-H Emwas","year":"2015","journal-title":"Metabolomics"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1586\/14737159.2016.1164037","article-title":"NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics","volume":"16","author":"D Kumar","year":"2016","journal-title":"Expert review of molecular diagnostics"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/acs.jproteome.5b00885","article-title":"Recommendations and Standardization of Biomarker Quantification Using NMR-based Metabolomics with Particular Focus on Urinary Analysis","volume":"15","author":"A-H Emwas","year":"2016","journal-title":"Journal of proteome research"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/bjc.2015.414","article-title":"1H-NMR urinary metabolomic profiling for diagnosis of gastric cancer","volume":"114","author":"AW Chan","year":"2015","journal-title":"British journal of cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1038\/srep14869","article-title":"Integrative metabonomics as potential method for diagnosis of thyroid malignancy","volume":"5","author":"Y Tian","year":"2015","journal-title":"Scientific Reports"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/1352458513504638","article-title":"Serum analysis by 1H nuclear magnetic resonance spectroscopy: a new tool for distinguishing neuromyelitis optica from multiple sclerosis","volume":"20","author":"F Moussallieh","year":"2014","journal-title":"Multiple Sclerosis Journal"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/nbm.1428","article-title":"NMR\u2010based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases\u2013a diagnostic tool?","volume":"23","author":"AJ Sinclair","year":"2010","journal-title":"NMR in Biomedicine"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrc.3915","article-title":"A metabonomics investigation of multiple sclerosis by nuclear magnetic resonance","volume":"51","author":"M Mehrpour","year":"2013","journal-title":"Magnetic Resonance in Chemistry"},{"issue":"17","key":"ref22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1212\/WNL.0000000000000905","article-title":"A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis","volume":"83","author":"AM Dickens","year":"2014","journal-title":"Neurology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"167156","DOI":"10.1155\/2011\/167156","article-title":"Serum metabolic profile in multiple sclerosis patients","volume":"2011","author":"B Tavazzi","year":"2011","journal-title":"Multiple sclerosis international"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0022-510X(96)00224-9","article-title":"High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques","volume":"144","author":"IL Simone","year":"1996","journal-title":"Journal of the neurological sciences"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"e595","DOI":"10.1371\/journal.pone.0000595","article-title":"Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid","volume":"2","author":"NW Lutz","year":"2007","journal-title":"PLoS One"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2174\/138920111795909122","article-title":"Metabolic profiling in multiple sclerosis and other disorders by quantitative analysis of cerebrospinal fluid using nuclear magnetic resonance spectroscopy","volume":"12","author":"N W Lutz","year":"2011","journal-title":"Current pharmaceutical biotechnology"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1177\/1352458513516528","article-title":"Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis","volume":"20","author":"S Reinke","year":"2014","journal-title":"Multiple Sclerosis Journal"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1212\/NXI.0000000000000185","article-title":"<sup>1<\/sup>H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis","volume":"3","author":"E Cocco","year":"2016","journal-title":"Neurology-Neuroimmunology Neuroinflammation"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/acs.jproteome.5b01111","article-title":"A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica","volume":"15","author":"T Gebregiworgis","year":"2016","journal-title":"Journal of proteome research"},{"issue":"suppl 2","key":"ref30","doi-asserted-by":"crossref","first-page":"W652","DOI":"10.1093\/nar\/gkp356","article-title":"MetaboAnalyst: a web server for metabolomic data analysis and interpretation","volume":"37","author":"J Xia","year":"2009","journal-title":"Nucleic acids research"},{"issue":"W1","key":"ref31","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2014making metabolomics more meaningful","volume":"43","author":"J Xia","year":"2015","journal-title":"Nucleic acids research"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1021\/ac0519312","article-title":"Scaling and normalization effects in NMR spectroscopic metabonomic data sets","volume":"78","author":"A Craig","year":"2006","journal-title":"Analytical chemistry"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/nbm.700","article-title":"NMR spectral quantitation by principal component analysis","volume":"14","author":"R Stoyanova","year":"2001","journal-title":"NMR in Biomedicine"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/pr060594q","article-title":"Chemometrics in metabonomics","volume":"6","author":"J Trygg","year":"2007","journal-title":"Journal of proteome research"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"R1440","DOI":"10.1152\/ajpregu.00281.2010","article-title":"A metabolomics approach to elucidate effects of food deprivation in juvenile rainbow trout (Oncorhynchus mykiss)","volume":"299","author":"A Kullgren","year":"2010","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1021\/ac0713510","article-title":"Visualization of GC\/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models","volume":"80","author":"S Wiklund","year":"2008","journal-title":"Analytical chemistry"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ab.2012.10.011","article-title":"Utilities for quantifying separation in PCA\/PLS-DA scores plots","volume":"433","author":"B Worley","year":"2013","journal-title":"Analytical biochemistry"},{"issue":"11\u201012","key":"ref38","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/cem.1187","article-title":"CV\u2010ANOVA for significance testing of PLS and OPLS\u00ae models","volume":"22","author":"L Eriksson","year":"2008","journal-title":"Journal of Chemometrics"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11306-007-0099-6","article-title":"Assessment of PLSDA cross validation","volume":"4","author":"JA Westerhuis","year":"2008","journal-title":"Metabolomics"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/10485250310001634719","article-title":"On the null distribution of the Kruskal\u2013Wallis statistic","volume":"15","author":"JD Spurrier","year":"2003","journal-title":"Nonparametric Statistics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","author":"Y Benjamini","year":"1995","journal-title":"Journal of the royal statistical society Series B (Methodological)"},{"issue":"2","key":"ref42","first-page":"627","article-title":"Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation","volume":"4","author":"K Hajian-Tilaki","year":"2013","journal-title":"Caspian journal of internal medicine"},{"key":"ref43","first-page":"523","article-title":"PLS-partial least squares projections to latent structures","volume":"1","author":"S Wold","year":"1993","journal-title":"3D QSAR in drug design"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0005-2728(98)00114-5","article-title":"Mitochondrial dysfunction in neurodegenerative diseases","volume":"1366","author":"MF Beal","year":"1998","journal-title":"Biochimica et Biophysica Acta (BBA)-Bioenergetics"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuron.2006.02.006","article-title":"Astrocytes promote myelination in response to electrical impulses","volume":"49","author":"T Ishibashi","year":"2006","journal-title":"Neuron"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbi.2015.04.013","article-title":"Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling","volume":"48","author":"T Zeis","year":"2015","journal-title":"Brain, behavior, and immunity"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients","volume":"59","author":"R Dutta","year":"2006","journal-title":"Annals of neurology"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nbd.2010.12.003","article-title":"Gene expression profiling in multiple sclerosis brain","volume":"45","author":"R Dutta","year":"2012","journal-title":"Neurobiology of disease"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jns.2011.03.038","article-title":"Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: results from 211 lumbar punctures","volume":"306","author":"S Jarius","year":"2011","journal-title":"Journal of the neurological sciences"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.mehy.2013.10.011","article-title":"Aquaporin-4 antibodies, CNS acidosis and neuromyelitis optica: A potential link","volume":"81","author":"S Jarius","year":"2013","journal-title":"Medical hypotheses"},{"issue":"79","key":"ref51","article-title":"Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions","volume":"3","author":"PG Nijland","year":"2015","journal-title":"Acta neuropathologica communications"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fneur.2014.00250","article-title":"Perturbed glucose metabolism: insights into multiple sclerosis pathogenesis","volume":"5","author":"D Mathur","year":"2014","journal-title":"Front Neurol"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"M B\u00e9langer","year":"2011","journal-title":"Cell metabolism"},{"key":"ref54","article-title":"Methylglyoxal, the dark side of glycolysis","author":"I Allaman","year":"2015","journal-title":"Front. Neurosci."},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jns.2011.02.018","article-title":"Neuromyelitis optica and astrocytic damage in its pathogenesis","volume":"306","author":"K Fujihara","year":"2011","journal-title":"Journal of the neurological sciences"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","article-title":"\u03b1-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population","volume":"5","author":"WE Gall","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0009-8981(83)90398-4","article-title":"Studies of urinary organic acid profiles of a patient with dihydrolipoyl dehydrogenase deficiency","volume":"133","author":"K Tomiko","year":"1983","journal-title":"Clinica Chimica Acta"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF00711898","article-title":"Physiology and pathophysiology of organic acids in cerebrospinal fluid","volume":"16","author":"G Hoffmann","year":"1993","journal-title":"Journal of inherited metabolic disease"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/bj2340295","article-title":"Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism","volume":"234","author":"R Paxton","year":"1986","journal-title":"Biochemical Journal"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/mrm.25716","article-title":"Hyperpolarized [13C] ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH isoforms","author":"C von Morze","year":"2016","journal-title":"Magnetic resonance in medicine"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0009-8981(73)90367-7","article-title":"The occurrence of 2-hydroxybutyric acid in urine from patients with lactic acidosis","volume":"48","author":"JE Pettersen","year":"1973","journal-title":"Clinica Chimica Acta"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrneurol.2012.168","article-title":"Progressive multiple sclerosis: pathology and pathogenesis","volume":"8","author":"H Lassmann","year":"2012","journal-title":"Nature Reviews Neurology"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2004.08.037","article-title":"Zou C-g. Redox regulation and reaction mechanism of human cystathionine-\u03b2-synthase: a PLP-dependent hemesensor protein","volume":"433","author":"R Banerjee","year":"2005","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jnr.10408","article-title":"Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels","volume":"70","author":"V Calabrese","year":"2002","journal-title":"Journal of neuroscience research"},{"issue":"4","key":"ref65","first-page":"119","article-title":"Changes in cerebrospinal fluid levels of malondialdehyde and glutathione reductase activity in multiple sclerosis","volume":"14","author":"V Calabrese","year":"1993","journal-title":"International journal of clinical pharmacology research"},{"issue":"2","key":"ref66","first-page":"288","article-title":"Pyroglutamic acid: throwing light on a lightly studied metabolite","volume":"102","author":"A Kumar","year":"2012","journal-title":"Curr Sci"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/iub.249","article-title":"The mitochondrial citrate carrier: metabolic role and regulation of its activity and expression","volume":"61","author":"GV Gnoni","year":"2009","journal-title":"IUBMB life"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-013-8481-z","article-title":"Mitochondrial complex enzyme activities and cytochrome C expression changes in multiple sclerosis","volume":"49","author":"P I\u00f1arrea","year":"2014","journal-title":"Molecular neurobiology"},{"issue":"6\u20107","key":"ref69","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/nbm.845","article-title":"Feeding versus infusion: a novel approach to study the NAA metabolism in rat brain","volume":"16","author":"G Karelson","year":"2003","journal-title":"NMR in biomedicine"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pneurobio.2006.12.003","article-title":"N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology","volume":"81","author":"JR Moffett","year":"2007","journal-title":"Progress in neurobiology"},{"issue":"4","key":"ref71","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1046\/j.1471-4159.2001.00456.x","article-title":"Intraneuronal N\u2010acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin\u2010associated aspartoacylase","volume":"78","author":"G Chakraborty","year":"2001","journal-title":"Journal of neurochemistry"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1176\/jnp.17.3.357","article-title":"Magnetic resonance spectroscopy of memory and frontal brain region in early multiple sclerosis","volume":"17","author":"W Staffen","year":"2005","journal-title":"The Journal of neuropsychiatry and clinical neurosciences"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1212\/WNL.0b013e31827b1a8c","article-title":"Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS","volume":"80","author":"II Kirov","year":"2013","journal-title":"Neurology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuroimage.2013.05.125","article-title":"Metabolomic approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis","volume":"82","author":"LK Vingara","year":"2013","journal-title":"Neuroimage"},{"issue":"14","key":"ref75","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1073\/pnas.0409184102","article-title":"Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan&apos;s disease","volume":"102","author":"CN Madhavarao","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref76","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/jcbfm.2011.84","article-title":"Labeled acetate as a marker of astrocytic metabolism","volume":"31","author":"MT Wyss","year":"2011","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"288S","DOI":"10.1093\/jn\/136.1.288S","article-title":"Branched-chain amino acids and immunity","volume":"136","author":"PC Calder","year":"2006","journal-title":"The Journal of nutrition"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"364976","DOI":"10.1155\/2014\/364976","article-title":"Metabolic and physiological roles of branched-chain amino acids","volume":"2014","author":"M Monirujjaman","year":"2014","journal-title":"Advances in Molecular Biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0181758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:18:44Z","timestamp":1719346724000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0181758"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Motta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":78,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0181758","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,26]]}}}