{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:38:23Z","timestamp":1790858303637,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["UO1AG22376"],"award-info":[{"award-number":["UO1AG22376"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["3U01AG22376-05A2S"],"award-info":[{"award-number":["3U01AG22376-05A2S"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1P30AG028740"],"award-info":[{"award-number":["1P30AG028740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1P30AG21332"],"award-info":[{"award-number":["1P30AG21332"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1P30AG031679"],"award-info":[{"award-number":["1P30AG031679"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1P30AG024827"],"award-info":[{"award-number":["1P30AG024827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR025744"],"award-info":[{"award-number":["UL1RR025744"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006937","name":"National Center for Medical Rehabilitation Research","doi-asserted-by":"publisher","award":["1R24HD065688"],"award-info":[{"award-number":["1R24HD065688"]}],"id":[{"id":"10.13039\/100006937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["58-1950-4-003"],"award-info":[{"award-number":["58-1950-4-003"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182155","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T13:26:41Z","timestamp":1503062801000},"page":"e0182155","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":137,"title":["Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-9020","authenticated-orcid":true,"given":"Roger A.","family":"Fielding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrine","family":"Tudor-Locke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Axtell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Chi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jack","family":"Rejeski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the LIFE study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pu.13.050192.002345","article-title":"Effects of physical activity on health status in older adults. II. Intervention studies","volume":"13","author":"DM Buchner","year":"1992","journal-title":"Annu Rev Public Health"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0277-9536(98)00370-0","article-title":"Risk factors for functional status decline in community-living elderly people: a systematic literature review","volume":"48","author":"AE Stuck","year":"1999","journal-title":"Soc Sci Med"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/bjsm.34.1.7","article-title":"Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials","volume":"34","author":"MM Gardner","year":"2000","journal-title":"Br J Sports Med"},{"issue":"3","key":"ref4","first-page":"CD000340","article-title":"Interventions for preventing falls in elderly people","author":"LD Gillespie","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"ref5","first-page":"CD000340","article-title":"Interventions for preventing falls in elderly people","author":"LD Gillespie","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJM199409293311301","article-title":"A multifatorial intervention to reduce risk of falling among elderly people living in the community","volume":"331","author":"ME Tinetti","year":"1994","journal-title":"N Engl J Med"},{"issue":"18","key":"ref7","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1001\/jama.288.18.2300","article-title":"Walking and leisure-time activity and risk of hip fracture in postmenopausal women","volume":"288","author":"D Feskanich","year":"2002","journal-title":"Jama"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S8756-3282(03)00082-6","article-title":"Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial","volume":"33","author":"K Uusi-Rasi","year":"2003","journal-title":"Bone"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1161\/01.CIR.89.6.2540","article-title":"Physical activity and 23-year incidence of coronary heart disease morbidity and mortality among middle-aged men. The Honolulu Heart Program","volume":"89","author":"BL Rodriguez","year":"1994","journal-title":"Circulation"},{"issue":"15","key":"ref10","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.282.15.1433","article-title":"Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study","volume":"282","author":"FB Hu","year":"1999","journal-title":"Jama"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.1992.03490010065031","article-title":"A prospective study of exercise and incidence of diabetes among US male physicians","volume":"268","author":"JE Manson","year":"1992","journal-title":"Jama"},{"issue":"8770","key":"ref12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0140-6736(91)90664-B","article-title":"Physical activity and incidence of non-insulin-dependent diabetes mellitus in women","volume":"338","author":"JE Manson","year":"1991","journal-title":"Lancet"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/oxfordjournals.aje.a116747","article-title":"Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity, and body mass index","volume":"137","author":"AZ LaCroix","year":"1993","journal-title":"Am J Epidemiol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/oxfordjournals.aje.a009866","article-title":"Aging successfully until death in old age: opportunities for increasing active life expectancy","volume":"149","author":"SG Leveille","year":"1999","journal-title":"Am J Epidemiol"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1532-5415.2000.tb03903.x","article-title":"Long-term exercise and its effect on balance in older, osteoarthritic adults: results from the Fitness, Arthritis, and Seniors Trial (FAST)","volume":"48","author":"SP Messier","year":"2000","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/gerona\/59.2.M154","article-title":"The effects of multidimensional home-based exercise on functional performance in elderly people","volume":"59","author":"ME Nelson","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/gerona\/61.11.1157","article-title":"Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study","volume":"61","author":"M Pahor","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1001\/archinternmed.2010.522","article-title":"Translating weight loss and physical activity programs into the community to preserve mobility in older, obese adults in poor cardiovascular health","volume":"171","author":"WJ Rejeski","year":"2011","journal-title":"Arch Intern Med"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2013.7231","article-title":"Home-based walking exercise intervention in peripheral artery disease: a randomized clinical trial","volume":"310","author":"MM McDermott","year":"2013","journal-title":"JAMA"},{"key":"ref20","first-page":"91","article-title":"Who will stay and who will go? A review of older adults&apos; adherence to randomized controlled trials of exercise","volume":"9","author":"KA Martin","year":"2001","journal-title":"J Aging and Phys Activ"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1249\/mss.0b013e318145348d","article-title":"Activity adherence and physical function in older adults with functional limitations","volume":"39","author":"RA Fielding","year":"2007","journal-title":"Med Sci Sports Exerc"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/gerona\/glr123","article-title":"The Lifestyle Interventions and Independence for Elders Study: design and methods","volume":"66","author":"RA Fielding","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"23","key":"ref23","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1001\/jama.2014.5616","article-title":"Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial","volume":"2014","author":"M Pahor","journal-title":"JAMA"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/gerona\/glt064","article-title":"Lifestyle interventions and independence for elders study: recruitment and baseline characteristics","volume":"68","author":"AP Marsh","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJM199503023320902","article-title":"Lower extremity function over the age of 70 years as a predictor of subsequent disability","volume":"332","author":"JM Guralnik","year":"1995","journal-title":"N Engl J Med"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"M221","DOI":"10.1093\/gerona\/55.4.M221","article-title":"Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery","volume":"55","author":"JM Guralnik","year":"2000","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"8","key":"ref27","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"EL Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2147\/CIA.S49737","article-title":"Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention","volume":"8","author":"WJ Rejeski","year":"2013","journal-title":"Clin Interv Aging"},{"key":"ref29","unstructured":"United States. Dept. of Health and Human Services. Physical Activity guidelines Advisory Committee., United States. Dept. of Health and Human Services. Physical Activity Guidelines Advisory Committee report, 2008 to the Secretary of Health and Human Services Washington, DC: U.S. Dept. of Health and Human Services; 2008. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.health.gov\/paguidelines\/committeereport.aspx\" xlink:type=\"simple\">http:\/\/www.health.gov\/paguidelines\/committeereport.aspx<\/ext-link> <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.health.gov\/paguidelines\/Report\/pdf\/CommitteeReport.pdf\" xlink:type=\"simple\">http:\/\/www.health.gov\/paguidelines\/Report\/pdf\/CommitteeReport.pdf<\/ext-link>"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCULATIONAHA.107.185650","article-title":"Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association","volume":"116","author":"ME Nelson","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0749-3797(98)00085-3","article-title":"Physical activity interventions targeting older adults. A critical review and recommendations","volume":"15","author":"AC King","year":"1998","journal-title":"Am J Prev Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality in nursing home admission","volume":"49","author":"JM Guralnik","year":"1994","journal-title":"J Gerontol"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"e0116058","DOI":"10.1371\/journal.pone.0116058","article-title":"Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study","volume":"10","author":"D Bann","year":"2015","journal-title":"PloS one"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1123\/japa.17.1.17","article-title":"Accelerometer assessment of physical activity in active, healthy older adults","volume":"17","author":"JL Copeland","year":"2009","journal-title":"J Aging Phys Act"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.1249\/01.mss.0000185659.11982.3d","article-title":"Calibration of accelerometer output for adults","volume":"37","author":"CE Matthews","year":"2005","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"ref36","article-title":"Analysis and Interpretation of Accelerometry Data in Older Adults: The LIFE Study","author":"WJ Rejeski","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/00005768-200107000-00010","article-title":"CHAMPS physical activity questionnaire for older adults: outcomes for interventions","volume":"33","author":"AL Stewart","year":"2001","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000052765","article-title":"The impact of long-term moderate physical activity on functional performance, bone mineral density and fracture incidence in elderly women","volume":"47","author":"KA Ringsberg","year":"2001","journal-title":"Gerontology"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1532-5415.2004.52154.x","article-title":"The association between physical function and lifestyle activity and exercise in the health, aging and body composition study","volume":"52","author":"JS Brach","year":"2004","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/ageing\/afn148","article-title":"Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study","volume":"37","author":"HJ Martin","year":"2008","journal-title":"Age Ageing"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1532-5415.2010.03008.x","article-title":"Relationship between physical functioning and physical activity in the lifestyle interventions and independence for elders pilot","volume":"58","author":"A Chale-Rush","year":"2010","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1532-5415.2002.50055.x","article-title":"Lower extremity performance is associated with daily life physical activity in individuals with and without peripheral arterial disease","volume":"50","author":"MM McDermott","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1111\/j.1532-5415.2010.03012.x","article-title":"Habitual physical activity levels are associated with performance in measures of physical function and mobility in older men","volume":"58","author":"M Morie","year":"2010","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s12603-015-0640-7","article-title":"Accelerometer Assessment of Physical Activity and Its Association with Physical Function in Older Adults Residing at Assisted Care Facilities","volume":"20","author":"MP Corcoran","year":"2016","journal-title":"J Nutr Health Aging"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7326\/0003-4819-144-1-200601030-00005","article-title":"Physical performance in peripheral arterial disease: a slower rate of decline in patients who walk more","volume":"144","author":"MM McDermott","year":"2006","journal-title":"Ann Intern Med"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/jama.2010.1923","article-title":"Gait speed and survival in older adults","volume":"305","author":"S Studenski","year":"2011","journal-title":"Jama"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s12603-009-0104-z","article-title":"What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study)","volume":"13","author":"S Kwon","year":"2009","journal-title":"J Nutr Health Aging"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","article-title":"Meaningful change and responsiveness in common physical performance measures in older adults","volume":"54","author":"S Perera","year":"2006","journal-title":"J Am Geriatr Soc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:23:29Z","timestamp":1692923009000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182155"}},"subtitle":[],"editor":[{"given":"Nigel Keith","family":"Stepto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,18]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182155","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,18]]}}}