{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:19:29Z","timestamp":1790799569175,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400896"],"award-info":[{"award-number":["81400896"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371216"],"award-info":[{"award-number":["81371216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270028"],"award-info":[{"award-number":["31270028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182471","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T13:32:32Z","timestamp":1502112752000},"page":"e0182471","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-3318","authenticated-orcid":true,"given":"Yujie","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuibing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangchun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1399-6576.2001.045003275.x","article-title":"The assessment of postoperative cognitive function","volume":"45","author":"LS Rasmussen","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/bmb\/ldt006","article-title":"The neuroinflammatory response of postoperative cognitive decline","volume":"106","author":"S Vacas","year":"2013","journal-title":"Br Med Bull"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.anclin.2009.07.011","article-title":"Postoperative cognitive dysfunction in the elderly","volume":"27","author":"R Ramaiah","year":"2009","journal-title":"Anesthesiol Clin"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.anes.0000296071.19434.1e","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery","volume":"108","author":"TG Monk","year":"2008","journal-title":"Anesthesiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/MCC.0b013e328348bece","article-title":"Postoperative cognitive disorders","volume":"17","author":"TG Monk","year":"2011","journal-title":"Curr Opin Crit Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12974-016-0592-9","article-title":"Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis","volume":"13","author":"X Zhang","year":"2016","journal-title":"J Neuroinflammation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.1073\/pnas.1014557107","article-title":"Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline","volume":"107","author":"N Terrando","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"M Cibelli","year":"2010","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cca.2016.02.007","article-title":"Postoperative plasma 8-iso-prostaglandin F2alpha levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery","volume":"455","author":"YB Zheng","year":"2016","journal-title":"Clin Chim Acta"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbi.2015.08.002","article-title":"NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice","volume":"51","author":"LL Qiu","year":"2016","journal-title":"Brain Behav Immun"},{"key":"ref11","first-page":"e106837","article-title":"Aging Differentially Affects the Loss of Neuronal Dendritic Spine, Neuroinflammation and Memory Impairment at Rats after Surgery","volume":"9","author":"Y Le","year":"2014"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"17737","DOI":"10.1523\/JNEUROSCI.2049-13.2013","article-title":"Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice","volume":"33","author":"X Zhang","year":"2013","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/01.anes.0000296071.19434.1e","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery","volume":"108","author":"TG Monk","year":"2008","journal-title":"Anesthesiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0021-7697(08)74310-2","article-title":"Pathophysiology of post-operative cognitive dysfunction: current hypotheses","volume":"145","author":"FZ Laalou","year":"2008","journal-title":"J Chir (Paris)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1038\/srep03766","article-title":"Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice","volume":"4","author":"Z Xu","year":"2014","journal-title":"Sci Rep"},{"key":"ref16","first-page":"e106837","article-title":"Aging Differentially Affects the Loss of Neuronal Dendritic Spine, Neuroinflammation and Memory Impairment at Rats after Surgery","volume":"9","author":"Y Le","year":"2014"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/ALN.0000000000000671","article-title":"Preexisting cognitive impairment is associated with postoperative cognitive dysfunction after hip joint replacement surgery","volume":"122","author":"B Silbert","year":"2015","journal-title":"Anesthesiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00540-012-1548-6","article-title":"Hippocampal volume reduction in elderly patients at risk for postoperative cognitive dysfunction","volume":"27","author":"MH Chen","year":"2013","journal-title":"J Anesth"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/PSY.0b013e3182383a94","article-title":"Preoperative cerebral hypoperfusion in the left, not in the right, hemisphere is associated with cognitive decline after cardiac surgery","volume":"74","author":"BS Messerotti","year":"2012","journal-title":"Psychosom Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1001\/jama.2016.7207","article-title":"Effect of a Primary Care Management Intervention on Mental Health-Related Quality of Life Among Survivors of Sepsis: A Randomized Clinical Trial","volume":"315","author":"K Schmidt","year":"2016","journal-title":"JAMA"},{"key":"ref21","first-page":"1306","article-title":"Mental and physical disability after sepsis","volume":"79","author":"C Jones","year":"2013","journal-title":"Minerva Anestesiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1001\/jama.2016.7211","article-title":"The Challenging Task of Improving the Recovery of ICU Survivors","volume":"315","author":"SL Goddard","year":"2016","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lfs.2015.07.015","article-title":"Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice","volume":"137","author":"YR Liao","year":"2015","journal-title":"Life Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/gerona\/glt136","article-title":"A clinical frailty index in aging mice: comparisons with frailty index data in humans","volume":"69","author":"JC Whitehead","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tins.2010.02.001","article-title":"CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models","volume":"33","author":"E Benito","year":"2010","journal-title":"Trends Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2013.04.033","article-title":"Senescent-induced dysregulation of cAMP\/CREB signaling and correlations with cognitive decline","volume":"1516","author":"RR Hansen","year":"2013","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lfs.2015.07.015","article-title":"Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice","volume":"137","author":"YR Liao","year":"2015","journal-title":"Life Sci"},{"key":"ref28","first-page":"e143863","article-title":"Roemerine Improves the Survival Rate of Septicemic BALB\/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus","volume":"10","author":"S Yin","year":"2015","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/cns.12018","article-title":"Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats","volume":"18","author":"HJ He","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e141596","DOI":"10.1371\/journal.pone.0141596","article-title":"Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering beta-Amyloid Accumulation via the Transforming Growth Factor-beta (TGFbeta)\/Smad Signaling Pathway","volume":"10","author":"A Tian","year":"2015","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/bja\/aeq093","article-title":"Clinically relevant doses of lidocaine and bupivacaine do not impair cutaneous wound healing in mice","volume":"104","author":"A Waite","year":"2010","journal-title":"Br J Anaesth"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/acn3.303","article-title":"alpha5GABAA receptor deficiency causes autism-like behaviors","volume":"3","author":"AA Zurek","year":"2016","journal-title":"Ann Clin Transl Neurol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainres.2012.11.046","article-title":"Increased vulnerability of hippocampal CA1 neurons to hypoperfusion in ataxia and male sterility (AMS) mouse","volume":"1494","author":"X Liang","year":"2013","journal-title":"Brain Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e45250","DOI":"10.1371\/journal.pone.0045250","article-title":"The neuron-astrocyte-microglia triad in normal brain ageing and in a model of neuroinflammation in the rat hippocampus","volume":"7","author":"F Cerbai","year":"2012","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00005-015-0333-2","article-title":"A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-beta1 and Suppresses Ongoing Hepatic Fibrosis","volume":"63","author":"Y Li","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/jcbfm.2015.1","article-title":"Protection of hypoglycemia-induced neuronal death by beta-hydroxybutyrate involves the preservation of energy levels and decreased production of reactive oxygen species","volume":"35","author":"A Julio-Amilpas","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","article-title":"Review: microglia of the aged brain: primed to be activated and resistant to regulation","volume":"39","author":"DM Norden","year":"2013","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1523\/JNEUROSCI.5806-09.2010","article-title":"Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors","volume":"30","author":"G Kochlamazashvili","year":"2010","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuropharm.2008.07.046","article-title":"Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity","volume":"55","author":"K Yashiro","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(97)07382-0","article-title":"Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction","volume":"351","author":"JT Moller","year":"1998","journal-title":"Lancet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"885","DOI":"10.4065\/mcp.2011.0332","article-title":"Perioperative cognitive decline in the aging population","volume":"86","author":"N Terrando","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"ref43","article-title":"Frailty and Subsequent Disability and Mortality Among Patients With Critical Illness","author":"NE Brummel","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/aas.12320","article-title":"Serum high-mobility group box 1 protein correlates with cognitive decline after gastrointestinal surgery","volume":"58","author":"GX Lin","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuropharm.2014.12.020","article-title":"Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1beta, BDNF and synaptic plasticity","volume":"96","author":"SL Patterson","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neulet.2011.04.063","article-title":"Systemic inflammation enhances surgery-induced cognitive dysfunction in mice","volume":"498","author":"AR Fidalgo","year":"2011","journal-title":"Neurosci Lett"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T11:46:46Z","timestamp":1540036006000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182471"}},"subtitle":[],"editor":[{"given":"Zhiyi","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182471","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}