{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:14:26Z","timestamp":1790727266637,"version":"4.1.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research (CA)","award":["82753"],"award-info":[{"award-number":["82753"]}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["213089"],"award-info":[{"award-number":["213089"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de Recherche du Qu\u00e9bec - Nature et Technologies (CA)","award":["140544"],"award-info":[{"award-number":["140544"]}]},{"name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (CA)","award":["EQPEQ\/406373-2011"],"award-info":[{"award-number":["EQPEQ\/406373-2011"]}]},{"name":"Canada Foundation for Innovation (CA)","award":["203653"],"award-info":[{"award-number":["203653"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182519","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T20:31:43Z","timestamp":1502310703000},"page":"e0182519","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of neurons in the primate medial intraparietal area reveals a joint representation of intended reach direction and amplitude"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-1681","authenticated-orcid":true,"given":"Rishi","family":"Rajalingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Musallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Heath M, Neely K, Krigolson O, Binsted G, Elliott D. Memory-guided reaching: what the visuomotor system knows and how long it knows it. Vision and goal-directed movement: neurobahevioral perspectives Human Kinetics, Champaign. 2010:79\u201396.","DOI":"10.5040\/9781492597322.ch-005"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1523\/JNEUROSCI.02-11-01527.1982","article-title":"On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex","volume":"2","author":"AP Georgopoulos","year":"1982","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF00237200","article-title":"Cortical mechanisms related to the direction of two-dimensional arm movements: relations in parietal area 5 and comparison with motor cortex","volume":"51","author":"J Kalaska","year":"1983","journal-title":"Experimental Brain Research"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1523\/JNEUROSCI.08-08-02913.1988","article-title":"Primate motor cortex and free arm movements to visual targets in three-dimensional space. I. Relations between single cell discharge and direction of movement","volume":"8","author":"AB Schwartz","year":"1988","journal-title":"The Journal of Neuroscience"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1523\/JNEUROSCI.11-05-01182.1991","article-title":"Making arm movements within different parts of space: the premotor and motor cortical representation of a coordinate system for reaching to visual targets","volume":"11","author":"R Caminiti","year":"1991","journal-title":"J Neurosci"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nn726","article-title":"Direction of action is represented in the ventral premotor cortex","volume":"4","author":"S Kakei","year":"2001","journal-title":"Nature neuroscience"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1152\/jn.01050.2009","article-title":"Neural representation during visually guided reaching in macaque posterior parietal cortex","volume":"104","author":"B Heider","year":"2010","journal-title":"Journal of neurophysiology"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.neuron.2012.03.041","article-title":"Coding of the reach vector in parietal area 5d","volume":"75","author":"LR Bremner","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/jn.00443.2001","article-title":"Simultaneous encoding of multiple potential reach directions in dorsal premotor cortex","volume":"87","author":"P Cisek","year":"2002","journal-title":"Journal of Neurophysiology"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1460-9568.2005.04288.x","article-title":"Spatial tuning of reaching activity in the medial parieto-occipital cortex (area V6A) of macaque monkey","volume":"22","author":"P Fattori","year":"2005","journal-title":"European Journal of Neuroscience"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1152\/jn.90359.2008","article-title":"Parietal reach region encodes reach depth using retinal disparity and vergence angle signals","volume":"102","author":"R Bhattacharyya","year":"2009","journal-title":"Journal of neurophysiology"},{"issue":"37","key":"ref12","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1523\/JNEUROSCI.1305-09.2009","article-title":"Reaching in depth: hand position dominates over binocular eye position in the rostral superior parietal lobule","volume":"29","author":"S Ferraina","year":"2009","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/cercor\/bht021","article-title":"Common neural substrate for processing depth and direction signals for reaching in the monkey medial posterior parietal cortex","volume":"24","author":"K Hadjidimitrakis","year":"2014","journal-title":"Cerebral Cortex"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1152\/jn.00486.2015","article-title":"Overlapping representations for reach depth and direction in caudal superior parietal lobule of macaques","volume":"114","author":"K Hadjidimitrakis","year":"2015","journal-title":"Journal of neurophysiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"bhw039","DOI":"10.1093\/cercor\/bhw039","article-title":"Mixed body\/hand reference frame for reaching in 3D space in macaque parietal area PEc","author":"V Piserchia","year":"2016","journal-title":"Cerebral Cortex"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1523\/JNEUROSCI.08-08-02928.1988","article-title":"Primate motor cortex and free arm movements to visual targets in three-dimensional space. II. Coding of the direction of movement by a neuronal population","volume":"8","author":"AP Georgopoulos","year":"1988","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/jn.1989.61.3.534","article-title":"Monkey primary motor and premotor cortex: single-cell activity related to prior information about direction and extent of an intended movement","volume":"61","author":"A Riehle","year":"1989","journal-title":"Journal of Neurophysiology"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1152\/jn.1993.70.5.2097","article-title":"Neuronal specification of direction and distance during reaching movements in the superior precentral premotor area and primary motor cortex of monkeys","volume":"70","author":"Q Fu","year":"1993","journal-title":"Journal of Neurophysiology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/jn.1995.73.2.836","article-title":"Temporal encoding of movement kinematics in the discharge of primate primary motor and premotor neurons","volume":"73","author":"Q Fu","year":"1995","journal-title":"Journal of Neurophysiology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1152\/jn.2000.84.1.152","article-title":"Covariation of primate dorsal premotor cell activity with direction and amplitude during a memorized-delay reaching task","volume":"84","author":"J Messier","year":"2000","journal-title":"Journal of Neurophysiology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/jn.1993.69.1.187","article-title":"Premotor cortex of monkeys: set-and movement-related activity reflecting amplitude and direction of wrist movements","volume":"69","author":"K Kurata","year":"1993","journal-title":"Journal of Neurophysiology"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1152\/jn.00435.2011","article-title":"Distributed sensitivity for movement amplitude in directionally tuned neuronal populations","volume":"107","author":"S Fabbri","year":"2012","journal-title":"Journal of neurophysiology"},{"issue":"6621","key":"ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/386167a0","article-title":"Coding of intention in the posterior parietal cortex","volume":"386","author":"L Snyder","year":"1997","journal-title":"Nature"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00236024","article-title":"Posterior parietal projections to the intraparietal sulcus of the rhesus monkey","volume":"62","author":"B Seltzer","year":"1986","journal-title":"Experimental Brain Research"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1046\/j.1460-9568.1998.00327.x","article-title":"A visuo-somatomotor pathway through superior parietal cortex in the macaque monkey: cortical connections of areas V6 and V6A","volume":"10","author":"S Shipp","year":"1998","journal-title":"European Journal of Neuroscience"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1046\/j.1460-9568.1999.00801.x","article-title":"Early coding of reaching: frontal and parietal association connections of parieto-occipital cortex","volume":"11","author":"R Caminiti","year":"1999","journal-title":"European Journal of Neuroscience"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/1096-9861(20001204)428:1<112::AID-CNE8>3.0.CO;2-9","article-title":"Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey","volume":"428","author":"JW Lewis","year":"2000","journal-title":"Journal of Comparative Neurology"},{"issue":"33","key":"ref28","doi-asserted-by":"crossref","first-page":"11719","DOI":"10.1523\/JNEUROSCI.1068-15.2015","article-title":"Inactivation of Parietal Reach Region Affects Reaching But Not Saccade Choices in Internally Guided Decisions","volume":"35","author":"VN Christopoulos","year":"2015","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1152\/jn.00533.2012","article-title":"Modulation of neural activity by reward in medial intraparietal cortex is sensitive to temporal sequence of reward","volume":"112","author":"R Rajalingham","year":"2014","journal-title":"Journal of neurophysiology"},{"key":"ref30","article-title":"Springer series in statistics","author":"J Friedman","year":"2001"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1523\/JNEUROSCI.4028-11.2012","article-title":"Eye position encoding in three-dimensional space: Integration of version and vergence signals in the medial posterior parietal cortex","volume":"32","author":"R Breveglieri","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/PL00005716","article-title":"Differential effect of task conditions on errors of direction and extent of reaching movements","volume":"115","author":"J Messier","year":"1997","journal-title":"Experimental Brain Research"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002210050669","article-title":"Comparison of variability of initial kinematics and endpoints of reaching movements","volume":"125","author":"J Messier","year":"1999","journal-title":"Experimental Brain Research"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/jn.1997.77.3.1195","article-title":"Preferential representation of instructed target location versus limb trajectory in dorsal premotor area","volume":"77","author":"L Shen","year":"1997","journal-title":"Journal of Neurophysiology"},{"key":"ref35","first-page":"bhr257","article-title":"Topographic maps within Brodmann&apos;s area 5 of macaque monkeys","author":"AM Seelke","year":"2011","journal-title":"Cerebral Cortex"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/1096-9861(20001204)428:1<79::AID-CNE7>3.0.CO;2-Q","article-title":"Mapping of architectonic subdivisions in the macaque monkey, with emphasis on parieto-occipital cortex","volume":"428","author":"JW Lewis","year":"2000","journal-title":"Journal of Comparative Neurology"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.humov.2004.10.011","article-title":"Background visual cues and memory-guided reaching","volume":"23","author":"O Krigolson","year":"2004","journal-title":"Human movement science"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/00222890309602128","article-title":"No evidence for accurate visuomotor memory: Systematic and variable error in memory-guided reaching","volume":"35","author":"DA Westwood","year":"2003","journal-title":"Journal of motor behavior"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00221-006-0613-5","article-title":"The effect of target modality on visual and proprioceptive contributions to the control of movement distance","volume":"176","author":"FR Sarlegna","year":"2007","journal-title":"Experimental Brain Research"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/7.5.6","article-title":"The role of memory in visually guided reaching","volume":"7","author":"A-M Brouwer","year":"2007","journal-title":"Journal of Vision"},{"issue":"5425","key":"ref41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1126\/science.285.5425.257","article-title":"Reach plans in eye-centered coordinates","volume":"285","author":"AP Batista","year":"1999","journal-title":"Science"},{"issue":"6881","key":"ref42","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/416632a","article-title":"Direct visuomotor transformations for reaching","volume":"416","author":"CA Buneo","year":"2002","journal-title":"Nature"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuron.2007.09.031","article-title":"Posterior parietal cortex encodes autonomously selected motor plans","volume":"56","author":"H Cui","year":"2007","journal-title":"Neuron"},{"issue":"37","key":"ref44","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1523\/JNEUROSCI.1570-06.2006","article-title":"Neural dynamics in monkey parietal reach region reflect context-specific sensorimotor transformations","volume":"26","author":"A Gail","year":"2006","journal-title":"The Journal of neuroscience"},{"issue":"4724","key":"ref45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.4048942","article-title":"Encoding of spatial location by posterior parietal neurons","volume":"230","author":"RA Andersen","year":"1985","journal-title":"Science"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cne.902990404","article-title":"Visual receptive field organization and cortico-cortical connections of the lateral intraparietal area (area LIP) in the macaque","volume":"299","author":"GJ Blatt","year":"1990","journal-title":"Journal of Comparative Neurology"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s002210100785","article-title":"Representation of the visual field in the lateral intraparietal area of macaque monkeys: a quantitative receptive field analysis","volume":"140","author":"SB Hamed","year":"2001","journal-title":"Experimental Brain Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T17:13:53Z","timestamp":1602695633000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182519"}},"subtitle":[],"editor":[{"given":"Markus","family":"Lappe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182519","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]}}}