{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:23:13Z","timestamp":1788571393291,"version":"build-2803163510"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK081367"],"award-info":[{"award-number":["DK081367"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182534","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T18:06:44Z","timestamp":1502993204000},"page":"e0182534","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate"],"prefix":"10.1371","volume":"12","author":[{"given":"Wenxi","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhara","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Rao","family":"Maddipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-5426","authenticated-orcid":true,"given":"Miriam L.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/BST20150215","article-title":"Phosphate, inositol and polyphosphates","volume":"44","author":"TM Livermore","year":"2016","journal-title":"Biochemical Society transactions"},{"issue":"Pt 17","key":"ref2","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1113\/jphysiol.2010.192153","article-title":"Phosphoinositides: lipid regulators of membrane proteins","volume":"588","author":"BH Falkenburger","year":"2010","journal-title":"J Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/0-387-27600-9_11","article-title":"Inositol phosphates and phosphoinositides in health and disease","volume":"39","author":"Y Shi","year":"2006","journal-title":"Sub-cellular biochemistry"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BJ20140361","article-title":"Inositol lipid phosphatases in membrane trafficking and human disease","volume":"461","author":"PG Billcliff","year":"2014","journal-title":"The Biochemical journal"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/bj2060587","article-title":"Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands","volume":"206","author":"MJ Berridge","year":"1982","journal-title":"The Biochemical journal"},{"issue":"6239","key":"ref6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/341197a0","article-title":"Inositol phosphates and cell signalling","volume":"341","author":"MJ Berridge","year":"1989","journal-title":"Nature"},{"issue":"18","key":"ref7","doi-asserted-by":"crossref","first-page":"15466","DOI":"10.1074\/jbc.M004179200","article-title":"Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis","volume":"276","author":"DL Vaden","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.biopsych.2004.08.027","article-title":"Valproate decreases inositol biosynthesis","volume":"56","author":"G Shaltiel","year":"2004","journal-title":"Biological psychiatry"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1128\/MCB.6.10.3320","article-title":"Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis","volume":"6","author":"JP Hirsch","year":"1986","journal-title":"Mol Cell Biol"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/nar\/19.7.1687","article-title":"Analysis of sequences in the INO1 promoter that are involved in its regulation by phospholipid precursors","volume":"19","author":"JM Lopes","year":"1991","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1365-2958.1997.4881840.x","article-title":"Regulation of inositol monophosphatase in Saccharomyces cerevisiae","volume":"25","author":"M Murray","year":"1997","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1046\/j.1365-2958.1999.01267.x","article-title":"The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair","volume":"31","author":"F Lopez","year":"1999","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1534\/genetics.111.130286","article-title":"Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae","volume":"190","author":"SA Henry","year":"2012","journal-title":"Genetics"},{"issue":"34","key":"ref14","doi-asserted-by":"crossref","first-page":"24898","DOI":"10.1074\/jbc.M113.493353","article-title":"Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae","volume":"288","author":"C Ye","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"20","key":"ref15","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1074\/jbc.M116.714816","article-title":"Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells","volume":"291","author":"W Yu","year":"2016","journal-title":"The Journal of biological chemistry"},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-013-1597-7","article-title":"Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein","volume":"378","author":"RN Parthasarathy","year":"2013","journal-title":"Molecular and cellular biochemistry"},{"issue":"37","key":"ref17","doi-asserted-by":"crossref","first-page":"26822","DOI":"10.1074\/jbc.M113.479121","article-title":"Phosphorylation regulates myo-inositol-3- phosphate synthase: a novel regulatory mechanism of inositol biosynthesis","volume":"288","author":"RM Deranieh","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"21","key":"ref18","doi-asserted-by":"crossref","first-page":"21759","DOI":"10.1074\/jbc.M312078200","article-title":"Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast","volume":"279","author":"S Ju","year":"2004","journal-title":"The Journal of biological chemistry"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"PS Klein","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/dbio.1997.8552","article-title":"Activation of the Wnt signaling pathway: a molecular mechanism for lithium action","volume":"185","author":"CM Hedgepeth","year":"1997","journal-title":"Developmental biology"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells","volume":"6","author":"V Stambolic","year":"1996","journal-title":"Current biology: CB"},{"issue":"40","key":"ref22","doi-asserted-by":"crossref","first-page":"25326","DOI":"10.1074\/jbc.272.40.25326","article-title":"Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3","volume":"272","author":"M Hong","year":"1997","journal-title":"The Journal of biological chemistry"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1046\/j.1471-4159.1999.02073.x","article-title":"Lithium inhibits neurite growth and tau protein kinase I\/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons","volume":"73","author":"M Takahashi","year":"1999","journal-title":"Journal of neurochemistry"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1006\/bbrc.2000.4169","article-title":"Lithium inhibits glycogen synthase kinase-3 by competition for magnesium","volume":"280","author":"WJ Ryves","year":"2001","journal-title":"Biochemical and biophysical research communications"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.2000.0721327.x","article-title":"The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3","volume":"72","author":"G Chen","year":"1999","journal-title":"Journal of neurochemistry"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/mcne.2002.1117","article-title":"Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons","volume":"20","author":"AC Hall","year":"2002","journal-title":"Molecular and cellular neurosciences"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1046\/j.1471-4159.2001.00495.x","article-title":"CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium","volume":"78","author":"CA Grimes","year":"2001","journal-title":"Journal of neurochemistry"},{"issue":"Pt 1","key":"ref28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1242\/jcs.01562","article-title":"Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3","volume":"118","author":"AJ Kim","year":"2005","journal-title":"Journal of cell science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2012.00001","article-title":"GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder","volume":"5","author":"AJ Valvezan","year":"2012","journal-title":"Frontiers in molecular neuroscience"},{"issue":"Pt 7","key":"ref30","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.00384","article-title":"GSK-3: tricks of the trade for a multi-tasking kinase","volume":"116","author":"BW Doble","year":"2003","journal-title":"Journal of cell science"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tibs.2003.12.004","article-title":"The glamour and gloom of glycogen synthase kinase-3","volume":"29","author":"RS Jope","year":"2004","journal-title":"Trends in biochemical sciences"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1471-4159.2002.00918.x","article-title":"Alternative splicing isoform of tau protein kinase I\/glycogen synthase kinase 3beta","volume":"81","author":"F Mukai","year":"2002","journal-title":"Journal of neurochemistry"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/j.1460-2075.1990.tb07419.x","article-title":"Molecular cloning and expression of glycogen synthase kinase-3\/factor A","volume":"9","author":"JR Woodgett","year":"1990","journal-title":"The EMBO journal"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.2174\/1389450110607011421","article-title":"Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions","volume":"7","author":"RS Jope","year":"2006","journal-title":"Current drug targets"},{"issue":"4","key":"ref35","first-page":"433","article-title":"Mechanisms of action of the mood stabilizer valproate: a focus on GSK-3 inhibition","volume":"3","author":"AN Azab","year":"2008","journal-title":"Future medicine"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.biopsych.2004.01.008","article-title":"Rapid antidepressive- like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus","volume":"55","author":"O Kaidanovich-Beilin","year":"2004","journal-title":"Biological psychiatry"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1017\/S1461145704004535","article-title":"AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test","volume":"7","author":"TD Gould","year":"2004","journal-title":"The international journal of neuropsychopharmacology \/ official scientific journal of the Collegium Internationale Neuropsychopharmacologicum"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.mcn.2006.12.006","article-title":"Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury","volume":"34","author":"M Shapira","year":"2007","journal-title":"Molecular and cellular neurosciences"},{"issue":"14","key":"ref39","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.0307921101","article-title":"Lithium antagonizes dopamine-dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade","volume":"101","author":"JM Beaulieu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2217\/fnl-2016-0003","article-title":"Inositol depletion, GSK3 inhibition and bipolar disorder","volume":"11","author":"W Yu","year":"2016","journal-title":"Future Neurology"},{"issue":"18","key":"ref41","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1128\/MCB.20.18.6712-6720.2000","article-title":"Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5","volume":"20","author":"T Andoh","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref42","first-page":"113","article-title":"Methods in Inositide Research","author":"J Maslanski","year":"1990"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1046\/j.1365-2958.2003.03641.x","article-title":"Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis","volume":"49","author":"S Ju","year":"2003","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj1190183","article-title":"A colorimetric determination of inositol monophosphates as an assay for D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase","volume":"119","author":"JE Barnett","year":"1970","journal-title":"The Biochemical journal"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1365-2958.2007.05591.x","article-title":"Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol","volume":"63","author":"AN Azab","year":"2007","journal-title":"Molecular microbiology"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00018-002-8465-z","article-title":"Phosphoinositides and signal transduction","volume":"59","author":"A Toker","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0955-0674(00)00240-4","article-title":"The role of phosphoinositides in membrane transport","volume":"13","author":"A Simonsen","year":"2001","journal-title":"Curr Opin Cell Biol"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"9106","DOI":"10.1074\/jbc.M411770200","article-title":"Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast","volume":"280","author":"SA Jesch","year":"2005","journal-title":"The Journal of biological chemistry"},{"issue":"Pt 5","key":"ref49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1042\/BST0371099","article-title":"Cellular consequences of inositol depletion","volume":"37","author":"RM Deranieh","year":"2009","journal-title":"Biochemical Society transactions"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:04:12Z","timestamp":1719396252000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182534"}},"subtitle":[],"editor":[{"given":"Howard","family":"Riezman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182534","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}