{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:11:26Z","timestamp":1772201486620,"version":"3.50.1"},"reference-count":134,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100702"],"award-info":[{"award-number":["81100702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Family Planning Foundation of Jilin Province","award":["20152046"],"award-info":[{"award-number":["20152046"]}]},{"name":"Science and technology Development plan Foundation of Jilin Province","award":["20160101070JC"],"award-info":[{"award-number":["20160101070JC"]}]},{"name":"Science and technology Development plan Foundation of Jilin Province","award":["20150204084SF"],"award-info":[{"award-number":["20150204084SF"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182592","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T13:26:26Z","timestamp":1502112386000},"page":"e0182592","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meni\u00e8re's disease"],"prefix":"10.1371","volume":"12","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YanShu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-8910","authenticated-orcid":true,"given":"Lifeng","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiangYin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"issue":"3","key":"ref1","first-page":"245","article-title":"Improvement in symptoms and cochlear flow with Pycnogenol (R) in patients with Meniere's disease and tinnitus","volume":"105","author":"R Luzzi","year":"2014","journal-title":"Minerva Med"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1097\/MAO.0000000000000202","article-title":"Cochlear Implantation in Patients With Advanced Meniere's Disease","volume":"35","author":"P Mick","year":"2014","journal-title":"Otol Neurotol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"457318","DOI":"10.1155\/2015\/457318","article-title":"Simultaneous Labyrinthectomy and Cochlear Implantation for Patients with Single-Sided Meniere's Disease and Profound Sensorineural Hearing Loss","volume":"2015","author":"G Doobe","year":"2015","journal-title":"Biomed Research International"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/14992020802716778","article-title":"Short-term hearing fluctuation in Meniere's disease","volume":"48","author":"C McNeill","year":"2009","journal-title":"International Journal Of Audiology"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.otohns.2009.12.009","article-title":"Intratympanic gentamicin treatment of patients with Meniere's disease with normal hearing","volume":"142","author":"H Silverstein","year":"2010","journal-title":"Otolaryngology-Head And Neck Surgery"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/VES-2005-15106","article-title":"Vestibular function at the end of intratympanic gentamicin treatment of patients with Meniere's disease","volume":"15","author":"N Perez","year":"2005","journal-title":"J Vestibul Res-Equil"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/MAO.0000000000001206","article-title":"Electrocochleography for the Diagnosis of Meniere's Disease: The Wrong Stimulus","volume":"37","author":"J Hornibrook","year":"2016","journal-title":"Otol Neurotol"},{"key":"ref8","article-title":"Evaluation of vestibular evoked myogenic potentials (VEMP) and electrocochleography for the diagnosis of Meniere's disease","author":"P Lamounier","year":"2016","journal-title":"Brazilian journal of otorhinolaryngology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000375393","article-title":"Meniere's Disease Treatment: A Patient-Centered Systematic Review","volume":"20","author":"M Tassinari","year":"2015","journal-title":"Audiol Neuro-Otol"},{"issue":"5","key":"ref10","first-page":"492","article-title":"Novel techniques for the diagnosis of Meniere's disease","volume":"21","author":"CH Le","year":"2013","journal-title":"Curr Opin Otolaryngo"},{"issue":"3","key":"ref11","first-page":"264","article-title":"Intratympanic gentamicin treatment: preliminary results in two patients with Meniere's disease","volume":"6","author":"MB Trine","year":"1995","journal-title":"Journal of the American Academy of Audiology"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.anl.2016.01.006","article-title":"The change of hippocampal volume and its relevance with inner ear function in Meniere's disease patients","volume":"43","author":"YJ Seo","year":"2016","journal-title":"Auris, nasus, larynx"},{"issue":"Suppl 12","key":"ref13","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/lary.25579","article-title":"Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease","volume":"125","author":"M Hoa","year":"2015","journal-title":"The Laryngoscope"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1097\/AUD.0000000000000041","article-title":"Prevalence, associated factors, and comorbid conditions for Meniere's disease","volume":"35","author":"JS Tyrrell","year":"2014","journal-title":"Ear and hearing"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5152\/iao.2016.2177","article-title":"Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere's Disease Patients","volume":"12","author":"N Atrache Al Attrache","year":"2016","journal-title":"The journal of international advanced otology"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1001\/jamaoto.2014.1249","article-title":"Comparison of second-echelon treatments for Meniere's disease","volume":"140","author":"GJ Basura","year":"2014","journal-title":"JAMA otolaryngology\u2014head & neck surgery"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/14992020802716778","article-title":"Short-term hearing fluctuation in Meniere's disease","volume":"48","author":"C McNeill","year":"2009","journal-title":"Int J Audiol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.anl.2015.10.007","article-title":"Surgical results and psychological status in patients with intractable Meniere's disease","volume":"43","author":"Y Yokota","year":"2016","journal-title":"Auris, nasus, larynx"},{"issue":"Suppl 1","key":"ref19","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meniere's disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"R Gurkov","year":"2016","journal-title":"Journal of neurology"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/lary.25207","article-title":"Genetic aspects and clinical characteristics of familial Meniere's disease in a South Korean population","volume":"125","author":"JM Lee","year":"2015","journal-title":"The Laryngoscope"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1089\/dna.2012.1631","article-title":"Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population","volume":"31","author":"M Teranishi","year":"2012","journal-title":"DNA Cell Biol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00251-013-0683-z","article-title":"Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease","volume":"65","author":"T Requena","year":"2013","journal-title":"Immunogenetics"},{"issue":"5\u20136","key":"ref23","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.06.004","article-title":"Water channel proteins in the inner ear and their link to hearing impairment and deafness","volume":"33","author":"A Eckhard","year":"2012","journal-title":"Molecular Aspects Of Medicine"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"e112171","DOI":"10.1371\/journal.pone.0112171","article-title":"Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease","volume":"9","author":"S Cabrera","year":"2014","journal-title":"Plos One"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00441-012-1481-x","article-title":"Cochlin expression in vestibular endorgans obtained from patients with Meniere's disease","volume":"350","author":"AP Calzada","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/01.mao.0000226315.27811.c8","article-title":"Familial Meniere's disease in five generations","volume":"27","author":"C Frykholm","year":"2006","journal-title":"Otol Neurotol"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00405-012-2268-0","article-title":"Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Meniere's disease","volume":"270","author":"I Gazquez","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"4","key":"ref28","first-page":"351","article-title":"Development of a Statistical Model for the Prediction of Common Vestibular Diagnoses","volume":"142","author":"DR Friedland","year":"2016","journal-title":"Jama Otolaryngol"},{"issue":"Suppl 4","key":"ref29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12918-016-0353-5","article-title":"Pretata: predicting TATA binding proteins with novel features and dimensionality reduction strategy","volume":"10","author":"Q Zou","year":"2016","journal-title":"BMC Syst Biol"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00438-016-1240-x","article-title":"Identification of compound-protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds","volume":"291","author":"L Chen","year":"2016","journal-title":"Molecular genetics and genomics: MGG"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.artmed.2017.02.001","article-title":"Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways","volume":"76","author":"L Chen","year":"2017","journal-title":"Artificial Intelligence in Medicine"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"AL Barabasi","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref33","article-title":"Inferring microRNA-disease associations by random walk on a heterogeneous network with multiple data sources","author":"Y Liu","year":"2016","journal-title":"IEEE\/ACM Transactions on Computational Biology and Bioinformatics"},{"issue":"1","key":"ref34","first-page":"55","article-title":"Similarity computation strategies in the microRNA-disease network: a survey","volume":"15","author":"Q Zou","year":"2016","journal-title":"Briefings in Functional Genomics"},{"key":"ref35","article-title":"Prediction and validation of disease genes using HeteSim Scores","author":"X Zeng","year":"2016","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"ref36","first-page":"10","article-title":"Approaches for Recognizing Disease Genes Based on Network","volume":"2014","author":"Q Zou","year":"2014","journal-title":"BioMed Research International"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"33870","DOI":"10.1038\/srep33870","article-title":"Complex Network Clustering by a Multi-objective Evolutionary Algorithm Based on Decomposition and Membrane Structure","volume":"6","author":"Y Ju","year":"2016","journal-title":"Sci Rep"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/jmg.2006.041376","article-title":"Predicting disease genes using protein-protein interactions","volume":"43","author":"M Oti","year":"2006","journal-title":"Journal of medical genetics"},{"issue":"42","key":"ref39","doi-asserted-by":"crossref","first-page":"15148","DOI":"10.1073\/pnas.0404315101","article-title":"Molecular triangulation: Bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease","volume":"101","author":"M Krauthammer","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/504300","article-title":"Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes","volume":"78","author":"L Franke","year":"2006","journal-title":"American journal of human genetics"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajhg.2008.02.013","article-title":"Walking the interactome for prioritization of candidate disease genes","volume":"82","author":"S Kohler","year":"2008","journal-title":"The Amerian Journal of Human Genetics"},{"issue":"Suppl 2","key":"ref42","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1752-0509-5-S2-S2","article-title":"Constructing a gene semantic similarity network for the inference of disease genes","volume":"5","author":"R Jiang","year":"2011","journal-title":"BMC Systems Biology"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"e0175185","DOI":"10.1371\/journal.pone.0175185","article-title":"An integrated method for the identification of novel genes related to oral cancer","volume":"12","author":"L Chen","year":"2017","journal-title":"PLoS ONE"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1574893611666151119220024","article-title":"Application of the Shortest Path Algorithm for the Discovery of Breast Cancer-Related Genes","volume":"11","author":"L Chen","year":"2016","journal-title":"Current Bioinformatics"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/cmb.2014.0122","article-title":"Identification of Hepatocellular Carcinoma\u2014Related Genes with a Machine Learning and Network Analysis","volume":"22","author":"T Gui","year":"2015","journal-title":"Journal of Computational Biology"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/07391102.2015.1042915","article-title":"Mining for novel tumor suppressor genes using a shortest path approach","volume":"34","author":"L Chen","year":"2016","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neucom.2015.09.136","article-title":"Identification of novel proliferative diabetic retinopathy related genes on protein\u2014protein interaction network","volume":"217","author":"J Zhang","year":"2016","journal-title":"Neurocomputing"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1016\/j.bbagen.2016.05.018","article-title":"Investigation of the roles of trace elements during hepatitis C virus infection using protein-protein interactions and a shortest path algorithm","volume":"1860","author":"LC Zhu","year":"2016","journal-title":"Bba-Gen Subjects"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/acs.jproteome.6b00950","article-title":"Identification of genes associated with breast cancer metastasis to bone on a protein-protein interaction network with a shortest path algorithm","volume":"16","author":"Y-D Cai","year":"2017","journal-title":"J Proteome Res"},{"issue":"7","key":"ref50","doi-asserted-by":"crossref","first-page":"e0159519","DOI":"10.1371\/journal.pone.0159519","article-title":"A Shortest-Path-Based Method for the Analysis and Prediction of Fruit-Related Genes in Arabidopsis thaliana","volume":"11","author":"L Zhu","year":"2016","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"29849","DOI":"10.1038\/srep29849","article-title":"Identification of novel candidate drivers connecting different dysfunctional levels for lung adenocarcinoma using protein-protein interactions and a shortest path approach","volume":"6","author":"L Chen","year":"2016","journal-title":"Scientific Reports"},{"issue":"Database issue","key":"ref52","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gks1094","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"A Franceschini","year":"2013","journal-title":"Nucleic Acids Research"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1056\/NEJM199801223380407","article-title":"Respiratory function of hemoglobin","volume":"338","author":"CC Hsia","year":"1998","journal-title":"N Engl J Med"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.compbiomed.2010.01.001","article-title":"Prediction of protein functions based on function-function correlation relations","volume":"40","author":"KL Ng","year":"2010","journal-title":"Comput Biol Med"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"e45944","DOI":"10.1371\/journal.pone.0045944","article-title":"Predicting Metabolic Pathways of Small Molecules and Enzymes Based on Interaction Information of Chemicals and Proteins","volume":"7","author":"YF Gao","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"e17668","DOI":"10.1371\/journal.pone.0017668","article-title":"Predicting protein phenotypes based on protein-protein interaction network","volume":"6","author":"L Hu","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2174\/092986612802084528","article-title":"Prediction of Human Genes Regulatory Functions Based on Proteinprotein Interaction Network","volume":"19","author":"P Gao","year":"2012","journal-title":"Protein and Peptide Letters"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"e14556","DOI":"10.1371\/journal.pone.0014556","article-title":"Predicting functions of proteins in mouse based on weighted protein-protein interaction network and protein hybrid properties","volume":"6","author":"L Hu","year":"2011","journal-title":"PLoS One"},{"key":"ref59","first-page":"4895476","article-title":"The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases","volume":"2016","author":"Q Zhang","year":"2016","journal-title":"Biomed Research International"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"e0166580","DOI":"10.1371\/journal.pone.0166580","article-title":"Exploring Mouse Protein Function via Multiple Approaches","volume":"11","author":"G Huang","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/cmb.2014.0122","article-title":"Identification of hepatocellular carcinoma-related genes with a machine learning and network analysis","volume":"22","author":"T Gui","year":"2015","journal-title":"Journal of computational biology: a journal of computational molecular cell biology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"25515","DOI":"10.1038\/srep25515","article-title":"Identifying novel genes and chemicals related to nasopharyngeal cancer in a heterogeneous network","volume":"6","author":"Z Li","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1574893611666151119220024","article-title":"Application of the shortest path algorithm for the discovery of breast cancer related genes","volume":"11","author":"L Chen","year":"2016","journal-title":"Current Bioinformatics"},{"issue":"11 Pt B","key":"ref64","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/j.bbagen.2016.04.010","article-title":"A network-based method for the identification of putative genes related to infertility","volume":"1860","author":"S Wang","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2174\/0929866523666161021165506","article-title":"OPMSP: A computational method integrating protein interaction and sequence information for the identification of novel putative oncogenes","volume":"23","author":"L Chen","year":"2016","journal-title":"Protein Pept Lett"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00438-015-1157-9","article-title":"Identifying novel protein phenotype annotations by hybridizing protein-protein interactions and protein sequence similarities","volume":"291","author":"L Chen","year":"2016","journal-title":"Molecular Genetics and Genomics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"623121","DOI":"10.1155\/2015\/623121","article-title":"Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach","volume":"2015","author":"F Yuan","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"715639","DOI":"10.1155\/2015\/715639","article-title":"Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network","volume":"2015","author":"B Wang","year":"2015","journal-title":"Comput Math Methods Med"},{"issue":"Database issue","key":"ref69","first-page":"D1049","article-title":"Gene Ontology Consortium: going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"M Kanehisa","year":"2000","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"ref71","doi-asserted-by":"crossref","first-page":"e107202","DOI":"10.1371\/journal.pone.0107202","article-title":"Analysis of tumor suppressor genes based on gene ontology and the KEGG pathway","volume":"9","author":"J Yang","year":"2014","journal-title":"PLoS One"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"450386","DOI":"10.1155\/2014\/450386","article-title":"Gene ontology and KEGG enrichment analyses of genes related to age-related macular degeneration","volume":"2014","author":"J Zhang","year":"2014","journal-title":"Biomed Res Int"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1002\/eji.201445378","article-title":"Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate","volume":"45","author":"YX Zhao","year":"2015","journal-title":"European Journal Of Immunology"},{"issue":"8","key":"ref74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1080\/0036554021000028069","article-title":"Increased CD4+ T cells during acute attack of Meniere's disease","volume":"122","author":"B Mamikoglu","year":"2002","journal-title":"Acta oto-laryngologica"},{"issue":"3","key":"ref75","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.otc.2011.03.004","article-title":"Allergic and Immunologic Features of Meniere's Disease","volume":"44","author":"MJ Derebery","year":"2011","journal-title":"Otolaryngologic clinics of North America"},{"issue":"5","key":"ref76","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.otc.2010.05.004","article-title":"Allergy and Its Relation to Meniere's Disease","volume":"43","author":"MJ Derebery","year":"2010","journal-title":"Otolaryngologic clinics of North America"},{"issue":"9","key":"ref77","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1258\/0022215042244822","article-title":"Meniere's disease and allergy: allergens and cytokines","volume":"118","author":"E Keles","year":"2004","journal-title":"Journal Of Laryngology And Otology"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/mnfr.201400761","article-title":"Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation","volume":"59","author":"CP Wong","year":"2015","journal-title":"Molecular Nutrition & Food Research"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0609.2011.01631.x","article-title":"Erythropoietin, GDF15, IL6, hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown cause","volume":"87","author":"J Waalen","year":"2011","journal-title":"Eur J Haematol"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.exphem.2007.09.006","article-title":"Long-term platelet production assessed in NOD\/SCID mice injected with cord blood CD34(+) cells, thrombopoietin-amplified in clinical grade serum-free culture","volume":"36","author":"G Mattia","year":"2008","journal-title":"Experimental hematology"},{"issue":"7","key":"ref81","doi-asserted-by":"crossref","first-page":"e102450","DOI":"10.1371\/journal.pone.0102450","article-title":"Porphyromonas gingivalis GroEL Induces Osteoclastogenesis of Periodontal Ligament Cells and Enhances Alveolar Bone Resorption in Rats","volume":"9","author":"FY Lin","year":"2014","journal-title":"Plos One"},{"issue":"8","key":"ref82","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrd3800","article-title":"Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases","volume":"11","author":"CA Dinarello","year":"2012","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"ref83","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/jcmm.12898","article-title":"Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1beta\/IL-1R1\/MyD88\/NF-kappaB pathway","volume":"20","author":"C Song","year":"2016","journal-title":"J Cell Mol Med"},{"issue":"5","key":"ref84","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1158\/1940-6207.CAPR-15-0347","article-title":"Inflammation-Related IL1beta\/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma","volume":"9","author":"Y Kadariya","year":"2016","journal-title":"Cancer Prev Res (Phila)"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1684\/ecn.2011.0293","article-title":"Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis","volume":"22","author":"M Mahmoudi","year":"2011","journal-title":"Eur Cytokine Netw"},{"issue":"3","key":"ref86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1744-313X.2011.01004.x","article-title":"Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease","volume":"38","author":"T Furuta","year":"2011","journal-title":"International journal of immunogenetics"},{"issue":"1\u20134","key":"ref87","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000235340","article-title":"Regulation of immune responses by T cells with different cytokine secretion phenotypes: role of a new cytokine, cytokine synthesis inhibitory factor (IL10)","volume":"94","author":"TR Mosmann","year":"1991","journal-title":"International archives of allergy and applied immunology"},{"issue":"7","key":"ref88","doi-asserted-by":"crossref","first-page":"e100970","DOI":"10.1371\/journal.pone.0100970","article-title":"Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells","volume":"9","author":"P Sakthivel","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/gt.2011.88","article-title":"Experimental autoimmune hearing loss is exacerbated in IL-10-deficient mice and reversed by IL-10 gene transfer","volume":"19","author":"B Zhou","year":"2012","journal-title":"Gene Therapy"},{"issue":"2","key":"ref90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0272-2712(18)30690-5","article-title":"Autoimmunity And Otologic Disease\u2014Clinical And Experimental Aspects","volume":"8","author":"BP Barna","year":"1988","journal-title":"Clinics In Laboratory Medicine"},{"issue":"18","key":"ref91","doi-asserted-by":"crossref","first-page":"10412","DOI":"10.1128\/JVI.00111-14","article-title":"Downregulation of Interleukin-18-Mediated Cell Signaling and Interferon Gamma Expression by the Hepatitis B Virus e Antigen","volume":"88","author":"S Jegaskanda","year":"2014","journal-title":"J Virol"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/0036554021000028074","article-title":"Immunological responses in acute low-tone sensorineural hearing loss and Meniere's disease","volume":"123","author":"T Fuse","year":"2003","journal-title":"Acta oto-laryngologica"},{"issue":"2","key":"ref93","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cyto.2015.04.015","article-title":"Osteopontin, CCL5 and CXCL9 are independently associated with psoriasis, regardless of the presence of obesity","volume":"74","author":"GV Duarte","year":"2015","journal-title":"Cytokine"},{"issue":"4","key":"ref94","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3349\/ymj.2015.56.4.1134","article-title":"Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis","volume":"56","author":"L Zhang","year":"2015","journal-title":"Yonsei Med J"},{"issue":"2","key":"ref95","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/000348949110000211","article-title":"Ultrastructural evidence of a merocrine secretion in the human endolymphatic sac","volume":"100","author":"H Rask-Andersen","year":"1991","journal-title":"The Annals of otology, rhinology, and laryngology"},{"issue":"7","key":"ref96","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00405-015-3731-5","article-title":"Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease","volume":"273","author":"MN Moller","year":"2016","journal-title":"European Archives Of Oto-Rhino-Laryngology"},{"issue":"8","key":"ref97","doi-asserted-by":"crossref","first-page":"E269","DOI":"10.1002\/lary.25242","article-title":"Gene expression demonstrates an immunological capacity of the human endolymphatic sac","volume":"125","author":"MN Moller","year":"2015","journal-title":"The Laryngoscope"},{"issue":"6","key":"ref98","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00432-014-1869-y","article-title":"The chemokine CXCL9 exacerbates chemotherapy-induced acute intestinal damage through inhibition of mucosal restitution","volume":"141","author":"HL Lu","year":"2015","journal-title":"Journal Of Cancer Research And Clinical Oncology"},{"issue":"1","key":"ref99","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cyto.2013.05.012","article-title":"Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats","volume":"64","author":"JQ Shen","year":"2013","journal-title":"Cytokine"},{"issue":"5","key":"ref100","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/hep.25545","article-title":"Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice","volume":"55","author":"H Sahin","year":"2012","journal-title":"Hepatology"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/cei.12579","article-title":"CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis","volume":"180","author":"D Petrovic-Djergovic","year":"2015","journal-title":"Clinical And Experimental Immunology"},{"issue":"4","key":"ref102","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1189\/jlb.71.4.669","article-title":"IFN-alpha2a induces IP-10\/CXCL10 and MIG\/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells","volume":"71","author":"E Padovan","year":"2002","journal-title":"Journal of leukocyte biology"},{"issue":"6","key":"ref103","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3109\/00016489.2014.880795","article-title":"Genes involved in immunity and apoptosis are associated with human presbycusis based on microarray analysis","volume":"134","author":"Y Dong","year":"2014","journal-title":"Acta oto-laryngologica"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fimmu.2015.00426","article-title":"HIV-1 structural proteins serve as PAMPs for TLR2 heterodimers significantly increasing infection and innate immune activation","volume":"6","author":"BM Henrick","year":"2015","journal-title":"Front Immunol"},{"issue":"1","key":"ref105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0022034514557545","article-title":"TLR2 Promoter Hypermethylation Creates Innate Immune Dysbiosis","volume":"94","author":"M Benakanakere","year":"2015","journal-title":"Journal Of Dental Research"},{"issue":"10","key":"ref106","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/j.1462-5822.2008.01189.x","article-title":"The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls","volume":"10","author":"LO Moreira","year":"2008","journal-title":"Cellular microbiology"},{"issue":"6","key":"ref107","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1203\/PDR.0b013e3181f90810","article-title":"Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4\/MD2, and MyD88 During Bacterial Infection In Vivo","volume":"68","author":"JP Zhang","year":"2010","journal-title":"Pediatric research"},{"issue":"2","key":"ref108","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/joa.12559","article-title":"Innate immune defense in the inner ear\u2014mucines are expressed by the human endolymphatic sac","volume":"230","author":"MN Moller","year":"2017","journal-title":"J Anat"},{"issue":"5","key":"ref109","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s00405-012-2246-6","article-title":"Dynamics of pure tone audiometry and DPOAE changes induced by glycerol in Meniere's disease","volume":"270","author":"A Jablonka-Strom","year":"2013","journal-title":"European Archives Of Oto-Rhino-Laryngology"},{"issue":"2","key":"ref110","first-page":"145","article-title":"Critical-Evaluation Of the Glycerol Test In Menieres-Disease","volume":"8","author":"J Thomsen","year":"1979","journal-title":"J Otolaryngol"},{"issue":"3","key":"ref111","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1167\/iovs.14-16087","article-title":"In Vivo Role of TLR2 and MyD88 Signaling in Eliciting Innate Immune Responses in Staphylococcal Endophthalmitis","volume":"56","author":"D Talreja","year":"2015","journal-title":"Invest Ophth Vis Sci"},{"issue":"2","key":"ref112","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/ijms17020242","article-title":"Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides","volume":"17","author":"XC Pan","year":"2016","journal-title":"International journal of molecular sciences"},{"issue":"3","key":"ref113","doi-asserted-by":"crossref","first-page":"e0121371","DOI":"10.1371\/journal.pone.0121371","article-title":"Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners","volume":"10","author":"C Ma","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"ref114","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1007\/s10875-013-9926-x","article-title":"Innate Immune Recognition of Molds and Homology to the Inner Ear Protein, Cochlin, in Patients with Autoimmune Inner Ear Disease","volume":"33","author":"S Pathak","year":"2013","journal-title":"J Clin Immunol"},{"issue":"21","key":"ref115","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1523\/JNEUROSCI.0791-13.2013","article-title":"Dynamic Interactions between Intermediate Neurogenic Progenitors and Radial Glia in Embryonic Mouse Neocortex: Potential Role in Dll1-Notch Signaling","volume":"33","author":"BR Nelson","year":"2013","journal-title":"J Neurosci"},{"issue":"3","key":"ref116","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.bpj.2011.11.4022","article-title":"Different Cell Fates from Cell-Cell Interactions: Core Architectures of Two-Cell Bistable Networks","volume":"102","author":"H Rouault","year":"2012","journal-title":"Biophys J"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.12659\/MSM.889815","article-title":"Inner ear symptoms and disease: Pathophysiological understanding and therapeutic options","volume":"19","author":"RR Ciuman","year":"2013","journal-title":"Med Sci Monitor"},{"issue":"2","key":"ref118","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jnnp.2006.092064","article-title":"The inner ear and the neurologist","volume":"78","author":"C Agrup","year":"2007","journal-title":"J Neurol Neurosur Ps"},{"issue":"19","key":"ref119","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/dev.02002","article-title":"The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear","volume":"132","author":"AE Kiernan","year":"2005","journal-title":"Development"},{"issue":"3","key":"ref120","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jnr.20957","article-title":"Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity","volume":"84","author":"JR Liddell","year":"2006","journal-title":"Journal of neuroscience research"},{"issue":"3","key":"ref121","first-page":"359","article-title":"Effects Of Cigarette Smoke on Salivary Superoxide Dismutase And Glutathione Peroxidase Activity","volume":"24","author":"MR Giuca","year":"2010","journal-title":"J Biol Reg Homeos Ag"},{"issue":"4","key":"ref122","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20140857","article-title":"T cell lipid peroxidation induces ferroptosis and prevents immunity to infection","volume":"212","author":"M Matsushita","year":"2015","journal-title":"Journal Of Experimental Medicine"},{"issue":"46","key":"ref123","doi-asserted-by":"crossref","first-page":"31532","DOI":"10.1074\/jbc.M109.059246","article-title":"Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases","volume":"284","author":"M Gutsche","year":"2009","journal-title":"Journal Of Biological Chemistry"},{"issue":"10","key":"ref124","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1097\/MAO.0000000000001215","article-title":"Two Common Second Causes of Dizziness in Patients With Meniere's Disease","volume":"37","author":"BF van Esch","year":"2016","journal-title":"Otol Neurotol"},{"issue":"11","key":"ref125","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3109\/00016489.2014.936624","article-title":"One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease","volume":"134","author":"A Taura","year":"2014","journal-title":"Acta oto-laryngologica"},{"issue":"10","key":"ref126","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3109\/00016489.2012.680980","article-title":"Assessment of Meniere's disease from a radiological aspect\u2014saccular otoconia as a cause of Meniere's disease?","volume":"132","author":"H Yamane","year":"2012","journal-title":"Acta oto-laryngologica"},{"issue":"9","key":"ref127","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1093\/humrep\/det237","article-title":"Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation","volume":"28","author":"A Taylor","year":"2013","journal-title":"Human Reproduction"},{"issue":"2","key":"ref128","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/humrep\/dev302","article-title":"A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models","volume":"31","author":"P Gharagozloo","year":"2016","journal-title":"Human Reproduction"},{"issue":"12","key":"ref129","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1007\/s11064-010-0304-2","article-title":"Oxidative Stress, Redox Homeostasis and Cellular Stress Response in Meniere's Disease: Role of Vitagenes","volume":"35","author":"V Calabrese","year":"2010","journal-title":"Neurochemical Research"},{"issue":"1\u20132","key":"ref130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.heares.2004.10.002","article-title":"Activation of caspase-3 Is associated with oxidative stress in the hydropic guinea pig cochlea","volume":"202","author":"D Labbe","year":"2005","journal-title":"Hearing Res"},{"issue":"5","key":"ref131","first-page":"44","article-title":"Oxidative Stress and Low Glutathione in Common Ear, Nose, and Throat Conditions: A Systematic Review","volume":"22","author":"BF Asher","year":"2016","journal-title":"Altern Ther Health M"},{"issue":"3","key":"ref132","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jc.2013-2950","article-title":"Hormonal Therapy Deregulates Prostaglandin-Endoperoxidase Synthase 2 (PTGS2) Expression in Endometriotic Tissues","volume":"99","author":"P Santulli","year":"2014","journal-title":"Journal Of Clinical Endocrinology & Metabolism"},{"issue":"37","key":"ref133","doi-asserted-by":"crossref","first-page":"39941","DOI":"10.18632\/oncotarget.5402","article-title":"Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E-2 synthase up-regulation for colorectal cancer progression","volume":"6","author":"K Stamatakis","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"ref134","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0385-8146(12)80196-9","article-title":"Effects of prostaglandin E2 on the fluctuating hearing loss in Meniere's disease","volume":"19","author":"O Michel","year":"1992","journal-title":"Auris, nasus, larynx"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:57:53Z","timestamp":1692899873000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182592"}},"subtitle":[],"editor":[{"given":"Quan","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":134,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182592","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727964907.793549280","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}