{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:49:24Z","timestamp":1790520564664,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Foundation","award":["31003A_135740"],"award-info":[{"award-number":["31003A_135740"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0182813","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T13:33:18Z","timestamp":1504186398000},"page":"e0182813","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway"],"prefix":"10.1371","volume":"12","author":[{"given":"Ruslan","family":"Hlushchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Styp-Rekowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehona","family":"Dzambazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wnuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen","family":"Huynh-Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Makanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-1169","authenticated-orcid":true,"given":"Valentin","family":"Djonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"issue":"6S","key":"ref1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0098-2997(02)00096-1","article-title":"Intussusceptive angiogenesis\u2014the alternative to capillary sprouting","volume":"23","author":"PH Burri","year":"2002","journal-title":"Mol Aspects Med"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/dvdy.20184","article-title":"Intussusceptive angiogenesis: its emergence, its characteristics, and its significance","volume":"231","author":"PH Burri","year":"2004","journal-title":"Dev Dyn"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-003-0784-3","article-title":"Vascular remodeling by intussusceptive angiogenesis","volume":"314","author":"V Djonov","year":"2003","journal-title":"Cell Tissue Res"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.ajpath.2010.12.049","article-title":"The effects of PTK787\/ZK222584, an inhibitor of VEGFR and PDGFRbeta pathways, on intussusceptive angiogenesis and glomerular recovery from Thy1.1 nephritis","volume":"178","author":"M Wnuk","year":"2011","journal-title":"Am J Pathol"},{"issue":"4\u20135","key":"ref5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1387\/ijdb.103231rh","article-title":"Escape mechanisms after antiangiogenic treatment, or why are the tumors growing again?","volume":"55","author":"R Hlushchuk","year":"2011","journal-title":"Int J Dev Biol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2353\/ajpath.2008.071131","article-title":"Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787\/ZK222584 or ionizing radiation","volume":"173","author":"R Hlushchuk","year":"2008","journal-title":"Am J Pathol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/j.gastro.2011.12.052","article-title":"Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice","volume":"142","author":"MT Dill","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10456-013-9366-5","article-title":"Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells","volume":"16","author":"I Dimova","year":"2013","journal-title":"Angiogenesis"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.krcp.2013.01.003","article-title":"Transforming growth factor-beta and the glomerular filtration barrier","volume":"32","author":"A Ghayur","year":"2013","journal-title":"Kidney Res Clin Pract"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nm1731","article-title":"The Notch pathway in podocytes plays a role in the development of glomerular disease","volume":"14","author":"T Niranjan","year":"2008","journal-title":"Nat Med"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/path.4101","article-title":"Notch3 and kidney injury: never two without three","volume":"228","author":"MD Sanchez-Nino","year":"2012","journal-title":"J Pathol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ki.2012.17","article-title":"Podocyte EphB4 signaling helps recovery from glomerular injury","volume":"81","author":"M Wnuk","year":"2012","journal-title":"Kidney Int"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1479-5876-2-18","article-title":"Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer","volume":"2","author":"E Fonsatti","year":"2004","journal-title":"J Transl Med"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tcb.2010.06.006","article-title":"Signaling by members of the TGF-beta family in vascular morphogenesis and disease","volume":"20","author":"E Pardali","year":"2010","journal-title":"Trends Cell Biol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10456-008-9101-9","article-title":"Endoglin in angiogenesis and vascular diseases","volume":"11","author":"P ten Dijke","year":"2008","journal-title":"Angiogenesis"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1002\/dvdy.22066","article-title":"Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis","volume":"238","author":"ML Mancini","year":"2009","journal-title":"Dev Dyn"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/CIRCRESAHA.108.177808","article-title":"Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations","volume":"103","author":"DA Venkatesh","year":"2008","journal-title":"Circ Res"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7150\/ijbs.8.195","article-title":"TGFbeta signaling and cardiovascular diseases","volume":"8","author":"E Pardali","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/carcin\/bgp327","article-title":"ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1\/5\/8 signaling and endothelial cell migration","volume":"31","author":"BN Ray","year":"2010","journal-title":"Carcinogenesis"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.devcel.2011.06.022","article-title":"Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase","volume":"21","author":"AC Chang","year":"2011","journal-title":"Dev Cell"},{"issue":"29","key":"ref21","doi-asserted-by":"crossref","first-page":"19452","DOI":"10.1074\/jbc.M109.011833","article-title":"Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells","volume":"284","author":"Y Fu","year":"2009","journal-title":"J Biol Chem"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1007\/PL00000624","article-title":"COUP-TF orphan nuclear receptors in development and differentiation","volume":"57","author":"FA Pereira","year":"2000","journal-title":"Cell Mol Life Sci"},{"issue":"1\u20136 Spec No","key":"ref23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0960-0760(95)00225-1","article-title":"Chicken ovalbumin upstream promoter-transcription factors and their regulation","volume":"56","author":"Y Qiu","year":"1996","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1161\/CIRCRESAHA.108.188805","article-title":"Arterial-venous specification during development","volume":"104","author":"MR Swift","year":"2009","journal-title":"Circ Res"},{"issue":"7038","key":"ref25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature03511","article-title":"Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity","volume":"435","author":"LR You","year":"2005","journal-title":"Nature"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1073\/pnas.0914619107","article-title":"COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis","volume":"107","author":"J Qin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7431","key":"ref27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature11674","article-title":"COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis","volume":"493","author":"J Qin","year":"2013","journal-title":"Nature"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00395-013-0362-0","article-title":"Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells","volume":"108","author":"S Korten","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"7333","key":"ref29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature09677","article-title":"SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression","volume":"470","author":"Z Ding","year":"2011","journal-title":"Nature"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/01.RES.86.3.286","article-title":"Intussusceptive angiogenesis: its role in embryonic vascular network formation","volume":"86","author":"V Djonov","year":"2000","journal-title":"Circ Res"},{"issue":"22","key":"ref31","doi-asserted-by":"crossref","first-page":"23759","DOI":"10.1074\/jbc.M402178200","article-title":"Opposite Smad and chicken ovalbumin upstream promoter transcription factor inputs in the regulation of the collagen VII gene promoter by transforming growth factor-beta","volume":"279","author":"MJ Calonge","year":"2004","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"ref32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0925-4773(01)00562-7","article-title":"Endoglin expression in early development is associated with vasculogenesis and angiogenesis","volume":"110","author":"L Jonker","year":"2002","journal-title":"Mech Dev"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1159\/000337762","article-title":"Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse","volume":"33","author":"EJ Choi","year":"2012","journal-title":"Cerebrovasc Dis"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1161\/CIRCRESAHA.109.211037","article-title":"Pathogenesis of arteriovenous malformations in the absence of endoglin","volume":"106","author":"M Mahmoud","year":"2010","journal-title":"Circ Res"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/annonc\/mds057","article-title":"Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: clinical activity, molecular response, and biomarkers","volume":"23","author":"E Seront","year":"2012","journal-title":"Ann Oncol"},{"issue":"1","key":"ref36","first-page":"61","article-title":"Everolimus dual effects of an area vasculosa angiogenesis and lymphangiogenesis","volume":"27","author":"RA Ceausu","year":"2013","journal-title":"In Vivo"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1083\/jcb.200305112","article-title":"Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3","volume":"163","author":"A Blokzijl","year":"2003","journal-title":"J Cell Biol"},{"key":"ref38","article-title":"Physiologic and Pathologic Angiogenesis\u2014Signaling Mechanisms and Targeted Therapy","author":"DV Dimova I","year":"2017"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1158\/0008-5472.CAN-07-5074","article-title":"A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer","volume":"68","author":"S Yang","year":"2008","journal-title":"Cancer Res"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/pros.2990240406","article-title":"Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells","volume":"24","author":"SE Harris","year":"1994","journal-title":"Prostate"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1158\/0008-5472.CAN-06-3946","article-title":"Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium","volume":"67","author":"M Ao","year":"2007","journal-title":"Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0182813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T10:21:05Z","timestamp":1540203665000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0182813"}},"subtitle":[],"editor":[{"given":"Domenico","family":"Ribatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0182813","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,31]]}}}