{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:38:39Z","timestamp":1780468719560,"version":"3.54.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183073","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T13:42:49Z","timestamp":1503582169000},"page":"e0183073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Septic shock and the use of norepinephrine in an intermediate care unit: Mortality and adverse events"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-8511","authenticated-orcid":true,"given":"Mikael","family":"Hallengren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"\u00c5strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Eksborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Barle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Frostell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"DC Angus","year":"2013","journal-title":"N Engl J Med"},{"key":"ref2","unstructured":"Nationella v\u00e5rdprogrammet f\u00f6r sv\u00e5r sepsis och septisk chock. Uppsala; 2012."},{"key":"ref3","unstructured":"D\u00f6dsorsaker 2012. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.socialstyrelsen.se:\" xlink:type=\"simple\">www.socialstyrelsen.se:<\/ext-link> Socialstyrelsen; 2013."},{"key":"ref4","unstructured":"Stockholm. Sweden ICUR. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/icuregswe.org\/utdata\/:\" xlink:type=\"simple\">http:\/\/icuregswe.org\/utdata\/:<\/ext-link> Intensive Care Unit Register Sweden 2012."},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"RP Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"E Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"ref7","unstructured":"Klassifikation av sepsis, sv\u00e5r sepsis och septisk chock <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.socialstyrelsen.se:\" xlink:type=\"simple\">www.socialstyrelsen.se:<\/ext-link> Socialstyrelsen; 2013 ["},{"issue":"16","key":"ref8","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMoa1404380","article-title":"Goal-directed resuscitation for patients with early septic shock","volume":"371","author":"SL Peake","year":"2014","journal-title":"N Engl J Med"},{"issue":"18","key":"ref9","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"DM Yealy","year":"2014","journal-title":"N Engl J Med"},{"issue":"14","key":"ref10","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of early, goal-directed resuscitation for septic shock","volume":"372","author":"PR Mouncey","year":"2015","journal-title":"N Engl J Med"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"WA Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"ref12","unstructured":"Group. KDIGOKAKIW. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Inter., Suppl.2012. p. 1\u2013138."},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1055\/s-2000-8865","article-title":"A comparison of the indirect estimate of mean arterial pressure calculated by the conventional equation and calculated to compensate for a change in heart rate","volume":"21","author":"G Rogers","year":"2000","journal-title":"Int J Sports Med"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/jech.38.1.85","article-title":"Simple exact analysis of the standardised mortality ratio","volume":"38","author":"FD Liddell","year":"1984","journal-title":"J Epidemiol Community Health"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13312-011-0055-4","article-title":"Receiver operating characteristic (ROC) curve for medical researchers","volume":"48","author":"R Kumar","year":"2011","journal-title":"Indian Pediatr"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"JA Hanley","year":"1982","journal-title":"Radiology"},{"issue":"4","key":"ref17","first-page":"362","article-title":"Relative adrenal insufficiency as a predictor of disease severity and mortality in severe septic shock","volume":"24","author":"D Dalegrave","year":"2012","journal-title":"Rev Bras Ter Intensiva"},{"issue":"3","key":"ref18","first-page":"177","article-title":"Enteral nutrition for patients in septic shock: a retrospective cohort study","volume":"12","author":"SS Rai","year":"2010","journal-title":"Crit Care Resusc"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/0310057X1103900316","article-title":"The relationship between blood lactate and survival following the use of adrenaline in the treatment of septic shock","volume":"39","author":"S Omar","year":"2011","journal-title":"Anaesth Intensive Care"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11908-013-0361-1","article-title":"Determinants of hospital mortality among patients with sepsis or septic shock receiving appropriate antibiotic treatment","volume":"15","author":"C McEvoy","year":"2013","journal-title":"Curr Infect Dis Rep"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/CCM.0b013e318250aa72","article-title":"The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment*","volume":"40","author":"A Labelle","year":"2012","journal-title":"Crit Care Med"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/CCM.0b013e31829a6e89","article-title":"Profile of the risk of death after septic shock in the present era: an epidemiologic study","volume":"41","author":"A Pavon","year":"2013","journal-title":"Crit Care Med"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s13054-014-0532-y","article-title":"Early versus delayed administration of norepinephrine in patients with septic shock","volume":"18","author":"X Bai","year":"2014","journal-title":"Crit Care"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.resuscitation.2004.03.016","article-title":"Early and exclusive use of norepinephrine in septic shock","volume":"62","author":"H Morimatsu","year":"2004","journal-title":"Resuscitation"},{"issue":"6","key":"ref26","first-page":"701","article-title":"Update on hemodynamic monitoring and management in septic patients","volume":"80","author":"M Cecconi","year":"2014","journal-title":"Minerva Anestesiol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13613-015-0085-5","article-title":"Personalizing blood pressure management in septic shock","volume":"5","author":"R Kato","year":"2015","journal-title":"Ann Intensive Care"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/bja\/aev349","article-title":"A rational approach to fluid therapy in sepsis","volume":"116","author":"P Marik","year":"2016","journal-title":"Br J Anaesth"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"653 e9","DOI":"10.1016\/j.jcrc.2015.01.014","article-title":"A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters","volume":"30","author":"OM Loubani","year":"2015","journal-title":"J Crit Care"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1651-2227.2012.02725.x","article-title":"Noradrenaline use for septic shock in children: doses, routes of administration and complications","volume":"101","author":"ME Lampin","year":"2012","journal-title":"Acta Paediatr"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/PEC.0b013e3181ea71e1","article-title":"The use of vasoactive agents via peripheral intravenous access during transport of critically III infants and children","volume":"26","author":"DA Turner","year":"2010","journal-title":"Pediatr Emerg Care"},{"issue":"5","key":"ref32","first-page":"300","article-title":"Complications Related to Insertion and Use of Central Venous Catheters (CVC)","volume":"68","author":"S Hodzic","year":"2014","journal-title":"Med Arch"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1097\/CCM.0b013e31828a42c5","article-title":"Central or peripheral catheters for initial venous access of ICU patients: a randomized controlled trial","volume":"41","author":"JD Ricard","year":"2013","journal-title":"Crit Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:42:22Z","timestamp":1570030942000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183073"}},"subtitle":[],"editor":[{"given":"Chiara","family":"Lazzeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,24]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183073","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,24]]}}}