{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:47:33Z","timestamp":1771656453692,"version":"3.50.1"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183101","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T18:10:34Z","timestamp":1502388634000},"page":"e0183101","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["A novel whole-bacterial enzyme linked-immunosorbant assay to quantify Chlamydia trachomatis specific antibodies reveals distinct differences between systemic and genital compartments"],"prefix":"10.1371","volume":"12","author":[{"given":"Hannah L.","family":"Albritton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Kozlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Lillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris L.","family":"McGowin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia D.","family":"Siren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie N.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce A.","family":"Ibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndsey R.","family":"Buckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-1292","authenticated-orcid":true,"given":"Alison J.","family":"Quayle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143304","article-title":"Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting","volume":"10","author":"L Newman","year":"2015","journal-title":"PLoS One"},{"issue":"Suppl 2","key":"ref2","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1086\/652394","article-title":"<italic>Chlamydia trachomatis<\/italic> persistence in vitro: An overview","volume":"201","author":"PB Wyrick","year":"2010","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMcp030542","article-title":"Genital chlamydial infections","volume":"349","author":"JF Peipert","year":"2003","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"ref4","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/652397","article-title":"Pathogenesis of genital tract disease due to <italic>Chlamydia trachomatis<\/italic>","volume":"201","author":"T Darville","year":"2010","journal-title":"J Infect Dis"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00007435-200007000-00006","article-title":"Duration of untreated genital infections with <italic>Chlamydia trachomatis<\/italic>: A review of the literature","volume":"27","author":"MR Golden","year":"2000","journal-title":"Sex Transm Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/infdis\/173.6.1437","article-title":"Risk factors for <italic>Chlamydia trachomatis<\/italic> pelvic inflammatory disease among sex workers in Nairobi, Kenya","volume":"173","author":"J Kimani","year":"1996","journal-title":"J Infect Dis"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00007435-199301000-00006","article-title":"Decreased prevalence of <italic>Chlamydia trachomatis<\/italic> infection associated with a selective screening program in family planning clinics in Wisconsin","volume":"20","author":"DG Addiss","year":"1993","journal-title":"Sex Transm Dis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/OLQ.0b013e31813e0c26","article-title":"Increasing <italic>Chlamydia<\/italic> positivity in women screened in family planning clinics: Do we know why?","volume":"35","author":"D Fine","year":"2008","journal-title":"Sex Transm Dis"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/00007435-200212000-00016","article-title":"Findings from STD screening of adolescents and adults entering corrections facilities: Implications for STD control strategies","volume":"29","author":"KJ Mertz","year":"2002","journal-title":"Sex Transm Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/sti.75.1.3","article-title":"From epidemiological synergy to public health policy and practice: The contribution of other sexually transmitted diseases to sexual transmission of HIV infection","volume":"75","author":"DT Fleming","year":"1999","journal-title":"Sex Transm Infect"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1097\/00002030-199712000-00001","article-title":"The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d&apos;lvoire","volume":"11","author":"PD Ghys","year":"1997","journal-title":"AIDS"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/MMBR.55.1.143-190.1991","article-title":"Interaction of Chlamydiae and host cells in vitro","volume":"55","author":"JW Moulder","year":"1991","journal-title":"Microbiol Rev"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/OLQ.0b013e318151497d","article-title":"The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment","volume":"35","author":"WM Geisler","year":"2008","journal-title":"Sex Transm Dis"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007435-198707000-00008","article-title":"Effect of prior sexually transmitted disease on the isolation of <italic>Chlamydia trachomatis<\/italic>","volume":"14","author":"BP Katz","year":"1986","journal-title":"Sex Transm Dis"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/clinids\/7.6.717","article-title":"Importance of reinfection in the pathogenesis of trachoma","volume":"7","author":"JT Grayston","year":"1985","journal-title":"Rev Infect Dis"},{"issue":"Suppl 2","key":"ref16","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1086\/652402","article-title":"Duration of untreated, uncomplicated <italic>Chlamydia trachomatis<\/italic> genital infection and factors associated with chlamydia resolution: A review of human studies","volume":"201","author":"WM Geisler","year":"2010","journal-title":"J Infect Dis"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/OLQ.0b013e3181a2a933","article-title":"Repeating infection with <italic>Chlamydia<\/italic> and <italic>Gonorrhea<\/italic> among females: A systematic review of the literature","volume":"36","author":"CB Hosenfeld","year":"2009","journal-title":"Sex Transm Dis"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/infdis\/jit094","article-title":"3rd. Spontaneous resolution of genital <italic>Chlamydia trachomatis<\/italic> infection in women and protection from reinfection","volume":"207","author":"WM Geisler","year":"2013","journal-title":"J Infect Dis"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1093\/infdis\/jit095","article-title":"Immunity to <italic>Chlamydia trachomatis<\/italic>","volume":"207","author":"RC Brunham","year":"2013","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.0019-2805.2001.01354.x","article-title":"Fc receptor regulation of protective immunity against <italic>Chlamydia trachomatis<\/italic>","volume":"105","author":"T Moore","year":"2002","journal-title":"Immunol"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1128\/IAI.68.12.6979-6987.2000","article-title":"Immunity to murine <italic>Chlamydia trachomatis<\/italic> genital tract reinfection involves B cells and CD4+ T cells but not CD8+ T cells","volume":"68","author":"SG Morrison","year":"2000","journal-title":"Infect Immun"},{"issue":"22","key":"ref22","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.4049\/jimmunol.175.11.7536","article-title":"A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection","volume":"175","author":"SG Morrison","year":"2005","journal-title":"J Immunol"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1128\/IAI.65.6.1993-1999.1997","article-title":"<italic>Chlamydia trachomatis<\/italic> genital tract infection of antibody deficient gene knockout mice","volume":"65","author":"H Su","year":"1997","journal-title":"Infect Immun"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/icb.2013.110","article-title":"Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens","volume":"92","author":"CW Armitage","year":"2014","journal-title":"Immunol Cell Biol"},{"issue":"4","key":"ref25","first-page":"520","article-title":"Evaluation of intra- and extra-epithelial secretory IgA in chlamydial infections","volume":"143","author":"CW Armitage","year":"2014","journal-title":"."},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/IAI.48.3.847-849.1985","article-title":"Chronic chlamydial genital infection in congenitally athymic nude mice","volume":"48","author":"RG Rank","year":"1985","journal-title":"Infect Immun"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1128\/IAI.59.3.925-931.1991","article-title":"Resolution of chlamydial genital infection with antigen-specific T-lymphocyte lines","volume":"59","author":"KH Ramsey","year":"1991","journal-title":"Infect Immun"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3782::AID-IMMU3782>3.0.CO;2-B","article-title":"IFN-gamma knockout mice show Th2-associated delayed-type hypersensitivity and the inflammatory cells fail to localize and control chlamydial infection","volume":"29","author":"S Wang","year":"1999","journal-title":"Eur J Immunol"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/IAI.65.6.2145-2152.1997","article-title":"Dissemination of <italic>Chlamydia trachomatis<\/italic> chronic genital tract infection in gamma interferon gene knockout mice","volume":"65","author":"TW Cotter","year":"1997","journal-title":"Infect Immun"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.4049\/jimmunol.175.11.7536","article-title":"A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection","volume":"175","author":"SG Morrison","year":"2005","journal-title":"J Immunol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/infdis\/jis621","article-title":"Immunoglobulin-specific responses to <italic>Chlamydia<\/italic> elementary bodies in individuals with and at risk for genital chlamydial infection","volume":"206","author":"WM Geisler","year":"2012","journal-title":"J Infect Dis"},{"key":"ref32","article-title":"Immunoglobulin-based investigation of spontaneous resolution of <italic>Chlamydia trachomatis<\/italic> infection","author":"R Bakshi","year":"2017","journal-title":"J Infect Dis"},{"issue":"Suppl 3","key":"ref33","doi-asserted-by":"crossref","first-page":"S470","DOI":"10.1086\/314806","article-title":"Immunology of the human genital tract","volume":"179","author":"J Mestecky","year":"1999","journal-title":"J Infect Dis"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001432-200302000-00008","article-title":"Immunology of the human genital tract","volume":"16","author":"M Johansson","year":"2003","journal-title":"Curr Opin Infect Dis"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0897.1995.tb00948.x","article-title":"Normal uterine cervix: Characterization of isolated lymphocyte phenotypes and immunoglobulin secretion","volume":"34","author":"P Crowley-Nowick","year":"1995","journal-title":"Am J Reprod Immunol"},{"key":"ref36","first-page":"131","article-title":"Antibody- and TRIM21-dependent intracellular restriction of <italic>Salmonella enterica<\/italic>","volume":"72","author":"N Rakebrandt","year":"2014","journal-title":"Pathog Dis"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1073\/pnas.1012861108","article-title":"Transfer of IgG in the female genital tract by MHC class I related neonatal Fc receptor confers protective immunity to vaginal infection","volume":"108","author":"Z Li","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(02)00341-2","article-title":"Secretory component: A new role in secretory IgA mediated immune exclusion in vivo","volume":"17","author":"A Phalipon","year":"2002","journal-title":"Immunity"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/mi.2013.120","article-title":"IgG in cervicovaginal mucus traps HSV and prevents vaginal herpes infections","volume":"7","author":"YY Wang","year":"2014","journal-title":"Mucosal Immunol"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1128\/IAI.59.10.3492-3497.1991","article-title":"Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens","volume":"59","author":"AR Biesbrock","year":"1991","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.4049\/jimmunol.174.8.4828","article-title":"Intraepithelial cell neutralization of HIV-1 replication by IgA","volume":"174","author":"YT Huang","year":"2005","journal-title":"J Immunol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1074-7613(00)80610-X","article-title":"Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM","volume":"9","author":"M Bomsel","year":"1998","journal-title":"Immunity"},{"issue":"37","key":"ref43","doi-asserted-by":"crossref","first-page":"13463","DOI":"10.1073\/pnas.1410980111","article-title":"Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells","volume":"111","author":"SR Bidgood","year":"2014","journal-title":"Proc Natl Acad Sci"},{"issue":"45","key":"ref44","doi-asserted-by":"crossref","first-page":"18406","DOI":"10.1073\/pnas.1115348108","article-title":"Intracellular neutralization of viral infection in polarized epithelial cells by FcRn mediated IgG transport","volume":"108","author":"Y Bai","year":"2011","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/377134","article-title":"Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens","volume":"188","author":"T Moore","year":"2003","journal-title":"J Infect Dis"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050327","article-title":"A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular <italic>Chlamydia psittaci<\/italic>","volume":"7","author":"J Bode","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1128\/IAI.39.3.1491-1494.1983","article-title":"Correlation of host immune response with quantitative recovery of <italic>Chlamydia trachomatis<\/italic> from the human endocervix","volume":"39","author":"RC Brunham","year":"1983","journal-title":"Infect Immun"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/01.olq.0000216027.71144.74","article-title":"Association of <italic>Chlamydia trachomatis<\/italic> serovar Ia infection with black race in a sexually transmitted diseases clinic patient population in Birmingham, Alabama","volume":"33","author":"WM Geisler","year":"2006","journal-title":"Sex Transm Dis"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/infdis\/160.2.332","article-title":"Correlation of infecting serovar and local inflammation in genital chlamydial infections","volume":"160","author":"BE Batteiger","year":"1989","journal-title":"J Infect Dis"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/IAI.41.2.865-868.1983","article-title":"Immunotypes of <italic>Chlamydia trachomatis<\/italic> isolates in Seattle, Washington","volume":"41","author":"C Kuo","year":"1983","journal-title":"Infect Immun"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/beog.2002.0321","article-title":"The role of serology, antibiotic susceptibility testing and serovar determination in genital chlamydial infections","volume":"16","author":"K Persson","year":"2002","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"66","key":"ref52","article-title":"The major CD8 T cell effector memory subset in the normal and <italic>Chlamydia trachomatis<\/italic>-infected human endocervix is low in perforin","volume":"13","author":"JS Ibana","year":"2012","journal-title":"BMC Immunol"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.mimet.2012.08.012","article-title":"Isolation of <italic>Chlamydia trachomatis<\/italic> and membrane vesicles derived from host and bacteria","volume":"91","author":"K Frohlich","year":"2012","journal-title":"J Microbiol Methods"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/IAI.58.1.205-213.1990","article-title":"Characterization of murine monoclonal and murine, rabbit, and human polyclonal antibodies against chlamydial lipopolysaccharide","volume":"58","author":"L Brade","year":"1990","journal-title":"Infect Immun"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1073\/pnas.0508983103","article-title":"<italic>Chlamydia trachomatis<\/italic> polymorphic membrane protein D is a species-common pan-neutralizing antigen","volume":"103","author":"DD Crane","year":"2006","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"ref56","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/IAI.55.11.2570-2573.1987","article-title":"The low-molecular-mass, cysteine-rich outer membrane protein of <italic>Chlamydia trachomatis<\/italic> possesses both biovar- and species-specific epitopes","volume":"55","author":"Y Zhang","year":"1987","journal-title":"Infect Immun"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1128\/IAI.66.3.1167-1173.1998","article-title":"Characterization of <italic>Chlamydia psittaci<\/italic> DNA binding protein (euo) synthesized during the early and middle phases of the developmental cycle","volume":"66","author":"L Zhang","year":"1998","journal-title":"Infect Immun"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1128\/IAI.60.6.2288-2296.1992","article-title":"Monoclonal antibodies define genus-specific, species-specific, and cross-reactive epitopes of the chlamydial 60-kilodalton heat shock protein (hsp60): Specific immunodetection and purification of chlamydial hsp60","volume":"60","author":"Y Yuan","year":"1992","journal-title":"Infect Immun"},{"issue":"15","key":"ref59","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1101\/gad.1784009","article-title":"A regulator from <italic>Chlamydia trachomatis<\/italic> modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary alpha subunit","volume":"23","author":"X Rao","year":"2009","journal-title":"Genes Dev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.170.4.2236","article-title":"In vivo efficacy of anti-glycoprotein 41, but no anti-glycoprotein 120, immunotoxins in a mouse model of HIV infection","volume":"170","author":"SH Pincus","year":"2003","journal-title":"J Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/aid.1994.10.359","article-title":"Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization","volume":"10","author":"A Buchacher","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.virol.2007.03.007","article-title":"Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis","volume":"364","author":"R Pantophlet","year":"2007","journal-title":"Virology"},{"issue":"8","key":"ref63","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1128\/JVI.67.8.4785-4796.1993","article-title":"Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop","volume":"67","author":"JP Moore","year":"1993","journal-title":"J Virol"},{"issue":"10","key":"ref64","first-page":"1093","article-title":"Loss of serum antibodies to a conformational epitope of HIV-1\/gp120 identified by a human monoclonal antibody is associated with disease progression","volume":"6","author":"LA Cavacini","year":"1993","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref65","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11544","article-title":"Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits","volume":"7","author":"JE Robinson","year":"2016","journal-title":"Nat Commun"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4049\/jimmunol.1201469","article-title":"Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8","volume":"190","author":"X Yu","year":"2013","journal-title":"J Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00042560-200008010-00001","article-title":"Modified wick method using Weck-Cel sponges for collection of human rectal secretions and analysis of mucosal HIV antibody","volume":"24","author":"PA Kozlowski","year":"2000","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"7","key":"ref68","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/aid.1994.10.813","article-title":"Contrasting IgA and IgG neutralization capacities and responses to HIV Type 1 gpl20 V3 loop in HIV-infected individuals","volume":"10","author":"PA Kozlowski","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0008-8749(92)90256-O","article-title":"Transforming growth factor-beta inhibits the production of IgG, IgM, and IgA in human lymphocyte cultures","volume":"144","author":"AWL van den Wall Blake","year":"1992","journal-title":"Cell Immunol"},{"issue":"5","key":"ref70","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/aid.2010.0169","article-title":"Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women","volume":"27","author":"J Mestecky","year":"2011","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1600-0897.2008.00639.x","article-title":"A distinct cellular profile is seen in the human endocervix during <italic>Chlamydia trachomatis<\/italic> infection","volume":"60","author":"M Ficarra","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fcimb.2014.00071","article-title":"Morphologic and molecular evaluation of Chlamydia trachomatis growth in human endocervix reveals distinct growth patterns","volume":"4","author":"ME Lewis","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"ref73","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1001\/jama.1988.03720080057028","article-title":"Diagnosis of trichomoniasis: Comparison of conventional wet-mount examination with cytologic studies, cultures, and monoclonal antibody staining of direct specimens","volume":"259","author":"JN Krieger","year":"1988","journal-title":"J Am Med Assoc"},{"issue":"7","key":"ref74","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1128\/JCM.00159-14","article-title":"<italic>Mycoplasma genitalium<\/italic> infection is associated with microscopic signs of cervical inflammation in liquid cytology specimens","volume":"52","author":"PM Dehon","year":"2014","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref75","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/JCM.29.2.297-301.1991","article-title":"Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation","volume":"29","author":"RP Nugent","year":"1991","journal-title":"J Clin Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0022-1759(99)00037-X","article-title":"Cytokine and immunoglobulin concentrations in cervical secretions reproducibility of the weck cel collection instrument and correlates of immune measures","volume":"225","author":"A Hildesheim","year":"1999","journal-title":"J Immunol Methods"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.169.1.566","article-title":"Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: Influence of the menstrual cycle","volume":"169","author":"PA Kozlowski","year":"2002","journal-title":"J Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fcimb.2014.00072","article-title":"Influence of the tryptophan-indole-IFNgamma axis on human genital <italic>Chlamydia trachomatis<\/italic> infection: Role of vaginal co-infections","volume":"4","author":"A Aiyar","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"ref79","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00103-014-2054-9","article-title":"Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2)","volume":"57","author":"S Castell","year":"2014","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"15","key":"ref80","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/jnci\/djg018","article-title":"Specific antibody levels at the cervix during the menstrual cycle of women caccinated with human papillomavirus 16 virus-like particles","volume":"95","author":"D Nardelli-Haefliger","year":"2003","journal-title":"J Nati Cancer Inst"},{"issue":"11","key":"ref81","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0264-410X(95)00016-T","article-title":"Human immune responses to influenza virus vaccines administered by systemic or mucosal routes","volume":"13","author":"Z Moldoveanu","year":"1995","journal-title":"Vaccine"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00005176-200010000-00003","article-title":"Immunization against bacterial diseases of the intestine","volume":"31","author":"MM Levin","year":"2000","journal-title":"J Ped Gastro Nutr"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.micro.51.1.311","article-title":"Interactions of antigens and antibodies at mucosal surfaces","volume":"51","author":"ME Lamm","year":"1997","journal-title":"Ann Rev Microbiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1084\/jem.184.5.1879","article-title":"Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization","volume":"184","author":"WS Gallichan","year":"1996","journal-title":"J Exp Med"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: The promise and the challenge","volume":"6","author":"MR Neutra","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ref86","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.70.6.2741-2751.2002","article-title":"Immunity to Murine Chlamydial Genital Infection","volume":"70","author":"RP Morrison","year":"2002","journal-title":"Infect Immun"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/IAI.39.1.463-465.1983","article-title":"Humoral immune response in acquired immunity to chlamydial genital infection of female guinea pigs","volume":"39","author":"RG Rank","year":"1983","journal-title":"Infect Immun"},{"issue":"2","key":"ref88","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.imlet.2015.02.004","article-title":"A re-evaluation of the role of B cells in protective immunity to Chlamydia infection","volume":"164","author":"LX Li","year":"2015","journal-title":"Immunol Lett"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0022-1759(92)90306-E","article-title":"Detection of lipopolysaccharide (LPS) and identification of its serotype by an enzyme-linked immunosorbent assay (ELISA) using poly-L-lysine.","volume":"153","author":"K Takahashi","year":"1992","journal-title":"J Immunol Methods"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1136\/jcp.34.9.1040","article-title":"Enzyme-linked immunosorbent assay (ELISA) to detect antibodies in gonorrhea using whole cells","volume":"34","author":"CA Ison","year":"1981","journal-title":"J Clin Pathol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0166-0934(91)90003-I","article-title":"Effect of glutaraldehyde-fixation on the immunogenicity, particle stability, and antigenic reactivity of alfalfa mosaic virus, and the specificty of elicited antibodies","volume":"33","author":"MR Hajimorad","year":"1991","journal-title":"J Virol Methods"},{"issue":"1\u20132","key":"ref92","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0022-1759(01)00464-1","article-title":"Evaluation of the cervical cytobrush sampling technique for the preparation of CD45+ mononuclear cells from the human cervix","volume":"258","author":"M Prakash","year":"2001","journal-title":"J Immunol Methods"},{"issue":"24","key":"ref93","first-page":"6132","article-title":"Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes","volume":"59","author":"R Klaes","year":"1999","journal-title":"Cancer Res"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/096914130601300409","article-title":"Acceptability of unsupervised HPV self-sampling using written instructions","volume":"13","author":"J Waller","year":"2006","journal-title":"J Med Screen"},{"issue":"3","key":"ref95","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1128\/JVI.69.3.1895-1902.1995","article-title":"Bone marrow is a major site of long-term antibody production after acute viral infection","volume":"69","author":"MK Slifka","year":"1995","journal-title":"J Virol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1471-0528.1981.tb00964.x","article-title":"Follicular cervicitis\u2014colposcopic appearances and association with <italic>Chlamydia trachomatis<\/italic>","volume":"88","author":"MJ Hare","year":"1981","journal-title":"Br J Obstet Gynaec"},{"key":"ref97","first-page":"712","article-title":"Colposcopic and histologic findings in cervical chlamydial infection","volume":"59","author":"J Paavonen","year":"1982","journal-title":"Obstet Gynecol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/infdis\/173.4.950","article-title":"The epidemiology of <italic>Chlamydia trachomatis<\/italic> within a sexually transmitted diseases core group","volume":"173","author":"RC Brunham","year":"1996","journal-title":"J Infect Dis"},{"issue":"5","key":"ref99","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1128\/JCM.16.5.895-900.1982","article-title":"Long term clinical, microbiological, and immunological observations of a volunteer repeatedly infected with Chlamydia trachomatis","volume":"16","author":"L Hanna","year":"1982","journal-title":"Journal of Clinical Microbiology"},{"issue":"4","key":"ref100","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4049\/jimmunol.113.4.1262","article-title":"Type specific antibodies in human Chlamydia trachomatis infections of the eye","volume":"113","author":"OC Briones","year":"1974","journal-title":"Journal of Immunology"},{"issue":"6","key":"ref101","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/IAI.67.6.3019-3025.1999","article-title":"Prior genital tract infection with a murine or human biovar of <italic>Chlamydia trachomatis<\/italic> protects mice against heterotypic challenge infection","volume":"67","author":"KH Ramsey","year":"1999","journal-title":"Infect Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T23:26:02Z","timestamp":1692919562000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183101"}},"subtitle":[],"editor":[{"given":"Deborah","family":"Dean","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,10]]},"references-count":101,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183101","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,10]]}}}