{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:24:59Z","timestamp":1790249099509,"version":"4.1.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPESP Sao Paulo Research Foundation","award":["13\/08135-2"],"award-info":[{"award-number":["13\/08135-2"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183287","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T19:15:01Z","timestamp":1502910901000},"page":"e0183287","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma"],"prefix":"10.1371","volume":"12","author":[{"given":"Fl\u00e1via S.","family":"Donaires","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia F.","family":"Scatena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel M.","family":"Alves-Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Podlevsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhenugen","family":"Logeswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza C.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian J.-L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo T.","family":"Calado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L. C.","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(01)00492-5","article-title":"Switching and signaling at the telomere","volume":"106","author":"EH Blackburn","year":"2001","journal-title":"Cell"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nchembio.2007.38","article-title":"Telomere length, stem cells and aging","volume":"3","author":"MA Blasco","year":"2007","journal-title":"Nat Chem Biol"},{"issue":"24","key":"ref3","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMra0903373","article-title":"Telomere diseases","volume":"361","author":"RT Calado","year":"2009","journal-title":"N Engl J Med"},{"issue":"2 Pt 1","key":"ref4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"CW Greider","year":"1985","journal-title":"Cell"},{"issue":"5312","key":"ref5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.276.5312.561","article-title":"Reverse transcriptase motifs in the catalytic subunit of telomerase","volume":"276","author":"J Lingner","year":"1997","journal-title":"Science"},{"issue":"5820","key":"ref6","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1126\/science.1138596","article-title":"Protein composition of catalytically active human telomerase from immortal cells","volume":"315","author":"SB Cohen","year":"2007","journal-title":"Science"},{"issue":"Suppl","key":"ref7","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0140-6736(01)07040-4","article-title":"Dyskeratosis congenita. A disease of premature ageing","volume":"358","author":"I Dokal","year":"2001","journal-title":"Lancet"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"e7926","DOI":"10.1371\/journal.pone.0007926","article-title":"A spectrum of severe familial liver disorders associate with telomerase mutations","volume":"4","author":"RT Calado","year":"2009","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-0-12-397898-1.00007-4","article-title":"The role of telomeres in liver disease","volume":"125","author":"Y Sunami","year":"2014","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jhep.2004.06.010","article-title":"Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma","volume":"41","author":"A Lechel","year":"2004","journal-title":"J Hepatol"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/hep.24217","article-title":"Telomerase gene mutations are associated with cirrhosis formation","volume":"53","author":"D Hartmann","year":"2011","journal-title":"Hepatology"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hep.24304","article-title":"Telomerase mutation: a genetic risk factor for cirrhosis","volume":"53","author":"R Chaiteerakij","year":"2011","journal-title":"Hepatology"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hep.24173","article-title":"Constitutional telomerase mutations are genetic risk factors for cirrhosis","volume":"53","author":"RT Calado","year":"2011","journal-title":"Hepatology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/ijms17030383","article-title":"Telomeres, NAFLD and Chronic Liver Disease","volume":"17","author":"B Donati","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"e113747","DOI":"10.1371\/journal.pone.0113747","article-title":"Direct comparison of flow-FISH and qPCR as diagnostic tests for telomere length measurement in humans","volume":"9","author":"F Gutierrez-Rodrigues","year":"2014","journal-title":"PLoS One"},{"issue":"14","key":"ref16","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa042980","article-title":"Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia","volume":"352","author":"H Yamaguchi","year":"2005","journal-title":"N Engl J Med"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"P Kumar","year":"2009","journal-title":"Nat Protoc"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"M Kircher","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/emboj.2011.363","article-title":"RNA\/DNA hybrid binding affinity determines telomerase template-translocation efficiency","volume":"31","author":"X Qi","year":"2012","journal-title":"EMBO J"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"e1001352","DOI":"10.1371\/journal.pgen.1001352","article-title":"Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis","volume":"7","author":"JK Alder","year":"2011","journal-title":"PLoS Genet"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1172\/JCI78554","article-title":"Telomerase mutations in smokers with severe emphysema","volume":"125","author":"SE Stanley","year":"2015","journal-title":"J Clin Invest"},{"issue":"18","key":"ref23","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1182\/blood-2012-08-447755","article-title":"A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome","volume":"121","author":"MM Gramatges","year":"2013","journal-title":"Blood"},{"issue":"7127","key":"ref24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature05454","article-title":"The POT1-TPP1 telomere complex is a telomerase processivity factor","volume":"445","author":"F Wang","year":"2007","journal-title":"Nature"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1073\/pnas.0807057106","article-title":"Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia","volume":"106","author":"RT Calado","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref26","first-page":"656","article-title":"Mutations in telomerase catalytic protein in Japanese children with aplastic anemia","volume":"91","author":"J Liang","year":"2006","journal-title":"Haematologica"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2012.09.011","article-title":"Liver transplantation for hepatocellular carcinoma in a patient with a novel telomerase mutation and steatosis","volume":"58","author":"L Valenti","year":"2013","journal-title":"J Hepatol"},{"issue":"19","key":"ref28","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1093\/nar\/gkt653","article-title":"Many disease-associated variants of hTERT retain high telomerase enzymatic activity","volume":"41","author":"AJ Zaug","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1182\/blood-2006-07-035089","article-title":"Functional characterization of natural telomerase mutations found in patients with hematologic disorders","volume":"109","author":"ZT Xin","year":"2007","journal-title":"Blood"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/nar\/gkq1083","article-title":"Direct involvement of the TEN domain at the active site of human telomerase","volume":"39","author":"J Jurczyluk","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bcmd.2004.12.008","article-title":"Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure","volume":"34","author":"TJ Vulliamy","year":"2005","journal-title":"Blood Cells Mol Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T14:54:37Z","timestamp":1540306477000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183287"}},"subtitle":[],"editor":[{"given":"Arthur J.","family":"Lustig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183287","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]}}}