{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:32:03Z","timestamp":1790541123214,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572487"],"award-info":[{"award-number":["31572487"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MoSTRCUK international cooperation project","award":["2013DFG32500"],"award-info":[{"award-number":["2013DFG32500"]}]},{"name":"Funding of State Key Lab of Agrobiotechnology","award":["2012SKLAB06-14"],"award-info":[{"award-number":["2012SKLAB06-14"]}]},{"name":"2016 CAU Foreign Experts Major Projects","award":["2012z018"],"award-info":[{"award-number":["2012z018"]}]},{"name":"High-end Foreign Experts Recruitment Program","award":["GDT20161100071"],"award-info":[{"award-number":["GDT20161100071"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183666","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T17:59:25Z","timestamp":1503597565000},"page":"e0183666","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differences in pathogenicity of three animal isolates of Mycobacterium species in a mouse model"],"prefix":"10.1371","volume":"12","author":[{"given":"Haodi","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinand","family":"Sreevatsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/S2214-109X(14)70361-4","article-title":"The WHO 2014 global tuberculosis report\u2014further to go","volume":"3","author":"A Zumla","year":"2015","journal-title":"Lancet Glob Health"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.4081\/idr.2016.6570","article-title":"Tuberculosis 2015: Burden, Challenges and Strategy for Control and Elimination","volume":"8","author":"M Raviglione","year":"2016","journal-title":"Infect Dis Rep"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.vaccine.2012.11.042","article-title":"Prime-boost BCG vaccination with DNA vaccines based in beta-defensin-2 and mycobacterial antigens ESAT6 or Ag85B improve protection in a tuberculosis experimental model","volume":"31","author":"AR Cervantes-Villagrana","year":"2013","journal-title":"Vaccine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.vetmic.2009.08.029","article-title":"Mycobacterium bovis at the animal\u2013human interface: A problem, or not?","volume":"140","author":"AL Michel","year":"2010","journal-title":"Veterinary Microbiology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2217\/imt.14.119","article-title":"Prophylactic potential of defensins and L-isoleucine in tuberculosis household contacts: an experimental model","volume":"7","author":"B Rivas-Santiago","year":"2015","journal-title":"Immunotherapy"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1128\/IAI.63.9.3428-3437.1995","article-title":"Virulence ranking of some Mycobacterium tuberculosis and Mycobacterium bovis strains according to their ability to multiply in the lungs, induce lung pathology, and cause mortality in mice","volume":"63","author":"PL Dunn","year":"1995","journal-title":"Infect Immun"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.tube.2008.05.005","article-title":"Development of a Mycobacterium bovis intranasal challenge model in mice","volume":"88","author":"KE Logan","year":"2008","journal-title":"Tuberculosis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-0711-13-1","article-title":"Molecular identification of clinical &quot;difficult-to-identify&quot; microbes from sequencing 16S ribosomal DNA and internal transcribed spacer 2","volume":"13","author":"C Cheng","year":"2014","journal-title":"Annals of clinical microbiology and antimicrobials"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tube.2005.04.003","article-title":"Superior virulence of Mycobacterium bovis over Mycobacterium tuberculosis (Mtb) for Mtb-resistant and Mtb-susceptible mice is manifest as an ability to cause extrapulmonary disease","volume":"86","author":"E Medina","year":"2006","journal-title":"Tuberculosis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tube.2014.02.001","article-title":"Increased virulence of Mycobacterium tuberculosis H37Rv overexpressing LipY in a murine model","volume":"94","author":"SM Singh VK","year":"2014","journal-title":"Tuberculosis"},{"key":"ref11","first-page":"75","article-title":"Two varieties of the tubercle bacillus from mammals","volume":"11","author":"S T","year":"1896","journal-title":"Trans Assoc Am Physicians"},{"issue":"2117","key":"ref12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bmj.2.2117.189","article-title":"An Address on the Fight against Tuberculosis in the Light of the Experience that has been Gained in the Successful Combat of other Infectious Diseases","volume":"2","author":"R Koch","year":"1901","journal-title":"Br Med J"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"e8527","DOI":"10.1371\/journal.pone.0008527","article-title":"Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle","volume":"5","author":"AO Whelan","year":"2010","journal-title":"PloS one"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1128\/JCM.43.7.3555-3557.2005","article-title":"Transmission of Mycobacterium tuberculosis from human to cattle","volume":"43","author":"M Ocepek","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"e76891","DOI":"10.1371\/journal.pone.0076891","article-title":"Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia","volume":"8","author":"G Ameni","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref16","first-page":"26","article-title":"Isolation of Mycobacterium bovis &amp; M. tuberculosis from cattle of some farms in north India\u2014possible relevance in human health","volume":"128","author":"K Srivastava","year":"2008","journal-title":"Indian J Med Res"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1128\/IAI.57.2.322-330.1989","article-title":"Phenolic glycolipids of Mycobacterium bovis: new structures and synthesis of a corresponding seroreactive neoglycoprotein","volume":"57","author":"D Chatterjee","year":"1989","journal-title":"Infect Immun"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2460\/ajvr.1983.44.10.1920","article-title":"Rapid identification of Mycobacterium bovis by a thin-layer chromatographic technique","volume":"44","author":"JL Jarnagin","year":"1983","journal-title":"American journal of veterinary research"},{"issue":"7004","key":"ref19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature02837","article-title":"A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response","volume":"431","author":"MB Reed","year":"2004","journal-title":"Nature"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1472-9792(03)00055-6","article-title":"Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosis","volume":"83","author":"DN Wedlock","year":"2003","journal-title":"Tuberculosis"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.actatropica.2011.02.015","article-title":"Use of recombinant proteins MPB70 or MPB83 as capture antigens in ELISAs to confirm bovine tuberculosis infections in Brazil","volume":"118","author":"CD Marassi","year":"2011","journal-title":"Acta tropica"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s11250-012-0347-2","article-title":"A complementary diagnosis of naturally occurring tuberculosis in water buffaloes (Bubalus bubalis) in Rio de Janeiro using a MPB70-ELISA, Brazil","volume":"45","author":"CF Zarden","year":"2013","journal-title":"Tropical animal health and production"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-3083.1995.tb03624.x","article-title":"Homology between the MPB70 and MPB83 proteins of Mycobacterium bovis BCG","volume":"42","author":"M Harboe","year":"1995","journal-title":"Scandinavian journal of immunology"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1111\/j.1365-2958.2006.05455.x","article-title":"Mutations in Mycobacterium tuberculosis Rv0444c, the gene encoding anti-SigK, explain high level expression of MPB70 and MPB83 in Mycobacterium bovis","volume":"62","author":"B Said-Salim","year":"2006","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2008.01.002","article-title":"Mutation in the transcriptional regulator PhoP contributes to avirulence of Mycobacterium tuberculosis H37Ra strain","volume":"3","author":"JS Lee","year":"2008","journal-title":"Cell host & microbe"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1074\/jbc.C500388200","article-title":"The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis","volume":"281","author":"J Gonzalo Asensio","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1371\/journal.ppat.0040033","article-title":"Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP","volume":"4","author":"W Frigui","year":"2008","journal-title":"PLoS pathogens"},{"issue":"31","key":"ref28","doi-asserted-by":"crossref","first-page":"11491","DOI":"10.1073\/pnas.1406693111","article-title":"Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator","volume":"111","author":"J Gonzalo-Asensio","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1084\/jem.20062665","article-title":"Type I interferon signaling is required for activation of the inflammasome during Francisella infection","volume":"204","author":"T Henry","year":"2007","journal-title":"The Journal of experimental medicine"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.4049\/jimmunol.1301331","article-title":"Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-beta and AIM2 inflammasome-dependent IL-1beta production via its ESX-1 secretion system","volume":"191","author":"S Shah","year":"2013","journal-title":"Journal of immunology"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.4049\/jimmunol.1100926","article-title":"Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1beta production in human macrophages","volume":"187","author":"A Novikov","year":"2011","journal-title":"Journal of immunology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nm.3813","article-title":"A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis","volume":"21","author":"B Dey","year":"2015","journal-title":"Nature medicine"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.1401088","article-title":"Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-\u03b3 for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages","volume":"193","author":"FW Mcnab","year":"2014","journal-title":"Journal of Immunology"},{"issue":"7446","key":"ref34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"TA Wynn","year":"2013","journal-title":"Nature"},{"issue":"15","key":"ref35","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent","volume":"345","author":"J Keane","year":"2001","journal-title":"N Engl J Med"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01023-15","article-title":"Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines","volume":"7","author":"A Olsen","year":"2016","journal-title":"MBio"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.4049\/jimmunol.1001952","article-title":"Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells","volume":"186","author":"OM Pena","year":"2011","journal-title":"Journal of immunology"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.immuni.2015.11.016","article-title":"Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection","volume":"43","author":"NC Di Paolo","year":"2015","journal-title":"Immunity"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijmm.2014.06.001","article-title":"Genetic characterization of German Mycobacterium avium strains isolated from different hosts and specimens by multilocus sequence typing","volume":"304","author":"J Kolb","year":"2014","journal-title":"International journal of medical microbiology: IJMM"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.prevetmed.2014.09.003","article-title":"Occurrence of Mycobacterium avium subspecies paratuberculosis and Neospora caninum in Alberta cow-calf operations","volume":"117","author":"M Pruvot","year":"2014","journal-title":"Preventive veterinary medicine"},{"issue":"3\u20134","key":"ref41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.prevetmed.2014.09.009","article-title":"Molecular epidemiology of Mycobacterium avium subsp. paratuberculosis isolated from sheep, cattle and deer on New Zealand pastoral farms","volume":"117","author":"C Verdugo","year":"2014","journal-title":"Preventive veterinary medicine"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1385\/IR:35:3:179","article-title":"Pathogenesis of Mycobacterium avium infection: typical responses to an atypical mycobacterium?","volume":"35","author":"R Appelberg","year":"2006","journal-title":"Immunologic research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:00:14Z","timestamp":1750816814000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183666"}},"subtitle":[],"editor":[{"given":"Selvakumar","family":"Subbian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,24]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183666","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,24]]}}}