{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:31:38Z","timestamp":1789723898250,"version":"4.0.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A2A2A05001217"],"award-info":[{"award-number":["NRF-2017R1A2A2A05001217"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C1090"],"award-info":[{"award-number":["HI14C1090"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183916","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T17:42:47Z","timestamp":1504201367000},"page":"e0183916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients"],"prefix":"10.1371","volume":"12","author":[{"given":"Ji Ye","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-7421","authenticated-orcid":true,"given":"Ho Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Hyun","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Chai","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choong Gon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1001\/jama.2016.8096","article-title":"Association Between Gadolinium Contrast Exposure and the Risk of Parkinsonism","volume":"316","author":"B Welk","year":"2016","journal-title":"Jama-J Am Med Assoc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/jmri.21969","article-title":"Biodistribution of gadolinium-based contrast agents, including gadolinium deposition","volume":"30","author":"S Aime","year":"2009","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejrad.2008.01.025","article-title":"Extracellular gadolinium contrast agents: differences in stability","volume":"66","author":"SK Morcos","year":"2008","journal-title":"European journal of radiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/RLI.0000000000000273","article-title":"Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus","volume":"51","author":"VM Runge","year":"2016","journal-title":"Investigative radiology"},{"key":"ref5","first-page":"152864","article-title":"Extent of Signal Hyperintensity on Unenhanced T1-weighted Brain MR Images after More than 35 Administrations of Linear Gadolinium-based Contrast Agents","author":"Y Zhang","year":"2016","journal-title":"Radiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.3174\/ajnr.A4378","article-title":"Hyperintense Dentate Nuclei on T1-Weighted MRI: Relation to Repeat Gadolinium Administration","volume":"36","author":"ME Adin","year":"2015","journal-title":"AJNR American journal of neuroradiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2214\/AJR.15.15327","article-title":"Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol","volume":"206","author":"Y Cao","year":"2016","journal-title":"AJR American journal of roentgenology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/RLI.0000000000000242","article-title":"Signal Increase on Unenhanced T1-Weighted Images in the Rat Brain After Repeated, Extended Doses of Gadolinium-Based Contrast Agents: Comparison of Linear and Macrocyclic Agents","volume":"51","author":"G Jost","year":"2016","journal-title":"Investigative radiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1148\/radiol.13131669","article-title":"High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material","volume":"270","author":"T Kanda","year":"2014","journal-title":"Radiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1148\/radiol.2015150872","article-title":"High Signal Intensity in Globus Pallidus and Dentate Nucleus on Unenhanced T1-weighted MR Images: Evaluation of Two Linear Gadolinium-based Contrast Agents","volume":"276","author":"J Ramalho","year":"2015","journal-title":"Radiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3174\/ajnr.A4757","article-title":"T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences","volume":"37","author":"J Ramalho","year":"2016","journal-title":"AJNR American journal of neuroradiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/RLI.0000000000000181","article-title":"T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats: Difference Between Linear and Macrocyclic Agents","volume":"50","author":"P Robert","year":"2015","journal-title":"Investigative radiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/RLI.0000000000000206","article-title":"Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration","volume":"50","author":"LD Weberling","year":"2015","journal-title":"Investigative radiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.15150025","article-title":"Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging","volume":"275","author":"RJ McDonald","year":"2015","journal-title":"Radiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1148\/radiol.14140364","article-title":"High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration","volume":"275","author":"T Kanda","year":"2015","journal-title":"Radiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiol.2015150337","article-title":"Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent","volume":"275","author":"A Radbruch","year":"2015","journal-title":"Radiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/RLI.0000000000000227","article-title":"High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol","volume":"50","author":"A Radbruch","year":"2015","journal-title":"Investigative radiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00330-015-3879-9","article-title":"Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol","volume":"26","author":"DA Stojanov","year":"2016","journal-title":"European radiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00330-015-4019-2","article-title":"What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS?","volume":"26","author":"J Agris","year":"2016","journal-title":"European radiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s00330-015-4020-9","article-title":"Reply to Letter to the Editor re: Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: Correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol","volume":"26","author":"DA Stojanov","year":"2016","journal-title":"European radiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2466\/pr0.1966.19.1.3","article-title":"The intraclass correlation coefficient as a measure of reliability","volume":"19","author":"JJ Bartko","year":"1966","journal-title":"Psychological reports"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jacr.2015.11.009","article-title":"National Institutes of Health Perspective on Reports of Gadolinium Deposition in the Brain","volume":"13","author":"AA Malayeri","year":"2016","journal-title":"Journal of the American College of Radiology: JACR"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3174\/ajnr.A4615","article-title":"Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update","volume":"37","author":"J Ramalho","year":"2016","journal-title":"AJNR American journal of neuroradiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1148\/rg.311105041","article-title":"Differential diagnosis for bilateral abnormalities of the basal ganglia and thalamus","volume":"31","author":"AN Hegde","year":"2011","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1021\/ac504488k","article-title":"Diagnosis of nephrogenic systemic fibrosis by means of elemental bioimaging and speciation analysis","volume":"87","author":"M Birka","year":"2015","journal-title":"Analytical chemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/RLI.0000000000000252","article-title":"Macrocyclic and Other Non-Group 1 Gadolinium Contrast Agents Deposit Low Levels of Gadolinium in Brain and Bone Tissue: Preliminary Results From 9 Patients With Normal Renal Function","volume":"51","author":"N Murata","year":"2016","journal-title":"Investigative radiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:21:05Z","timestamp":1589008865000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183916"}},"subtitle":[],"editor":[{"given":"Tomonori","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183916","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,31]]}}}