{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:54:45Z","timestamp":1790394885677,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["#22390015"],"award-info":[{"award-number":["#22390015"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["#23590082"],"award-info":[{"award-number":["#23590082"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Society for the Promotion Science (JSPS) program on Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation","award":["R2803"],"award-info":[{"award-number":["R2803"]}]},{"name":"Alport Syndrome Foundation (ASF), the Pedersen Family, and the Kidney Foundation of Canada"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183959","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T13:43:18Z","timestamp":1504618998000},"page":"e0183959","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome"],"prefix":"10.1371","volume":"12","author":[{"given":"Tsubasa","family":"Yokota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Omachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Suico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"Kamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Kaseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kuwazuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Shuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"issue":"4514","key":"ref1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.7022654","article-title":"The essential trace elements","volume":"213","author":"W Mertz","year":"1981","journal-title":"Science"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.cell.2014.05.009","article-title":"Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture","volume":"157","author":"AS McCall","year":"2014","journal-title":"Cell"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/nchembio.1038","article-title":"Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis","volume":"8","author":"G Bhave","year":"2012","journal-title":"Nature chemical biology"},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1242\/dev.049189","article-title":"The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration","volume":"137","author":"JR Gotenstein","year":"2010","journal-title":"Development"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrneph.2012.259","article-title":"Alport syndrome\u2014insights from basic and clinical research","volume":"9","author":"J Kruegel","year":"2013","journal-title":"Nature reviews Nephrology"},{"issue":"25","key":"ref6","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1056\/NEJMra022296","article-title":"Alport's syndrome, Goodpasture's syndrome, and type IV collagen","volume":"348","author":"BG Hudson","year":"2003","journal-title":"The New England journal of medicine"},{"issue":"18","key":"ref7","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1113\/jphysiol.2014.274449","article-title":"Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment","volume":"592","author":"J Savige","year":"2014","journal-title":"The Journal of physiology"},{"key":"ref8","article-title":"Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome","author":"D Cosgrove","year":"2016","journal-title":"Matrix biology: journal of the International Society for Matrix Biology"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ki.2009.223","article-title":"Treatment of Alport syndrome: beyond animal models","volume":"76","author":"O Gross","year":"2009","journal-title":"Kidney international"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yebeh.2009.02.030","article-title":"Drug treatment of epilepsy: options and limitations","volume":"15","author":"D Schmidt","year":"2009","journal-title":"Epilepsy & behavior: E&B"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/01.ASN.0000130562.90255.8F","article-title":"Mouse model of X-linked Alport syndrome","volume":"15","author":"MN Rheault","year":"2004","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"e43852","DOI":"10.1371\/journal.pone.0043852","article-title":"Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome","volume":"7","author":"T Koga","year":"2012","journal-title":"PloS one"},{"issue":"38","key":"ref13","doi-asserted-by":"crossref","first-page":"26143","DOI":"10.1074\/jbc.M114.580209","article-title":"The transcription factor MEF\/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism","volume":"289","author":"MA Suico","year":"2014","journal-title":"The Journal of biological chemistry"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.seizure.2014.06.016","article-title":"Epilepsy of infancy with migrating focal seizures: six patients treated with bromide","volume":"23","author":"R Caraballo","year":"2014","journal-title":"Seizure"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/0883073807309771","article-title":"Migrating focal seizures in infancy: analysis of the electroclinical patterns in 17 patients","volume":"23","author":"RH Caraballo","year":"2008","journal-title":"Journal of child neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/jps.2600501014","article-title":"Reduction of tetramine toxicity by sedatives and anticonvulsants","volume":"50","author":"E Voss","year":"1961","journal-title":"Journal of pharmaceutical sciences"},{"key":"ref17","article-title":"Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model","author":"K Omachi","year":"2017","journal-title":"Clinical and experimental nephrology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1681\/ASN.2014111109","article-title":"Podocyte p53 Limits the Severity of Experimental Alport Syndrome","volume":"27","author":"R Fukuda","year":"2016","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"4","key":"ref19","first-page":"1338","article-title":"Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis","volume":"63","author":"KD Rodgers","year":"2003","journal-title":"Kidney international"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/01.mnh.0000133974.24935.fe","article-title":"Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease","volume":"13","author":"T Li","year":"2004","journal-title":"Current opinion in nephrology and hypertension"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/CS20120252","article-title":"Role of the TGF-beta\/BMP-7\/Smad pathways in renal diseases","volume":"124","author":"XM Meng","year":"2013","journal-title":"Clinical science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"20475","DOI":"10.1038\/srep20475","article-title":"MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy","volume":"6","author":"X Bai","year":"2016","journal-title":"Scientific reports"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"e89355","DOI":"10.1371\/journal.pone.0089355","article-title":"Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction","volume":"9","author":"Y Ikeda","year":"2014","journal-title":"PloS one"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00441-011-1275-6","article-title":"Role of TGF-beta in chronic kidney disease: an integration of tubular, glomerular and vascular effects","volume":"347","author":"FJ Lopez-Hernandez","year":"2012","journal-title":"Cell and tissue research"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbadis.2009.06.004","article-title":"TGF-beta and fibrosis in different organs\u2014molecular pathway imprints","volume":"1792","author":"D Pohlers","year":"2009","journal-title":"Biochimica et biophysica acta"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/ndt\/gfk010","article-title":"Bone morphogenic protein-7 and the kidney: current concepts and open questions","volume":"21","author":"M Zeisberg","year":"2006","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"issue":"1\u20134","key":"ref27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0168-583X(01)01122-3","article-title":"Trace elements in renal disease and hemodialysis","volume":"189","author":"Y Miura","year":"2002","journal-title":"Nuclear Inst Meth in Phys Res Sec B: Beam Interactions with Materials and Atoms"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ki.1986.227","article-title":"Trace elements in serum, packed cells, and dialysate of CAPD patients","volume":"30","author":"B Wallaeys","year":"1986","journal-title":"Kidney international"},{"issue":"Suppl 1","key":"ref29","first-page":"S81","article-title":"Metabolism of bromide and its interference with the metabolism of iodine","volume":"53","author":"S Pavelka","year":"2004","journal-title":"Physiological research \/ Academia Scientiarum Bohemoslovaca"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.krcp.2016.02.001","article-title":"Changes in urinary potassium excretion in patients with chronic kidney disease","volume":"35","author":"Y Ueda","year":"2016","journal-title":"Kidney research and clinical practice"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tibs.2014.05.005","article-title":"Peroxidasins: novel players in tissue genesis","volume":"39","author":"Z Peterfi","year":"2014","journal-title":"Trends in biochemical sciences"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2353\/ajpath.2009.080693","article-title":"Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney","volume":"175","author":"Z Peterfi","year":"2009","journal-title":"The American journal of pathology"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S1474-4422(12)70153-9","article-title":"Adverse effects of antiepileptic drugs","volume":"11","author":"P Perucca","year":"2012","journal-title":"The Lancet Neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:20:19Z","timestamp":1540282819000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183959"}},"subtitle":[],"editor":[{"given":"Prasun K.","family":"Datta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183959","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.730774104.793550208","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}