{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:43:16Z","timestamp":1761709396672,"version":"3.37.3"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0183988","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T13:31:59Z","timestamp":1504186319000},"page":"e0183988","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cyclocarya paliurus extract activates insulin signaling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-880X","authenticated-orcid":true,"given":"Hisae","family":"Yoshitomi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Tsuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1210\/jc.2007-0955","article-title":"Low-grade inflammation, obesity, and insulin resistance in adolescents","volume":"92","author":"C Herder","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 5","key":"ref2","first-page":"S1","article-title":"The rising global burden of diabetes and its complications: estimates and projections to the year 2010","volume":"14","author":"AF Amos","year":"1997","journal-title":"Diabet Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00125-002-0974-7","article-title":"Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways","volume":"45","author":"AH Khan","year":"2002","journal-title":"Diabetologia"},{"key":"ref4","first-page":"863","article-title":"Clinical observation on regulation action of Green Qian Willow tea on blood lipid level","volume":"2","author":"MQ Chen","year":"2002","journal-title":"Chin. J. Pract. Chin. Mod. Med"},{"key":"ref5","first-page":"39","article-title":"Study on reducing blood sugar of polysaccharide from Cyclocarya paliurus (Batal.) Iljinsk","volume":"25","author":"L Li","year":"2002","journal-title":"Zhong Yao Cai"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1055\/s-2006-959369","article-title":"Cyclocariosides II and III: two secodammarane triterpenoid saponins from Cyclocarya paliurus","volume":"61","author":"RG Shu","year":"1995","journal-title":"Planta Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1271\/bbb.67.877","article-title":"Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice","volume":"67","author":"H Kurihara","year":"2003","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jep.2013.10.040","article-title":"Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats","volume":"150","author":"Q Wang","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.tiv.2010.06.008","article-title":"Protective potential of trans-resveratrol against 4-hydroxynonenal induced damage in PC12 cells","volume":"24","author":"MA Siddiqui","year":"2010","journal-title":"Toxicol In Vitro"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/mnfr.201200500","article-title":"Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells","volume":"57","author":"I Cordero-Herrera","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/352073a0","article-title":"Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein","volume":"352","author":"XJ Sun","year":"1991","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrd895","article-title":"Protein tyrosine phosphatases 1B inhibitors for diabetes","volume":"1","author":"TO Johnson","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1128\/MCB.17.11.6633","article-title":"Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling","volume":"17","author":"L Rui","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1073\/pnas.051042298","article-title":"A phosphatidylinositol 3-kinase\/Akt\/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1","volume":"10","author":"ON Ozes","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrendo.2009.101","article-title":"SIRT1 and insulin resistance","volume":"5","author":"F Liang","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1093\/jn\/128.12.2319","article-title":"Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice","volume":"128","author":"AM Gray","year":"1998","journal-title":"J Nutr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.lfs.2006.03.007","article-title":"Sennidin stimulates glucose incorporation in rat adipocytes","volume":"79","author":"D Abe","year":"2006","journal-title":"Life Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.phymed.2015.05.058","article-title":"Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation","volume":"22","author":"KN Zhu","year":"2015","journal-title":"Phytomedicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1172\/JCI110399","article-title":"Synergistic interaction between exercise and insulin on peripheral glucose uptake","volume":"68","author":"RA DeFronzo","year":"1981","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"29174","DOI":"10.1074\/jbc.M603274200","article-title":"A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160","volume":"281","author":"G Ramm","year":"2006","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/372746a0","article-title":"Crystal structure of the tyrosine kinase domain of the human insulin receptor","volume":"372","author":"SR Hubbard","year":"1994","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.284.5416.974","article-title":"Discovery of a small molecule insulin mimetic with antidiabetic activity in mice","volume":"284","author":"B Zhang","year":"1999","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jn\/135.2.165","article-title":"Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells","volume":"135","author":"X Liu","year":"2005","journal-title":"J Nutr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"13","author":"AR Saltiel","year":"2001","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0962-8924(01)81297-6","article-title":"Insulin resistance: a phosphorylation-based uncoupling of insulin signaling","volume":"11","author":"Y Zick","year":"2001","journal-title":"Trends Cell Biol"},{"key":"ref26","first-page":"1864","article-title":"Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance","volume":"15","author":"GP Sykiotis","year":"2001","journal-title":"Mol Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"C1071","DOI":"10.1152\/ajpcell.00040.2008","article-title":"Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways","volume":"295","author":"M Jing","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long-standing partnership?","volume":"298","author":"NB Ruderman","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1055\/s-0031-1280411","article-title":"New triterpenoids from the leaves of Cyclocarya paliurus","volume":"78","author":"S Li","year":"2012","journal-title":"Planta Med"},{"key":"ref30","first-page":"558","article-title":"Studies on the triterpenoids of Cyclocarya paliurus (Batal.) Iljinsk","volume":"28","author":"R Shu","year":"2005","journal-title":"Zhong Yao Cai"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0183988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T20:39:43Z","timestamp":1570048783000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0183988"}},"subtitle":[],"editor":[{"given":"Guillermo","family":"L\u00f3pez Lluch","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0183988","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,8,31]]}}}