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Jimenez","year":"2012","journal-title":"Journal of cell science"},{"issue":"2\u20133","key":"ref78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0925-4773(95)00407-R","article-title":"Breathless, a Drosophila FGF receptor homolog, is required for the onset of tracheal cell migration and tracheole formation","volume":"52","author":"M Reichman-Fried","year":"1995","journal-title":"Mechanisms of development"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1242\/dev.117.2.751","article-title":"Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos","volume":"117","author":"E Shishido","year":"1993","journal-title":"Development"},{"issue":"1\u20132","key":"ref80","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(93)80494-F","article-title":"Distinct expression of two Drosophila homologs of fibroblast growth factor receptors in imaginal discs","volume":"332","author":"Y Emori","year":"1993","journal-title":"FEBS letters"},{"issue":"8","key":"ref81","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cub.2004.03.058","article-title":"FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula","volume":"14","author":"T Gryzik","year":"2004","journal-title":"Current biology: CB"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1101\/gad.8.4.428","article-title":"Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration","volume":"8","author":"M Reichman-Fried","year":"1994","journal-title":"Genes & development"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1101\/gad.1166404","article-title":"pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos","volume":"18","author":"A Stathopoulos","year":"2004","journal-title":"Genes & development"},{"issue":"5","key":"ref84","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1242\/dev.027904","article-title":"FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation","volume":"136","author":"S Kadam","year":"2009","journal-title":"Development"},{"issue":"45","key":"ref85","doi-asserted-by":"crossref","first-page":"17937","DOI":"10.1523\/JNEUROSCI.6075-11.2013","article-title":"Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity","volume":"33","author":"B Berke","year":"2013","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"6","key":"ref86","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00702-004-0226-8","article-title":"Transgenic activation of Ras in neurons increases synapse formation in mouse neocortex","volume":"112","author":"G Seeger","year":"2005","journal-title":"J Neural Transm"},{"issue":"3","key":"ref87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1947601911408079","article-title":"RAS Interaction with PI3K: More Than Just Another Effector Pathway","volume":"2","author":"E Castellano","year":"2011","journal-title":"Genes & cancer"},{"issue":"2","key":"ref88","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(00)81168-X","article-title":"rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans","volume":"26","author":"AM Schaefer","year":"2000","journal-title":"Neuron"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/dbio.1999.9282","article-title":"TGF-beta family signal transduction in Drosophila development: from Mad to Smads","volume":"210","author":"LA Raftery","year":"1999","journal-title":"Developmental biology"},{"issue":"5","key":"ref90","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2005.08.010","article-title":"LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor","volume":"47","author":"BA Eaton","year":"2005","journal-title":"Neuron"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1534\/genetics.116.197343","article-title":"Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire","volume":"205","author":"M Borgen","year":"2017","journal-title":"Genetics"},{"issue":"6\u20137","key":"ref92","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ejcb.2010.11.008","article-title":"The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7","volume":"90","author":"W Haeusgen","year":"2011","journal-title":"European journal of cell biology"},{"issue":"11","key":"ref93","doi-asserted-by":"crossref","first-page":"e7709","DOI":"10.1371\/journal.pone.0007709","article-title":"A non-redundant role for Drosophila Mkk4 and hemipterous\/Mkk7 in TAK1-mediated activation of JNK","volume":"4","author":"P Geuking","year":"2009","journal-title":"PloS one"},{"issue":"4","key":"ref94","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1101\/gad.12.4.557","article-title":"puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila","volume":"12","author":"E Martin-Blanco","year":"1998","journal-title":"Genes & development"},{"issue":"1\u20132","key":"ref95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0925-4773(02)00093-X","article-title":"An essential function of AP-1 heterodimers in Drosophila development","volume":"115","author":"L Ciapponi","year":"2002","journal-title":"Mechanisms of development"},{"issue":"4","key":"ref96","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0896-6273(04)00078-9","article-title":"Coordinating synaptic growth without being a nervous wreck","volume":"41","author":"CA Collins","year":"2004","journal-title":"Neuron"},{"issue":"1\u20132","key":"ref97","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molbrainres.2004.07.004","article-title":"Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP","volume":"130","author":"P Gass","year":"2004","journal-title":"Brain research Molecular brain research"},{"issue":"6883","key":"ref98","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/416870a","article-title":"AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila","volume":"416","author":"S Sanyal","year":"2002","journal-title":"Nature"},{"issue":"10","key":"ref99","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.128.10.1845","article-title":"Drosophila puckered regulates Fos\/Jun levels during follicle cell morphogenesis","volume":"128","author":"LL Dobens","year":"2001","journal-title":"Development"},{"issue":"10","key":"ref100","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1073\/pnas.97.10.5351","article-title":"LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator","volume":"97","author":"D Szuts","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1101\/gad.13.1.98","article-title":"The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development","volume":"13","author":"T Brummel","year":"1999","journal-title":"Genes & development"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.devcel.2010.12.002","article-title":"Cooperative regulation of growth by Yorkie and Mad through bantam","volume":"20","author":"H Oh","year":"2011","journal-title":"Developmental cell"},{"issue":"3","key":"ref103","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuron.2012.07.005","article-title":"MicroRNAs shape the neuronal landscape","volume":"75","author":"E McNeill","year":"2012","journal-title":"Neuron"},{"issue":"6159","key":"ref104","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.1243971","article-title":"The Hippo signaling pathway interactome","volume":"342","author":"Y Kwon","year":"2013","journal-title":"Science"},{"issue":"Pt 17","key":"ref105","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1242\/jcs.085902","article-title":"p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors","volume":"124","author":"Y Sekine","year":"2011","journal-title":"Journal of cell science"},{"issue":"6","key":"ref106","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1128\/MCB.18.6.3527","article-title":"A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression","volume":"18","author":"ZS Han","year":"1998","journal-title":"Molecular and cellular biology"},{"issue":"14","key":"ref107","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1038\/emboj.2013.147","article-title":"Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst","volume":"32","author":"RO Teodoro","year":"2013","journal-title":"The EMBO journal"},{"issue":"10","key":"ref108","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1210\/en.2004-0488","article-title":"Cross-talk between phosphatidylinositol 3-kinase\/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets","volume":"145","author":"R Aikin","year":"2004","journal-title":"Endocrinology"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/bs.ctdb.2016.12.001","article-title":"The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease","volume":"123","author":"CM Pfleger","year":"2017","journal-title":"Current topics in developmental biology"},{"issue":"9","key":"ref110","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.celrep.2016.07.066","article-title":"The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular Synapses","volume":"16","author":"C Sakuma","year":"2016","journal-title":"Cell reports"},{"issue":"22","key":"ref111","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1523\/JNEUROSCI.6410-09.2010","article-title":"Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment","volume":"30","author":"D Dumitriu","year":"2010","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"21","key":"ref112","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1016\/j.febslet.2005.06.088","article-title":"The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways","volume":"579","author":"ST Lee-Hoeflich","year":"2005","journal-title":"FEBS letters"},{"issue":"17","key":"ref113","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1242\/dev.02513","article-title":"Dual function of the Drosophila Alk1\/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc","volume":"133","author":"E Bangi","year":"2006","journal-title":"Development"},{"issue":"5","key":"ref114","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.celrep.2014.05.001","article-title":"Intertissue control of the nucleolus via a myokine-dependent longevity pathway","volume":"7","author":"F Demontis","year":"2014","journal-title":"Cell reports"},{"issue":"15","key":"ref115","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1073\/pnas.1319116111","article-title":"Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster","volume":"111","author":"AC Ghosh","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"20","key":"ref116","doi-asserted-by":"crossref","first-page":"16820","DOI":"10.1074\/jbc.M112.342667","article-title":"Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons","volume":"287","author":"K Koles","year":"2012","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref117","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2009.07.051","article-title":"Trans-synaptic transmission of vesicular Wnt signals through Evi\/Wntless","volume":"139","author":"C Korkut","year":"2009","journal-title":"Cell"},{"key":"ref118","article-title":"Wnts contribute to neuromuscular junction formation through distinct signaling pathways","author":"J Messeant","year":"2017","journal-title":"Development"},{"issue":"5","key":"ref119","doi-asserted-by":"crossref","first-page":"e1006062","DOI":"10.1371\/journal.pgen.1006062","article-title":"Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila","volume":"12","author":"W Li","year":"2016","journal-title":"PLoS 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(Review)","volume":"47","author":"HF Zhao","year":"2015","journal-title":"International journal of oncology"},{"issue":"7","key":"ref123","doi-asserted-by":"crossref","first-page":"e42369","DOI":"10.1371\/journal.pone.0042369","article-title":"Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif","volume":"7","author":"RL Gonda","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"ref124","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbrc.2012.01.015","article-title":"The Drosophila DUSP puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress","volume":"418","author":"K Karkali","year":"2012","journal-title":"Biochemical and biophysical research communications"},{"issue":"24","key":"ref125","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1242\/dev.02673","article-title":"The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila","volume":"133","author":"L Parker","year":"2006","journal-title":"Development"},{"issue":"Pt 10","key":"ref126","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1242\/jcs.044339","article-title":"RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC","volume":"122","author":"G Lalli","year":"2009","journal-title":"Journal of cell science"},{"issue":"2","key":"ref127","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.devcel.2007.11.020","article-title":"The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase","volume":"14","author":"H Zhang","year":"2008","journal-title":"Developmental cell"},{"issue":"8","key":"ref128","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cub.2004.04.001","article-title":"Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis","volume":"14","author":"T Awasaki","year":"2004","journal-title":"Current biology: CB"},{"issue":"8","key":"ref129","doi-asserted-by":"crossref","first-page":"e1000184","DOI":"10.1371\/journal.pbio.1000184","article-title":"Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris","volume":"7","author":"Y Fuentes-Medel","year":"2009","journal-title":"PLoS biology"},{"issue":"12","key":"ref130","doi-asserted-by":"crossref","first-page":"e8083","DOI":"10.1371\/journal.pone.0008083","article-title":"How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch","volume":"4","author":"L Marucci","year":"2009","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T17:23:13Z","timestamp":1659460993000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184238"}},"subtitle":[],"editor":[{"given":"Marie-Laure","family":"Parmentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":130,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184238","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,11]]}}}