{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:59:59Z","timestamp":1779292799225,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H02575"],"award-info":[{"award-number":["15H02575"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184395","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:39:43Z","timestamp":1504719583000},"page":"e0184395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Runx1 mediates the development of the granular convoluted tubules in the submandibular glands"],"prefix":"10.1371","volume":"12","author":[{"given":"Hitomi","family":"Ono Minagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiye Esra","family":"Sarper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kurosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh-ichi","family":"Kuremoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Taniuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-4896","authenticated-orcid":true,"given":"Takayoshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1242\/dev.068338","article-title":"Mechanisms of tissue fusion during development","volume":"139","author":"HJ Ray","year":"2012","journal-title":"Development (Cambridge, England)"},{"key":"ref2","first-page":"33","article-title":"Advances in Cancer Research","volume":"Volume 99","author":"Y Ito","year":"2008"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.4049\/jimmunol.132.3.1130","article-title":"Hormonal influence on the secretory immune system of the eye: androgen regulation of secretory component levels in rat tears","volume":"132","author":"DA Sullivan","year":"1984","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1167\/iovs.13-11791","article-title":"Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration","volume":"54","author":"D Voronov","year":"2013","journal-title":"Investigative ophthalmology & visual science"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcb.20664","article-title":"RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region","volume":"97","author":"M Fowler","year":"2006","journal-title":"Journal of cellular biochemistry"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.18632\/oncotarget.2949","article-title":"RUNX1, an androgen- and EZH2-regulated gene, has differential roles in AR-dependent and -independent prostate cancer","volume":"6","author":"K Takayama","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jemt.1070270102","article-title":"The granular convoluted tubule (GCT) cell of rodent submandibular glands","volume":"27","author":"EW Gresik","year":"1994","journal-title":"Microsc Res Tech"},{"key":"ref8","first-page":"115","article-title":"Mophometric studies on the development and sexual dimophism of the submandibular-gland of the mouse","volume":"172","author":"NR Jayasinghe","year":"1990","journal-title":"J Anat"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/00220345750540012601","article-title":"Sexual dimorphism in the rat submandibular gland","volume":"54","author":"WS Mudd BD","year":"1975","journal-title":"Jornal of Dental Resarch"},{"issue":"22","key":"ref10","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"HR Dassule","year":"2000","journal-title":"Development"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1084\/jem.20062456","article-title":"Repression of interleukin-4 in T helper type 1 cells by Runx\/Cbf beta binding to the Il4 silencer","volume":"204","author":"Y Naoe","year":"2007","journal-title":"The Journal of experimental medicine"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1182\/blood-2004-08-3280","article-title":"Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype","volume":"106","author":"JD Growney","year":"2005","journal-title":"Blood"},{"key":"ref13","first-page":"293570","article-title":"Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells","volume":"2015","author":"H Ono","year":"2015","journal-title":"BioMed research international"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5858\/arpa.2014-0167-RA","article-title":"Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors","volume":"139","author":"S Zhu","year":"2015","journal-title":"Archives of pathology & laboratory medicine"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s004280000186","article-title":"Keratin 14 immunoreactive cells in pleomorphic adenomas and adenoid cystic carcinomas of salivary glands","volume":"437","author":"Y Ogawa","year":"2000","journal-title":"Virchows Archiv"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s004280100537","article-title":"A morphogenetic concept of salivary duct regeneration and metaplasia","volume":"440","author":"S Ihrler","year":"2002","journal-title":"Virchows Archiv: an international journal of pathology"},{"issue":"14","key":"ref17","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1016\/S0021-9258(18)34340-0","article-title":"alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs","volume":"257","author":"JE Godine","year":"1982","journal-title":"The Journal of biological chemistry"},{"issue":"8","key":"ref18","first-page":"59","article-title":"Biologically active polypeptides in submandibular glands","volume":"28","author":"B Tibor","year":"1980","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"ref19","first-page":"224","article-title":"Androgen receptors in early and castration resistant prostate cancer: friend or foe?","volume":"12","author":"V Pelekanou","year":"2013","journal-title":"Horm-Int J Endocrinol Metab"},{"issue":"Pt 3","key":"ref20","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/bj3090831","article-title":"Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-3 (CRISP-3) gene","volume":"309","author":"U Schwidetzky","year":"1995","journal-title":"The Biochemical journal"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/bbrc.1999.1828","article-title":"Involvement of vesicle-cytoskeleton interaction in AQP5 trafficking in AQP5-gene-transfected HSG cells","volume":"266","author":"J Tada","year":"1999","journal-title":"Biochemical and biophysical research communications"},{"issue":"1\u20132","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevEukaryotGeneExpr.v14.i12.10","article-title":"Regulatory controls for osteoblast growth and differentiation: Role of Runx\/Cbfa\/AML factors","volume":"14","author":"JB Lian","year":"2004","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/dev.012799","article-title":"Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation","volume":"135","author":"KM Osorio","year":"2008","journal-title":"Development"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/dvdy.24231","article-title":"Runx\/Cbfb Signaling Regulates Postnatal Development of Granular Convoluted Tubule in the Mouse Submandibular Gland","volume":"244","author":"MN Islam","year":"2015","journal-title":"Dev Dyn"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1006\/scdb.2000.0182","article-title":"CBF\u2014A biophysical perspective","volume":"11","author":"JH Bushweller","year":"2000","journal-title":"Seminars in cell & developmental biology"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"SP Humphrey","year":"2001","journal-title":"J Prosthet Dent"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1177\/00220345940730080401","article-title":"Flow rates of resting whole and stimulated parotid saliva in relation to age and gender","volume":"73","author":"RS Percival","year":"1994","journal-title":"Journal of dental research"},{"issue":"2","key":"ref28","first-page":"6","article-title":"Sexual dimorphism of sublingual glands in tree shrews","volume":"24","author":"C Pinkastaff","year":"1980","journal-title":"Basic Appl Histochem"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2108\/zsj.12.243","article-title":"Developmental Pattern of Androgen Receptor Immunoreactivity in the Mouse Submandibular-Gland","volume":"12","author":"K Sawada","year":"1995","journal-title":"Zoological Science"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00424-003-1109-9","article-title":"Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland","volume":"446","author":"T Akamatsu","year":"2003","journal-title":"Pflugers Archiv: European journal of physiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.68.1.425","article-title":"Cellular and molecular biology of the aquaporin water channels","volume":"68","author":"M Borgnia","year":"1999","journal-title":"Annu Rev Biochem"},{"issue":"29","key":"ref32","doi-asserted-by":"crossref","first-page":"20071","DOI":"10.1074\/jbc.274.29.20071","article-title":"Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels","volume":"274","author":"TH Ma","year":"1999","journal-title":"J Biol Chem"},{"issue":"6","key":"ref33","first-page":"1071","article-title":"Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjogren&apos;s syndrome","volume":"32","author":"YT Konttinen","year":"2005","journal-title":"J Rheumatol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/labinvest.3780221","article-title":"Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjogren&apos;s syndrome patients","volume":"81","author":"S Steinfeld","year":"2001","journal-title":"Lab Invest"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3353\/omp.12.115","article-title":"Multifunctional roles of growth factors or biologically active peptides in salivary glands and saliva","volume":"12","author":"M Mori","year":"2008","journal-title":"Oral Medicine & Pathology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0014-4835(03)00202-1","article-title":"Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion","volume":"78","author":"DA Dartt","year":"2004","journal-title":"Experimental Eye Research"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/03009742.2011.580000","article-title":"Failure of oral DHEA treatment to increase local salivary androgen outputs of female patients with Sjogren&apos;s syndrome","volume":"40","author":"P Porola","year":"2011","journal-title":"Scandinavian journal of rheumatology"},{"issue":"11","key":"ref38","first-page":"2413","article-title":"Are women with Sjogren&apos;s syndrome androgen-deficient?","volume":"30","author":"DA Sullivan","year":"2003","journal-title":"The Journal of rheumatology"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/art.22828","article-title":"Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjogren&apos;s syndrome","volume":"56","author":"M Laine","year":"2007","journal-title":"Arthritis and rheumatism"},{"issue":"5","key":"ref40","first-page":"2632","article-title":"Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjogren&apos;s syndrome","volume":"35","author":"EH Sato","year":"1994","journal-title":"Investigative ophthalmology & visual science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:35:54Z","timestamp":1692974154000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184395"}},"subtitle":[],"editor":[{"given":"Diego","family":"Fraidenraich","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184395","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]}}}