{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:37:42Z","timestamp":1764603462802,"version":"3.37.3"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184399","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T17:30:23Z","timestamp":1505323823000},"page":"e0184399","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium"],"prefix":"10.1371","volume":"12","author":[{"given":"Marco","family":"Sbracia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Scarpellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric","family":"Simmilion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eytan R.","family":"Barnea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-0532","authenticated-orcid":true,"given":"Martin","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"LC Giudice","year":"2010","journal-title":"N Engl J Med"},{"issue":"2","key":"ref2","first-page":"93","article-title":"Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation","volume":"3","author":"JA Sampson","year":"1927","journal-title":"Am J Pathol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ogc.2012.10.002","article-title":"Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility","volume":"39","author":"ML Macer","year":"2012","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2015.10.034","article-title":"Estrogen Receptor beta Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis","volume":"163","author":"SJ Han","year":"2015","journal-title":"Cell"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jri.2010.11.004","article-title":"Regulatory T cells and other leukocytes in the pathogenesis of endometriosis","volume":"88","author":"M Berbic","year":"2011","journal-title":"J Reprod Immunol"},{"issue":"5","key":"ref6","first-page":"1621","article-title":"Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells","volume":"82","author":"D Hornung","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.fertnstert.2007.05.075","article-title":"Basal and cytokine-stimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial epithelial and stromal cells","volume":"89","author":"NA Bersinger","year":"2008","journal-title":"Fertil Steril"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00404-010-1520-3","article-title":"Dose-response effect of interleukin (IL)-1beta, tumour necrosis factor (TNF)-alpha, and interferon-gamma on the in vitro production of epithelial neutrophil activating peptide-78 (ENA-78), IL-8, and IL-6 by human endometrial stromal cells","volume":"283","author":"NA Bersinger","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1436","DOI":"10.1038\/cddis.2014.414","article-title":"CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions","volume":"5","author":"MQ Li","year":"2014","journal-title":"Cell Death Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.0105-2896.2006.00421.x","article-title":"Regulatory T-cell physiology and application to treat autoimmunity","volume":"212","author":"Q Tang","year":"2006","journal-title":"Immunol Rev"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1002\/eji.201141532","article-title":"Human tumor-induced and naturally occurring Treg cells differentially affect NK cells activated by either IL-2 or target cells","volume":"41","author":"C Bergmann","year":"2011","journal-title":"Eur J Immunol"},{"issue":"21","key":"ref12","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1158\/1078-0432.CCR-07-1403","article-title":"The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck","volume":"13","author":"L Strauss","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"E928","DOI":"10.1002\/ijc.27613","article-title":"Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrate","volume":"131","author":"W Wang","year":"2012","journal-title":"Int J Cancer"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2889","article-title":"Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases","volume":"10","author":"JH Buckner","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"11\u201312","key":"ref15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1242\/dmm.002535","article-title":"A conditional mouse model for human MUC1-positive endometriosis shows the presence of anti-MUC1 antibodies and Foxp3+ regulatory T cells","volume":"2","author":"RA Budiu","year":"2009","journal-title":"Dis Model Mech"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/humrep\/deq020","article-title":"The role of Foxp3+ regulatory T-cells in endometriosis: a potential controlling mechanism for a complex, chronic immunological condition","volume":"25","author":"M Berbic","year":"2010","journal-title":"Hum Reprod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1477-7827-9-63","article-title":"PreImplantation Factor (PIF) correlates with early mammalian embryo development-bovine and murine models","volume":"9","author":"CW Stamatkin","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1477-7827-11-105","article-title":"PreImplantation factor (PIF) detection in maternal circulation in early pregnancy correlates with live birth (bovine model)","volume":"11","author":"S Ramu","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.imbio.2016.02.004","article-title":"PreImplantation factor (PIF*) regulates systemic immunity and targets protective regulatory and cytoskeleton proteins","volume":"221","author":"ER Barnea","year":"2016","journal-title":"Immunobiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pharmthera.2015.10.008","article-title":"Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult","volume":"156","author":"ER Barnea","year":"2015","journal-title":"Pharmacology & therapeutics"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"313 e1","DOI":"10.1016\/j.ajog.2012.07.017","article-title":"PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells","volume":"207","author":"ER Barnea","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1477-7827-10-50","article-title":"Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-alpha2beta3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua","volume":"10","author":"ER Barnea","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"459 e1","DOI":"10.1016\/j.ajog.2010.03.024","article-title":"A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells","volume":"202","author":"MJ Paidas","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"402 e1","DOI":"10.1016\/j.ajog.2010.06.060","article-title":"Preimplantation factor promotes first trimester trophoblast invasion","volume":"203","author":"CM Duzyj","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1095\/biolreprod.114.119156","article-title":"Preimplantation factor (PIF) promotes human trophoblast invasion","volume":"91","author":"H Moindjie","year":"2014","journal-title":"Biol Reprod"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12020-011-9438-5","article-title":"Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice","volume":"40","author":"L Weiss","year":"2011","journal-title":"Endocrine"},{"issue":"1\u20132","key":"ref27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jns.2011.07.050","article-title":"Preimplantation factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model","volume":"312","author":"L Weiss","year":"2012","journal-title":"J Neurol Sci"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbmt.2012.12.011","article-title":"Preimplantation factor reduces graft-versus-host disease by regulating immune response and lowering oxidative stress (murine model)","volume":"19","author":"Y Azar","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1038\/cdd.2015.55","article-title":"PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling","volume":"22","author":"M Mueller","year":"2015","journal-title":"Cell death and differentiation"},{"issue":"38","key":"ref30","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1073\/pnas.1411674111","article-title":"PreImplantation factor promotes neuroprotection by targeting microRNA let-7","volume":"111","author":"M Mueller","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref31","article-title":"PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies","author":"R Shainer","year":"2016","journal-title":"Oncotarget"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"21834","DOI":"10.18632\/oncotarget.15662","article-title":"PIF* promotes brain re-myelination locally while regulating systemic inflammation- clinically relevant multiple sclerosis M.smegmatis model","volume":"8","author":"G Migliara","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"e0180642","DOI":"10.1371\/journal.pone.0180642","article-title":"Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response","volume":"12","author":"N Di Simone","year":"2017","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ajog.2012.07.017","article-title":"PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells","volume":"207","author":"ER Barnea","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","year":"1997","journal-title":"Fertil Steril"},{"issue":"8","key":"ref36","first-page":"716","article-title":"Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies","volume":"109","author":"KS McCarty Jr.","year":"1985","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.fertnstert.2011.06.039","article-title":"Increased endometrial placenta growth factor (PLGF) gene expression in women with successful implantation","volume":"96","author":"A Santi","year":"2011","journal-title":"Fertil Steril"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1210\/jc.2013-1019","article-title":"Induction of the neurokinin 1 receptor by TNFalpha in endometriotic tissue provides the potential for neurogenic control over endometriotic lesion growth","volume":"98","author":"BD McKinnon","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/S0002-9440(10)63583-3","article-title":"Successful immortalization of endometrial glandular cells with normal structural and functional characteristics","volume":"163","author":"S Kyo","year":"2003","journal-title":"Am J Pathol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/bjc.2012.26","article-title":"Creation of immortalised epithelial cells from ovarian endometrioma","volume":"106","author":"Y Bono","year":"2012","journal-title":"Br J Cancer"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"L Gautier","year":"2004","journal-title":"Bioinformatics"},{"issue":"20","key":"ref42","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1093\/nar\/gni179","article-title":"Evolving gene\/transcript definitions significantly alter the interpretation of GeneChip data","volume":"33","author":"M Dai","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"ME Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1160\/TH15-08-0640","article-title":"PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids","volume":"115","author":"YC Chen","year":"2016","journal-title":"Thromb Haemost"},{"issue":"1\u20132","key":"ref45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jns.2011.07.050","article-title":"Preimplantation factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model","volume":"312","author":"L Weiss","year":"2012","journal-title":"J Neurol Sci"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"S Sakaguchi","year":"2008","journal-title":"Cell"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.fertnstert.2008.04.052","article-title":"Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells","volume":"91","author":"Y Tagashira","year":"2009","journal-title":"Fertil Steril"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/humrep\/des346","article-title":"CD4(+) CD25(+) FOXP3(+) regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis","volume":"28","author":"J Olkowska-Truchanowicz","year":"2013","journal-title":"Hum Reprod"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1933719115594019","article-title":"Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: The Possible Immune Privilege of Ectopic Endometrium","volume":"23","author":"M Sbracia","year":"2016","journal-title":"Reprod Sci"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ni.3345","article-title":"Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces","volume":"17","author":"C Nakahashi-Oda","year":"2016","journal-title":"Nat Immunol"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/molehr\/gaw054","article-title":"TNFalpha-induced IKKbeta complex activation influences epithelial, but not stromal cell survival in endometriosis","volume":"22","author":"V Kocbek","year":"2016","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.rbmo.2011.06.009","article-title":"Preimplantation factor negates embryo toxicity and promotes embryo development in culture","volume":"23","author":"CW Stamatkin","year":"2011","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tem.2014.10.003","article-title":"Inflammation and nerve fiber interaction in endometriotic pain","volume":"26","author":"BD McKinnon","year":"2015","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fertnstert.2011.11.011","article-title":"Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations","volume":"97","author":"B McKinnon","year":"2012","journal-title":"Fertil Steril"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:03:48Z","timestamp":1588971828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184399"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Bob\u00e9","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,13]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184399","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,9,13]]}}}