{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:43:15Z","timestamp":1772901795678,"version":"3.50.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184483","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T17:56:45Z","timestamp":1506621405000},"page":"e0184483","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["A study on the modulation of alpha-synuclein fibrillation by Scutellaria pinnatifida extracts and its neuroprotective properties"],"prefix":"10.1371","volume":"12","author":[{"given":"Mahdyeh","family":"Sashourpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saber","family":"Zahri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayebeh","family":"Radjabian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Pan-Montojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-8772","authenticated-orcid":true,"given":"Dina","family":"Morshedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","article-title":"Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030","volume":"68","author":"E Dorsey","year":"2007","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tins.2007.03.009","article-title":"Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease","volume":"30","author":"D Sulzer","year":"2007","journal-title":"Trends in neurosciences"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1212\/01.wnl.0000183359.50822.f2","article-title":"Progression of motor impairment and disability in Parkinson disease a population-based study","volume":"65","author":"G Alves","year":"2005","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/ar050073t","article-title":"The aggregation and fibrillation of \u03b1-synuclein","volume":"39","author":"AL Fink","year":"2006","journal-title":"Accounts of chemical research"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000","article-title":"Synucleins are developmentally expressed, and \u03b1-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons","volume":"20","author":"DD Murphy","year":"2000","journal-title":"The Journal of Neuroscience"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1021\/bi961799n","article-title":"NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded","volume":"35","author":"PH Weinreb","year":"1996","journal-title":"Biochemistry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1046\/j.1471-4159.2001.00408.x","article-title":"Identification of the region of non\u2010A\u03b2 component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity","volume":"78","author":"AM Bodles","year":"2001","journal-title":"Journal of neurochemistry"},{"key":"ref8","article-title":"Extensive uptake of alpha-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage","author":"V Lindstrom","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"ref9","article-title":"alpha-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production","author":"S Paillusson","year":"2017","journal-title":"Acta Neuropathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2174\/138920371608150828114357","article-title":"Hot, Hotter, and Hottest Trends in alpha-Synuclein Research","volume":"16","author":"VN Uversky","year":"2015","journal-title":"Curr Protein Pept Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.expneurol.2009.03.006","article-title":"Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease","volume":"218","author":"H B\u00fceler","year":"2009","journal-title":"Experimental neurology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson\u2019s disease: focus on astrocytes","volume":"49","author":"R Niranjan","year":"2014","journal-title":"Molecular neurobiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jmb.2008.08.039","article-title":"Structural characteristics of \u03b1-synuclein oligomers stabilized by the flavonoid baicalein","volume":"383","author":"D-P Hong","year":"2008","journal-title":"Journal of molecular biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/cbic.201000604","article-title":"Baicalein Inhibits Formation of \u03b1\u2010Synuclein Oligomers within Living Cells and Prevents A\u03b2 Peptide Fibrillation and Oligomerisation","volume":"12","author":"JH Lu","year":"2011","journal-title":"Chembiochem"},{"key":"ref15","article-title":"Effects of various flavonoids on the-synuclein fibrillation process","volume":"2010","author":"X Meng","year":"2010","journal-title":"Parkinson\u2019s Disease"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.1021\/bi900506b","article-title":"Molecular mechanisms underlying the flavonoid-induced inhibition of \u03b1-synuclein fibrillation","volume":"48","author":"X Meng","year":"2009","journal-title":"Biochemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1073\/pnas.0910723107","article-title":"EGCG remodels mature \u03b1-synuclein and amyloid-\u03b2 fibrils and reduces cellular toxicity","volume":"107","author":"J Bieschke","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1021\/ja3115696","article-title":"Toward the molecular mechanism (s) by which EGCG treatment remodels mature amyloid fibrils","volume":"135","author":"FL Palhano","year":"2013","journal-title":"Journal of the American Chemical Society"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bbadis.2016.07.008","article-title":"Baicalein inhibits \u03b1-synuclein oligomer formation and prevents progression of \u03b1-synuclein accumulation in a rotenone mouse model of Parkinson's disease","volume":"1862","author":"Q Hu","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1471-4159.2001.00490.x","article-title":"Green tea polyphenol (\u2013)\u2010epigallocatechin\u20103\u2010gallate prevents N\u2010methyl\u20104\u2010phenyl\u20101, 2, 3, 6\u2010tetrahydropyridine\u2010induced dopaminergic neurodegeneration","volume":"78","author":"Y Levites","year":"2001","journal-title":"Journal of neurochemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"C28","DOI":"10.1111\/j.1750-3841.2009.01401.x","article-title":"Total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants","volume":"75","author":"R Mustafa","year":"2010","journal-title":"Journal of food science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1271\/bbb.50698","article-title":"Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI","volume":"70","author":"W-H Huang","year":"2006","journal-title":"Bioscience, biotechnology, and biochemistry"},{"key":"ref23","first-page":"2861","article-title":"Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin","volume":"20","author":"D-e Shieh","year":"1999","journal-title":"Anticancer Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000085383","article-title":"Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids","volume":"14","author":"K Suk","year":"2004","journal-title":"Neuro-Signals"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.it.2008.05.002","article-title":"Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression","volume":"29","author":"H-M Gao","year":"2008","journal-title":"Trends in immunology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/BF02975846","article-title":"Neuroprotective effect of wogonin: potential roles of inflammatory cytokines","volume":"27","author":"HZ Piao","year":"2004","journal-title":"Archives of pharmacal research"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0006-2952(00)00255-0","article-title":"roxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-\u03baB activation","volume":"59","author":"Y-C Chen","year":"2000","journal-title":"Biochemical Pharmacology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.mad.2006.05.002","article-title":"Short-term feeding of baicalin inhibits age-associated NF-\u03baB activation","volume":"127","author":"DH Kim","year":"2006","journal-title":"Mechanisms of ageing and development"},{"key":"ref29","author":"KC Huang","year":"2010"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.etap.2014.12.002","article-title":"Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines","volume":"39","author":"M Boozari","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref31","first-page":"55","article-title":"Antioxidative Activity of Sixty Plants from Iran","volume":"3","author":"E Souria","year":"2004","journal-title":"Iranian Journal of Pharmaceutical Research"},{"issue":"4","key":"ref32","first-page":"304","article-title":"Assessment of free-radical-scavenging and antibacterial activities, and brine shrimp toxicity of Scutellaria pinnatifida","volume":"10","author":"S Sauvage","year":"2010","journal-title":"Oriental Pharmacy and Experimental Medicine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pep.2005.02.014","article-title":"A new method for purification of recombinant human alpha-synuclein in Escherichia coli","volume":"42","author":"C Huang","year":"2005","journal-title":"Protein Expr Purif"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbrc.2011.06.135","article-title":"Single particle analysis of tau oligomer formation induced by metal ions and organic solvents","volume":"411","author":"B Bader","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ymeth.2004.03.012","article-title":"Techniques to study amyloid fibril formation in vitro","volume":"34","year":"2004","journal-title":"Methods"},{"key":"ref36","author":"DM Jameson","year":"2014"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0308-8146(02)00423-5","article-title":"Antioxidant capacity of phenolic phytochemicals from various cultivars of plums","volume":"81","author":"D-O Kim","year":"2003","journal-title":"Food chemistry"},{"key":"ref38","first-page":"315","article-title":"Teneurs en principaux flavonoids des fleurs de Crataegeus monogyna Jacq et de Crataegeus laevigata (Poiret D.C.) en fonction de la vegetation","volume":"65","author":"J.L.C. CA Lamaison","year":"1990","journal-title":"Pharm Acta Helv"},{"key":"ref39","first-page":"543","article-title":"TLC determination of flavonoids from different cultivars of Allium cepa and Allium ascalonicum","volume":"66","author":"L Pob\u0142ocka-Olech","year":"2016"},{"key":"ref40","unstructured":"Krenna L, Mironb A, Pempa E, Petra U, Koppb B (2003) Flavonoids from Achillea nobilis L."},{"key":"ref41","article-title":"Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival","author":"Y Toyoda","year":"2014","journal-title":"Biology open"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0022-1759(89)90397-9","article-title":"Re-examination and further development of a precise and rapid dye method for measuring cell growth\/cell kill","volume":"119","author":"MB Hansen","year":"1989","journal-title":"Journal of immunological methods"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.18388\/abp.2006_3366","article-title":"Congo red interaction with \u03b1-proteins","volume":"53","author":"J Sereikaite","year":"2006","journal-title":"Acta Biochimica Polonica"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1021\/acs.langmuir.6b02935","article-title":"Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit \u03b1-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects","volume":"32","author":"N Taebnia","year":"2016","journal-title":"Langmuir"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuint.2016.10.001","article-title":"Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease","volume":"101","author":"N Bhattacharjee","year":"2016","journal-title":"Neurochemistry International"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpba.2010.04.002","article-title":"Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography\u2013tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria\u2013coptis herb couple","volume":"53","author":"J Feng","year":"2010","journal-title":"Journal of pharmaceutical and biomedical analysis"},{"key":"ref47","first-page":"553","article-title":"Growth inhibition and apoptosis induction of Scutellaria luteo-coerulea Bornm. & Sint. on leukemia cancer cell lines K562 and HL-60","volume":"5","author":"M Motaez","year":"2015","journal-title":"Avicenna journal of phytomedicine"},{"key":"ref48","first-page":"215","article-title":"Biological Activity and Phytochemical Study of Scutellaria platystegia","volume":"14","author":"A Delazar","year":"2015","journal-title":"Iranian journal of pharmaceutical research: IJPR"},{"key":"ref49","author":"A Ghahreman","year":"1999"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/biom5020282","article-title":"Seeking a mechanism for the toxicity of oligomeric \u03b1-synuclein","volume":"5","author":"HL Roberts","year":"2015","journal-title":"Biomolecules"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1126\/science.1079469","article-title":"Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis","volume":"300","author":"R Kayed","year":"2003","journal-title":"Science"},{"key":"ref52","author":"I Smallwood","year":"2012"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Meng X, Munishkina LA, Fink AL, Uversky VN (2010) Effects of Various Flavonoids on the Parkinson's disease 2010.","DOI":"10.4061\/2010\/650794"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/bi0600749","article-title":"Small molecule inhibitors of \u03b1-synuclein filament assembly","volume":"45","author":"M Masuda","year":"2006","journal-title":"Biochemistry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"B Uttara","year":"2009","journal-title":"Current neuropharmacology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0028-3908(01)00019-3","article-title":"Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier","volume":"40","author":"Y Gilgun-Sherki","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref57","first-page":"165","article-title":"Antioxidants in therapy and preventive medicine","author":"W Bors","year":"1990"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.2000.80.1.315","article-title":"Mitochondria and neuronal survival","volume":"80","author":"DG Nicholls","year":"2000","journal-title":"Physiological reviews"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In vivo demonstration that \u03b1-synuclein oligomers are toxic","volume":"108","author":"B Winner","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref60","first-page":"102","article-title":"Phytochemical investigation on Scutellaria pinnatifida roots","volume":"4","author":"A AJ Mohammadi","year":"2012","journal-title":"Natural Products & Medicinal Plants Suplemntry"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.etap.2014.12.002","article-title":"Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines","volume":"39","author":"M Boozari","year":"2015","journal-title":"Environmental toxicology and pharmacology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0006-8993(03)03197-4","article-title":"Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate-and glucose deprivation-induced neuronal death","volume":"986","author":"H-H Lee","year":"2003","journal-title":"Brain research"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1527-3458.2005.tb00266.x","article-title":"Therapeutic potential of wogonin: a naturally occurring flavonoid","volume":"11","author":"MC Tai","year":"2005","journal-title":"CNS drug reviews"},{"key":"ref64","first-page":"419","article-title":"Anticancer properties of Scutellaria baicalensis root in aspect of innate immunity regulation","volume":"19","author":"L Lamer-Zarawska","year":"2010","journal-title":"Adv Clin Exp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:58:10Z","timestamp":1719482290000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184483"}},"subtitle":[],"editor":[{"given":"Reza","family":"Khodarahmi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":64,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184483","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}