{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:10Z","timestamp":1762459510593,"version":"3.37.3"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["UAMS#271G141616-01"],"award-info":[{"award-number":["UAMS#271G141616-01"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH-NIDDK","award":["R56DK076735"],"award-info":[{"award-number":["R56DK076735"]}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1TR000039"],"award-info":[{"award-number":["UL1TR000039"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184499","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T17:39:31Z","timestamp":1505237971000},"page":"e0184499","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver myofibroblasts of murine origins express mesothelin: Identification of novel rat mesothelin splice variants*"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-9360","authenticated-orcid":true,"given":"Michel","family":"Fausther","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"G. Lavoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Dranoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"YA Lee","year":"2015","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.28948","article-title":"The origin of fibrogenic myofibroblasts in fibrotic liver","volume":"65","author":"T Kisseleva","year":"2017","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.20427","article-title":"A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations","volume":"40","author":"ST Magness","year":"2004","journal-title":"Hepatology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"NC Henderson","year":"2013","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"I Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"K Iwaisako","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jhep.2016.01.010","article-title":"Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers","volume":"64","author":"I Lua","year":"2016","journal-title":"J Hepatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e0121161","DOI":"10.1371\/journal.pone.0121161","article-title":"Establishment and characterization of rat portal myofibroblast cell lines","volume":"10","author":"M Fausther","year":"2015","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1172\/JCI88845","article-title":"Mesothelin\/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis","volume":"127","author":"Y Koyama","year":"2017","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1158\/0008-5472.CAN-14-0337","article-title":"Discovery of mesothelin and exploiting it as a target for immunotherapy","volume":"74","author":"I Pastan","year":"2014","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1200\/JCO.2016.68.3672","article-title":"Mesothelin Immunotherapy for Cancer: Ready for Prime Time?","volume":"34","author":"R Hassan","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.7150\/jca.1.141","article-title":"Mesothelin as a potential therapeutic target in human cholangiocarcinoma","volume":"1","author":"L Yu","year":"2010","journal-title":"J Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.9738\/INTSURG-D-13-00001.1","article-title":"Mesothelin expression is a prognostic factor in cholangiocellular carcinoma","volume":"98","author":"R Nomura","year":"2013","journal-title":"Int Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4291\/wjgp.v7.i2.218","article-title":"Clinical impacts of mesothelin expression in gastrointestinal carcinomas","volume":"7","author":"T Einama","year":"2016","journal-title":"World J Gastrointest Pathophysiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2174\/1871520611313020014","article-title":"The role of mesothelin in tumor progression and targeted therapy","volume":"13","author":"Z Tang","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9055","DOI":"10.1158\/0008-5472.CAN-07-0474","article-title":"High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif","volume":"67","author":"T Hucl","year":"2007","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-213X-3-2","article-title":"Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells","volume":"3","author":"MG Prieve","year":"2003","journal-title":"BMC Dev Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/MCB.20.8.2902-2906.2000","article-title":"Mesothelin is not required for normal mouse development or reproduction","volume":"20","author":"TK Bera","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1158\/2326-6066.CIR-16-0330","article-title":"Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity","volume":"5","author":"Y Leshem","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"G904","DOI":"10.1152\/ajpgi.00015.2012","article-title":"Activated hepatic stellate cells upregulate transcription of ecto-5'-nucleotidase\/CD73 via specific SP1 and SMAD promoter elements","volume":"303","author":"M Fausther","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0022-2275(20)32030-7","article-title":"An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro","volume":"41","author":"S Vogel","year":"2000","journal-title":"J Lipid Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e56116","DOI":"10.1371\/journal.pone.0056116","article-title":"Overexpression of endoglin modulates TGF-beta1-signalling pathways in a novel immortalized mouse hepatic stellate cell line","volume":"8","author":"SK Meurer","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/hep.22697","article-title":"Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses","volume":"49","author":"J Guo","year":"2009","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/hep.22088","article-title":"A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines","volume":"47","author":"AE Sirica","year":"2008","journal-title":"Hepatology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"W597","DOI":"10.1093\/nar\/gks400","article-title":"ExPASy: SIB bioinformatics resource portal","volume":"40","author":"P Artimo","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"W580","DOI":"10.1093\/nar\/gkv279","article-title":"The EMBL-EBI bioinformatics web and programmatic tools framework","volume":"43","author":"W Li","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/protein\/gzh013","article-title":"Prediction of proprotein convertase cleavage sites","volume":"17","author":"P Duckert","year":"2004","journal-title":"Protein Eng Des Sel"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nsmb.1550","article-title":"Nonsense-mediated mRNA decay (NMD) mechanisms","volume":"16","author":"S Brogna","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11694","DOI":"10.18632\/oncotarget.3429","article-title":"High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis","volume":"6","author":"A Thomas","year":"2015","journal-title":"Oncotarget"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1158\/1078-0432.CCR-06-2161","article-title":"Mesothelin expression in human lung cancer","volume":"13","author":"M Ho","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3892\/ijo.2012.1662","article-title":"Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer","volume":"41","author":"F Kawamata","year":"2012","journal-title":"Int J Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"21984","DOI":"10.1074\/jbc.270.37.21984","article-title":"Molecular cloning and expression of megakaryocyte potentiating factor cDNA","volume":"270","author":"T Kojima","year":"1995","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1073\/pnas.93.1.136","article-title":"Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers","volume":"93","author":"K Chang","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1073\/pnas.96.20.11531","article-title":"Soluble member(s) of the mesothelin\/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma","volume":"96","author":"N Scholler","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e104388","DOI":"10.1371\/journal.pone.0104388","article-title":"Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice","volume":"9","author":"J Zhang","year":"2014","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T18:59:22Z","timestamp":1659466762000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184499"}},"subtitle":[],"editor":[{"given":"Heather","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184499","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}