{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:31:26Z","timestamp":1790422286885,"version":"4.1.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0034\/0007"],"award-info":[{"award-number":["RD12\/0034\/0007"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0008\/0012"],"award-info":[{"award-number":["RD16\/0008\/0012"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184569","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T18:02:58Z","timestamp":1504893778000},"page":"e0184569","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["A new approach to keratoconus detection based on corneal morphogeometric analysis"],"prefix":"10.1371","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-0688","authenticated-orcid":true,"given":"Francisco","family":"Cavas-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Fern\u00e1ndez-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J. F.","family":"Ca\u00f1avate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Ali\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jcrs.2010.10.046","article-title":"Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics","volume":"37","author":"JL Alio","year":"2011","journal-title":"Journal of cataract and refractive surgery"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jcrs.2012.10.022","article-title":"Characterization of corneal structure in keratoconus","volume":"38","author":"DP Pinero","year":"2012","journal-title":"Journal of cataract and refractive surgery"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"YS Rabinowitz","year":"1998","journal-title":"Survey of ophthalmology"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s00417-013-2261-3","article-title":"Comparative analysis of the relationship between anterior and posterior corneal shape analyzed by Scheimpflug photography in normal and keratoconus eyes","volume":"251","author":"R Montalb\u00e1n","year":"2013","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0161-6420(00)00159-7","article-title":"Changes in anterior and posterior corneal curvatures in keratoconus","volume":"107","author":"A Tomidokoro","year":"2000","journal-title":"Ophthalmology"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.ophtha.2008.02.020","article-title":"Sensitivity and specificity of posterior corneal elevation measured by Pentacam in discriminating keratoconus\/subclinical keratoconus","volume":"115","author":"U de Sanctis","year":"2008","journal-title":"Ophthalmology"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/2008-322X.156085","article-title":"Sensitivity and specificity of posterior and anterior corneal elevation measured by orbscan in diagnosis of clinical and subclinical keratoconus","volume":"10","author":"MR Jafarinasab","year":"2015","journal-title":"Journal of ophthalmic & vision research"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/OPX.0b013e3182843f2a","article-title":"Screening subclinical keratoconus with placido-based corneal indices","volume":"90","author":"D Ramos-Lopez","year":"2013","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"920","DOI":"10.5301\/ejo.5000184","article-title":"Corneal biomechanical properties and anterior segment parameters in forme fruste keratoconus","volume":"22","author":"V Kozobolis","year":"2012","journal-title":"European journal of ophthalmology"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/eye.2011.365","article-title":"A new, pachymetry-based approach for diagnostic cutoffs for normal, suspect and keratoconic cornea","volume":"26","author":"G Prakash","year":"2012","journal-title":"Eye (London, England)"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/OPX.0b013e318249d727","article-title":"Aberrations and topography in normal, keratoconus-suspect, and keratoconic eyes","volume":"89","author":"A Gordon-Shaag","year":"2012","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.jcrs.2011.06.029","article-title":"Early biomechanical keratoconus pattern measured with an ocular response analyzer: curve analysis","volume":"37","author":"D Touboul","year":"2011","journal-title":"Journal of cataract and refractive surgery"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.jcrs.2010.12.049","article-title":"Evaluation of Scheimpflug imaging parameters in subclinical keratoconus, keratoconus, and normal eyes","volume":"37","author":"OO Ucakhan","year":"2011","journal-title":"Journal of cataract and refractive surgery"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jcrs.2009.11.012","article-title":"Corneal volume, pachymetry, and correlation of anterior and posterior corneal shape in subclinical and different stages of clinical keratoconus","volume":"36","author":"DP Pinero","year":"2010","journal-title":"Journal of cataract and refractive surgery"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/ICO.0b013e3182904950","article-title":"Correlation of anterior and posterior corneal shape in keratoconus","volume":"32","author":"R Montalban","year":"2013","journal-title":"Cornea"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"e110249","DOI":"10.1371\/journal.pone.0110249","article-title":"Geometrical Custom Modeling of Human Cornea In Vivo and Its Use for the Diagnosis of Corneal Ectasia","volume":"9","author":"F Cavas-Mart\u00ednez","year":"2014","journal-title":". PLOS ONE"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jcrs.2012.10.033","article-title":"Intrasubject repeatability in keratoconus-eye measurements obtained with a new Scheimpflug photography-based system","volume":"39","author":"R Montalban","year":"2013","journal-title":"Journal of cataract and refractive surgery"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.ophtha.2012.06.005","article-title":"Use of a support vector machine for keratoconus and subclinical keratoconus detection by topographic and tomographic data","volume":"119","author":"MC Arbelaez","year":"2012","journal-title":"Ophthalmology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6392472","DOI":"10.1155\/2016\/6392472","article-title":"Rotating Scheimpflug Imaging Indices in Different Grades of Keratoconus","volume":"2016","author":"SS Wahba","year":"2016","journal-title":"Journal of ophthalmology"},{"issue":"4","key":"ref20","first-page":"714","article-title":"Topographic characteristics of keratoconus among a sample of Jordanian patients","volume":"7","author":"MA Abu Ameerh","year":"2014","journal-title":"International journal of ophthalmology"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0886-3350(99)00355-7","article-title":"Keratoconus evaluation using the Orbscan Topography System","volume":"26","author":"GU Auffarth","year":"2000","journal-title":"Journal of cataract and refractive surgery"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/opo.12179","article-title":"Peripheral nasal-temporal corneal asymmetry in relation to corneal thickness: a Scheimpflug imaging study","volume":"35","author":"S Jonuscheit","year":"2015","journal-title":"Ophthalmic & physiological optics: the journal of the British College of Ophthalmic Opticians (Optometrists)"},{"issue":"3","key":"ref23","first-page":"203","article-title":"Investigation of the Efficacy of the Cone Location and Magnitude Index in the Diagnosis of Keratoconus","volume":"31","author":"SI Kocamis","year":"2016","journal-title":"Seminars in ophthalmology"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1111\/aos.12590","article-title":"Correlation of the KISA% index and Scheimpflug tomography in 'normal', 'subclinical', 'keratoconus-suspect' and 'clinically manifest' keratoconus eyes","volume":"93","author":"J Steinberg","year":"2015","journal-title":"Acta ophthalmologica"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajo.2014.03.018","article-title":"Pentacam Scheimpflug tomography findings in topographically normal patients and subclinical keratoconus cases","volume":"158","author":"PR Ruisenor Vazquez","year":"2014","journal-title":"American journal of ophthalmology"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ajo.2013.07.018","article-title":"Expanding the cone location and magnitude index to include corneal thickness and posterior surface information for the detection of keratoconus","volume":"156","author":"AM Mahmoud","year":"2013","journal-title":"American journal of ophthalmology"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5005\/jp-journals-10025-1019","article-title":"Validation of a New Scoring System for the Detection of Early Forme of Keratoconus","volume":"1","author":"A Saad","year":"2012","journal-title":"International Journal of Keratoconus and Ectatic Corneal Diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:47:27Z","timestamp":1589003247000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184569"}},"subtitle":[],"editor":[{"given":"Michele","family":"Madigan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184569","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,8]]}}}