{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:57:39Z","timestamp":1790881059463,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFA0101002"],"award-info":[{"award-number":["2016YFA0101002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170736, 81570715"],"award-info":[{"award-number":["81170736, 81570715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation for Young Scholars of China","award":["81300649"],"award-info":[{"award-number":["81300649"]}]},{"name":"China Scholarship Council Foundation","award":["201308110443"],"award-info":[{"award-number":["201308110443"]}]},{"name":"PUMC Youth Fund","award":["33320140022"],"award-info":[{"award-number":["33320140022"]}]},{"name":"China Diabetes Young Scientific Talent Research Funding"},{"name":"Diabetes Research Fund from Clinical Research of Chinese Medical Association and Chinese Diabetes Society","award":["12030500350"],"award-info":[{"award-number":["12030500350"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Scientific Activities Foundation for Selected Returned Overseas Professional of Human Resources and Social Security Ministry"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184735","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T17:34:28Z","timestamp":1508175268000},"page":"e0184735","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":97,"title":["Vildagliptin increases butyrate-producing bacteria in the gut of diabetic rats"],"prefix":"10.1371","volume":"12","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-7766","authenticated-orcid":true,"given":"Xinhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12944-016-0278-4","article-title":"The role of Gut Microbiota in the development of obesity and Diabetes","volume":"15","author":"OA Baothman","year":"2016","journal-title":"Lipids Health Dis"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11154-015-9309-0","article-title":"The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity","volume":"16","author":"N Tai","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/MCO.0b013e328348c06d","article-title":"Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?","volume":"14","author":"E Esteve","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.molmet.2016.10.001","article-title":"Dietary fat and gut microbiota interactions determine diet-induced obesity in mice","volume":"5","author":"R Kubeck","year":"2016","journal-title":"Mol Metab"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"A123","DOI":"10.1289\/ehp.120-a123a","article-title":"Gut check: do interactions between environmental chemicals and intestinal microbiota affect obesity and diabetes?","volume":"120","author":"W Holtcamp","year":"2012","journal-title":"Environ Health Perspect"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"6ra14","DOI":"10.1126\/scitranslmed.3000322","article-title":"The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice","volume":"1","author":"PJ Turnbaugh","year":"2009","journal-title":"Sci Transl Med"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1096\/fj.10-164921","article-title":"Germ-free C57BL\/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism","volume":"24","author":"S Rabot","year":"2010","journal-title":"FASEB J"},{"issue":"7122","key":"ref8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"PJ Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"31","key":"ref9","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"RE Ley","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/gmic.19625","article-title":"Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity","volume":"3","author":"PD Cani","year":"2012","journal-title":"Gut Microbes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"I Kimura","year":"2013","journal-title":"Nat Commun"},{"issue":"13","key":"ref12","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/138161209788168164","article-title":"The role of the gut microbiota in energy metabolism and metabolic disease","volume":"15","author":"PD Cani","year":"2009","journal-title":"Curr Pharm Des"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.diabres.2016.06.014","article-title":"Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"118","author":"S Samah","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"issue":"7","key":"ref14","first-page":"639","article-title":"Incretin agents in type 2 diabetes","volume":"56","author":"SA Ross","year":"2010","journal-title":"Can Fam Physician"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.phrs.2016.12.003","article-title":"A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?","volume":"117","author":"K Maniar","year":"2017","journal-title":"Pharmacol Res"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"890","DOI":"10.2337\/dc06-1732","article-title":"Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin","volume":"30","author":"E Bosi","year":"2007","journal-title":"Diabetes Care"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101767","article-title":"Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways","volume":"17","author":"Q Zhang","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"RC Edgar","year":"2013","journal-title":"Nat Methods"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data.","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nat Methods"},{"issue":"16","key":"ref20","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"TZ DeSantis","year":"2006","journal-title":"Appl Environ Microbiol"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"C Lozupone","year":"2005","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"N Segata","year":"2011","journal-title":"Genome Biol"},{"issue":"7464","key":"ref24","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"E Le Chatelier","year":"2013","journal-title":"Nature"},{"issue":"7464","key":"ref25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"A Cotillard","year":"2013","journal-title":"Nature"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"e42529","DOI":"10.1371\/journal.pone.0042529","article-title":"Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats","volume":"7","author":"X Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"19","key":"ref27","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1128\/AEM.01357-14","article-title":"Effect of metformin on metabolic improvement and gut microbiota","volume":"80","author":"H Lee","year":"2014","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1053\/j.gastro.2009.08.042","article-title":"High-fat diet determines the composition of the murine gut microbiome independently of obesity","volume":"137","author":"MA Hildebrandt","year":"2009","journal-title":"Gastroenterology"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/gut.2010.215665","article-title":"Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models","volume":"59","author":"EF Murphy","year":"2010","journal-title":"Gut"},{"issue":"43","key":"ref30","doi-asserted-by":"crossref","first-page":"16767","DOI":"10.1073\/pnas.0808567105","article-title":"Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41","volume":"105","author":"BS Samuel","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/BJN19960026","article-title":"Fate of fructo-oligosaccharides in the human intestine","volume":"76","author":"MS Alles","year":"1996","journal-title":"Br J Nutr"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004836-200603000-00015","article-title":"Colonic health: fermentation and short chain fatty acids","volume":"40","author":"JM Wong","year":"2006","journal-title":"J Clin Gastroenterol"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1023\/A:1018819032620","article-title":"Systemic short-chain fatty acids rapidly alter gastrointestinal structure, function, and expression of early response genes","volume":"43","author":"KA Tappenden","year":"1998","journal-title":"Dig Dis Sci"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ajcn\/68.1.118","article-title":"Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats","volume":"68","author":"KA Tappenden","year":"1998","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"PD Cani","year":"2008","journal-title":"Diabetes"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"PD Cani","year":"2009","journal-title":"Gut"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"e71108","DOI":"10.1371\/journal.pone.0071108","article-title":"Human gut microbiota changes reveal the progression of glucose intolerance","volume":"8","author":"X Zhang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00284-010-9582-9","article-title":"Molecular characterisation of the faecal microbiota in patients with type II diabetes","volume":"61","author":"X Wu","year":"2010","journal-title":"Curr Microbiol"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40168-016-0189-7","article-title":"Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions","volume":"4","author":"M Estaki","year":"2016","journal-title":"Microbiome"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"14405","DOI":"10.1038\/srep14405","article-title":"Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats","volume":"5","author":"X Zhang","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1017\/S0007114516001045","article-title":"Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet","volume":"116","author":"M Candela","year":"2016","journal-title":"Br J Nutr"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"e25792","DOI":"10.1371\/journal.pone.0025792","article-title":"Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes","volume":"6","author":"CT Brown","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.2337\/db10-0253","article-title":"Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers","volume":"59","author":"JP Furet","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/hep.26319","article-title":"Intestinal microbiota in patients with nonalcoholic fatty liver disease","volume":"58","author":"M Mouzaki","year":"2013","journal-title":"Hepatology"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/09637486.2016.1197185","article-title":"Effects of bitter melon (Momordica charantia L.) on the gut microbiota in high fat diet and low dose streptozocin-induced rats","volume":"67","author":"Y Zhu","year":"2016","journal-title":"Int J Food Sci Nutr"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"e34233","DOI":"10.1371\/journal.pone.0034233","article-title":"Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice","volume":"7","author":"YY Lam","year":"2012","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"30887","DOI":"10.1038\/srep30887","article-title":"Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice","volume":"6","author":"MJ Jung","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1128\/JCM.38.2.931-934.2000","article-title":"Bacteremia caused by a strain of Desulfovibrio related to the provisionally named Desulfovibrio fairfieldensis","volume":"38","author":"J Loubinoux","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ref49","first-page":"991","article-title":"Desulfovibrio desulfuricans lipopolysaccharides induce endothelial cell IL-6 and IL-8 secretion and E-selectin and VCAM-1 expression","volume":"8","author":"L Weglarz","year":"2003","journal-title":"Cell Mol Biol Lett"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1093\/ajcn\/30.11.1770","article-title":"Sulfate-reducing anaerobic bacteria in human feces","volume":"30","author":"H Beerens","year":"1977","journal-title":"Am J Clin Nutr"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7489","DOI":"10.1038\/ncomms8489","article-title":"Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota","volume":"6","author":"CJ Chang","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ismej.2009.112","article-title":"Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice","volume":"4","author":"C Zhang","year":"2010","journal-title":"ISME J"},{"issue":"15","key":"ref53","doi-asserted-by":"crossref","first-page":"19355","DOI":"10.18632\/oncotarget.8466","article-title":"Distinctly altered gut microbiota in the progression of liver disease","volume":"7","author":"G Xie","year":"2016","journal-title":"Oncotarget"},{"issue":"7484","key":"ref54","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"LA David","year":"2014","journal-title":"Nature"},{"issue":"7405","key":"ref55","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"S Devkota","year":"2012","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:16:47Z","timestamp":1603153007000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184735"}},"subtitle":[],"editor":[{"given":"Jonathan M.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,16]]},"references-count":55,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184735","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,16]]}}}