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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.thefreelibrary.com\/A+review+of+whole+body+hyperthermia+and+the+experience+of+Klinik+St\u2026.-a0206620309\" xlink:type=\"simple\">https:\/\/www.thefreelibrary.com\/A+review+of+whole+body+hyperthermia+and+the+experience+of+Klinik+St\u2026.-a0206620309<\/ext-link>."},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1191\/0267659102pf588oa","article-title":"Whole-body hyperthermia: a review of theory, design and application","volume":"17","author":"RA1 Vertree","year":"2002","journal-title":"Perfusion"},{"issue":"3","key":"ref5","first-page":"487","article-title":"Effect of heating on lethality due to hyperthermia and selected chemotherapeutic drugs","volume":"68","author":"TS Herman","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"ref6","unstructured":"Suvernev AV. An experience of whole body hyperthermia in treatment of oncological pathology. Visceral Tumors. Tomsk. 1995; 97\u201399."},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.clon.2007.03.015","article-title":"Hyperthermia: a potent enhancer of radiotherapy","volume":"19","author":"MR Horsman","year":"2007","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"Suppl 1","key":"ref8","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.ijsu.2008.12.028","article-title":"Microwave tumors ablation: principles, clinical applications and review of preliminary experiences","volume":"6","author":"G Carrafiello","year":"2008","journal-title":"Int J Surg"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/02656730150201561","article-title":"Whole-body hyperthermia with water-filtered infrared radiation: technical-physical aspects and clinical experiences","volume":"17","author":"H Wehner","year":"2001","journal-title":"Int J Hyperthermia"},{"key":"ref10","first-page":"374","article-title":"Hyperthermia combined with chemotherapy\u2014biological rationale, clinical application, and results","volume":"22","author":"R Issels","year":"1999","journal-title":"Onkologie"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/ctrv.2001.0232","article-title":"Rationale and techniques of intra-operative hyperthermic intraperitoneal chemotherapy","volume":"27","author":"AJ Witkamp","year":"2001","journal-title":"Cancer Treat Rev"},{"key":"ref12","unstructured":"Mathe G. From mechanisms of action to relation indications of hyperthermia at 40\u00b0C of 43\u00b0C in cancer treatment. XXIV International Congress on Clinical Hyperthermia. Rome. 2001."},{"key":"ref13","article-title":"Cancer Treatment: A Primer","author":"GF Baronzio","year":"2006"},{"key":"ref14","first-page":"1","article-title":"Quality and comfort in head and neck hyperthermia: A redesign according to clinical experience and simulation studies","author":"Z Rijnen","year":"2015","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13014-015-0503-8","article-title":"Current state of the art of regional hyperthermia treatment planning: a review","volume":"10","author":"HP Kok","year":"2015","journal-title":"Radiat Oncol"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4155\/tde.11.72","article-title":"Nanoparticle-mediated hyperthermia in cancer therapy","volume":"2","author":"DK Chatterjee","year":"2011","journal-title":"Ther Deliv"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.critrevonc.2015.08.003","article-title":"Therapeutic hyperthermia: The old, the new, and the upcoming","volume":"97","author":"M Mallory","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"13","key":"ref18","first-page":"1657","article-title":"Fundamentals of thermochemotherapy of cancer","volume":"33","author":"E Kano","year":"1987","journal-title":"Gan No Rinsho"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal ablation of tumours: biological mechanisms and advances in therapy","volume":"14","author":"F. Chu Katrina","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3109\/02656736.2010.534527","article-title":"Thresholds for thermal damage to normal tissues: an update","volume":"27","author":"PS Yarmolenko","year":"2011","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1620\/tjem.177.39","article-title":"Histological and immunohistochemical changes after transurethral ballon laser hyperthermia in the canine prostate","volume":"177","author":"T Suzuki","year":"1995","journal-title":"Tohoku J Exp Med"},{"issue":"3","key":"ref22","first-page":"184","article-title":"Histological changes in mammalian liver and heart in response to graded hyperthermia","volume":"5","author":"LP Singh","year":"2015","journal-title":"Int j Curr Pharm Clinical Res"},{"issue":"3","key":"ref23","first-page":"271","article-title":"Effects of microwave-induced hypethermia on the anterior segment of healthy rabbit eyes","volume":"227","author":"JG Bollemeijer","year":"1998","journal-title":"Laboratory Investigations"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/bjsm.2006.032540","article-title":"Changes in muscle temperature induced by 434 MHz microwave hyperthermia","volume":"41","author":"N Ichinoseki-Sekine","year":"2007","journal-title":"British Journal of Sports Medicine"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/mrm.24322","article-title":"Irreversible change in T1 temperature dependence with thermal dose using proton resonance frequency-T1 technique","volume":"69","author":"M Diakite","year":"2013","journal-title":"Magn Res Med"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/02656730500271668","article-title":"Re-setting the biologic rationale for thermal therapy","volume":"21","author":"MW Dewhirst","year":"2005","journal-title":"Int J Hyperthermia"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1245\/ASO.2004.03.059","article-title":"Focused Microwave Phased Array Thermotherapy for Ablation of Early-Stage Breast Cancer: Results of Thermal Dose Escalation","volume":"11","author":"Hernan I. Vargas","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S1076-6332(96)80443-0","article-title":"Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size","volume":"3","author":"SN Goldberg","year":"1996","journal-title":"Acad Radiol"},{"issue":"2","key":"ref29","first-page":"165","article-title":"Time-temperature relationships for hyperthermal radiosensitisation in mouse intestine: Influence of thermotolerance. Radiotherapy &amp;","volume":"3","author":"SP Hume","year":"1985","journal-title":"Oncology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1088\/0143-0807\/29\/2\/017","article-title":"The surface-to-volume ratio in thermal physics: from cheese cube physics to animal metabolism","volume":"29","author":"G Planinsic","year":"2008","journal-title":"Eur J Phys"},{"key":"ref31","unstructured":"Winkler R. A Twisted\/Shielded Tale Putting a Lid on Electromagnetic Interference. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.omega.com\/Temperature\/pdf\/Twisted_Shielded_Case.pdf\" xlink:type=\"simple\">https:\/\/www.omega.com\/Temperature\/pdf\/Twisted_Shielded_Case.pdf<\/ext-link>"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/08327823.2000.11688440","article-title":"Modification of a household microwave oven for continuous temperature and weight measurements during drying of foods","volume":"35","author":"Z Okmen","year":"2000","journal-title":"Journal of Microwave Power and Electromagnetic Energy"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/08327823.2002.11688473","article-title":"A combined electromagnetic and heat transfer model for heating of foods in microwave combination ovens","volume":"37","author":"B W\u00e4ppling-Raaholt","year":"2002","journal-title":"Journal of Microwave Power and Electromagnetic Energy"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1365-2621.1991.tb05321.x","article-title":"Feed-back temperature control system for microwave ovens using a shielded thermocouple","volume":"56","author":"H Ramashwamy","year":"1991","journal-title":"J. Food Sci"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1067\/j.cpradiol.2007.08.011","article-title":"Microwave ablation technology: what every user should know","volume":"38","author":"CL Brace","year":"2009","journal-title":"Curr Probl Diagn Radiol"},{"issue":"10","key":"ref36","first-page":"4736s","article-title":"Deep local hyperthermia for cancer therapy: external electromagnetic and ultrasound techniques","volume":"44","author":"AY Cheung","year":"1984","journal-title":"Cancer Res"},{"key":"ref37","article-title":"Physical properties of tissue: A comprehensive reference book","author":"FA Duck","year":"1990"},{"issue":"1","key":"ref38","first-page":"79","article-title":"Pathophysiological alterations induced by sustained 35-GHz radiofrequency energu heating","volume":"27","author":"JR Jauchem","year":"2016","journal-title":"J Basic Physiol Pharmacol"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1001\/archopht.122.10.1510","article-title":"Histological effect and protein expression in subthreshold transpupillary thermotherapy in rabbit eyes","volume":"122","author":"Y Morimura","year":"2004","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/0265673031000119006","article-title":"Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia","volume":"19","author":"MW Dewhirst","year":"2003","journal-title":"Int J Hyperthermia"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3109\/02656736.2015.1068957","article-title":"Design and characterization of miniaturized cavity-backed patch antenna for microwave hyperthermia","volume":"31","author":"G Chakaravarthi","year":"2015","journal-title":"Int J Hyperthermia"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3109\/02656736.2013.803606","article-title":"Thermal distribution of microwave antenna for atrial fibrillation catheter ablation","volume":"29","author":"H Zhang","year":"2013","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/15368378.2014.954289","article-title":"The effects of fat layer on temperature distribution during microwave atrial fibrillation catheter ablation","volume":"35","author":"F Zhai","year":"2016","journal-title":"Electromagn Biol Med"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.medengphy.2015.01.015","article-title":"Optimization of dual slot antenna using floating metallic sleeve for microwave ablation","volume":"37","author":"ZA Ibitoye","year":"2015","journal-title":"Med Eng Phys"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3109\/02656736.2015.1007399","article-title":"Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with carboplatin in the treatment of advanced stage ovarian carcinoma","volume":"31","author":"MA Rettenmaier","year":"2015","journal-title":"Int j Hyperthermia"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3109\/02656736.2015.1052855","article-title":"Accurate 3D temperature deosimetry during hyperthermia therapy by combining invasive measurements and patient specific simulations","volume":"31","author":"RF Verhaart","year":"2015","journal-title":"Int J Hyperthermia"},{"issue":"35","key":"ref47","doi-asserted-by":"crossref","first-page":"57367","DOI":"10.18632\/oncotarget.10350","article-title":"Local hyperthermia in head and neck cancer: mechanism, application and advance","volume":"7","author":"S Gao","year":"2016","journal-title":"Oncotarget"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T17:15:42Z","timestamp":1540228542000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184810"}},"subtitle":[],"editor":[{"given":"Alfred S","family":"Lewin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184810","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}