{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:31:58Z","timestamp":1782754318871,"version":"3.54.5"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0184893","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T17:42:10Z","timestamp":1506015730000},"page":"e0184893","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Twelve years of chiari-like malformation and syringomyelia scanning in Cavalier King Charles Spaniels in the Netherlands: Towards a more precise phenotype"],"prefix":"10.1371","volume":"12","author":[{"given":"Katrien","family":"Wijnrocx","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie W. L.","family":"Van Bruggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieteke","family":"Eggelmeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Noorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Buys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-6673","authenticated-orcid":true,"given":"Paul J. J.","family":"Mandigers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Rusbridge C. Chiari-like malformation and Syringomyelia in the Cavalier King Charles Spaniel. PhD Thesis. University of Utrecht; 2007.","DOI":"10.1111\/j.1532-950X.2007.00285.x"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tvjl.2013.07.014","article-title":"An update on the pathogenesis of syringomyelia secondary to Chiari-like malformations in dogs","volume":"198","author":"CJ Driver","year":"2013","journal-title":"Vet J"},{"issue":"4","key":"ref3","article-title":"Increase in cerebellar volume in Cavalier King Charles Spaniels with Chiari-like malformation and its role in the development of syringomyelia","volume":"7","author":"TA Shaw","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2460\/ajvr.73.1.105","article-title":"Morphometric features of craniocervical junction region in dogs with suspected Chiari-like malformation determined by combined use of magnetic resonance imaging and computed tomography","volume":"73","author":"DJ Marino","year":"2012","journal-title":"Am J Vet Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1746-6148-8-215","article-title":"Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation","volume":"8","author":"CJ Driver","year":"2012","journal-title":"BMC Vet Res"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1748-5827.2009.00799.x","article-title":"Comparison of cerebral cranium volumes between cavalier king charles spaniels with chiari-like malformation, small breed dogs and labradors","volume":"50","author":"HR Cross","year":"2009","journal-title":"J Small Anim Pract"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088120","article-title":"Quantitative analysis of Chiari-like malformation and syringomyelia in the Griffon Bruxellois dog","volume":"9","author":"SP Knowler","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1748-5827.2007.00344.x","article-title":"Syringomyelia in cavalier King Charles spaniels: The relationship between syrinx dimensions and pain","volume":"48","author":"C Rusbridge","year":"2007","journal-title":"J Small Anim Pract"},{"key":"ref9","author":"D Falconer","year":"1996"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3168\/jds.S0022-0302(05)72792-2","article-title":"Selection indices in Holstein cattle of various countries","volume":"88","author":"F Miglior","year":"2005","journal-title":"J Dairy Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1439-0388.2008.00725.x","article-title":"Genetic variation and genetic trends in hip and elbow dysplasia in Swedish Rottweiler and Bernese Mountain Dog","volume":"125","author":"S Malm","year":"2008","journal-title":"J Anim Breed Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.2527\/jas.2007-0166","article-title":"Comparison of estimates of hip dysplasia genetic parameters in Estrela Mountain Dog using linear and threshold models","volume":"85","author":"M Silvestre a","year":"2007","journal-title":"J Anim Sci"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2156-14-16","article-title":"Comparative analyses of genetic trends and prospects for selection against hip and elbow dysplasia in 15 UK dog breeds","volume":"14","author":"T Lewis","year":"2013","journal-title":"BMC Genet"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"e12797","DOI":"10.1371\/journal.pone.0012797","article-title":"Genetic evaluation of hip score in UK Labrador Retrievers","volume":"5","author":"T Lewis","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/jvim.12475","article-title":"Prevalence and Heritability of Symptomatic Syringomyelia in Cavalier King Charles Spaniels and Long-term Outcome in Symptomatic and Asymptomatic Littermates","volume":"29","author":"MS Th\u00f8fner","year":"2015","journal-title":"J Vet Intern Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tvjl.2009.10.022","article-title":"Heritability of syringomyelia in Cavalier King Charles spaniels","volume":"183","author":"T Lewis","year":"2010","journal-title":"Vet J"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10278-004-1014-6","article-title":"OsiriX: An open-source software for navigating in multidimensional DICOM images","volume":"17","author":"A Rosset","year":"2004","journal-title":"J Digit Imaging"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1109\/TAC.1974.1100705","article-title":"A new look at the statistical model identification","volume":"19","author":"H Akaike","year":"1974","journal-title":"IEEE Trans Autom Control"},{"key":"ref19","unstructured":"Misztal I, Tsuruta S, Strabel T, Auvray B, Druet T, Lee DH. BLUPF90 and related programs (BGF90). In: 7th World Congress on Genetics Applied to Livestock Production, Montpelier, 19\u201323 August. Montpellier; 2002."},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/jvim.12421","article-title":"Chiari-Like Malformation and Syringomyelia in American Brussels Griffon Dogs","volume":"28","author":"AC Freeman","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1748-5827.2009.00744.x","article-title":"Chiari-like malformation in the Griffon Bruxellois","volume":"50","author":"C Rusbridge","year":"2009","journal-title":"J Small Anim Pract"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/vr.d1726","article-title":"Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels","volume":"168","author":"JE Parker","year":"2011","journal-title":"Vet Rec"},{"issue":"26","key":"ref23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/vr.100062","article-title":"Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia","volume":"169","author":"SP Knowler","year":"2011","journal-title":"Vet Rec"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/vr.b4886","article-title":"Relationship between pharyngeal conformation and otitis media with effusion in Cavalier King Charles spaniels","volume":"167","author":"GM Hayes","year":"2010","journal-title":"Vet Rec"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1748-5827.2003.tb00151.x","article-title":"Primary secretory otitis media in the Cavalier King Charles spaniel: a review of 61 cases","volume":"44","author":"W Stern-Bertholtz","year":"2003","journal-title":"J Small Anim Pract"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"e0151280","DOI":"10.1371\/journal.pone.0151280","article-title":"Inheritance of Chiari-Like Malformation: Can a Mixed Breeding Reduce the Risk of Syringomyelia?","volume":"11","author":"SP Knowler","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e9410","DOI":"10.1371\/journal.pone.0009410","article-title":"Retrospective analysis for genetic improvement of hip joints of cohort labrador retrievers in the United States: 1970\u20132007","volume":"5","author":"Y Hou","year":"2010","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0962728600002281","article-title":"Optimisation of breeding strategies to reduce the prevalence of inherited disease in pedigree dogs","volume":"19","author":"T Lewis","year":"2010","journal-title":"Anim Welf"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tvjl.2011.06.024","article-title":"Genetic evaluation of elbow scores and the relationship with hip scores in UK Labrador retrievers","volume":"189","author":"T Lewis","year":"2011","journal-title":"Vet J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0184893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T06:30:08Z","timestamp":1693031408000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0184893"}},"subtitle":[],"editor":[{"given":"Claire","family":"Wade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0184893","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}